Youth and Community Development through Rites of Passage: A Pilot Evaluation Model

This project presents a pilot program evaluation model for measuring the effectiveness of rites of passage strategies for youth and community development. It begins by clarifying the key elements and meaning of modern day, community-based rites of passage experiences for youth transitioning into and through adolescence. An effective rite of passage for adolescence is an intentional and transformative process that increases the youth’s community status while supporting and challenging youth to adopt attitudes, behaviors, and skills for a healthy transition through this developmental period and beyond. Next, the project applies a systems-based program evaluation model (Wasserman, 2010) to a rite of passage strategy in order to measure the effects of this experience on both youth and community members. A review of the relevant literature focuses on the current understanding and application of rites of passage experiences for youth and community development, the challenges in defining and measuring this bidirectional process, and the application of Self-Determination Theory to the program evaluation model with the goal of improving the capacity to measure locally meaningful outcomes. The pilot model provides a method for measuring the often assumed, yet key, bidirectional interactions and relationships in effective rites of passage processes. Guided by the application of select pulse points, the model introduces research questions as starting points for stakeholders to measure the effectiveness of these strategies in relation to the program outcome: Basic Psychological Need Satisfaction in relation to authority. A discussion of data collection and analysis, possible results and implications for the research questions, limitations, and future directions follows

Youth and Community Development through Rites of Passage: A Pilot Evaluation Model

This project presents a pilot program evaluation model for measuring the effectiveness of rites of passage strategies for youth and community development. It begins by clarifying the key elements and meaning of modern day, community-based rites of passage experiences for youth transitioning into and through adolescence. An effective rite of passage for adolescence is an intentional and transformative process that increases the youth’s community status while supporting and challenging youth to adopt attitudes, behaviors, and skills for a healthy transition through this developmental period and beyond. Next, the project applies a systems-based program evaluation model (Wasserman, 2010) to a rite of passage strategy in order to measure the effects of this experience on both youth and community members. A review of the relevant literature focuses on the current understanding and application of rites of passage experiences for youth and community development, the challenges in defining and measuring this bidirectional process, and the application of Self-Determination Theory to the program evaluation model with the goal of improving the capacity to measure locally meaningful outcomes. The pilot model provides a method for measuring the often assumed, yet key, bidirectional interactions and relationships in effective rites of passage processes. Guided by the application of select pulse points, the model introduces research questions as starting points for stakeholders to measure the effectiveness of these strategies in relation to the program outcome: Basic Psychological Need Satisfaction in relation to authority. A discussion of data collection and analysis, possible results and implications for the research questions, limitations, and future directions follows

Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project.

Objective: Studies of "healthy" cognitive aging often focus on a limited set of measures that decline with age. The current study argues that defining and supporting healthy cognition requires understanding diverse cognitive performance across the lifespan. Method: Data from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort was examined across a range of cognitive domains. Performance was related to lifestyle including education, social engagement, and enrichment activities. Results: Results indicate variable relationships between cognition and age (positive, negative, or no relationship). Principal components analysis indicated maintained cognitive diversity across the adult lifespan, and that cognition-lifestyle relationships differed by age and domain. Discussion: Our findings support a view of normal cognitive aging as a lifelong developmental process with diverse relationships between cognition, lifestyle, and age. This reinforces the need for large-scale studies of cognitive aging to include a wider range of both ages and cognitive tasks.The Cambridge Centre for Aging and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1)

Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial

Introduction-HIV infection and certain antiretroviral therapy (ART) medications increase atherosclerotic cardiovascular disease risk, mediated, in part, through traditional cardiovascular disease risk factors. Methods and Results-We studied cardiovascular disease risk factor changes in the START (Strategic Timing of Antiretroviral Treatment) trial, a randomized study of immediate versus deferred ART initiation among HIV-positive persons with CD4+ cell counts >500 cells/mm(3). Mean change from baseline in risk factors and the incidence of comorbid conditions were compared between groups. The characteristics among 4685 HIV-positive START trial participants include a median age of 36 years, a CD4 cell count of 651 cells/mm(3), an HIV viral load of 12 759 copies/mL, a current smoking status of 32%, a median systolic/diastolic blood pressure of 120/76 mm Hg, and median levels of total cholesterol of 168 mg/dL, low-density lipoprotein cholesterol of 102 mg/dL, and high-density lipoprotein cholesterol of 41 mg/dL. Mean follow-up was 3.0 years. The immediate and deferred ART groups spent 94% and 28% of follow-up time taking ART, respectively. Compared with patients in the deferral group, patients in the immediate ART group had increased total cholesterol and low-density lipoprotein cholesterol and higher use of lipid-lowering therapy (1.2%;95% CI, 0.1-2.2). Concurrent increases in high-density lipoprotein cholesterol with immediate ART resulted in a 0.1 lower total cholesterol to high-density lipoprotein cholesterol ratio (95% CI, 0.1-0.2). Immediate ART resulted in 2.3% less BP-lowering therapy use (95% CI, 0.9-3.6), but there were no differences in new-onset hypertension or diabetes mellitus. Conclusions-Among HIV-positive persons with preserved immunity, immediate ART led to increases in total cholesterol and lowdensity lipoprotein cholesterol but also concurrent increases in high-density lipoprotein cholesterol and decreased use of blood pressure medications. These opposing effects suggest that, in the short term, the net effect of early ART on traditional cardiovascular disease risk factors may be clinically insignificant.

