Novità per il servizio GARR MIRROR 2004

L’anno 2004 segnerà il rinnovamento architetturale e il potenziamento del servizio GARR MIRROR e WEBCACHE, in coincidenza con la nascita dei nuovi POP GARR finalmente fuori dalle sedi Telecom. Secondo il parere del Comitato Tecnico GARR il mantenimento della gerarchia nazionale di cache web non ha più una grande rilevanza, tenuto conto dell’ampliamento di banda globale dell’infrastruttura GARR e dei limiti delle attuali macchine per il cache nazionale, mentre continua ad avere una notevole importanza per la comunità il mantenimento e potenziamento del servizio di ftp-mirroring. In questo articolo verranno illustrate le caratteristiche di tale innovazione architetturale

Efficient optical pumping of Zeeman spin levels in Nd3+:YVO4

We demonstrate that Zeeman ground-state spin levels in Nd3+:YVO4 provides the possibility to create an efficient lambda-system for optical pumping experiments. The branching ratio R in the lambda-system is measured experimentally via absorption spectroscopy and is compared to a theoretical model. We show that R can be tuned by changing the orientation of the magnetic field. These results are applied to optical pumping experiments, where significant improvement is obtained compared to previous experiments in this system. The tunability of the branching ratio in combination with its good coherence properties and the high oscillator strength makes Nd3+:YVO4 an interesting candidate for various quantum information protocols.Comment: 8 pages, 6 figure

Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?

<p>Abstract</p> <p>Background</p> <p>Premature ovarian failure (POF) is a secondary hypergonadotrophic amenorrhea occurring before the age of 40 and affecting 1-3% of females. Chromosome anomalies account for 6-8% of POF cases, but only few cases are associated with translocations involving X and Y chromosomes.</p> <p>This study shows the cytogenetic and molecular analysis of a POF patient came to our attention as she developed a left ovary choriocarcinoma at the age of 10 and at 14 years of age she presented secondary amenorrhea with elevated levels of gonadotropins.</p> <p>Results</p> <p>Breakpoint position on X and Y chromosomes was investigated using Fluorescent In Situ Hybridisation (FISH) with a panel of specific BAC probes, microsatellite analysis and evaluation of copy number changes and loss of heterozigosity by Affymetrix^®GeneChip platform (Santa Clara, CA, USA). Patient's karyotype resulted 46, X, der(Y)t(X;Y)(q13.1;q11.223). X inactivation study was assessed by RBA banding and showed preferential inactivation of derivative chromosome. The reciprocal spatial disposition of sexual chromosome territories was investigated using whole chromosome painting and centromeres probes: patient's results didn't show a significant difference in comparison to normal controls.</p> <p>Conclusion</p> <p>The peculiar clinical case come to our attention highlighted the complexity of POF aetiology and of the translocation event, even if our results seem to exclude any effect on nuclear organisation. POF phenotype could be partially explained by skewed X chromosome inactivation that influences gene expression.</p

Riflessioni sulla viabilit\ue0 forestale e opere connesse a supporto delle iniziative per la predisposizione dei decreti attuativi del Testo Unico in materia di Foreste e Filiere Forestali

The forest road network provides access to the forest area to facilitate the conservation, the management and the value of forest ecosystems. In the case of poor design as well as poor or absent maintenance, the forest road network can cause significant environmental impacts, which can result in erosion and sedimentation, landslides, effects on flora and fauna and landscape impacts. In order to avoid such impacts, the road network must be planned, built and maintained in a correct and adequate way according to the environment in which the same roads are inserted. As consequence, the present paper would like to propose some considerations about forest road functions, definitions as well as in term of standard design and planning to support the implementation of the operative guidelines of the recent consolidate law on forestry

Efficient 1400-1600 nm Circularly Polarized Luminescence from a Tuned Chiral Erbium Complex

Novel chiral Er complexes based on both enantiomers of extended (i)PrPyBox (2,6-Bis[4-isopropyl-4,5-dihydrooxazol-2-yl)]pyridine) show strong near-infrared circularly polarized luminescence (CPL) within the 1400 to 1600 nm spectral region under 450 nm irradiation. CPL activity in this region, despite being particularly rare, would open the way to potential applications in the domain, e.g., of fiber-optic telecommunications and free-space long-distance optical communications employing circularly polarized light. Moreover, the long wavelength excitation is advantageous for applications in the field of (circularly polarized) microscopy and bioimaging

Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes

In this contribution, we present the spectroscopic study of two NIR emitting hydrophobic heteroleptic (R,R)-YbL1(tta) and (R,R)-NdL1(tta) complexes (with tta = 2-thenoyltrifluoroacetonate and L1 = N,N0 -bis(2-(8-hydroxyquinolinate)methylidene)-1,2-(R,R or S,S)-cyclohexanediamine), both in methanol solution and embedded in water dispersible and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles. Thanks to their absorption properties in a wide range of wavelengths extending from the UV up to the blue and green visible regions, the emission of these complexes can be effectively sensitized using visible radiation, which is much less harmful to tissues and skin than the UV one. The encapsulation of the two Ln(III)-based complexes in PLGA allows us to preserve their nature, making them stable in water and to test their cytotoxicity on two different cell lines, with the aim of using them in the future as potential bioimaging optical probes

