Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease

Behcet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behcet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behcet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production

Empire and trans-imperial subjects in the Muslim Mediterranean

During the nineteenth century, the Muslim Mediterranean became a locus of competing imperial projects led by the Ottomans and European powers. This article examines how the migration of people and ideas across North Africa and Asia complicated processes of imperial consolidation and exposed the ways in which North Africa, Europe, and Asia were connected through trans-imperial influences that often undermined the jurisdictional sovereignty of imperial states. It demonstrates that cross-border migrations and cultural transfers both frustrated and abetted imperial projects while allowing for the imagining of new types of solidarities that transcended national and imperial categorizations. In analysing these factors, this article argues for a rethinking of the metropole–periphery relationship by highlighting the important role print and trans-imperial networks played in shaping the Mediterranean region

Politics of discontent in the midst of the great depression : the Free Republican Party of Turkey (1930)

Cem Emrenc

Politics of discontent in the midst of the great depression: the free republican party of Turkey (1930).

Donated by Klaus KreiserReprinted from : New Perspectives on Turkey, No.23, Fall 2000

Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T

WOS: 000359435700004PubMed ID: 26251777Halomonas smyrnensis AAD6T is a gram negative, aerobic, and moderately halophilic bacterium, and is known to produce high levels of levan with many potential uses in foods, feeds, cosmetics, pharmaceutical and chemical industries due to its outstanding properties. Here, the whole-genome analysis was performed to gain more insight about the biological mechanisms, and the whole-genome organization of the bacterium. Industrially crucial genes, including the levansucrase, were detected and the genome-scale metabolic model of H. smyrnensis AAD6T was reconstructed. The bacterium was found to have many potential applications in biotechnology not only being a levan producer, but also because of its capacity to produce Pel exopolysaccharide, polyhydroxyalkanoates, and osmoprotectants. The genomic information presented here will not only provide additional information to enhance our understanding of the genetic and metabolic network of halophilic bacteria, but also accelerate the research on systematical design of engineering strategies for biotechnology applications.Scientific and Technological Research Council of Turkey (TUBITAK) [MAG/110M613]; Marmara University Research Fund [FEN-C-YLP-060911-0280]This research has been financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) through Grant MAG/110M613 and by Marmara University Research Fund through Grant FEN-C-YLP-060911-0280