Use of alternative and complementary medicine in menopause

Objectives: To review the clinical evidence available for the treatment of menopausal symptoms with alternative and complementary medicine. Methods: The MEDLINE, PREMEDLINE and COCHRANE electronic databases for the years 1980–2002 were searched for articles concerning soy products, black cohosh, dong quai, acupuncture, ginseng and evening primrose oil. Studies pertaining to menopausal vasomotor symptoms, lipid profiles and bone mineral densities of postmenopausal women were included. The data from clinical trials were reviewed. Results: Soy isoflavones slightly decrease total cholesterol and LDL levels. The clinical significance of this small change is yet to be determined. The synthetic isoflavone derivative ipriflavone increases bone mineral density in healthy peri‐ and postmenopausal women with moderate bone mineral densities. Although earlier reports have claimed that soy is beneficial for the improvement of vasomotor symptoms, recent data do not support this claim. There are insufficient data on the other alternative therapies for treating menopausal symptoms at this time. Conclusion: Alternative and complementary medicine may play a role in the management of menopause, however, well‐designed large studies are still needed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135146/1/ijgo195.pd

Postpartum mental health after Hurricane Katrina: A cohort study

<p>Abstract</p> <p>Background</p> <p>Natural disaster is often a cause of psychopathology, and women are vulnerable to post-traumatic stress disorder (PTSD) and depression. Depression is also common after a woman gives birth. However, no research has addressed postpartum women's mental health after natural disaster.</p> <p>Methods</p> <p>Interviews were conducted in 2006–2007 with women who had been pregnant during or shortly after Hurricane Katrina. 292 New Orleans and Baton Rouge women were interviewed at delivery and 2 months postpartum. Depression was assessed using the Edinburgh Depression Scale and PTSD using the Post-Traumatic Stress Checklist. Women were asked about their experience of the hurricane with questions addressing threat, illness, loss, and damage. Chi-square tests and log-binomial/Poisson models were used to calculate associations and relative risks (RR).</p> <p>Results</p> <p>Black women and women with less education were more likely to have had a serious experience of the hurricane. 18% of the sample met the criteria for depression and 13% for PTSD at two months postpartum. Feeling that one's life was in danger was associated with depression and PTSD, as were injury to a family member and severe impact on property. Overall, two or more severe experiences of the storm was associated with an increased risk for both depression (relative risk (RR) 1.77, 95% confidence interval (CI) 1.08–2.89) and PTSD (RR 3.68, 95% CI 1.80–7.52).</p> <p>Conclusion</p> <p>Postpartum women who experience natural disaster severely are at increased risk for mental health problems, but overall rates of depression and PTSD do not seem to be higher than in studies of the general population.</p

Olfactory event-related potentials in normal human subjects: effects of age and gender

Behavioral and electrophysiological testing of olfactory function was performed in 33 normal human male and female subjects, 18-83 years of age. Acuity for odor identification and odor detection was verified by standard psychophysical tests. For evoked potential testing, a constant flow olfactometer provided odorant stimuli (amyl acetate) or air control stimuli that were presented to the right nostril by a nasal cannula at a flow rate of 5 l/min, duration of 40 msec and random interstimulus intervals of 6-30 sec. The behavioral tests revealed no significant difference between males and females, whereas increasing age was associated with a decline in performance on the odor identification test. No reproducible evoked potentials were recorded in response to the air control stimulus. Potentials to the odorant stimulus consisted of 4 components named P1, N1, P2 and N2. A significant correlation was found between P2 latency and odor identification test scores, suggesting a relationship between the generation of the P2 component and olfactory processing. P2 peak latency increased significantly with age at 2.5 msec/year. An age-related decline in N1-P2 interpeak amplitude was seen in male subjects. Topographic differences were seen in the P2 peak amplitude and the N1-P2 and P2-N2 interpeak amplitudes such that their amplitudes were greatest at Cz and Pz. On average, N1-P2 interpeak amplitudes were larger in the female subjects than in the male subjects, possibly revealing a hormonal influence on the olfactory event-related potential