1,260 research outputs found
Thermophysical properties of a low-density phenolic-nylon ablation material
Thermophysical properties of nondegradated and thermally degradated low density phenolic-nylon ablating materia
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Guidance in the humanâmachine analytics process
In this paper, we list the goals for and the pros and cons of guidance, and we discuss the role that it can play not only in key low-level visualization tasks but also the more sophisticated model-generation tasks of visual analytics. Recent advances in artificial intelligence, particularly in machine learning, have led to high hopes regarding the possibilities of using automatic techniques to perform some of the tasks that are currently done manually using visualization by data analysts. However, visual analytics remains a complex activity, combining many different subtasks. Some of these tasks are relatively low-level, and it is clear how automation could play a roleâfor example, classification and clustering of data. Other tasks are much more abstract and require significant human creativity, for example, linking insights gleaned from a variety of disparate and heterogeneous data artifacts to build support for decision making. In this paper, we outline the potential applications of guidance, as well as the inputs to guidance. We discuss challenges in implementing guidance, including the inputs to guidance systems and how to provide guidance to users. We propose potential methods for evaluating the quality of guidance at different phases in the analytic process and introduce the potential negative effects of guidance as a source of bias in analytic decision making
Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture
Oral posture is considered to have a major influence on the development and reoccurrence of malocclusion. A biofunctional model was tested with the null hypotheses that (1) there are no significant differences between pressures during different oral functions and (2) between pressure measurements in different oral compartments in order to substantiate various postural conditions at rest by intra-oral pressure dynamics. Atmospheric pressure monitoring was simultaneously carried out with a digital manometer in the vestibular inter-occlusal space (IOS) and at the palatal vault (sub-palatal space, SPS). Twenty subjects with normal occlusion were evaluated during the open-mouth condition (OC), gently closed lips (semi-open compartment condition, SC), with closed compartments after the generation of a negative pressure (CCN) and swallowing (SW). Pressure curve characteristics were compared between the different measurement phases (OC, SC, CCN, SW) as well as between the two compartments (IOS, SPS) using analysis of variance and Wilcoxon matched-pairs tests adopting a significance level of αâ=â0.05. Both null hypotheses were rejected. Average pressures (IOS, SPS) in the experimental phases were 0.0, â0.08 (OC); â0.16, â1.0 (SC); â48.79, â81.86 (CCN); and â29.25, â62.51 (SW)âmbar. CCN plateau and peak characteristics significantly differed between the two compartments SPS and IOS. These results indicate the formation of two different intra-oral functional anatomical compartments which provide a deeper understanding of orofacial biofunctions and explain previous observations of negative intra-oral pressures at rest
Metabolic control of tobacco pollination by sugars and invertases
Pollination in flowering plants is initiated by germination of pollen grains on stigmas followed by fast growth of pollen tubes representing highly energy-consuming processes. The symplastic isolation of pollen grains and tubes requires import of Suc available in the apoplast. We show that the functional coupling of Suc cleavage by invertases and uptake of the released hexoses by monosaccharide transporters are critical for pollination in tobacco (Nicotiana tabacum). Transcript profiling, in situ hybridization, and immunolocalization of extracellular invertases and two monosaccharide transporters in vitro and in vivo support the functional coupling in supplying carbohydrates for pollen germination and tube growth evidenced by spatiotemporally coordinated expression. Detection of vacuolar invertases in maternal tissues by these approaches revealed metabolic cross talk between male and female tissues and supported the requirement for carbohydrate supply in transmitting tissue during pollination. Tissue-specific expression of an invertase inhibitor and addition of the chemical invertase inhibitor miglitol strongly reduced extracellular invertase activity and impaired pollen germination. Measurements of (competitive) uptake of labeled sugars identified two import pathways for exogenously available Suc into the germinating pollen operating in parallel: direct Suc uptake and via the hexoses after cleavage by extracellular invertase. Reduction of extracellular invertase activity in pollen decreases Suc uptake and severely compromises pollen germination. We further demonstrate that Glc as sole carbon source is sufficient for pollen germination, whereas Suc is supporting tube growth, revealing an important regulatory role of both the invertase substrate and products contributing to a potential metabolic and signaling-based multilayer regulation of pollination by carbohydrates.Peer Reviewe
