10,729 research outputs found
Occultation studies of planets and satellites: The occultation of epsilon Geminorum by Mars
The occultation of epsilon Geminorum by Mars on 1976 April 8 was observed at three wavelengths and 4 ms time resolution with the 91 cm telescope. Temperature, pressure, and number density profiles of the Martian atmosphere were obtained for both the immersion and emersion events. Within the altitude range of 50 to 80 km above the mean surface, the mean temperature is 145 K, and the profiles exhibit wavelike structures with a peak to peak amplitude of 35 K and a vertical scale of about 20 km. The ratio of the refractivity of the atmosphere at 4500 A and 7500 A, determined from the time shift of the light curves for these wavelengths, is consistent with the atmospheric composition measured by Viking 1, 15 weeks later. From the central flash - a bright feature in the light curve midway between immersion and emersion - an optical depth is found at 4500 A of 3.3 plus or minus 1.7 per km atm (about 0.23 per equivalent Martian air mass) for the atmosphere about 25 km above the mean surface, near the south polar region. This large value and its weak wavelength dependence rule out Rayleigh scattering as the principal cause of the observed extinction
Temperature Effects on Development of Three Cereal Aphid Parasitoids (Hymenoptera: Aphidiidae)
Temperature is an important climatological variable that influences the biology and ecology of insects. Poor climatic adaptation can limit the effectiveness of parasitic insects in biological control. Two exotic parasites (Syrian Diaeretiella rapae (M\u27Intosh) and Argentinean Aphidius colemani Viereck) imported for biological control of the Russian wheat aphid, Diuraphis noxia (Mordvilko), and one native parasite (Diaeretiella rapae) were reared in growth chambers in three fluctuating temperature regimes with average daily temperatures of 12, 18, and 24°C. Estimates of temperature thresholds for immature development were 3.3, 3.5, and 2.8°C, for Oklahoman D. rapae, Syrian D. rapae, and A. colemani, respectively. Estimates of thermal require- ments for development from egg to adult were 297, 278, and 301 degree-days for the three parasitoids. Dry weights of adults reared in different fluctuating temperature regimes did not differ significantly among sexes, but adults from regimes with low average temperatures of 12 and 18°C had significantly greater weights than those reared in a regime with an average temperature of 24°C. Results suggest that developmental response to temperature will not limit the effectiveness of the exotic parasites in biological control
Double Charge Exchange And Configuration Mixing
The energy dependence of forward pion double charge exchange reactions on
light nuclei is studied for both the Ground State transition and the
Double-Isobaric-Analog-State transitions. A common characteristic of these
double reactions is a resonance-like peak around 50 MeV pion lab energy. This
peak arises naturally in a two-step process in the conventional pion-nucleon
system with proper handling of nuclear structure and pion distortion. A
comparison among the results of different nuclear structure models demonstrates
the effects of configuration mixing. The angular distribution is used to fix
the single particle wave function.Comment: Added 1 figure (now 8) corrected references and various other change
Achievement goals, self-handicapping, and performance: A 2 × 2 achievement goal perspective
Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the
trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the
work of Elliot et al. by experimentally promoting all four goals proposed by the 262 model (Elliot & McGregor, 2001),
measuring the participants’ own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 262 model. The participants (n¼138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues’ findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did
not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on selfhandicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals
Differential regulation of the SMN2 gene by individual HDAC proteins
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder that is the leading genetic cause of infantile death. SMA is caused by homozygous deletion or mutation of the survival of motor neuron 1 gene (SMN1). The SMN2 gene is nearly identical to SMN1, however is alternatively spliced. The close relationship to SMN1 results in SMN2 being a very power genetic modifier of SMA disease severity and a target for therapies. We sought to identify the regulatory role individual HDAC proteins use to control expression of full length protein from the SMN2 genes. We used quantitative PCR to determine the effects shRNA silencing of individual HDACs on the steady state levels of a SMN2-luciferase reporter transcripts. We determined that reduction of individual HDAC proteins was sufficient to increase SMN protein levels in a transgenic reporter system. Knockdown of class I HDAC proteins preferentially activated the reporter by increased promoter transcription. Silencing of class II HDAC proteins maintained transcriptional activity; however silencing of HDAC 5 and 6 also appeared to enhance inclusion of an alternatively spliced exon. This work highlights HDAC proteins 2 and 6 as excellent investigative targets. These data are important to the basic understanding of SMN expression regulation and the refinements of current therapeutic compounds as well as the development of novel SMA therapeutics
