An assessment of the potential health impacts of food reformulation

Background/Objectives: Policies focused on food quality are intended to facilitate healthy choices by consumers, even those who are not fully informed about the links between food consumption and health. The goal of this paper is to evaluate the potential impact of such a food reformulation scenario on health outcomes. Subjects/Methods: We first created reformulation scenarios adapted to the French characteristics of foods. After computing the changes in the nutrient intakes of representative consumers, we determined the health effects of these changes. To do so, we used the DIETRON health assessment model, which calculates the number of deaths avoided by changes in food and nutrient intakes. Results: Depending on the reformulation scenario, the total impact of reformulation varies between 2408 and 3597 avoided deaths per year, which amounts to a 3.7–5.5% reduction in mortality linked to diseases considered in the DIETRON model. The impacts are much higher for men than for women and much higher for low-income categories than for high-income categories. These differences result from the differences in consumption patterns and initial disease prevalence among the various income categories. Conclusions: Even without any changes in consumers’ behaviors, realistic food reformulation may have significant health outcomes

Induced gravitational collapse at extreme cosmological distances: the case of GRB 090423

CONTEXT: The induced gravitational collapse (IGC) scenario has been introduced in order to explain the most energetic gamma ray bursts (GRBs), Eiso=10^{52}-10^{54}erg, associated with type Ib/c supernovae (SNe). It has led to the concept of binary-driven hypernovae (BdHNe) originating in a tight binary system composed by a FeCO core on the verge of a SN explosion and a companion neutron star (NS). Their evolution is characterized by a rapid sequence of events: [...]. AIMS: We investigate whether GRB 090423, one of the farthest observed GRB at z=8.2, is a member of the BdHN family. METHODS: We compare and contrast the spectra, the luminosity evolution and the detectability in the observations by Swift of GRB 090423 with the corresponding ones of the best known BdHN case, GRB 090618. RESULTS: Identification of constant slope power-law behavior in the late X-ray emission of GRB 090423 and its overlapping with the corresponding one in GRB 090618, measured in a common rest frame, represents the main result of this article. This result represents a very significant step on the way to using the scaling law properties, proven in Episode 3 of this BdHN family, as a cosmological standard candle. CONCLUSIONS: Having identified GRB 090423 as a member of the BdHN family, we can conclude that SN events, leading to NS formation, can already occur already at z=8.2, namely at 650 Myr after the Big Bang. It is then possible that these BdHNe originate stem from 40-60 M_{\odot} binaries. They are probing the Population II stars after the completion and possible disappearance of Population III stars.Comment: 9 pages, 9 figures, to appear on A&

Disease characteristics of MCT8 deficiency : an international, retrospective, multicentre cohort study

Background Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor disability resulting from cerebral hypothyroidism and chronic peripheral thyrotoxicosis. We sought to systematically assess the phenotypic characteristics and natural history of patients with MCT8 deficiency. Methods We did an international, multicentre, cohort study, analysing retrospective data from Jan 1, 2003, to Dec 31, 2019, from patients with MCT8 deficiency followed up in 47 hospitals in 22 countries globally. The key inclusion criterion was genetically confirmed MCT8 deficiency. There were no exclusion criteria. Our primary objective was to analyse the overall survival of patients with MCT8 deficiency and document causes of death. We also compared survival between patients who did or did not attain full head control by age 1·5 years and between patients who were or were not underweight by age 1–3 years (defined as a bodyweight-for-age Z score <–2 SDs or <5th percentile according to WHO definition). Other objectives were to assess neurocognitive function and outcomes, and clinical parameters including anthropometric characteristics, biochemical markers, and neuroimaging findings. Findings Between Oct 14, 2014, and Jan 17, 2020, we enrolled 151 patients with 73 different MCT8 (SLC16A2) mutations. Median age at diagnosis was 24·0 months (IQR 12·0-60·0, range 0·0-744·0). 32 (21%) of 151 patients died; the main causes of mortality in these patients were pulmonary infection (six [19%]) and sudden death (six [19%]). Median overall survival was 35·0 years (95% CI 8·3–61·7). Individuals who did not attain head control by age 1·5 years had an increased risk of death compared with patients who did attain head control (hazard ratio [HR] 3·46, 95% CI 1·76–8·34; log-rank test p=0·0041). Patients who were underweight during age 1–3 years had an increased risk for death compared with patients who were of normal bodyweight at this age (HR 4·71, 95% CI 1·26–17·58, p=0·021). The few motor and cognitive abilities of patients did not improve with age, as evidenced by the absence of significant correlations between biological age and scores on the Gross Motor Function Measure-88 and Bayley Scales of Infant Development III. Tri-iodothyronine concentrations were above the age-specific upper limit in 96 (95%) of 101 patients and free thyroxine concentrations were below the age-specific lower limit in 94 (89%) of 106 patients. 59 (71%) of 83 patients were underweight. 25 (53%) of 47 patients had elevated systolic blood pressure above the 90th percentile, 34 (76%) of 45 patients had premature atrial contractions, and 20 (31%) of 64 had resting tachycardia. The most consistent MRI finding was a global delay in myelination, which occurred in 13 (100%) of 13 patients. Interpretation Our description of characteristics of MCT8 deficiency in a large patient cohort reveals poor survival with a high prevalence of treatable underlying risk factors, and provides knowledge that might inform clinical management and future evaluation of therapies