Qualitative evaluation of a preventive intervention for the offspring of parents with a history of depression

Background: Meta-analyses of randomised controlled trials suggest that psychological interventions to reduce children’s risk of depression are effective. Nevertheless, these effects are modest and diminish over time. The Medical Research Council recommends a mixed-methods approach to the evaluation of complex interventions. By gaining a more thorough understanding of participants’ perspectives, qualitative evaluations of preventive interventions could improve their efficacy, longevity and transfer into clinical practice. Methods: 18 parents and 22 children who had received a 12-session family- and group-based cognitivebehavioural intervention to prevent youth depression as part of a randomised controlled trial took part in semistructured interviews or a focus group about aspects which had been perceived as helpful, elements they were still using after the intervention had ended, and suggestions they had for improving the intervention. Results: The chance to openly share and discuss their experiences of depression within and between families was considered helpful by both children and parents. Children benefitted the most from learning coping strategies for dealing with stress and many still used them in everyday life. Parents profited mostly from increasing positive family time, but noted that maintaining new routines after the end of the intervention proved difficult. Participants were generally content with the intervention but commented on how tiring and time consuming it was. Conclusions: Managing parents’ expectations of family-based interventions in terms of their own mental health needs (versus those of their children) and leaving more room for open discussions may result in interventions which are more appealing to participating families. Increasing intervals between sessions may be one means of improving the longevity of interventions. Trial registration: The original RCT this evaluation is a part of was registered under NCT02115880

On the discovery of doubly-magic 48^{48}Ni

The paper reports on the first observation of doubly-magic Nickel-48 in an experimental at the SISSI/LISE3 facility of GANIL. Four Nickel-48 isotopes were identified. In addition, roughly 100 Nickel-49, 50 Iron-45, and 290 Chromium-42 isotopes were observed. This opens the possibility to search for two-proton emission from these nuclei.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev. Let

The Most Likely Sources of High Energy Cosmic-Ray Electrons in Supernova Remnants

Evidences of non-thermal X-ray emission and TeV gamma-rays from the supernova remnants (SNRs) has strengthened the hypothesis that primary Galactic cosmic-ray electrons are accelerated in SNRs. High energy electrons lose energy via synchrotron and inverse Compton processes during propagation in the Galaxy. Due to these radiative losses, TeV electrons liberated from SNRs at distances larger than ~1 kpc, or times older than ~10^5 yr, cannot reach the solar system. We investigated the cosmic-ray electron spectrum observed in the solar system using an analytical method, and considered several candidate sources among nearby SNRs which may contribute to the high energy electron flux. Especially, we discuss the effects for the release time from SNRs after the explosion, as well as the deviation of a source spectrum from a simple power-law. From this calculation, we found that some nearby sources such as the Vela, Cygnus Loop, or Monogem could leave unique signatures in the form of identifiable structure in the energy spectrum of TeV electrons and show anisotropies towards the sources, depending on when the electrons are liberated from the remnant. This suggests that, in addition to providing information on the mechanisms of acceleration and propagation of cosmic-rays, specific cosmic-ray sources can be identified through the precise electron observation in the TeV region.Comment: 32 pages, 6 figures, submitted to Ap

Social preferences, accountability, and wage bargaining

We assess the extent of preferences for employment in a collective wage bargaining situation with heterogeneous workers. We vary the size of the union and introduce a treatment mechanism transforming the voting game into an individual allocation task. Our results show that highly productive workers do not take employment of low productive workers into account when making wage proposals, regardless of whether insiders determine the wage or all workers. The level of pro-social preferences is small in the voting game, while it increases as the game is transformed into an individual allocation task. We interpret this as an accountability effect

Galactic Cosmic Rays from Supernova Remnants: II Shock Acceleration of Gas and Dust

This is the second paper (the first was astro-ph/9704267) of a series analysing the Galactic Cosmic Ray (GCR) composition and origin. In this we present a quantitative model of GCR origin and acceleration based on the acceleration of a mixture of interstellar and/or circumstellar gas and dust by supernova remnant blast waves. We present results from a nonlinear shock model which includes (i) the direct acceleration of interstellar gas-phase ions, (ii) a simplified model for the direct acceleration of weakly charged dust grains to energies of order 100keV/amu simultaneously with the gas ions, (iii) frictional energy losses of the grains colliding with the gas, (iv) sputtering of ions of refractory elements from the accelerated grains and (v) the further shock acceleration of the sputtered ions to cosmic ray energies. The calculated GCR composition and spectra are in good agreement with observations.Comment: to appear in ApJ, 51 pages, LaTeX with AAS macros, 9 postscript figures, also available from ftp://wonka.physics.ncsu.edu/pub/elliso

Spallation of Iron in Black Hole Accretion Flows

In the local Galactic interstellar medium there is approximate energy equipartition between cosmic rays, magnetic fields and radiation. If this holds in the central regions of AGN, in particular Seyfert galaxies, then consideral nuclear spallation of Fe occurs, resulting in enhanced abundances of the sub-Fe elements Ti, V, Cr and Mn. These elements produce a cluster of X-ray flourescence lines at energies just below the 6.4 keV Fe-K$\alpha$ line. It is suggested that the red wings on the Fe lines observed with ASCA from various Seyfert AGN are due to the unresolved line emission from these elements. Future observations with more sensitive X-ray instruments should resolve these lines. The estimated gamma ray emission from nuclear deexcitation and neutral pion production is calculated and found to be below the sensitivities of any current instruments. However, very luminous nearby Seyferts displaying Fe lines with red wings would have $>100$ MeV continuum emission detectable by future instruments such as GLAST.Comment: 11 pages, Latex, requires AASTEX macros, 5 postscript figures, Astrophysical Journal in pres

The role of RIPK1 mediated cell death in acute on chronic liver failure

Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated mixed lineage kinase domain-like (pMLKL) are key components. This study was performed to determine the role of RIPK1 mediated cell death in ACLF. RIPK3 plasma levels and hepatic expression of RIPK1, RIPK3, and pMLKL were measured in healthy volunteers, stable patients with cirrhosis, and in hospitalized cirrhotic patients with acutely decompensated cirrhosis, with and without ACLF (AD). The role of necroptosis in ACLF was studied in two animal models of ACLF using inhibitors of RIPK1, necrostatin-1 (NEC-1) and SML2100 (RIPA56). Plasma RIPK3 levels predicted the risk of 28- and 90-day mortality (AUROC, 0.653 (95%CI 0.530–0.776), 0.696 (95%CI 0.593–0.799)] and also the progression of patients from no ACLF to ACLF [0.744 (95%CI 0.593–0.895)] and the results were validated in a 2nd patient cohort. This pattern was replicated in a rodent model of ACLF that was induced by administration of lipopolysaccharide (LPS) to bile-duct ligated rats and carbon tetrachloride-induced fibrosis mice administered galactosamine (CCL4/GalN). Suppression of caspase-8 activity in ACLF rodent model was observed suggesting a switch from caspase-dependent cell death to necroptosis. NEC-1 treatment prior to administration of LPS significantly reduced the severity of ACLF manifested by reduced liver, kidney, and brain injury mirrored by reduced hepatic and renal cell death. Similar hepato-protective effects were observed with RIPA56 in a murine model of ACLF induced by CCL4/GalN. These data demonstrate for the first time the importance of RIPK1 mediated cell death in human and rodent ACLF. Inhibition of RIPK1 is a potential novel therapeutic approach to prevent progression of susceptible patients from no ACLF to ACLF