Recent advances in biologically active coumarins from marine sources: Synthesis and evaluation

Producción CientíficaCoumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological, and in particular, pharmacological properties. Interesting families of coumarins have been found from marine sources, which has accelerated the drug discovery process by inspiring innovation or even by the identification of analogues with remarkable biological properties. The purpose of this review is to showcase the most interesting marine-derived coumarins from a medicinal chemistry point of view, as well as the novel and useful synthetic routes described to date to achieve these chemical structures. The references that compose this overview were collected from PubMed, Mendeley and SciFinder.Junta de Castilla y León - (grant VA294-P18)Ministerio de Ciencia e Innovación - (PID2020-116076RJI00/AEI/10.13039/501100011033

An efficient cloud scheduler design supporting preemptible instances

Maximizing resource utilization by performing an efficient resource provisioning is a key factor for any cloud provider: commercial actors can maximize their revenues, whereas scientific and non-commercial providers can maximize their infrastructure utilization. Traditionally, batch systems have allowed data centers to fill their resources as much as possible by using backfilling and similar techniques. However, in an IaaS cloud, where virtual machines are supposed to live indefinitely, or at least as long as the user is able to pay for them, these policies are not easily implementable. In this work we present a new scheduling algorithm for IaaS providers that is able to support preemptible instances, that can be stopped by higher priority requests without introducing large modifications in the current cloud schedulers. This scheduler enables the implementation of new cloud usage and payment models that allow more efficient usage of the resources and potential new revenue sources for commercial providers. We also study the correctness and the performace overhead of the proposed scheduler agains existing solutions

ooi: OpenStack OCCI interface

In this document we present an implementation of the Open Grid Forum’s Open Cloud Computing Interface (OCCI) for OpenStack, namely ooi (Openstack occi interface, 2015). OCCI is an open standard for management tasks over cloud resources, focused on interoperability, portability and integration. ooi aims to implement this open interface for the OpenStack cloud middleware, promoting interoperability with other OCCI-enabled cloud management frameworks and infrastructures. ooi focuses on being non-invasive with a vanilla OpenStack installation, not tied to a particular OpenStack release version