Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis

BACKGROUND Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess involvement in the metastatic process. METHODS 148 sections of primary invasive breast cancers, with 10 yr follow-up, were stained with anti-CLEVER-1. Leukocyte infiltration was assessed, along with involvement of specific subpopulations by staining with CD83 (mature dendritic cells, mDC), CD209 (immature DC, iDC) and CD68 (macrophage, Mϕ). In vitro expression of CLEVER-1 on lymphatic (LEC) and blood endothelial cells (BEC) was examined by flow cytometry. RESULTS In vitro results showed that although both endothelial cell types express CLEVER-1, surface expression was only evident on LEC. In tumour sections CLEVER-1 was expressed in blood vessels (BV, 61.4% of samples), lymphatic vessels (LV, 18.2% of samples) and in Mϕ/DCs (82.4% of samples). However, only CLEVER-1 expression in LV was associated with LN metastasis (p = 0.027) and with Mϕ indices (p = 0.021). Although LV CLEVER-1 was associated with LN positivity there was no significant correlation with recurrence or overall survival, BV CLEVER-1 expression was, however, associated with increased risk of recurrence (p = 0.049). The density of inflammatory infiltrate correlated with CLEVER-1 expression in BV (p < 0.001) and LV (p = 0.004). CONCLUSIONS The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. Its upregulation on LV, related surface expression, and association with LN metastasis suggest that it may be an important mediator of tumor cell metastasis to LN

Background Dependent Lorentz Violation: Natural Solutions to the Theoretical Challenges of the OPERA Experiment

To explain both the OPERA experiment and all the known phenomenological constraints/observations on Lorentz violation, the Background Dependent Lorentz Violation (BDLV) has been proposed. We study the BDLV in a model independent way, and conjecture that there may exist a "Dream Special Relativity Theory", where all the Standard Model (SM) particles can be subluminal due to the background effects. Assuming that the Lorentz violation on the Earth is much larger than those on the interstellar scale, we automatically escape all the astrophysical constraints on Lorentz violation. For the BDLV from the effective field theory, we present a simple model and discuss the possible solutions to the theoretical challenges of the OPERA experiment such as the Bremsstrahlung effects for muon neutrinos and the pion decays. Also, we address the Lorentz violation constraints from the LEP and KamLAMD experiments. For the BDLV from the Type IIB string theory with D3-branes and D7-branes, we point out that the D3-branes are flavour blind, and all the SM particles are the conventional particles as in the traditional SM when they do not interact with the D3-branes. Thus, we not only can naturally avoid all the known phenomenological constraints on Lorentz violation, but also can naturally explain all the theoretical challenges. Interestingly, the energy dependent photon velocities may be tested at the experiments.Comment: RevTex4, 14 pages, minor corrections, references adde

Filter Bank Multi-Sub-Band Transmission for Optical Systems with Mode Multiplexing

Mode-multiplexed optical transmission is subject to mode coupling and potentially large differential mode delays. In most recent implementations, these effects are compensated for at the receiver by complex adaptive multiple-input multiple-output (MIMO) equalizers. Although frequency-domain MIMO equalization requires a moderate complexity compared to time-domain equalization, the long required fast Fourier transforms may face implementation issues. In this paper, we evaluate an alternative transceiver architecture based on sub-band partitioning, implemented by filter banks, which enables concurrent time-domain equalization. Single-carrier (SC) and multi-sub-band (MSB) mode division multiplexing transmission are simulated using frequency-domain equalization and time-domain equalization, respectively. Their performance is compared in terms of static transmission performance, channel tracking capability, phase noise tolerance, and computational complexity. The results indicate that compared with an equivalent SC solution, the MSB architecture provides a high degree of parallelism at the cost of a penalty of 0.7-1.3 dB for a laser linewidth of 25-100 kHz and a moderate increase in complexity

Heterotic - type I superstring duality and low-energy effective actions

We compare order $R^4$ terms in the 10-dimensional effective actions of SO(32) heterotic and type I superstrings from the point of view of duality between the two theories. Some of these terms do not receive higher-loop corrections being related by supersymmetry to `anomaly-cancelling' terms which depend on the antisymmetric 2-tensor. At the same time, the consistency of duality relation implies that the `tree-level' $R^4$ super-invariant (the one which has $\zeta(3)$-coefficient in the sphere part of the action) should appear also at higher orders of loop expansion, i.e. should be multiplied by a non-trivial function of the dilaton.Comment: 16 pages, harvma

