Anatometric Point Guide for Canine Cranial Cruciate Ligament Suture Repair

Tears to the cranial cruciate ligament account for 90% of all canine hind-limb stifle injuries. The most common surgical repair method, lateral suture stabilization, has a 25% failure rate. The purpose of this project was to create an aiming guide to reproducibly locate anatometric points on the canine stifle. Cyclic cadaver testing and tibial translation testing was completed on 9 cadaver stifles. The results of these tests suggested that femoral point f2, and the tibial point t8 are the most anatometric points due to limited strain on the suture during the stifle range of motion and high forces required for tibial translation. A drill guide was created to aid surgeons in locating the points and ensuring a reproducible surgery. Veterinary surgeons validated the device’s function

Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis

10.1136/jmedgenet-2012-101325Journal of Medical Genetics504246-254JMDG

Sequencing analysis of the ATOH7 gene in individuals with optic nerve hypoplasia

Background: The Atonal Homolog 7 (ATOH7) gene has been implicated in association studies with optic nerve head diameter size. Hence, we screened optic nerve hypoplasia (ONH) patient DNA samples from Australia, France, and the United States for sequence variants in theATOH7 gene using Sanger sequencing. Methods: Sanger sequencing of theATOH7 gene was performed on 34 affected individual DNA samples. Sequencing was also carried out in three unaffected family members to confirm segregation of identified single nucleotide variations. Results: Seven sequence variations were identified in ATOH7. No disease-causing sequence changes in the ATOH7 gene was discovered in the ONH patient samples. Conclusions: Mutations within the ATOH7 gene are not implicated in the pathogenesis of optic nerve hypoplasia in our patient cohort