Determinación de factores influyentes sobre una respuesta en un dominio poco estructurado

This report focuses on results obtained from a classification technique applied to time series data in a medical ill-structured The statistical analysis and classification --in ill-structured-- of such data are often inadequate because of the intrinsic characteristics of those domains. The database in this analysis contains information relative to patients with major depressive disorders or esquizofrenia; as a consequence, a high quantity of database variables contain data corresponding to measures taken in different instant of time, making curves. For this reason we are motivated about how we can establish a useful classification technique of curves in a medical ill-structured domain.Postprint (published version

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Condiciones hidrogeológicas en Las Toninas y Santa Teresita, Partido de La Costa

Fil: Carretero, Silvina Claudia. Cátedra de Hidrología General. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Kruse, Eduardo Emilio. Cátedra de Hidrología General. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Rojo, Adolfo. Cátedra de Hidrología General. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study.

Besides regulating energy balance and reducing body-weight, the adipokine leptin has been recently shown to be neuroprotective and antiapoptotic by promoting neuronal survival after excitotoxic and oxidative insults. Here, we investigated the firing properties of mouse hippocampal neurons and the effects of leptin pretreatment on hypoxic damage (2 hours, 3% O(2)). Experiments were carried out by means of the microelectrode array (MEA) technology, monitoring hippocampal neurons activity from 11 to 18 days in vitro (DIV). Under normoxic conditions, hippocampal neurons were spontaneously firing, either with prevailing isolated and randomly distributed spikes (11 DIV), or with patterns characterized by synchronized bursts (18 DIV). Exposure to hypoxia severely impaired the spontaneous activity of hippocampal neurons, reducing their firing frequency by 54% and 69%, at 11 and 18 DIV respectively, and synchronized their firing activity. Pretreatment with 50 nM leptin reduced the firing frequency of normoxic neurons and contrasted the hypoxia-induced depressive action, either by limiting the firing frequency reduction (at both ages) or by increasing it to 126% (in younger neurons). In order to find out whether leptin exerts its effect by activating large conductance Ca(2+)-activated K(+) channels (BK), as shown on rat hippocampal neurons, we applied the BK channel blocker paxilline (1 µM). Our data show that paxilline reversed the effects of leptin, both on normoxic and hypoxic neurons, suggesting that the adipokine counteracts hypoxia through BK channels activation in mouse hippocampal neurons

Raiders of the Olympic Values: Perception of the Development of Women’s Canoeing in Spain for Tokyo 2021

Although canoeing is one of the oldest sports in the Olympic program, it was not until the Tokyo Olympics in 2021 that women’s canoeing was first included in the competition. This fact has posed a challenge to the initiation and technification systems of countries in order to obtain competitive results, particularly in Spain, as it is one of the sports that contributed the most medals to the Olympic medal tally. The aim of this study was to evaluate the promotion and development of talent in women’s canoeing in Spain for its first-ever Olympic participation. For this purpose, an analytical survey (n = 167) was carried out, the answers to which were contrasted by gender and modality practiced. The results showed a positive evaluation of the current position in flatwater female canoeing regarding talent that is consistent with the competitive results achieved. Additionally, we found that the gender of the respondents influences their perception of the age of sport initiation and the suitability of the progression in the competition systems for the promotion of women’s canoeing in Spain. Therefore, the results of the questionnaire will facilitate a quick diagnosis of critical aspects by sport managers, allowing them to take corrective actions in time for the development of female canoeists and, at the same time, to promote future studies that delve deeper into these topics

Variaciones de niveles freáticos en la cuenca del arroyo El Pescado (provincia de Buenos Aires)

Fil: Laurencena, Patricia Claudia. Facultad de Ciencias Naturales y Museo, UNLPFil: Kruse, Eduardo Emilio. Facultad de Ciencias Naturales y Museo, UNLPFil: Rojo, Adolfo. Facultad de Ciencias Naturales y Museo, UNLPFil: Deluchi, Marta Haydée. Facultad de Ciencias Naturales y Museo, UNLPFil: Carol, Eleonora Silvina. Facultad de Ciencias Naturales y Museo, UNL

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Condiciones hidrogeológicas en Las Toninas y Santa Teresita, Partido de La Costa