Loop Quantum Gravity Modification of the Compton Effect

Modified dispersion relations(MDRs) as a manifestation of Lorentz invariance violation, have been appeared in alternative approaches to quantum gravity problem. Loop quantum gravity is one of these approaches which evidently requires modification of dispersion relations. These MDRs will affect the usual formulation of the Compton effect. The purpose of this paper is to incorporate the effects of loop quantum gravity MDRs on the formulation of Compton scattering. Using limitations imposed on MDRs parameters from Ultra High Energy Cosmic Rays(UHECR), we estimate the quantum gravity-induced wavelength shift of scattered photons in a typical Compton process. Possible experimental detection of this wavelength shift will provide strong support for underlying quantum gravity proposal.Comment: 12 pages, 2 eps figures, revised versio

Optical cavity tests of Lorentz invariance for the electron

A hypothetical violation of Lorentz invariance in the electrons' equation of motion (expressed within the Lorentz-violating extension of the standard model) leads to a change of the geometry of crystals and thus shifts the resonance frequency of an electromagnetic cavity. This allows experimental tests of Lorentz invariance of the electron sector of the standard model. The material dependence of the effect allows to separate it from an additional shift caused by Lorentz violation in electrodynamics, and to place independent limits on both effects. From present experiments, upper limits on Lorentz violation in the electrons' kinetic energy term are deduced.Comment: 17 pages revte

DCC Dynamics in (2+1)D-O(3) model

The dynamics of symmetry-breaking after a quench is numerically simulated on a lattice for the (2+1)-dimensional O(3) model. In addition to the standard sigma-model with temperature-dependent Phi^4-potential the energy functional includes a four-derivative current-current coupling to stabilize the size of the emerging extended topological textures. The total winding number can be conserved by constraint. As a model for the chiral phase transition during the cooling phase after a hadronic collision this allows to investigate the interference of 'baryon-antibaryon' production with the developing disoriented aligned domains. The growth of angular correlations, condensate, average orientation is studied in dependence of texture size, quench rate, symmetry breaking. The classical dissipative dynamics determines the rate of energy emitted from the relaxing source for each component of the 3-vector field which provides a possible signature for domains of Disoriented Chiral Condensate. We find that the 'pions' are emitted in two distinct pulses; for sufficiently small lattice size the second one carries the DCC signal, but it is strongly suppressed as compared to simultaneous 'sigma'-meson emission. We compare the resulting anomalies in the distributions of DCC pions with probabilities derived within the commonly used coherent state formalism.Comment: 27 pages, 17 figures; several minor insertions in the text; two references adde

A Gribov equation for the photon Green's function

We present a derivation of the Gribov equation for the gluon/photon Green's function D(q). Our derivation is based on the second derivative of the gauge-invariant quantity Tr ln D(q), which we interpret as the gauge-boson `self-loop'. By considering the higher-order corrections to this quantity, we are able to obtain a Gribov equation which sums the logarithmically enhanced corrections. By solving this equation, we obtain the non-perturbative running coupling in both QCD and QED. In the case of QCD, alpha_S has a singularity in the space-like region corresponding to super-criticality, which is argued to be resolved in Gribov's light-quark confinement scenario. For the QED coupling in the UV limit, we obtain a \propto Q^2 behaviour for space-like Q^2=-q^2. This implies the decoupling of the photon and an NJLVL-type effective theory in the UV limit.Comment: 12 pages, 5 figures; version to be published in Eur. Phys. J.

Gauge-invariant gravitational wave modes in pre-big bang cosmology

The t<0 branch of pre-big bang cosmological scenarios is subject to a gravitational wave instability. The unstable behaviour of tensor perturbations is derived in a very simple way in Hwang's covariant and gauge-invariant formalism developed for extended theories of gravity. A simple interpretation of this instability as the effect of an "antifriction" is given, and it is argued that a universe must eventually enter the expanding phase.Comment: 4 pages, latex, to appear in Eur. Phys. J.

Newtonian versus relativistic nonlinear cosmology

Both for the background world model and its linear perturbations Newtonian cosmology coincides with the zero-pressure limits of relativistic cosmology. However, such successes in Newtonian cosmology are not purely based on Newton's gravity, but are rather guided ones by previously known results in Einstein's theory. The action-at-a-distance nature of Newton's gravity requires further verification from Einstein's theory for its use in the large-scale nonlinear regimes. We study the domain of validity of the Newtonian cosmology by investigating weakly nonlinear regimes in relativistic cosmology assuming a zero-pressure and irrotational fluid. We show that, first, if we ignore the coupling with gravitational waves the Newtonian cosmology is exactly valid even to the second order in perturbation. Second, the pure relativistic correction terms start appearing from the third order. Third, the correction terms are independent of the horizon scale and are quite small in the large-scale near the horizon. These conclusions are based on our special (and proper) choice of variables and gauge conditions. In a complementary situation where the system is weakly relativistic but fully nonlinear (thus, far inside the horizon) we can employ the post-Newtonian approximation. We also show that in the large-scale structures the post-Newtonian effects are quite small. As a consequence, now we can rely on the Newtonian gravity in analyzing the evolution of nonlinear large-scale structures even near the horizon volume.Comment: 8 pages, no figur