Linear s/n summer noise power density test results, appendix c final report

Noise power spectral density test of linear signal nois

Locked oscillator phase modulator, appendix d final report

Design parameters for linear phase modulation of locked oscillato

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus

Funding: This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001220), the UK Medical Research Council (FC001220), and the Wellcome Trust (FC001200). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are indebted to The Francis Crick Institute Flow Cytometry facility, and in particular Bhavik Patel, Graham Preece, Wayne Turnbull and Phil Hobson. We would also like to thank The Francis Crick Institute Procedural Service Section for production of GA lines and Biological Services, especially Trisha Norton, Keith Williams and Adebambo Adekoya for animal husbandry and technical support; to Riccardo Guidi for constructive discussions and technical assistance. We would like to thank Gitta Stockinger and AhR Immunity Laboratory for providing technical support and reagents throughout this study. We also thank Richard Rance and the Wellcome Trust Sanger Institute’s 454 pyrosequencing team for generating 16S rRNA gene data.Peer reviewedPublisher PD

Relational conceptions of paternalism : a way to rebut nanny-state accusations and evaluate public health interventions

This work is funded by NHMRC grant 1023197. Stacy Carter is funded by an NHMRC Career Development Fellowship 1032963. Acknowledgements An early version of this work was presented at a workshop on paternalism held on Friday 8 November 2013 at the Centre for Agency, Values and Ethics at Macquarie University. We thank participants in that workshop for their helpful comments. Thanks also to Prof Catriona Mackenzie for her helpful comments on an earlier draft of this manuscript and to Prof Paul Benson for providing us with an early version of his work on stereotype threat.Peer reviewedPostprintPostprin

Doctors\u27 perspectives on PSA testing illuminate established differences in prostate cancer screening rates between Australia and the UK: A qualitative study

Objectives: To examine how general practitioners (GPs) in the UK and GPs in Australia explain their prostate-specific antigen (PSA) testing practices and to illuminate how these explanations are similar and how they are different. Design: A grounded theory study. Setting: Primary care practices in Australia and the UK. Participants: 69 GPs in Australia (n=40) and the UK (n=29). We included GPs of varying ages, sex, clinical experience and patient populations. All GPs interested in participating in the study were included. Results: GPs’ accounts revealed fundamental differences in whether and how prostate cancer screening occurred in their practice and in the broader context within which they operate. The history of prostate screening policy, organisational structures and funding models appeared to drive more prostate screening in Australia and less in the UK. In Australia, screening processes and decisions were mostly at the discretion of individual clinicians, and varied considerably, whereas the accounts of UK GPs clearly reflected a consistent, organisationally embedded approach based on local evidence-based recommendations to discourage screening. Conclusions: The GP accounts suggested that healthcare systems, including historical and current organisational and funding structures and rules, collectively contribute to how and why clinicians use the PSA test and play a significant role in creating the mindlines that GPs employ in their clinic. Australia’s recently released consensus guidelines may support more streamlined and consistent care. However, if GP mindlines and thus routine practice in Australia are to shift, to ultimately reduce unnecessary or harmful prostate screening, it is likely that other important drivers at all levels of the screening process will need to be addressed

The spur planetary gear torsional stiffness and its crack sensitivity under quasi-static conditions

The sun-planet and ring-planet tooth mesh stiffness variations and the resulting transmission errors are the main internal vibration generation mechanisms for planetary gear systems. This paper presents the results of torsional stiffness analysis of involute spur planetary gear systems in mesh using finite element methods. A planetary gear model with three planet gears and fixed ring gear and its subsystem models have been developed to study the subsystem and overall torsional stiffnesses. Based on the analysis of torsional mesh stiffness, predictive models for single branch sun-planet-ring and overall planetary gear torsional stiffnesses have been proposed. A crack coefficient was introduced to the sun-planet and ring-planet meshes to predict the effect and sensitivity of changes to the overall torsional mesh stiffness. The resulting mesh stiffness crack sensitivity of the overall gear system was analysed under quasi-static conditions. It was found that the carrier arm stiffness has great influence on the crack sensitivity while the overall stiffness was most sensitive to the crack on the sun-planet mesh

Long-term flood controls on semi-arid river form: evidence from the Sabie and Olifants rivers, eastern South Africa

Rivers in the Kruger National Park, eastern South Africa, are characterised by bedrock-influenced ‘macrochannels’ containing variable alluvial thicknesses and riparian vegetation assemblages. Evidence from the Sabie and Olifants rivers suggests that flows up to moderate floods (<3500 m3 s-1) tend to result in net alluviation, with sediments gradually covering the underlying bedrock. More extreme floods strip alluvium and erode bedrock, effectively exerting the primary control over long-term river morphologic development. On the Olifants River, post-flood aerial LIDAR imagery reveals that the 2012 extreme flood (~14000 m3 s-1) resulted in extensive stripping of stored alluvial sediment, exposing and eroding the underlying weathered bedrock. On the Sabie River, preliminary optically stimulated luminescence ages for remnant alluvium are all less than 1000 years, highlighting typical timescales of sediment storage. Together, these results suggest that while periods of general alluviation occur on these systems, long-term river development results from extreme flood-generated bedrock erosion

Supporting the learning of deaf students in higher education: a case study at Sheffield Hallam University

This article is an examination of the issues surrounding support for the learning of deaf students in higher education (HE). There are an increasing number of deaf students attending HE institutes, and as such provision of support mechanisms for these students is not only necessary but essential. Deaf students are similar to their hearing peers, in that they will approach their learning and require differing levels of support dependant upon the individual. They will, however, require a different kind of support, which can be technical or human resource based. This article examines the issues that surround supporting deaf students in HE with use of a case study of provision at Sheffield Hallam University (SHU), during the academic year 1994-95. It is evident that by considering the needs of deaf students and making changes to our teaching practices that all students can benefit

Perspectives on environment and human health:an editorial

Human health and wellbeing are intimately linked to the state of the environment [...]</jats:p