La costa oriental bonaerense carece de un plan de monitoreo hidrodinámico e hidroquímico del acuífero de agua dulce, a pesar de ser la única fuente de agua potable. Se presenta una actualización del comportamiento de las aguas subterráneas en Las Toninas y Santa Teresita en relación a estudios previos de hace más de 25 años. Se construyeron mapas de flujo y de conductividad eléctrica con datos históricos (1987) y mediciones actuales (2012). El volumen de agua dulce disminuyó en un 30%. Si bien la salinidad mantiene sus rasgos generales, con un menor contenido salino en el médano (<1500 μS/cm) y un incremento hacia el oeste (3000 μS/cm), se detectó un proceso de salinización en Santa Teresita (11800 μS/cm). Las modificaciones descriptas se relacionan con factores antropogénicos, siendo necesario un plan de explotación sustentable que permita minimizar los efectos negativos que disminuyen la cantidad y calidad de agua dulce.Along the eastern coast of Buenos Aires there is a lack of hydrodynamic and hydrochemical monitoring for the freshwater aquifer despite it is the only source of drinking water. An update on the groundwater behavior in Las Toninas and Santa Teresita is presented in relation with previous studies older than 25 years. Groundwater flow and electrical conductivity maps were drawn using historical data (1987) and current measurements (2012). The volume of freshwater has reduced by 30%. Although salinity maintains its general characteristics, with a lower concentration in the dunes (<1500 μS/cm) rising to the west (3000μS/cm), a salinization process was detected in Santa Teresita (11800 μS/cm). The described modifications are related to anthropogenic factors making a sustainable exploitation plan necessary which allows for reducing the negative effects on the quantity and quality of the groundwater.Universidad Nacional de La Plat

An integrated account of expert perspectives on functioning in schizophrenia

An integrated and interdisciplinary care system for individuals with schizophrenia is essential, which implies the need for a tool that assesses the difficulties and contextual factors of relevance to their functioning, and facilitates coordinated working across the different professions involved in their care. The International Classification of Functioning, Disability and Health Core Sets (ICF-CS) cover these requirements. This study aimed to evaluate the content validity of the ICF-CSs for schizophrenia from the perspective of experts. Six three-round Delphi studies were conducted with expert panels from different professional backgrounds which have played a significant role in the treatment of individuals with schizophrenia (psychiatry, psychology, nursing, occupational therapy, social work and physiotherapy). In total, 790 experts from 85 different countries participated in the first round. In total, 90 ICF categories and 28 Personal factors reached expert consensus (reached consensus from four or more professional perspectives). All the categories in the brief version of the ICF-CS for schizophrenia reached consensus from all the professional perspectives considered. As for the comprehensive version, 89.7% of its categories reached expert consensus. The results support the worldwide content validity of the ICF-CSs for schizophrenia from an expert perspective and underline the importance of assessing functioning by considering all the components implied

Importancia del monitoreo del agua subterránea en zonas urbanizadas

Una herramienta esencial para evaluar la evolución química de las aguas subterráneas es el monitoreo periódico de su calidad. En las zonas urbanas esto permite estimar áreas contaminadas o el comienzo de alguna afectación en el agua suministrada a la población. En la ciudad de La Plata se efectuó en 2012 un muestreo de pozos de explotación de agua subterránea situados en el casco urbano y periferia, con el objeto de actualizar la información disponible. En el presente estudio se realizó un censo de perforaciones con la toma de 16 muestras para la determinación de iones mayoritarios, arsénico y flúor. El tratamiento de los datos se hizo mediante gráficos de relaciones iónicas, los cuales permitieron reconocer que las características químicas se han conservado relativamente estables a través del tiempo. Aunque se identificaron tres sectores con una composición química particular, dos ubicados en el ejido urbano y uno en la periferia.Periodic monitoring of groundwater quality is an essential tool to evaluate its chemical evolution. In ur ban areas this tool allows to estimate contaminated areas or to detect quality changes in the water supply to the population. A sampling of groundwater exploitation wells located in the urban area and the suburbs of La Plata were carried out in 2012 with the aim of update the hydrogeological information. For the current work a groundwater well census were carried out and 16 water samples were taken for major ions, arsenic and fluorine. Data analysis were made using ionic relationship graphs which allowed recognizing that chemical characteristics have preserved relatively stable over time. Although three sectors with particular chemical composition, two located in the urban conglomerate and one in the suburbs, were identified.Universidad Nacional de La Plat