Athletic pubalgia and associated rehabilitation

BACKGROUND: Evaluation and treatment of groin pain in athletes is challenging. The anatomy is complex, and multiple pathologies often coexist. Different pathologies may cause similar symptoms, and many systems can refer pain to the groin. Many athletes with groin pain have tried prolonged rest and various treatment regimens, and received differing opinions as to the cause of their pain. The rehabilitation specialist is often given a non-specific referral of groin pain or sports hernia. The cause of pain could be as simple as the effects of an adductor strain, or as complex as athletic pubalgia or inguinal disruption. The term sports hernia is starting to be replaced with more specific terms that better describe the injury. Inguinal disruption is used to describe the syndromes related to the injury of the inguinal canal soft tissue environs ultimately causing the pain syndrome. The term athletic pubalgia is used to describe the disruption and/or separation of the more medial common aponeurosis from the pubis, usually with some degree of adductor tendon pathology. TREATMENT: Both non-operative and post-operative treatment options share the goal of returning the athlete back to pain free activity. There is little research available to reference for rehabilitation guidelines and creation of a plan of care. Although each surgeon has their own specific set of post-operative guidelines, some common concepts are consistent among most surgeons. Effective rehabilitation of the high level athlete to pain free return to play requires addressing the differences in the biomechanics of the dysfunction when comparing athletic pubalgia and inguinal disruption. CONCLUSION: Proper evaluation and diagnostic skills for identifying and specifying the difference between athletic pubalgia and inguinal disruption allows for an excellent and efficient rehabilitative plan of care. Progression through the rehabilitative stages whether non-operative or post-operative allows for a focused rehabilitative program. As more information is obtained through MRI imaging and the diagnosis and treatment of inguinal disruption and athletic pubalgia becomes increasingly frequent, more research is warranted in this field to better improve the evidence based practice and rehabilitation of patients. LEVELS OF EVIDENCE: 5

Composition of primary cosmic rays near the bend from a study of hadrons in air showers at sea level

Data on hadrons in air showers arriving at sea level were studied to find sensitivity to primary cosmic ray composition. The rate of showers which satisfy minimum shower density and hadron energy requirements as well as the rate of showers containing hadrons delayed with respect to the electron shower front are compared to Monte Carlo simulations. The data on the rate of total triggers and delayed hadrons are compared to predicted rates for two models of primary composition. The data are consistent with models which require an increasing heavy nuclei fraction near 10 to the 15th power eV. The spectra which are consistent with the observed rate are also compared to the observed shower size spectrum at sea level and mountain level

Observations of Wood Bison Swimming across the Liard River, Northwest Territories, Canada

We observed a group of 18 wood bison, of mixed sex and age classes, swimming across a 1.7 km wide section of the Liard River on 16 July 2002. Water levels and flow rates were above the long-term average for that time of year, and there was a river current of 14-16 km/h. The animals took at least 27 minutes to negotiate their 3.6 km swim. Younger animals were able to keep more of their head and body above the water level than older mature males. Calves of the year, observed swimming across a secondary channel of the river on 15 July 2003, had only their heads above water. Bison are capable of swimming across lakes and rivers (Wood Buffalo National Park, Yellowstone National Park), but well-documented cases of bison navigating rapidly flowing northern rivers are rare. Open-water crossings of the Liard River are important to the ecology of the Nahanni wood bison population, especially since seismic activity in the Liard River Valley is likely to increase.Le 16 juillet 2002, on a observé un groupe de 18 bisons des bois, des deux sexes et de groupes d'âge divers, traversant à la nage une section de la rivière Liard large de 1,7 km. Le niveau d'eau et le débit fluvial dépassaient la moyenne à long terme pour cette période de l'année, et le courant fluvial y était de 14 à 16 km/h. Les animaux ont mis au moins 27 minutes pour négocier leur traversée de 3,6 km. Les plus jeunes pouvaient garder hors de l'eau une plus grande partie de leur tête et de leur corps que d'autres mâles plus âgés. Les veaux de l'année, que l'on a observés le 15 juillet 2003, durant leur traversée à la nage d'une branche secondaire de la rivière, n'avaient que la tête hors de l'eau. Les bisons sont capables de traverser des lacs et des rivières (parc national Wood Buffalo, parc national Yellowstone), mais on ne connaît que peu de cas bien documentés de bisons négociant la traversée de cours d'eau nordiques à courant rapide. La traversée des eaux libres de la Liard est importante pour l'écologie de la population du bison des bois de la Nahanni, en particulier si l'on considère que la prospection sismique va probablement augmenter dans la vallée de la Liard

The composition of cosmic rays near the Bend (10 to the 15th power eV) from a study of muons in air showers at sea level

