Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.

BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement. We evaluated the use of a point-of-care (POC) diagnostic device for blood lactate measurement to assess the severity of illness in children admitted to a district hospital in Tanzania. METHODS: Children between the ages of 2 months and 13 years with a history of fever were enrolled in the study during a period of 1 year. A full clinical history and examination were undertaken, and blood was collected for culture, microscopy, complete blood cell count, and POC measurement of blood lactate and glucose. RESULTS: The study included 3248 children, of whom 164 (5.0%) died; 45 (27.4%) of these had raised levels of blood lactate (>5 mmol/L) but no deep breathing. Compared with mortality in children with lactate levels of ≤ 3 mmol/L, the unadjusted odds of dying were 1.6 (95% confidence interval [CI].8-3.0), 3.4 (95% CI, 1.5-7.5), and 8.9 (95% CI, 4.7-16.8) in children with blood lactate levels of 3.1-5.0, 5.1-8.0, or >8.0 mmol/L, respectively. The prevalence of raised lactate levels (>5 mmol/L) was greater in children with malaria than in children with nonmalarial febrile illness (P < .001) although the associated mortality was greater in slide-negative children. CONCLUSIONS: POC lactate measurement can contribute to the assessment of children admitted to hospital with febrile illness and can also create an opportunity for more hospitals in resource-poor settings to participate in clinical trials of interventions to reduce mortality associated with hyperlactatemia

Rings and Jets around PSR J2021+3651: the `Dragonfly Nebula'

We describe recent Chandra ACIS observations of the Vela-like pulsar PSR J2021+3651 and its pulsar wind nebula (PWN). This `Dragonfly Nebula' displays an axisymmetric morphology, with bright inner jets, a double-ridged inner nebula, and a ~30" polar jet. The PWN is embedded in faint diffuse emission: a bow shock-like structure with standoff ~1' brackets the pulsar to the east and emission trails off westward for 3-4'. Thermal (kT=0.16 +/-0.02 keV) and power law emission are detected from the pulsar. The nebular X-rays show spectral steepening from Gamma=1.5 in the equatorial torus to Gamma=1.9 in the outer nebula, suggesting synchrotron burn-off. A fit to the `Dragonfly' structure suggests a large (86 +/-1 degree) inclination with a double equatorial torus. Vela is currently the only other PWN showing such double structure. The >12 kpc distance implied by the pulsar dispersion measure is not supported by the X-ray data; spectral, scale and efficiency arguments suggest a more modest 3-4 kpc.Comment: 22 pages, 5 figures, 3 tables, Accepted to Ap

Business Communication Students Appraisal Of Selected Communication Competencies

The purpose of this study was to determine business communication students perception of selected business communication competencies. Students enrolled in business communication classes at Texas A&amp;M University-Commerce from the summer of 2006 until the spring 2007 were survey. Students were asked to evaluate each of the listed 44 competencies. The two competencies that ranked the highest were Spells Correctly, and Understands the Importance of Business Relationships

Ultra-low noise microwave generation with fiber-based optical frequency comb and application to atomic fountain clock

We demonstrate the use of a fiber-based femtosecond laser locked onto an ultra-stable optical cavity to generate a low-noise microwave reference signal. Comparison with both a liquid Helium cryogenic sapphire oscillator (CSO) and a Ti:Sapphire-based optical frequency comb system exhibit a stability about $3\times10^{-15}$ between 1 s and 10 s. The microwave signal from the fiber system is used to perform Ramsey spectroscopy in a state-of-the-art Cesium fountain clock. The resulting clock system is compared to the CSO and exhibits a stability of $3.5\times10^{-14}\tau^{-1/2}$. Our continuously operated fiber-based system therefore demonstrates its potential to replace the CSO for atomic clocks with high stability in both the optical and microwave domain, most particularly for operational primary frequency standards.Comment: 3 pages, 3 figure

Metrological characterization of the pulsed Rb clock with optical detection

We report on the implementation and the metrological characterization of a vapor-cell Rb frequency standard working in pulsed regime. The three main parts that compose the clock, physics package, optics and electronics, are described in detail in the paper. The prototype is designed and optimized to detect the clock transition in the optical domain. Specifically, the reference atomic transition, excited with a Ramsey scheme, is detected by observing the interference pattern on a laser absorption signal. \ The metrological analysis includes the observation and characterization of the clock signal and the measurement of frequency stability and drift. In terms of Allan deviation, the measured frequency stability results as low as $1.7\times 10^{-13} \ \tau^{-1/2}$, $\tau$ being the averaging time, and reaches the value of few units of $10^{-15}$ for $\tau=10^{4}$ s, an unprecedent achievement for a vapor cell clock. We discuss in the paper the physical effects leading to this result with particular care to laser and microwave noises transferred to the clock signal. The frequency drift, probably related to the temperature, stays below $10^{-14}$ per day, and no evidence of flicker floor is observed. \ We also mention some possible improvements that in principle would lead to a clock stability below the $10^{-13}$ level at 1 s and to a drift of few units of $10^{-15}$ per day