Sustainability of using vineyard pruning residues as an energy source: Combustion performances and environmental impact

Open burning of agricultural waste is still a common practice as it is a rapid method for waste disposal, although natural biomass, including agriculture residues, can be exploited as a renewable energy source. We assessed the viability and sustainability of using vineyard pruning residues, as wood chips, for energy conversion. Wood chips, obtained from vineyards in the Prosecco DOCG region (Italy), were characterized in terms of chemical composition, calorific value, ash content and humidity. Combustion tests were performed in a medium-size biomass boiler (maximum power 500 kW) to assess the viability of the approach in terms of sustainable steady-state combustion. Primary emissions of both macro- and micro-pollutants were measured to assess the environmental impact. An analytical method was purposely developed for the determination of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and in three matrices: fly ashes, condensate and gas. The results showed that vineyard pruning residues can be used for energy conversion in medium- and large-scale biomass boilers. Primary emissions of measured pollutants were all below limit values set by current European legislation except for particulate matter, for which current available abatement technologies are required to contain emissions, abatement technologies are required to contain emissions, thus making the use of vineyard pruning residues unsuitable for combustion in domestic appliances where such technologies are not installed. Bottom ashes produced during combustion were also characterized to assess whether they can be recycled in the vineyard as soil amendments/fertilizer. Copper content in combustion ashes exceeded limit values for ashes to be used as fertilizers in agricultural fields for some European countries but not for others, indicating that ashes may need to be disposed as waste

TSH Receptor and Thyroid-Specific Gene Expression in Human Skin

Experimental evidence suggests that in autoimmune thyroid diseases (AITDs) the skin is a target of autoantibodies against thyroid-specific antigens; however, the role of these autoantibodies in skin alterations remains unclear. To gain insight into the function of nominally thyroid-specific genes in skin, we analyzed the expression of thyroid-stimulating hormone–receptor (TSH-R), thyroglobulin (Tg), sodium iodide symporter (NIS), and thyroperoxidase (TPO) genes in normal human skin biopsies and cultured primary keratinocytes and dermal fibroblasts. The results revealed the presence of all the transcripts in skin biopsies. However, in keratinocytes and fibroblasts, only TSH-R messenger RNA was always detected. Western blot and immunohistochemical analyses of skin specimens confirmed the presence of TSH-R protein in keratinocytes and fibroblasts. Moreover, TSH treatment induced the proliferation of cultured keratinocytes and fibroblasts and increased keratinocyte intracellular cAMP. Finally, affinity-purified IgGs from serum of patients affected by Graves’ disease, but not by chronic lymphocytic thyroiditis, stimulated cAMP accumulation in cultured keratinocytes, as well as their proliferation. In conclusion, the expression of thyroid-specific genes in cultured keratinocytes and fibroblasts and the mitogenic effects of TSH and IgGs on these cells support the concept that autoantibodies against thyroid-specific antigens may contribute to cutaneous symptoms in AITDs.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://network.nature.com/group/jidclu

Near Infared Circularly Polarized Luminescence from water stable organic nanoparticles containing a chiral Yb(III) complex

We report the first example of very efficient NIR Circularly Polarized Luminescence (CPL) (around 970 nm) in water, obtained thanks to the combined use of a chiral Yb complex and of poly lactic-co-glycolic acid (PLGA) nanoparticles. [Yb L (tta) 2 ]CH 3 COO ( L = N, N'-bis(2-pyridylmethylidene)-1,2-( R,R + S,S ) cyclohexanediamine and tta = 2-thenoyltrifluoroacetonate) shows good CPL in organic solvents, because the tta ligands efficiently sensitize Yb NIR luminescence and the readily prepared chiral ligand L endows the complex with the necessary dissymmetry. PLGA nanoparticles incorporate the complex and protect the metal ion from the intrusion of solvent molecules, while ensuring biocompatibility, water solubility and stability to the complex. Hydrophilic NIR-CPL optical probes can find applications in the field of NIR-CPL bio-assays

Nanophotonic rare-earth quantum memory with optically controlled retrieval

Optical quantum memories are essential elements in quantum networks for long distance distribution of quantum entanglement. Scalable development of quantum network nodes requires on-chip qubit storage functionality with control of its readout time. We demonstrate a high-fidelity nanophotonic quantum memory based on a mesoscopic neodymium ensemble coupled to a photonic crystal cavity. The nanocavity enables >95% spin polarization for efficient initialization of the atomic frequency comb memory, and time-bin-selective readout via enhanced optical Stark shift of the comb frequencies. Our solid-state memory is integrable with other chip-scale photon source and detector devices for multiplexed quantum and classical information processing at the network nodes