The distribution of muons near shower cores was studied at sea level at Fermilab using the E594 neutrino detector to sample the muon with E testing 3 GeV. These data are compared with detailed Monte Carlo simulations to derive conclusions about the composition of cosmic rays near the bend in the all particle spectrum. Monte Carlo simulations generating extensive air showers (EAS) with primary energy in excess of 50 TeV are described. Each shower record contains details of the electron lateral distribution and the muon and hadron lateral distributions as a function of energy, at the observation level of 100g/cm. The number of detected electrons and muons in each case was determined by a Poisson fluctuation of the number incident. The resultant predicted distribution of muons, electrons, the rate events are compared to those observed. Preliminary results on the rate favor a heavy primary dominated cosmic ray spectrum in energy range 50 to 1000 TeV

Amplification of HER2 is a marker for global genomic instability

<p>Abstract</p> <p>Background</p> <p>Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can be influenced by other genetic changes. To assess the broader genomic implications of structural changes at the HER2 locus, we investigated relationships between genomic instability and HER2 status in patients with invasive breast cancer.</p> <p>Methods</p> <p>HER2 status was determined using the PathVysion^®assay. DNA was extracted after laser microdissection from the 181 paraffin-embedded HER2 amplified (n = 39) or HER2 negative (n = 142) tumor specimens with sufficient tumor available to perform molecular analysis. Allelic imbalance (AI) was assessed using a panel of microsatellite markers representing 26 chromosomal regions commonly altered in breast cancer. Student t-tests and partial correlations were used to investigate relationships between genomic instability and HER2 status.</p> <p>Results</p> <p>The frequency of AI was significantly higher (<it>P </it>< 0.005) in HER2 amplified (27%) compared to HER2 negative tumors (19%). Samples with HER2 amplification showed significantly higher levels of AI (<it>P </it>< 0.05) at chromosomes 11q23, 16q22-q24 and 18q21. Partial correlations including ER status and tumor grade supported associations between HER2 status and alterations at 11q13.1, 16q22-q24 and 18q21.</p> <p>Conclusion</p> <p>The poor prognosis associated with HER2 amplification may be attributed to global genomic instability as cells with high frequencies of chromosomal alterations have been associated with increased cellular proliferation and aggressive behavior. In addition, high levels of DNA damage may render tumor cells refractory to treatment. In addition, specific alterations at chromosomes 11q13, 16q22-q24, and 18q21, all of which have been associated with aggressive tumor behavior, may serve as genetic modifiers to HER2 amplification. These data not only improve our understanding of HER in breast pathogenesis but may allow more accurate risk profiles and better treatment options to be developed.</p

Moral reasoning and homosexuality: the acceptability of arguments about lesbian and gay issues

In the political arena, lesbian and gay issues have typically been contested on grounds of human rights, but with variable success. Using a moral developmental framework, the purpose of this study was to explore preferences for different types of moral arguments when thinking about moral dilemmas around lesbian and gay issues. The analysis presented here comprised data collected from 545 students at UK universities, who completed a questionnaire, part of which comprised a moral dilemma task. Findings of the study showed that respondents do not apply moral reasoning consistently, and do not (clearly) favour human rights reasoning when thinking about lesbian and gay issues. Respondents tended to favour reasoning supporting existing social structures and frameworks, therefore this study highlights the importance of structural change in effecting widespread attitude change in relation to lesbian and gay rights issues. The implications of the findings for moral education are also discussed.</p

Emotions in context: examining pervasive affective sensing systems, applications, and analyses

Pervasive sensing has opened up new opportunities for measuring our feelings and understanding our behavior by monitoring our affective states while mobile. This review paper surveys pervasive affect sensing by examining and considering three major elements of affective pervasive systems, namely; “sensing”, “analysis”, and “application”. Sensing investigates the different sensing modalities that are used in existing real-time affective applications, Analysis explores different approaches to emotion recognition and visualization based on different types of collected data, and Application investigates different leading areas of affective applications. For each of the three aspects, the paper includes an extensive survey of the literature and finally outlines some of challenges and future research opportunities of affective sensing in the context of pervasive computing

Aerodynamic Flight-Test Results for the Adaptive Compliant Trailing Edge

The aerodynamic effects of compliant flaps installed onto a modified Gulfstream III airplane were investigated. Analyses were performed prior to flight to predict the aerodynamic effects of the flap installation. Flight tests were conducted to gather both structural and aerodynamic data. The airplane was instrumented to collect vehicle aerodynamic data and wing pressure data. A leading-edge stagnation detection system was also installed. The data from these flights were analyzed and compared with predictions. The predictive tools compared well with flight data for small flap deflections, but differences between predictions and flight estimates were greater at larger deflections. This paper describes the methods used to examine the aerodynamics data from the flight tests and provides a discussion of the flight-test results in the areas of vehicle aerodynamics, wing sectional pressure coefficient profiles, and air data