A utilização do marketing em campanhas sociais

Orientadora : Ana Paula Mussi Szabo CherobimMonografia (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas, Curso de Especialização em Marketing EmpresarialInclui referência

An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities

Ikaros DNA binding factor plays critical roles in lymphocyte development. Changes in Ikaros expression levels during lymphopoiesis are controlled by redundant but also unique regulatory elements of its locus that are critical for this developmental process. We have recently shown that Ikaros binds its own locus in thymocytes in vivo. Here, we evaluated the role of an Ikaros binding site within its major lympho-myeloid promoter. We identified an Ikaros/Ets binding site within a promoter sub-region that was highly conserved in mouse and human. Deletion of this binding site increased the percentage of the reporter-expressing mouse lines, indicating that its loss provided a more permissive chromatin environment. However, once transcription was established, the lack of this site decreased transcriptional activity. These findings implicate a dual role for Ikaros/Ets1 binding on Ikzf1 expression that is exerted at least through its promoter

Characterization of effluents from a tannery industry: A case study of Córdoba province, Argentina

Tannery effluents are considered to be severe pollutants around the world. The characterization of such effluents is a very important task in order to verify the compliance with legal requirements of the discharge and, if necessary, to optimize their treatment. In this study, we used the effluents from a local tannery (Córdoba, Argentina) that had implemented only a primary treatment. The effluents were periodically collected during one year to assess their physical, chemical, and microbiological characteristics, as well as their toxicity. The physical and chemical characteristics showed variations independently of the sampling time, although, in general, a high nutrient load was the most frequent finding. Moreover, parameters such as chemical oxygen demand, biochemical oxygen demand, total nitrogen, total phosphate, total phenols, Cr(VI) and settleable solids exceeded the limit set by the provincial legislation for the discharge of effluents into surface water bodies. The effluents were also characterized by a high count of bacteria, where pollutant-tolerant and some pathogenic bacteria were found. In sampling 9, Bacteroidetes, Firmicutes and Proteobacteria represented up to 93 % of the total number of sequences obtained, with Paludibacter, Tissierella Soehngenia, Proteocatella and Proteiniclasticum as the most abundant genera. In concordance with these results, all samples showed toxicity according to L. sativa and AMPHITOX bioas-says. Altogether, data from this report indicate the need to optimize primary treatment of the effluents, as well as to include complementary treatments in order to reduce the negative environmental impacts of the release of this kind of runoffs.Los efluentes de las curtidurías se consideran contaminantes graves en todo el mundo. La caracterización de dichos efluentes es una tarea muy importante para verificar el cumplimiento de los requisitos legales de vertido y, en caso de ser necesario, optimizar el tratamiento de efluentes. En este estudio utilizamos los efluentes de una curtiduría local (Córdoba, Argentina) que había implementado sólo un tratamiento primario. Los efluentes fueron recolectados periódicamente durante un año para evaluar sus caracte- rísticas físicas, químicas y microbiológicas, así como su toxicidad. Las características físicas y químicas mostraron variaciones independientemente del tiempo de muestreo, aunque, en general, el hallazgo más frecuente fue una alta carga de nutrientes. Además, parámetros como demanda química de oxígeno, demanda bioquímica de oxígeno, ni- trógeno total, fosfato total, fenoles totales, Cr(VI) y sólidos sedimentables, superaron los límites establecidos por la legislación provincial para el vertido de efluentes en aguas superficiales. Los efluentes también se caracterizaron por un alto recuento de bacterias, encontrándose bacterias tolerantes a contaminantes y algunos patógenos. En la muestra 9, Bacteroidetes, Firmicutes y Proteobacteria representaron en conjunto hasta el 93 % del número total de secuencias obtenidas, siendo Paludibacter, Tissierella Soehngenia, Proteocatella y Proteiniclasticum los géneros más abundantes. De acuerdo con estos resultados, todas las muestras presentaron toxicidad según los bioensayos de L. sativa y AMPHITOX. En conjunto, los datos de este informe indican la necesidad de optimizar el tratamiento primario de los efluentes, así como de incluir tratamientos complementarios para reducir los impactos ambientales negativos de la liberación de este tipo de efluentes.Fil: Fernandez, Marilina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: González, Paola Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; ArgentinaFil: Boarini, Milena Belen. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Mandille, Josefina. Universidad Nacional de Río Cuarto; ArgentinaFil: Barberón, Ignacio. Universidad Nacional de Río Cuarto; ArgentinaFil: Perotti, Romina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Pereira, Paola Patricia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Agostini, Elizabeth. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Paisio, Cintia Elizabeth. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentin

Anti-inflammatory Effects and Safety of Extracts and Essential Oil from Clinopodium gilliesii (muña muña)

The chemical machinery of vegetables offers a great diversity of biological properties and plays a fundamental role in the field of pharmacology. The search for new drugs with fewer adverse effects represents a challenge for researchers. The objective of the present work was to carry out to investigate the medicinal properties and safety of extracts and essential oil from aerial parts of Clinopodium gilliesii (muña muña) and evaluate their antioxidant and anti-inflammatory activities in vivo. The extractions were carried out serially, using 96º alcohol (EE) and boiled distilled water (AE). The essential oil (EO) was obtained by steam dragging. The AE in vivo antiinflammatory activity was determined by carrageenan induced plantar edema (acute inflammation) and granuloma formation by cotton disc (chronic inflammation) at oral doses of 250 and 500 mg/kg while that of the EO was established topically at doses of 50, 100µl/kg. In-vitro antioxidant activity was evaluated by DPPH depuration and inhibition of lipid peroxidation (β-carotene-linoleic acid method). Chemical study of the extracts was carried out by means of phytochemical screening and the essential oil was analyzed by GC-MS chromatography. The safety was evaluated with test of acute toxicity (48 h) and acute dermal toxicity (14 days). The results revealed that EE and EO had a significant acute and chronic anti-inflammatory activity, compared with positive patterns. EE (500 mg/kg), EO (100µl/kg), ibuprofen (100 mg/kg) and meprednisone (5 mg/kg) significantly reduced the weight of the exudate and cotton disc granuloma (24.17, 35.30, 45.56 and 57.17% respectively). The alcoholic and aqueous extracts presented important antioxidant activities with values higher than 90% (from 400μg/ml) in both methods and similar to the positive patterns (BHT and quercetin). The chromatographic profile of volatile oil compounds showed a great richness in terpene substances, pulegone, menthone and neomenthol, being its major constituents. The hydroalcoholic extracts revealed the presence of reducing compounds, polysaccharides, tannins, triterpenes, sterols and coumarins as major phytoconstituents. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. The essential oil at a single dose of 2000 and 5000 mg/kg of body weight did not produce treatment-related signs of toxicity or mortality in all rats tested during the 14 day observation period. These findings are encouraging to continue studies for the validation of popular use and development of a phytopharmaceutical with medicinal utility.Fil: Reynoso, Marcos Adrian. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Balderrama Coca, Maria Elizabeth. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Brodkiewicz, Ivana Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Jaime, Gloria Susana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Perotti, Marina Elvira. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Shuff, Carola. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Vera, Nancy Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentin

Integração universidade-empresa (setor produtivo) em cursos superiores de tecnologia: o relato do processo de pesquisa e ação no Setor de Educação Profissional e Tecnológica da Universidade Federal do Paraná

O presente artigo registra as ações de pesquisa e de aproximação com o setor produtivo levadas a cabo por professores e alunos do Curso Superior de Tecnologia em Gestão da Qualidade, que tem se dado no Setor de Educação Profissional e Tecnológica da Universidade Federal do Paraná realizadas entre o segundo semestre de 2009 e o início do primeiro semestre de 2011. Após a revisão da literatura que baliza tal processo, se apresenta o estado das atividades realizadas e as perspectivas de encaminhamento de esforços. Assevera-se também a necessidade de empenhos comuns a toda a comunidade acadêmica voltada a cursos superiores de tecnologia para que o setor produtivo e as universidades se aproximem e se integrem mutuamente

The Grizzly, September 18, 2003

Senate Debates Future of Pell Grants • Presidential Address on Iraq • Downloading a Lawsuit • Working for the Weekend • How Accessible is Ursinus College? • Time of the Month not Every Month • Doors Close on an Urban Myth: Elevator Danger • Opinions: Zack\u27s: Not Always a Good Alternative; Have you Thanked Your Cleaning Staff Today?; The Negative Side of Reality TV; Out of the Middle East: Part Two • Nonsense! • An Off-campus Opportunity: Southlander • Potions, Pills and Prescriptions: Careers in the Pharmaceutical Industry • Dance with the Best! • Dave Matthews\u27 Experience: From the Eyes of UC Students • Student Profile: Jennifer Cackowski Challenged at Frankfurt Consulate • Price Comparison: Gas Prices • Bears Defense Crushes Catholic • Volleyball Team Continues Streaky Play • UC Cross Country Battles Elements and Competition • Women\u27s Soccer Team off to Best Start Ever • Men\u27s Soccer: Continuing to Fight • Field Hockey: Bears Lose Tough Onehttps://digitalcommons.ursinus.edu/grizzlynews/1541/thumbnail.jp

The Grizzly, October 9, 2003

Choose to Reuse: Recycling at Ursinus • Volunteer Program Breaks the Bank • Get Registered to Get Out the Vote • Meet the Democratic Candidates for President • A Look at the Response to Rape at Ursinus • Opinions: How Safe do we Feel?; Out of the Middle East: End of a Journey; Text Messaging Behind Your S.O.\u27s Back; New Addiction: AIM; Domo Arigato, Dr. Roboto • Guster: Having Fun Being Young • Halloween Fun Around Collegeville • The Eger Gateway • Field Hockey Still Undefeated in Conference Play • Ursinus XC Takes on Div. 1 and 2 Opponents • Volleyball Splits First C.C Matches • Women\u27s Soccer Continues to Impress • Men\u27s Soccer Trying to Battle • Josh Kemp: Changing the Record Bookshttps://digitalcommons.ursinus.edu/grizzlynews/1544/thumbnail.jp

The Farm, the city, and the emergence of social security

We study the social, demographic and economic origins of social security. The data for the U.S. and for a cross section of countries suggest that urbanization and industrialization are associated with the rise of social insurance. We describe an OLG model in which demographics, technology, and social security are linked together in a political economy equilibrium. In the model economy, there are two locations (sectors), the farm (agricultural) and the city (industrial) and the decision to migrate from rural to urban locations is endogenous and linked to productivity differences between the two locations and survival probabilities. Farmers rely on land inheritance for their old age and do not support a pay-as-you-go social security system. With structural change, people migrate to the city, the land loses its importance and support for social security arises. We show that a calibrated version of this economy, where social security taxes are determined by majority voting, is consistent with the historical transformation in the United States

A utilização do marketing em campanhas sociais

Orientadora : Ana Paula Mussi Szabo CherobimMonografia (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas, Curso de Especialização em Marketing EmpresarialInclui referência