Enhanced Biostability and Cellular Uptake of Zinc Oxide Nanocrystals Shielded with Phospholipid Bilayer
The widespread use of ZnO nanomaterials for biomedical applications, including therapeutic drug delivery or stimuli-responsive activation, as well as imaging, imposes a careful control over the colloidal stability and long-term behaviour of ZnO in biological media. Moreover, the effect of ZnO nanostructures on living cells, in particular cancer cells, is still under debate. This paper discusses the role of surface chemistry and charge of zinc oxide nanocrystals, of around 15 nm in size, which influence their behaviour in biological fluids and effect on cancer cells. In particular, we address this problem by modifying the surface of pristine ZnO nanocrystals (NCs), rich of hydroxyl groups, with positively charged amino-propyl chains or, more innovatively, by self-assembling a double-lipidic membrane, shielding the ZnO NCs. Our findings show that the prolonged immersion in simulated human plasma and in the cell culture medium leads to highly colloidally dispersed ZnO NCs only when coated by the lipidic bilayer. In contrast, the pristine and amine-functionalized NCs form huge aggregates after already one hour of immersion. Partial dissolution of these two samples into potentially cytotoxic Zn2+ cations takes place, together with the precipitation of phosphate and carbonate salts on the NCsâ surface. When exposed to living HeLa cancer cells, higher amounts of lipid-shielded ZnO NCs are internalized with respect to the other samples, thus showing a reduced cytotoxicity, based on the same amount of internalized NCs. These results pave the way for the development of novel theranostic platforms based on ZnO NCs. The new formulation of ZnO shielded with a lipid-bilayer will prevent strong aggregation and premature degradation into toxic by-products, and promote a highly efficient cell uptake for further therapeutic or diagnostic functions
Volumetric Bone Mineral Density in Cementless Total Hip Arthroplasty in Postmenopausal Women: Effects on Primary Femoral Stem Stability and Clinical Recovery
AbstractBackgroundIn cementless total hip arthroplasty, femoral stems should preferably not migrate at all postoperatively. This goal is difficult to achieve in postmenopausal women with impaired bone quality. Here, we explored the clinical importance of initial stem migration, measured by radiostereometric analysis (RSA), in women who underwent quantitative computed tomography (CT) of the involved hip preoperatively.MethodsA prospective cohort of 65 postmenopausal women (mean age, 69 years) with hip osteoarthritis and Dorr type-A or B femoral anatomy underwent total hip arthroplasty with implantation of a tapered, single-wedge femoral stem. Volumetric bone mineral density (BMD) was measured using quantitative CT. Femoral stem translation and rotation were measured using model-based RSA within 3 days after the surgical procedure and were repeated at 3, 5, and 11 months. Postoperative recovery parameters included walking speed, walking activity, and patientâreported outcome measures. Subjects were categorized into 2 groups according to the magnitude of initial 5-month stem subsidence (ResultsSubjects with stem subsidence of â„2 mm (mean, 3.09 mm [95% confidence interval (CI), 2.70 to 3.47 mm]) had lower intertrochanteric volumetric BMD (p = 0.008). Subjects with subsidence of ConclusionsFemoral stem stability and resistance to subsidence were sensitive to adequate intertrochanteric volumetric BMD. Low intertrochanteric volumetric BMD was associated with greater stem migration. With initial migration, clinical recovery was slower and patient-reported outcome measures were less satisfactory.Level of EvidencePrognostic Level II. See Instructions for Authors for a complete description of levels of evidence.</p
Conditional Sampling for Max-Stable Processes with a Mixed Moving Maxima Representation
This paper deals with the question of conditional sampling and prediction for
the class of stationary max-stable processes which allow for a mixed moving
maxima representation. We develop an exact procedure for conditional sampling
using the Poisson point process structure of such processes. For explicit
calculations we restrict ourselves to the one-dimensional case and use a finite
number of shape functions satisfying some regularity conditions. For more
general shape functions approximation techniques are presented. Our algorithm
is applied to the Smith process and the Brown-Resnick process. Finally, we
compare our computational results to other approaches. Here, the algorithm for
Gaussian processes with transformed marginals turns out to be surprisingly
competitive.Comment: 35 pages; version accepted for publication in Extremes. The final
publication is available at http://link.springer.co
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