The Grizzly, October 27, 2016

How UC Students Get the News • International Students Sound Off on Election • Attorney General Candidate Discusses Platform • UC Alumni on the Campaign Trail • Local Volunteers Get Out the Vote • Opinions: The Difficulties of Voting from Past to Present; The Future of the Supreme Court is on the Ballot • UC Students Weigh in on Pro-Athlete Protests • Rein Wrestles Political Issueshttps://digitalcommons.ursinus.edu/grizzlynews/1653/thumbnail.jp

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial

Objective To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE. Methods This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Subjects received either oxygen plus 50 parts per million nitrogen (placebo) or oxygen plus 50 ppm NO for 24 h. The primary composite endpoint required a normal RV on echocardiography and a plasma troponin T concentration <14 pg/mL. The secondary endpoint required a blood brain natriuretic peptide concentration <90 pg/mL and a Borg dyspnea score ≤ 2. The sample size of N = 76 tested if 30% more patients treated with NO would achieve the primary endpoint with 80% power and alpha = 5%. Results We randomized 78 patients and after two withdrawals, 38 were treated per protocol in each group. Patients were well matched for baseline conditions. At 24 h, 5/38 (13%) of patients treated with placebo and 9/38 (24%) of patients treated with NO reached the primary endpoint (P = 0.375). The secondary endpoint was reached in 34% with placebo and 13% of the NO (P = 0.11). In a pre-planned post-hoc analysis, we examined how many patients with RV hypokinesis or dilation at enrollment resolved these abnormalities; 29% more patients treated with NO resolved both abnormalities at 24 h (P = 0.010, Cochrane's Q test). Conclusions In patients with severe submassive PE, inhaled nitric oxide failed to increase the proportion of patients with a normal troponin and echocardiogram but increased the probability of eliminating RV hypokinesis and dilation on echocardiography

The Grizzly, December 8, 2016

Music and Mocha Meet at Steel City • Collegeville Staple Speck\u27s Chicken Offers Unique, Throwback Experience • Local Pizza Place Looking for Love • International Perspective: Japanese TA Reflects on Dining Etiquette • Study Abroad Student Shares Experiences with Foreign Cuisine • Two UC Students Find an Appetizing Off-Campus Job • Opinions: Navigating Dietary Restrictions On and Off Campus; Car Access Impacts Students\u27 Dining Experiences • Senior Athletes Share Helpful Tips on Nutritionhttps://digitalcommons.ursinus.edu/grizzlynews/1657/thumbnail.jp

Parasites of an Arctic scavenger; the wolverine (Gulo gulo)

Parasites are fundamental components within all ecosystems, shaping interaction webs, host population dynamics and behaviour. Despite this, baseline data is lacking to understand the parasite ecology of many Arctic species, including the wolverine (Gulo gulo), a top Arctic predator and scavenger. Here, we combined traditional count methods (i.e. adult helminth recovery, where taxonomy was confirmed by molecular identification) with 18S rRNA high-throughput sequencing to document the wolverine parasite community. Further, we investigated whether the abundance of parasites detected using traditional methods were associated with host metadata, latitude, and longitude (ranging from the northern limit of the boreal forest to the low Arctic and Arctic tundra in Nunavut, Canada). Adult parasites in intestinal contents were identified as Baylisascaris devosi in 72% (n = 39) of wolverines and Taenia spp. in 22% (n = 12), of which specimens from 2 wolverines were identified as T. twitchelli based on COX1 sequence. 18S rRNA high-throughput sequencing on DNA extracted from faeces detected additional parasites, including a pseudophyllid cestode (Diplogonoporus spp. or Diphyllobothrium spp.), two metastrongyloid lungworms (Angiostrongylus spp. or Aelurostrongylus spp., and Crenosoma spp.), an ascarid nematode (Ascaris spp. or Toxocara spp.), a Trichinella spp. nematode, and the protozoan Sarcocystis spp., though each at a prevalence less than 13% (n = 7). The abundance of B. devosi significantly decreased with latitude (slope = -0.68; R2 = 0.17; P = 0.004), suggesting a northerly limit in distribution. We describe B. devosi and T. twitchelli in Canadian wolverines for the first time since 1978, and extend the recorded geographic distribution of these parasites ca 2000 km to the East and into the tundra ecosystem. Our findings illustrate the value of molecular methods in support of traditional methods, encouraging additional work to improve the advancement of molecular screening for parasites

Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection

Ebola virus is a highly lethal human pathogen and is rapidly driving many wild primate populations toward extinction. Several lines of evidence suggest that innate, nonspecific host factors are potentially critical for survival after Ebola virus infection. Here, we show that nonreplicating Ebola virus-like particles (VLPs), containing the glycoprotein (GP) and matrix protein virus protein (VP)40, administered 1–3 d before Ebola virus infection rapidly induced protective immunity. VLP injection enhanced the numbers of natural killer (NK) cells in lymphoid tissues. In contrast to live Ebola virus, VLP treatment of NK cells enhanced cytokine secretion and cytolytic activity against NK-sensitive targets. Unlike wild-type mice, treatment of NK-deficient or -depleted mice with VLPs had no protective effect against Ebola virus infection and NK cells treated with VLPs protected against Ebola virus infection when adoptively transferred to naive mice. The mechanism of NK cell–mediated protection clearly depended on perforin, but not interferon-γ secretion. Particles containing only VP40 were sufficient to induce NK cell responses and provide protection from infection in the absence of the viral GP. These findings revealed a decisive role for NK cells during lethal Ebola virus infection. This work should open new doors for better understanding of Ebola virus pathogenesis and direct the development of immunotherapeutics, which target the innate immune system, for treatment of Ebola virus infection

The Grizzly, November 10, 2016

Ursinus Picks New Dean / VPAA after Months-Long Search • Innovation and Discovery Center Breaks New Ground • Q&A with Anupy Singla • International Perspective: Chinese Teaching Assistant Embraces the Freedom to be Herself in the U.S. • U-Speak Talk to Explore Under-Represented Voices • Women Entrepreneurs Share Stories of Success • Opinions: Offensive Costumes are Micro-aggressions; UC Needs In-Person Activism to Make Progress • Wrestling Looks to Win it All in 2016-2017 • Field Hockey Tops Conference Once Againhttps://digitalcommons.ursinus.edu/grizzlynews/1655/thumbnail.jp

The Grizzly, November 3, 2016

Search for New VPAA / Dean Comes to an End • Alumni to Speak on AAAS Education Panel • Suspense Thriller Takes UC Stage • International Perspective: Chinese Student Takes on U.S. Public Transportation • Sustainable Students Create Change in Wismer • Homecoming King and Queen Reflect on Time at UC • Opinions: Drake\u27s Diss Track About Kid Cudi Crossed the Line; Tradition of Homecoming Court Needs to Go • Splash! Bears Back in Action! • UC Athlete Making a Difference Off the Fieldhttps://digitalcommons.ursinus.edu/grizzlynews/1654/thumbnail.jp

The Grizzly, March 24, 2016

Library Reveals Swank Database • Professors Find New Forms of Teaching • Presidential Election: How is Ursinus Involved? • Challenges of Studying Abroad: Work vs. Studying • U-Imagine Center to Host Symposium on Careers in Art • Slice of History: The Story of Marzella\u27s and its Close Relationship with Ursinus College • An Honorable Mention • CAB Rolling Out New Events • Opinions: It\u27s Always Sunny in Philly, But it\u27s Too Far Away; Scoop on Classroom Conflict • Four Gymnasts Earn All-American Honors • Making a Splashhttps://digitalcommons.ursinus.edu/grizzlynews/1686/thumbnail.jp

The Grizzly, September 28, 2016

Campus Safety Takes Safety Initiatives • Poet Comes to UC • ESL Program Promotes Community Between Students and Staff • New Club Aims to Get Money Out of Politics • Shakespeare in the Summer of Love • Family Day Branches Out • Opinions: Let\u27s (Finally) Talk About Sex Addiction; Frank Ocean\u27s Blonde was Worth Waiting For • Ursinus Men\u27s and Women\u27s Cross Country Team Off to a Hot Start • Rare Breed: The Two-Sport Athletehttps://digitalcommons.ursinus.edu/grizzlynews/1650/thumbnail.jp