Doctor of Philosophy

dissertationThe research detailed within this dissertation investigates the neurobiological changes associated with emotional processing of backward masked emotional faces in veterans with and without posttraumatic stress disorder (PTSD). PTSD affects millions of Americans, including approximately 20% of veterans, and is associated with a number of negative symptoms, including hyperarousal, avoidance, and flashbacks. In this dissertation, we examined a group of 15 veterans with PTSD and a group of 12 veterans without PTSD using both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Using fMRI, the blood oxygen level dependent (BOLD) signal of the amygdala and extrastriate cortex was measured, and using EEG, the P1 event-related potential (ERP) was recorded in response to masked affect. The veteran group with PTSD exhibited increased extrastriate BOLD signal but decreased P1 ERP amplitude in the right hemisphere. This was evidence of a right hemisphere specific visuosensory modulation in veterans with PTSD, which is most evident using EEG. Unexpectedly, the P1 ERP and extrastriate BOLD signal did not display a significant linear relationship in either veteran group, which indicates that although activity was measured from similar regions, the two methodologies provided distinct information regarding neuronal activity in this study. In addition, a relationship was observed between the BOLD signal of the amygdala and extrastriate cortex and the degree of combat exposure, based on the Combat Exposure Scale (CES). A veteran group without PTSD displayed a negative correlation between the extent of combat exposure and amygdalar BOLD activity. This was not the case for a veteran group with PTSD, who instead exhibited a negative correlation between the degree of combat exposure and extrastriate BOLD activity. When the total score of the CES was used as a covariate, the veteran group with PTSD displayed significantly increased amygdalar BOLD and extrastriate BOLD activity, compared to the veteran group without PTSD. This research highlights the importance of multimodal research, as differences between the two groups were observed using both methodologies. Our results suggest a relationship between the degree of combat exposure and the processing of masked emotional stimuli, even in veterans without PTSD

Subspace Correction for Constraints

We demonstrate that it is possible to construct operators that stabilize the constraint-satisfying subspaces of computational problems in their Ising representations. We provide an explicit recipe to construct unitaries and associated measurements for some such constraints. The stabilizer measurements allow the detection of constraint violations, and provide a route to recovery back into the constrained subspace. We call this technique ``subspace correction". As an example, we explicitly investigate the stabilizers using the simplest local constraint subspace: Independent Set. We find an algorithm that is guaranteed to produce a perfect uniform or weighted distribution over all constraint-satisfying states when paired with a stopping condition: a quantum analogue of partial rejection sampling. The stopping condition can be modified for sub-graph approximations. We show that it can prepare exact Gibbs distributions on $d-$regular graphs below a critical hardness $\lambda_d^*$ in sub-linear time. Finally, we look at a potential use of subspace correction for fault-tolerant depth-reduction. In particular we investigate how the technique detects and recovers errors induced by Trotterization in preparing maximum independent set using an adiabatic state preparation algorithm.Comment: 12 + 4 pages, 6 figure

A Human BRCA2 Complex Containing a Structural DNA Binding Component Influences Cell Cycle Progression

AbstractGermline mutations of the human BRCA2 gene confer susceptibility to breast cancer. Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations. We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BR CA2-A ssociated F actor 35 (BRAF35). BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain. Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index. Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation. Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression

Food for contagion : synthesis and future directions for studying host-parasite responses to resource shifts in anthropogenic environments

Human-provided resource subsidies for wildlife are diverse, common and have profound consequences for wildlife-pathogen interactions, as demonstrated by papers in this themed issue spanning empirical, theoretical and management perspectives from a range of study systems. Contributions cut across scales of organization, from the within-host dynamics of immune function, to population-level impacts on parasite transmission, to landscape-and regional-scale patterns of infection. In this concluding paper, we identify common threads and key findings from author contributions, including the consequences of resource subsidies for (i) host immunity; (ii) animal aggregation and contact rates; (iii) host movement and landscape-level infection patterns; and (iv) interspecific contacts and cross-species transmission. Exciting avenues for future work include studies that integrate mechanistic modelling and empirical approaches to better explore cross-scale processes, and experimental manipulations of food resources to quantify host and pathogen responses. Work is also needed to examine evolutionary responses to provisioning, and ask how diet-altered changes to the host microbiome influence infection processes. Given the massive public health and conservation implications of anthropogenic resource shifts, we end by underscoring the need for practical recommendations to manage supplemental feeding practices, limit human-wildlife conflicts over shared food resources and reduce cross-species transmission risks, including to humans. This article is part of the theme issue 'Anthropogenic resource subsidies and host-parasite dynamics in wildlife'.Peer reviewe