Ultrastable lasers based on vibration insensitive cavities

We present two ultra-stable lasers based on two vibration insensitive cavity designs, one with vertical optical axis geometry, the other horizontal. Ultra-stable cavities are constructed with fused silica mirror substrates, shown to decrease the thermal noise limit, in order to improve the frequency stability over previous designs. Vibration sensitivity components measured are equal to or better than 1.5e-11 per m.s^-2 for each spatial direction, which shows significant improvement over previous studies. We have tested the very low dependence on the position of the cavity support points, in order to establish that our designs eliminate the need for fine tuning to achieve extremely low vibration sensitivity. Relative frequency measurements show that at least one of the stabilized lasers has a stability better than 5.6e-16 at 1 second, which is the best result obtained for this length of cavity.Comment: 8 pages 12 figure

High Latitude Radio Emission in a Sample of Edge-On Spiral Galaxies

We have mapped 16 edge-on galaxies at 20 cm using the VLA. For 5 galaxies, we could form spectral index, energy and magnetic field maps. We find that all but one galaxy show evidence for non-thermal high latitude radio continuum emission, suggesting that cosmic ray halos are common in star forming galaxies. The high latitude emission is seen over a variety of spatial scales and in discrete and/or smooth features. In general, the discrete features emanate from the disk, but estimates of CR diffusion lengths suggest that diffusion alone is insufficient to transport the particles to the high latitudes seen (> 15 kpc in one case). Thus CRs likely diffuse through low density regions and/or are assisted by other mechanisms (e.g. winds). We searched for correlations between the prevalence of high latitude radio emission and a number of other properties, including the global SFR, supernova input rate per unit star forming, and do not find clear correlations with any of these properties.Comment: 40 pages of text, 3 figures, 6 tables, and an appendix of 21 jpeg figures (which is a radio continuum catalogue of 17 galaxies). to appear in A. J. (around January 1999

The association between dietary patterns and the novel inflammatory markers platelet-activating factor and lipoprotein-associated phospholipase A2: a systematic review

CONTEXT: Atherosclerosis is a disease of chronic inflammation. Recent research has identified 2 novel inflammatory biomarkers: platelet-activating factor (PAF) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)). Diet has been proposed as a mediator of inflammation, but to date, the focus for these novel biomarkers has been on individual foods and nutrients rather than overall dietary patterns. OBJECTIVE: To systematically review the literature on the association between dietary patterns and PAF and Lp-PLA(2). DATA SOURCES: The PubMed, Embase, CINAHL, and Cochrane CENTRAL literature databases were searched. DATA ANALYSIS: Study quality was evaluated using the Quality Criteria Checklist. Sixteen studies (n = 4 observational and n = 12 interventional) were included and assessed for associations between dietary patterns and PAF and Lp-PLA(2). CONCLUSION: Study quality varied from neutral (n = 10) to positive (n = 6). Mediterranean, heart healthy, and vegetarian dietary patterns were associated with improved levels of PAF and Lp-PLA(2). Conversely, Western dietary patterns were less favorable. A range of well-established, healthier dietary patterns may lower inflammation and the risk of atherosclerosis. More well-designed studies are needed to confirm these findings and identify other dietary patterns that improve inflammation

Mineral Acquisition from Clay by Budongo Forest Chimpanzees

Chimpanzees of the Sonso community, Budongo Forest, Uganda were observed eating clay and drinking clay-water from waterholes. We show that clay, clay-rich water, and clay obtained with leaf sponges, provide a range of minerals in different concentrations. The presence of aluminium in the clay consumed indicates that it takes the form of kaolinite. We discuss the contribution of clay geophagy to the mineral intake of the Sonso chimpanzees and show that clay eaten using leaf sponges is particularly rich in minerals. We show that termite mound soil, also regularly consumed, is rich in minerals. We discuss the frequency of clay and termite soil geophagy in the context of the disappearance from Budongo Forest of a formerly rich source of minerals, the decaying pith of Raphia farinifera palms