The Science Case for an Extended Spitzer Mission

Although the final observations of the Spitzer Warm Mission are currently scheduled for March 2019, it can continue operations through the end of the decade with no loss of photometric precision. As we will show, there is a strong science case for extending the current Warm Mission to December 2020. Spitzer has already made major impacts in the fields of exoplanets (including microlensing events), characterizing near Earth objects, enhancing our knowledge of nearby stars and brown dwarfs, understanding the properties and structure of our Milky Way galaxy, and deep wide-field extragalactic surveys to study galaxy birth and evolution. By extending Spitzer through 2020, it can continue to make ground-breaking discoveries in those fields, and provide crucial support to the NASA flagship missions JWST and WFIRST, as well as the upcoming TESS mission, and it will complement ground-based observations by LSST and the new large telescopes of the next decade. This scientific program addresses NASA's Science Mission Directive's objectives in astrophysics, which include discovering how the universe works, exploring how it began and evolved, and searching for life on planets around other stars.Comment: 75 pages. See page 3 for Table of Contents and page 4 for Executive Summar

OSIRIS-REx Encounters Bennu: Initial Assessment from the Approach Phase

The OSIRIS-REx spacecraft launched on September 8, 2016, on a seven-year journey to return samples from asteroid (101955) Bennu. This presentation summarizes the scientific results from the Approach and Preliminary Survey phases. Bennu observations are set to begin on August 17, 2018,when the asteroid is bright enough for detection by the PolyCam. PolyCam and MapCam collect data to survey the asteroid environment for any hazards and characterize the asteroid point-source photometric properties. Resolved images acquired during final approach, starting in late October 2018, allow the creation of a shape model using stereophotoclinometry (SPC), needed by both the navigation team and science planners. The OVIRS and OTES spectrometers characterize the point- source spectral properties over a full rotation period, providing a first look at any features and thermophysical properties. TAGSAM is released from the launch container and deployed into the sampling configuration then returned to the stow position.Preliminary Survey follows the Approach Phase in early December 2018. This phase consists of a series of hyperbolic trajectories that cross over the North and South poles and the equator of Bennu at a close-approach distance of 7 km. Images from these Preliminary Survey passes provide data to complete the 75-cm resolution SPC global shape model and solve for the rotation state. Once the shape model is complete, the asteroid coordinate system is defined for co-registration of all data products. These higher-resolution images also constrain the photometric properties and allow for an initial assessment of the geology. In Preliminary Survey the team also obtains the first OLA data, providing a measure of the surface topography. OVIRS and OTES collect data as "ride-along" instruments, with the spacecraft pointing driven by imaging constraints. These data provide a first look at the spectral variation across the surface of Bennu. Radio science measurements, combined with altimetry and imagery, determine Bennu's mass, a prerequisite to placing the spacecraft into orbit in late December 2018. Together, data from the Approach and Preliminary Survey phases set the stage for the extensive mapping planned for 2019. These dates are the baseline plan. Any contingency or unexpected discovery may change this mission profile

Ephemeris and hazard assessment for near-Earth asteroid (101955) Bennu based on OSIRIS-REx data

