The Relationship between Serum Uric Acid and Glucose, HbA1c, Lipid Profile, Body Mass Index and Blood Pressure in Patients with Chronic Kidney Disease

AMAÇ: Kronik böbrek hastalarında serum ürik asit düzeyi ile glukoz, HbA1c, lipid profili, vücut kitle indeksi ve kan basıncı arasındaki bir ilişkinin olup olmadığını incelemek. YÖNTEMLER: Çalışma, kronik böbrek hastalığı tanısı olan 55 ( 28 K, 27 E) hastada yapıldı. Hastaların biyokimyasal tetkikleri, 24 saatlik idrarda kreatinin klirensi ve proteinüri tetkikleri incelendi. Sistolik ve diastolik kan basıncı ölçüldü. İstatistiksel analizler SPSS 15.0 Windows versiyonu kullanılarak yapıldı. P<0.05 değeri istatistiksel olarak anlamlı olarak kabul edildi. BULGULAR: Verilerin analizinde serum ürik asit düzeyi ile glukoz, HbA1c ve vücut kitle indeksi arasında istatistiksel olarak anlamlı ilişkiler saptandı (sırasıyla P=0.01, P<0.01 ve P=0.03). Alt grup analizlerinde, hiperürisemili hastalarda glukoz, HbA1c ve vücut kitle indeksi düzeyleri ürik asit düzeyi normal olan hastalara göre anlamlı olarak daha yüksek bulundu (sırasıyla, P=0.02, P=0.02, P=0.04). HDL-kolesterol düzeyi ise hiperürisemili grupta daha düşük saptandı (P=0.02). Serum ürik asit düzeyi ile kan basıncı arasında anlamlı bir ilişki tespit edilmedi. SONUÇ: Çalışmamız, kronik böbrek hastalarında serum ürik asit düzeyi ile glukoz, HbA1c ve vücut kitle indeksi arasındaki anlamlı bir ilişkinin olduğunu göstermektedir. Ancak, daha fazla sayıda hastada yapılacak çalışmalara ihtiyaç vardır. OBJECTIVE: To investigate whether there is a relationship between serum uric acid and glucose, HbA1c, lipid profile, body mass index and blood pressure in patients with chronic kidney disease or not. METHODS: This study was performed in 55 (28 female, 27 male) patients with chronic kidney disease. Biochemical tests, 24 hour creatinine clearence and proteinuria were analysed. Systolic and diastolic blood pressures were measured. The statistical analysis was performed using SPSS version 15.0. P<0.05 was considered to be statistically significant. RESULTS: In data analysis, there were significant relationships between serum uric acid and glucose, HbA1c, and body mass index (P=0.01, P<0.01 and P=0.03, respectively). In subgroup analysis, it has been found that the level of glucose, HbA1c, and body mass index in hyperuricemic patients are significantly higher than in normouricemic patients (P=0.02, P=0.02, P=0.04, respectively). HDL-cholesterol level in hyperuricemic group is found to be higher than normouricemic group (P=0.02). There was no significant relation between serum uric acid and blood pressure. CONCLUSION: Our study suggests that serum uric acid level was significantly associated with glucose, HbA1c, and body mass index in chronic kidney disease. However, studies are needed in larger patients

Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated With Olfactory Neuroblastoma

This study reports a patient having olfactory neuroblastoma complicated by syndrome of inappropriate antidiuretic hormone secretion. Olfactory neuroblastoma is a rare tumor that begins in the olfactory membrane. Only 10 cases have been reported previously. Because of having nonspecific symptoms, most patients manifest at an advanced stage at the time of diagnosis. Olfactory neuroblastoma may show local invasion and/or distant metastasis. We demonstrated preoperatively clinical and biochemical parameters consistent with antidiuretic hormone syndrome turned to normal ranges after the treatment. Surgery, chemotherapy, and radiotherapy are the choices of treatment; among these, surgery is an indispensible treatment

Prenatal maternal risk factors for infantile colic

To examine maternal prenatal risk factors for infantile colic (IC). Mothers were asked to complete a standard pre-coded questionnaire form. Inclusion in the study consisted of four criteria. The case group comprised healthy children with infantile colic according to Wessel's definition. The control group comprised healthy children with no history of IC. Prenatal period characteristics of mothers were examined to determine associations with IC. Children with mothers who had prophylactic iron supplementation therapy during pregnancy suffered more from IC. Postpartum depression was found to be more frequent in the case group than in the control group. Gynaecological history, including suffering from migraine, presence of any premenstrual symptoms, dysmenorrhea and high pre-pregnancy body mass index, was associated with development of IC. Pre-gestational gynaecological complaints and pregnancy characteristics may point to IC. These characteristics should be investigated and families should be informed