Feynman-Hellmann theorem for resonances and the quest for QCD exotica

The generalization of the Feynman-Hellmann theorem for resonance states in quantum field theory is derived. On the basis of this theorem, a criterion is proposed to study the possible exotic nature of certain hadronic states emerging in QCD. It is shown that this proposal is supported by explicit calculations in Chiral Perturbation Theory and by large-$N_c$ arguments. Analyzing recent lattice data on the quark mass dependence in the pseudoscalar, vector meson, baryon octet and baryon decuplet sectors, we conclude that, as expected, these are predominately quark-model states, albeit the corrections are non-negligible.Comment: 26 pages, 2 figure

Reconciling threshold and subthreshold expansions for pion-nucleon scattering

Heavy-baryon chiral perturbation theory (ChPT) at one loop fails in relating the pion-nucleon amplitude in the physical region and for subthreshold kinematics due to loop effects enhanced by large low-energy constants. Studying the chiral convergence of threshold and subthreshold parameters up to fourth order in the small-scale expansion, we address the question to what extent this tension can be mitigated by including the $\Delta(1232)$ as an explicit degree of freedom and/or using a covariant formulation of baryon ChPT. We find that the inclusion of the $\Delta$ indeed reduces the low-energy constants to more natural values and thereby improves consistency between threshold and subthreshold kinematics. In addition, even in the $\Delta$-less theory the resummation of $1/m_N$ corrections in the covariant scheme improves the results markedly over the heavy-baryon formulation, in line with previous observations in the single-baryon sector of ChPT that so far have evaded a profound theoretical explanation.Comment: 10 pages, 4 tables, Mathematica notebook with the analytic expressions for threshold and subthreshold parameters included as supplementary material; journal versio

Chiral dynamics in form factors, spectral-function sum rules, meson-meson scattering and semilocal duality

In this work, we perform the one-loop calculation of the scalar and pseudoscalar form factors in the framework of U(3) chiral perturbation theory with explicit tree level exchanges of resonances. The meson-meson scattering calculation from Ref.[1] is extended as well. The spectral functions of the nonet scalar-scalar (SS) and pseudoscalar-pseudoscalar (PP) correlators are constructed by using the corresponding form factors. After fitting the unknown parameters to the scattering data, we discuss the resonance content of the resulting scattering amplitudes. We also study spectral-function sum rules in the SS-SS, PP-PP and SS-PP sectors as well as semi-local duality from scattering. The former relate the scalar and pseudoscalar spectra between themselves while the latter mainly connects the scalar spectrum with the vector one. Finally we investigate these items as a function of Nc for Nc > 3. All these results pose strong constraints on the scalar dynamics and spectroscopy that are discussed. They are successfully fulfilled by our meson-meson scattering amplitudes and spectral functions.Comment: 45 pages, 17 figures and 4 tables. To match the published version in PRD: a new paragraph is added in the Introduction and two new references are include

Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells

CD38 is a transmembrane exoenzyme that is associated with poor prognosis in chronic lymphocytic leukemia (CLL). High CD38 levels in CLL cells are linked to increased cell migration, but the molecular basis is unknown. CD38 produces nicotinic acid adenine dinucleotide phosphate and adenosine 5′-diphosphate-ribose, both of which can act to increase intracellular Ca2+ levels. Here we show that CD38 expression increases basal intracellular Ca2+ levels and stimulates CLL cell migration both with and without chemokine stimulation. We find that CD38 acts via intracellular Ca2+ to increase the activity of the Ras family GTPase Rap1, which is in turn regulated by the Ca2+-sensitive Rap1 guanine-nucleotide exchange factor RasGRP2. Both Rap1 and RasGRP2 are required for CLL cell migration, and RasGRP2 is polarized in primary CLL cells with high CD38 levels. These results indicate that CD38 promotes RasGRP2/Rap1-mediated CLL cell adhesion and migration by increasing intracellular Ca2+ levels

Copper content and resistance mechanisms in the terrestrial moss ptychostomum capillare: A case study in an abandoned Copper Mine in Central Spain

We present a case study on the tissue absorption of copper of a widely distributed moss species, Ptychostomum capillare in the polluted soil of an abandoned copper mine in central Spain. We studied the soil properties in a copper soil pollution gradient and sampled the moss tufts growing on them in four plots with contrasted soil copper levels. We determined the copper content in the soil and in the moss tissues. On these moss samples, we also performed histochemical tests and X-ray dispersive spectrometry coupled with scanning electron microscopy (SEM-EDX), both in untreated shoots and in samples where surface waxes were removed. We checked the behavior of this species using a metallophillous moss, Scopelophila cataractae, for comparative purposes. Copper contents in P. capillare seem to depend more on available, rather than total soil copper contents. Our results indicate that this moss is able to concentrate 12-fold the available soil copper in soil with low available copper content, whereas in the most polluted soil the concentration of Cu in the moss was only half those levels. Both histochemical and SEM-EDX tests show no surface copper in the mosses from the least polluted plot, whereas in samples from the soil with highest copper content, the removal of surface waxes also reduces or removes copper from the moss shoots. Our observations point at a mixed strategy in P. capillare in this copper mine, with metal accumulation behavior in the lowest Cu plot, and an exclusion mechanism involving wax-like substances acting as a barrier in the most polluted plots. These distortions impede the estimation of environmental levels and thus compromise the value of this moss in biomonitoring. We highlight the need of extending these studies to other moss species, especially those used in biomonitoring program