Small bodies such as the near-Earth asteroid Bennu drift in their orbit due to thermal radiation forces (the Yarkovsky effect). Ground-based observations have indicated a nonzero probability of Bennu impacting Earth, depending on how its orbit evolves. Thus, among the goals of the OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer) mission to Bennu were to precisely measure the Yarkovsky effect and refine the impact hazard assessment for this body. Here we address these objectives. Using OSIRIS-REx spacecraft tracking data, we derive meter-level constraints on the distance between Earth and Bennu from January 2019 to October 2020. While these data greatly improve the knowledge of the trajectory of Bennu, they also require an unprecedented fidelity for the modeling of an asteroid’s trajectory. In particular, special care is needed to take into account the contribution of 343 small-body perturbers and the uncertainty in their masses. Radiation effects such as the Poynting–Robertson drag, so far only considered for interplanetary dust dynamics, now become a consideration for modeling the trajectory of a 500-m asteroid such as Bennu. By employing a thermophysical model based on OSIRIS-REx’s characterization of Bennu, we estimate a semimajor axis drift of−284.6 ± 0.2m/yr (signal-to-noise ratio∼1400) at epoch 2011 January 1 caused by the Yarkovsky effect. The largest source of modeling error is solar wind drag, which may lower the magnitude of the semimajor axis drift from the Yarkovsky effect by up to 0.16 m/yr. The Yarkovsky-related semimajor axis drift varies by roughly±1m/yr as the orbit of Bennu evolves due to planetary perturbations from 1900 to 2135. The Yarkovsky thermophysical model proves to be extremely accurate by predicting a bulk density estimate within 0.1% of that estimated through gravity science analysis. Compared to the information available before the OSIRIS-REx mission, the knowledge of the circumstances of the scattering Earth encounter that will occur in 2135 improves by a factor of 20, thus allowing us to rule out many previously possible impact trajectories. However, there remain some impact trajectories compatible with the data. Prior to the spacecraft encounter, the overall impact probability through 2200 was 3.7 × 10−4 (1 in 2700). As a result of our analysis, the cumulative impact probability through 2300 becomes 5.7 × 10−4 (1 in 1750) and the most significant individual impact solution is for September 2182, with an impact probability of 3.7 × 10−4 (1 in 2700). Both Bennu and (29075) 1950 DA have a Palermo scale value of −1.42 and share the distinction as the currently most hazardous object in the asteroid catalog

Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation

Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications of nucleosomal histones. An essential modification for oligodendrocyte differentiation is the removal of acetyl groups from lysine residues which is catalyzed by histone deacetylases (HDACs). The transcriptional targets of HDAC activity within OPCs however, have remained elusive and have been identified in this study by interrogating the oligodendrocyte transcriptome. Using a novel algorithm that allows clustering of gene transcripts according to expression kinetics and expression levels, we defined major waves of co-regulated genes. The initial overall decrease in gene expression was followed by the up-regulation of genes involved in lipid metabolism and myelination. Functional annotation of the down-regulated gene clusters identified transcripts involved in cell cycle regulation, transcription, and RNA processing. To define whether these genes were the targets of HDAC activity, we cultured rat OPCs in the presence of trichostatin A (TSA), an HDAC inhibitor previously shown to inhibit oligodendrocyte differentiation. By overlaying the defined oligodendrocyte transcriptome with the list of ‘TSA sensitive’ genes, we determined that a high percentage of ‘TSA sensitive’ genes are part of a normal program of oligodendrocyte differentiation. TSA treatment increased the expression of genes whose down-regulation occurs very early after induction of OPC differentiation, but did not affect the expression of genes with a slower kinetic. Among the increased ‘TSA sensitive’ genes we detected several transcription factors including Id2, Egr1, and Sox11, whose down-regulation is critical for OPC differentiation. Thus, HDAC target genes include clusters of co-regulated genes involved in transcriptional repression. These results support a de-repression model of oligodendrocyte lineage progression that relies on the concurrent down-regulation of several inhibitors of differentiation

IL-2 Immunotherapy to Recently HIV-1 Infected Adults Maintains the Numbers of IL-17 Expressing CD4+ T (TH17) Cells in the Periphery

Little is known about the manipulation of IL-17 producing CD4+ T cells (TH17) on a per-cell basis in humans in vivo. Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results. We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1-infected adults receiving anti-retroviral therapy. We measured cytokine T cell responses to CD3/CD28, HIV-1 Gag, and CMV pp65 stimulation, and changes in multiple CD4+ T cell subsets. Those who received IL-2 showed a robust expansion of naive and total CD4+ T cell counts and T-reg counts. However, after IL-2 treatment, the frequency of TH17 cells declined, while counts of TH17 cells did not change due to an expansion of the CD4+ naïve T cell population (CD27+CD45RA+). Counts of HIV-1 Gag-specific T cells declined modestly, but CMV pp65 and CD3/CD28 stimulated populations did not change. Hence, in contrast with recent studies, our results suggest IL-2 is not a potent in vivo regulator of TH17 cell populations in HIV-1 disease. However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag