Deep neutral hydrogen observations of Leo T with the Westerbork Synthesis Radio Telescope

Leo T is the lowest mass gas-rich galaxy currently known and studies of its gas content help us understand how such marginal galaxies survive and form stars. We present deep neutral hydrogen (HI) observations from the Westerbork Synthesis Radio Telescope in order to understand its HI distribution and potential for star formation. We find a larger HI line flux than the previously accepted value, resulting in a 50% larger HI mass of 4.1 x 10^5 Msun. The additional HI flux is from low surface brightness emission that was previously missed; with careful masking this emission can be recovered even in shallower data. We perform a Gaussian spectral decomposition to find a cool neutral medium component (CNM) with a mass of 3.7 x 10^4 Msun, or almost 10% of the total HI mass. Leo T has no HI emission extending from the main HI body, but there is evidence of interaction with the Milky Way circumgalactic medium in both a potential truncation of the HI body and the offset of the peak HI distribution from the optical center. The CNM component of Leo T is large when compared to other dwarf galaxies, even though Leo T is not currently forming stars and has a lower star formation efficiency than other gas-rich dwarf galaxies. However, the HI column density associated with the CNM component in Leo T is low. One possible explanation is the large CNM component is not related to star formation potential but rather a recent, transient phenomenon related to the interaction of Leo T with the Milky Way circumgalactic medium.Comment: accepted for publication in A&A; 12 pages, 13 figure

A Community Conversation on Adolescent Pregnancy and Parenting Services: Networks of Support, Gatekeepers to Care, and Non-Compulsory Fathering in a Black Urban Community

This study employed Community-Based Participatory Research (CBPR) methods to document needs and capacity around adolescent pregnancy and parenting in one predominately Black, low-income urban community. Using an iterative focus group method, we engaged 60 participants in a two-day community conversation. Quantitative data from an enrollment questionnaire and qualitative transcripts of the discussions are analyzed. Our results indicate that the community’s greatest capacity lies in a network of women. Men tend to participate in parenting more holistically once formal paternity is established. Neighborhood women typically introduce adolescents to prenatal care, so delays in revealing the pregnancy to them serves as a barrier to accessing prenatal care. Overall, participants want health agencies to uphold their formal social contracts with the community, but to entrust informal services to community members who have the necessary insight and expertise to deliver support and information that is usable in their social context

Identifying galaxy candidates in WSRT HI imaging of ultra-compact high velocity clouds

Ultra-compact high velocity clouds (UCHVCs) were identified in the ALFALFA HI survey as potential gas-bearing dark matter halos. Here we present higher resolution neutral hydrogen (HI) observations of twelve UCHVCS with the Westerbork Synthesis Radio Telescope (WSRT). The UCHVCs were selected based on a combination of size, isolation, large recessional velocity and high column density as the best candidate dark matter halos. The WSRT data were tapered to image the UCHVCs at 210" (comparable to Arecibo) and 105" angular resolution. In a comparison of the single-dish to interferometer data, we find that the line flux recovered in the WSRT observations is comparable to that from the single-dish ALFALFA data. In addition, any structure seen in the ALFALFA data is reproduced in the WSRT maps at the same angular resolution. At 210'" resolution all the sources are generally compact with a smooth HI morphology, as expected from their identification as UCHVCs. At the higher angular resolution, a majority of the sources break into small clumps contained in a diffuse envelope. These UCHVCs also have no ordered velocity motion and are most likely Galactic halo clouds. We identify two UCHVCs, AGC 198606 and AGC 249525, as excellent galaxy candidates based on maintaining a smooth HI morphology at higher angular resolution and showing ordered velocity motion consistent with rotation. A third source, AGC 249565, lies between these two populations in properties and is a possible galaxy candidate. If interpreted as gas-bearing dark matter halos, the three candidate galaxies have rotation velocities of 8-15 km/s, HI masses of 0.6-50 x 10^5 Msun, HI radii of 0.3-2 kpc, and dynamical masses of 2-20 x 10^7 Msun for a range of plausible distances. These are the UCHVCs with the highest column density values in the ALFALFA HI data and we suggest this is the best way to identify further candidates.Comment: Accepted for publication in A&A. 26 pages, 19 figures, 5 table