The pion-pion scattering amplitude. IV: Improved analysis with once subtracted Roy-like equations up to 1100 MeV

We improve our description of pion-pion scattering data by imposing additional requirements to our previous fits, in the form of once-subtracted Roy-like equations, while extending our analysis up to 1100 MeV. We provide simple and ready to use parametrizations of the amplitude. In addition, we present a detailed description and derivation of these once-subtracted dispersion relations that, in the 450 to 1100 MeV region, provide an additional constraint which is much stronger than our previous requirements of Forward Dispersion Relations and standard Roy equations. The ensuing constrained amplitudes describe the existing data with rather small uncertainties in the whole region from threshold up to 1100 MeV, while satisfying very stringent dispersive constraints. For the S0 wave, this requires an improved matching of the low and high energy parametrizations. Also for this wave we have considered the latest low energy Kl4 decay results, including their isospin violation correction, and we have removed some controversial data points. These changes on the data translate into better determinations of threshold and subthreshold parameters which remove almost all disagreement with previous Chiral Perturbation Theory and Roy equation calculations below 800 MeV. Finally, our results favor the dip structure of the S0 inelasticity around the controversial 1000 MeV region.Comment: 34 pages, version to appear in Phys. Rev. D. Some references added and several errata correcte

QCD Short-distance Constraints and Hadronic Approximations

This paper discusses a general class of ladder resummation inspired hadronic approximations. It is found that this approach naturally reproduces many successes of single meson per channel saturation models (e.g. VMD) and NJL based models. In particular the existence of a constituent quark mass and a gap equation follows naturally. We construct an approximation that satisfies a large set of QCD short-distance and large $N_c$ constraints and reproduces many hadronic observables. We show how there exists in general a problem between QCD short-distance constraints for Green Functions and those for form factors and cross-sections following from the quark-counting rule. This problem while expected for Green functions that do not vanish in purely perturbative QCD also persists for many Green functions that are order parameters.Comment: 27 page

Adaptation and evaluation of the bottle assay for monitoring insecticide resistance in disease vector mosquitoes in the Peruvian Amazon

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to establish whether the "bottle assay", a tool for monitoring insecticide resistance in mosquitoes, can complement and augment the capabilities of the established WHO assay, particularly in resource-poor, logistically challenging environments.</p> <p>Methods</p> <p>Laboratory reared <it>Aedes aegypti </it>and field collected <it>Anopheles darlingi </it>and <it>Anopheles albimanus </it>were used to assess the suitability of locally sourced solvents and formulated insecticides for use with the bottle assay. Using these adapted protocols, the ability of the bottle assay and the WHO assay to discriminate between deltamethrin-resistant <it>Anopheles albimanus </it>populations was compared. The diagnostic dose of deltamethrin that would identify resistance in currently susceptible populations of <it>An. darlingi </it>and <it>Ae. aegypti </it>was defined. The robustness of the bottle assay during a surveillance exercise in the Amazon was assessed.</p> <p>Results</p> <p>The bottle assay (using technical or formulated material) and the WHO assay were equally able to differentiate deltamethrin-resistant and susceptible <it>An. albimanus </it>populations. A diagnostic dose of 10 μg a.i./bottle was identified as the most sensitive discriminating dose for characterizing resistance in <it>An. darlingi </it>and <it>Ae. aegypti</it>. Treated bottles, prepared using locally sourced solvents and insecticide formulations, can be stored for > 14 days and used three times. Bottles can be stored and transported under local conditions and field-assays can be completed in a single evening.</p> <p>Conclusion</p> <p>The flexible and portable nature of the bottle assay and the ready availability of its components make it a potentially robust and useful tool for monitoring insecticide resistance and efficacy in remote areas that require minimal cost tools.</p

Charged Kaon K \to 3 pi CP Violating Asymmetries at NLO in CHPT

We give the first full next-to-leading order analytical results in Chiral Perturbation Theory for the charged Kaon K \to 3 pi slope g and decay rates CP-violating asymmetries. We have included the dominant Final State Interactions at NLO analytically and discussed the importance of the unknown counterterms. We find that the uncertainty due to them is reasonable just for \Delta g_C, i.e. the asymmetry in the K^+ \to pi^+ pi^+ pi^- slope g; we get \Delta g_C = -(2.4 +- 1.2) 10^{-5}. The rest of the asymmetries are very sensitive to the unknown counterterms. In particular, the decay rate asymmetries can change even sign. One can use this large sentivity to get valuable information on those counterterms and on Im(G_8) coupling --very important for the CP-violating parameter epsilon'_K-- from the eventual measurement of these asymmetries. We also provide the one-loop O(e^2 p^2) electroweak octet contributions for the neutral and charged Kaon K \to 3 pi decays.Comment: 43+2 pages, 2 figures. Version accepted in JHEP. Small changes in the final numerics of CP asymmetries due to change in input valu