Commensurate and modulated magnetic phases in orthorhombic A1C60
Competing magnetically ordered structures in polymerized orthorhombic A1C60
are studied. A mean-field theory for the equilibrium phases is developed using
an Ising model and a classical Heisenberg model to describe the competition
between inter- and intra-chain magnetic order in the solid. In the Ising model,
the limiting commensurate one-dimensional and three-dimensional phases are
separated by a commensurate three-sublattice state and by two sectors
containing higher-order commensurate phases. For the Heisenberg model the
quasi-1D phase is never the equilibrium state; instead the 3D commensurate
phases exhibits a transition to a continuum of coplanar spiral magnetic phases.Comment: 11 pages REVTeX 3.0 plus 4 figures appende
Buoyancy waves in Pluto's high atmosphere: Implications for stellar occultations
We apply scintillation theory to stellar signal fluctuations in the
high-resolution, high signal/noise, dual-wavelength data from the MMT
observation of the 2007 March 18 occultation of P445.3 by Pluto. A well-defined
high wavenumber cutoff in the fluctuations is consistent with viscous-thermal
dissipation of buoyancy waves (internal gravity waves) in Pluto's high
atmosphere, and provides strong evidence that the underlying density
fluctuations are governed by the gravity-wave dispersion relation.Comment: Accepted 18 June 2009 for publication in Icaru
Neuronal activation for semantically reversible sentences
Semantically reversible sentences are prone to misinterpretation and take longer for typically developing children and adults to comprehend; they are also particularly problematic for those with language difficulties such as aphasia or Specific Language Impairment. In our study, we used fMRI to compare the processing of semantically reversible and nonreversible sentences in 41 healthy participants to identify how semantic reversibility influences neuronal activation. By including several linguistic and nonlinguistic conditions within our paradigm, we were also able to test whether the processing of semantically reversible sentences places additional load on sentence-specific processing, such as syntactic processing and syntactic-semantic integration, or on phonological working memory. Our results identified increased activation for reversible sentences in a region on the left temporal–parietal boundary, which was also activated when the same group of participants carried out an articulation task which involved saying “one, three” repeatedly. We conclude that the processing of semantically reversible sentences places additional demands on the subarticulation component of phonological working memory
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A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remains poorly understood. Here we report that a bulky glycocalyx promotes the expansion of disseminated tumor cells in vivo by fostering integrin adhesion assembly to permit G1 cell cycle progression. We engineered tumor cells to display glycocalyces of various thicknesses by coating them with synthetic mucin-mimetic glycopolymers. Cells adorned with longer glycopolymers showed increased metastatic potential, enhanced cell cycle progression, and greater levels of integrin-FAK mechanosignaling and Akt signaling in a syngeneic mouse model of metastasis. These effects were mirrored by expression of the ectodomain of cancer-associated mucin MUC1. These findings functionally link mucinous proteins with tumor aggression, and offer a new view of the cancer glycocalyx as a major driver of disease progression
The Hubble Space Telescope high speed photometer
The Hubble Space Telescope will provide the opportunity to perform precise astronomical photometry above the disturbing effects of the atmosphere. The High Speed Photometer is designed to provide the observatory with a stable, precise photometer with wide dynamic range, broad wavelenth coverage, time resolution in the microsecond region, and polarimetric capability. Here, the scientific requirements for the instrument are examined, the unique design features of the photometer are explored, and the improvements to be expected over the performance of ground-based instruments are projected
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