The developmental influence of skin tone on psychosocial outcomes among African American youth

This doctoral dissertation is the first to explore the longitudinal impact of skin tone bias among African American adolescents. The relationships between skin tone, self-esteem, peer discrimination, and race socialization were explored using a data from the Youth Identity Project. African American adolescents (N = 189) were surveyed in Grades 5, 7, 10 and 12. During the final wave of data collection a skin tone measure was added to the study, and youths' skin tone was rated on a 3-point scale (1 = Light, 2 = Brown, 3 = Dark). In exploring changes in the relationship between skin tone and self-esteem across time, youth with light-skinned youth reported higher self-esteem than dark and brown-skinned youth in Grades 5 and 7, yet by Grade 12 these differences were no longer significant. Further, results from latent growth curve analyses demonstrate that skin tone predicts a quadratic trajectory, such that skin tone predicts the initial downturn and subsequent rebound of self-esteem during adolescence. In terms of the relationship between skin tone race socialization, light and dark-skinned girls reported receiving more preparation for bias messages than brown-skinned girls, and both light and dark-skinned youth reported receiving more cultural socialization messages than brown-skinned youth. Additionally, parents reported transmitting significantly more cultural socialization messages to their light and dark-skinned youth than to those rated as brown-skinned. Contrary to expectations, skin tone was not a significant predictor of peer discrimination frequency or peer discrimination distress, and peer discrimination distress did not moderate the relationship between skin tone and self-esteem. Finally the results from this dissertation are discussed in terms of implications for parents and clinicians.Doctor of Philosoph

Augmenter of liver regeneration enhances the success rate of fetal pancreas transplantation in rodents

Background. Treatment of fetal pancreas (FP) isografts with insulin- like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is a newly described polypeptide growth factor found in weanling rat livers. ALR has trophic effects on regenerating liver. We studied the effects of in situ administration of this agent on FP isografts in rats. Methods. Streptozotocin-diabetic Lewis rats (blood glucose >300 mg/dl) received 16 FP isografts transplanted intramuscularly. ALR was delivered from day 1 through day 14, in doses of 40 or 400 ng/kg/d. Animals were followed for 3 months with serial weights and blood glucose monitoring. These animals were compared with those treated with vehicle alone. Results. Of the group treated with ALR at 40 ng/kg/day for 14 days, 89% (eight of nine) were euglycemic (P=0.0003). Of the group treated with ALR at 400 ng/kg/day for 14 days, 88% (seven of eight) were euglycemic (P=0.0007). Of the group treated with vehicle alone, none of the six were euglycemic. Euglycemia is defined here as glucose<200 mg/dl for 3 days. Pathology of the intramuscular transplant site showed patches of islet tissue embedded in fat. These patches demonstrated insulin immunoreactivity. Conclusions. Diabetes was reversed in a significantly greater proportion of FP + ALR-treated recipients than those animals treated with vehicle alone. Local delivery of growth factors my be used as an adjunct to FP transplantation to improve the rate of success. This in situ model may be useful to further evaluate other soluble factors

A gene regulatory network armature for T lymphocyte specification

Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression trajectories from the beginning to the end of specification, tests of the short-term Notch dependence of these gene expression changes, and analyses of the effects of overexpression of two essential transcription factors, namely PU.1 and GATA-3. Quantitative expression measurements of >50 transcription factor and marker genes have been used to derive the principal components of regulatory change through which T cell precursors progress from primitive multipotency to T lineage commitment. Our analyses reveal separate contributions of Notch signaling, GATA-3 activity, and down-regulation of PU.1. Using BioTapestry (www.BioTapestry.org), the results have been assembled into a draft gene regulatory network for the specification of T cell precursors and the choice of T as opposed to myeloid/dendritic or mast-cell fates. This network also accommodates effects of E proteins and mutual repression circuits of Gfi1 against Egr-2 and of TCF-1 against PU.1 as proposed elsewhere, but requires additional functions that remain unidentified. Distinctive features of this network structure include the intense dose dependence of GATA-3 effects, the gene-specific modulation of PU.1 activity based on Notch activity, the lack of direct opposition between PU.1 and GATA-3, and the need for a distinct, late-acting repressive function or functions to extinguish stem and progenitor-derived regulatory gene expression