Truck Selection with the Fuzzy-WSM Method in Transportation Systems of Open Pit Mines

Open pit mines gain width and become more complicated as they are deeper today, and it is inevitable to carry the produced material with a truck transportation system. Therefore, in large-scale businesses, truck selection has great importance for the transportation costs to be sustainable. This study investigates the main factors and corresponding criteria influential in selection of trucks, which are the most frequent used means of transportation in open pit mines. Analytic hierarchy process and fuzzy weighted sum model are employed to solve the selection problem. Six different truck types and 20 selection criteria are considered. As a result of technical analysis, most suitable trucks are found

A novel technique for the non-surgical management of inadvertent bowel catheterization during percutaneous abscess drainage: a technical note

Percutaneous abscess drainage-related inadvertent bowel catheterization is an undesired complication that requires treatment. In two cases without signs of peritonitis that we examined, it was possible to achieve successful abscess drainage, and to treat abscess-related inadvertent bowel catheterization by using a novel technique without surgery

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome using RNA sequencing. Senescence was induced in human fetal astrocytes by transient oxidative stress. Brain-expressed genes, including those involved in neuronal development and differentiation, were downregulated in senescent astrocytes. Remarkably, several genes indicative of astrocytic responses to injury were also downregulated, including glial fibrillary acidic protein and genes involved in the processing and presentation of antigens by major histocompatiblity complex class II proteins, while pro-inflammatory genes were upregulated. Overall, our findings suggest that senescence-related changes in the function of astrocytes may impact the pathogenesis of age-related brain disorders

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Examining of rock drilling properties in underground metal mine excavation

In underground metal mines, drilling and blasting is widely used production method. Drilling holes is especially a time consuming operation. The aim of this study is to examine and analyze drilling operation and its duration in underground ore and dead rock. Drillability experiments are carried out on samples taken from the field. In core sampling two different types of core samples are taken whether it is parallel or perpendicular to ore bedding and dead rock. Results of drillability experiments are compared between the two types of core samples. DRI values are found to be 51 and 47 for the parallel and perpendicular core samples to ore bedding, respectively. DRI values for the parallel and perpendicular core samples to dead rock bedding are found to be 57 and 55 for the, respectively. In addition, graphs of drilling speed and drilling depth belonging to ore and dead rock are analyzed. It is examined that drilling speed increases steadily to maximum point in the first 5sec. and stays stable after that point. Therefore, it is concluded that production galleries and holes which are formed parallel to bedding would increase production efficiency

Disturbance factor effects on the selected geotechnical properties of the discontinuities

Günümüz açık ocak madenciliğinde ocak üretim maliyetinin yaklaşık yüzde otuzu patlatma işlemlerinden kaynaklanmaktadır. Ayrıca patlatma işleminde ve patlatma verimindeki en önemli parametrelerden biri de süreksizliklerdir. Süreksizliklerin devamlılığı ve açıklığı, patlatma verimine doğrudan etki eden unsurlardır. Açık ocaklarda yapılan patlatma işlemlerinden kaya kütlesi içindeki süreksizlikler etkilenmekte ve açıklıkları artmaktadır._x000B_Bu bilgiler doğrultusunda gerçekleştirilen bu çalışmada iki farklı işletmede arazi çalışmaları gerçekleştirilmiş ve arazilerde yapılan patlatma işlemleri sonrasında kaya kütlelerinde meydana gelen örselenmenin, süreksizliklerin açıklığına olan etkileri araştırılmıştır._x000B_Yapılan çalışmalarda, her patlatmaya ait özgül şarj miktarları hesaplanmış ve özgül şarj miktarları ile patlatma işlemi sonrasında süreksizliklerde meydana gelen değişimler arasında bağlantı kurulmaya çalışılmıştır._x000B_Ayrıca, patlatma yapılan aynalardaki süreksizlik aralıkları ve patlatma parametreleri dikkate alınarak patlatmadan sonraki tane yığın boyut dağılımları görüntü analizi yöntemi yardımıyla tanımlanmıştır. The cost of blasting operations is about thirty percentage of all production expenses for open pit mine operations. Discontinuities are one of the most important parameters for blasting operations. The persistency and the aperture of discontinuities are directly affected from the blasting efficiency. Blasting operations in open pit mines affect the discontinuities into the rock mass and change its properties._x000B_In this study, the field studies were computed for two different quarries and the effect of disturbance on discontinuities into the rock mass after blasting operations were studied._x000B_The specific charge for blasting were calculated for every blasting operation and the relationships between specific charge and change of the discontinuity aperture after the blasting operations were studied._x000B_Also particle size distribution were tried to be determined by considering spacing of discontinuities and the blasting parameters by using the image analyzing method

Determination of Most Suitable Working Height of Powered Roof Support Considering Roof Stresses

In order to meet the increasing demand for coal, longwalls having large working heights up to 7.3 m are being operated worlwide. As the working heights increase, the load-bearing capacities of powered roof supports used at such longwalls are to be raised too. From a powered roof support it is expected that it safely bears the roof loads and transmits them to the footwall at different working heights. This article presents the results of numerical analyses on roof stresses at different longwall working heights. In order to determine the most suitable longwall working height, average stress distributions that occur on roof and gob zones are calculated for different longwall working heights. For this purpose, numerical models are built up and the procedure is applied to a real-life underground coal mine. Six distinct longwalls are modeled considering rock mass properties and working heights. In conclusion, the most suitable longwall working height for the mine under study is determined considering stresses occurring on roof strata and the gob zone