Naming Names: The Impact of Supreme Court Opinion Attribution on Citizen Assessment of Policy Outcomes

The manner in which political institutions convey their policy outcomes can have important implications for how the public views institutions\u27 policy decisions. This paper explores whether the way in which the U.S. Supreme Court communicates its policy decrees affects how favorably members of the public assess its decisions. Specifically, we investigate whether attributing a decision to the nation\u27s High Court or to an individual justice influences the public\u27s agreement with the Court\u27s rulings. Using an experimental design, we find that when a Supreme Court outcome is ascribed to the institution as a whole, rather than to a particular justice, people are more apt to agree with the policy decision. We also find that identifying the gender of the opinion author affects public agreement under certain conditions. Our findings have important implications for how public support for institutional policymaking operates, as well as the dynamics of how the Supreme Court manages to accumulate and maintain public goodwill

Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: a case study of bats

The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from people to naïve wildlife and other animal populations. The establishment of new wildlife reservoirs for SARS-CoV-2 would further complicate public health control measures and could lead to wildlife health and conservation impacts. Given the likely bat origin of SARS-CoV-2 and related beta-coronaviruses (β-CoVs), free-ranging bats are a key group of concern for spillover from humans back to wildlife. Here, we review the diversity and natural host range of β-CoVs in bats and examine the risk of humans inadvertently infecting free-ranging bats with SARS-CoV-2. Our review of the global distribution and host range of β-CoV evolutionary lineages suggests that 40+ species of temperate-zone North American bats could be immunologically naïve and susceptible to infection by SARS-CoV-2. We highlight an urgent need to proactively connect the wellbeing of human and wildlife health during the current pandemic and to implement new tools to continue wildlife research while avoiding potentially severe health and conservation impacts of SARS-CoV-2 "spilling back" into free-ranging bat populations

Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: a case study of bats

The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from people to naïve wildlife and other animal populations. The establishment of new wildlife reservoirs for SARS-CoV-2 would further complicate public health control measures and could lead to wildlife health and conservation impacts. Given the likely bat origin of SARS-CoV-2 and related beta-coronaviruses (β-CoVs), free-ranging bats are a key group of concern for spillover from humans back to wildlife. Here, we review the diversity and natural host range of β-CoVs in bats and examine the risk of humans inadvertently infecting free-ranging bats with SARS-CoV-2. Our review of the global distribution and host range of β-CoV evolutionary lineages suggests that 40+ species of temperate-zone North American bats could be immunologically naïve and susceptible to infection by SARS-CoV-2. We highlight an urgent need to proactively connect the wellbeing of human and wildlife health during the current pandemic and to implement new tools to continue wildlife research while avoiding potentially severe health and conservation impacts of SARS-CoV-2 "spilling back" into free-ranging bat populations

The Coevolution of Finance and Property Rights: Evidence from Transition Economies

The transition from communism to capitalism was necessarily accompanied by a sudden and abrupt increase in the financialization of society. This increase occurred in an environment that, even now, still has little experience with or expertise in financialization. Given that financialization occurred simultaneously with the growth and evolution of other political and economic institutions, the question arises: What was the effect on these other nascent institutions like property rights? This article empirically analyzes the relationship between financialization and property rights in transition countries. Using a unique monthly database of twenty transition countries over a period from 1989 to 2012, this article finds that the influence of financialization depends on which definition of “financialization” is used. In particular, increases in basic financial intermediation improved property rights. However, higher-order “financialization,” proxied here by the size of capital markets and the wages in the financial sector, appeared to have a negative impact on the development of broad-based property rights in transition