Socio-relational and visuospatial skills: a correlational study in a sample of elementary school children

openLe abilità sociali contribuiscono alla qualità della vita, il successo accademico e futuro del bambino (Jones et al., 2015). Il termine si riferisce ai comportamenti verbali e nonverbali che vengono appresi attraverso i quali i bambini creano delle relazioni con le altre pesone nei vari contesti sociali (Rinn et al., 1979). Le abilità visuospaziali si riferiscono alla “capacità di rappresentare, trasformare, generare e recuperare informazioni simboliche di tipo non linguistico” (Linn & Petersen, 1985, p.1482). Fragilità nei due domini sono spesso osservate in diversi disturbi del neurosviluppo, tra cui il Disturbo visuospaziale. L’obiettivo di questo studio è esplorare il pattern di correlazioni tra abilità socio-relazionali e visuospaziali. Nello specifico si ipotizza che tali abilità siano significativamente correlate con una relazione lineare positiva (Boyatzis & Satyaprasad, 1994; Custrini & Feldman, 1989; Bloom et al., 2010). A tal fine è stato coinvolto un campione di bambini della scuola primaria. Gli strumenti di valutazione utilizzati sono il Social Skills Improvement System (SSIS, Gresham & Elliott, 2008) e il Visuospatial Questionnaire (VSQ, adatt. da Cornoldi et al., 2003; Ferrara & Mammarella, 2013; Hegarty et al., 2002). Nel presente elaborato saranno presentati i risultati delle analisi dei dati, che saranno successivamente discusse alla luce delle ipotesi e della letteratura di riferimento.Social skills are related either to the quality of life, academic and future adaptation of children (Jones et al., 2015). The term refers to nonverbal and verbal behavior by which children interact with others in multiple social contexts (Rinn et al., 1979). Visuospatial skills are the "ability to represent, transform, generate, and retrieve symbolic information of a nonlinguistic type" (Linn & Petersen, 1985, p.1482). Visuo-spatial and social weaknesses are the core feature of some Neurodevelopmental disorders, for instance Developmental Visuospatial Disorder. The aim of this study is to explore the correlational pattern between socio-relational and visuospatial skills. We hypothesize that visuospatial abilities and social skills are significantly positively correlated (Boyatzis & Satyaprasad, 1994; Custrini & Feldman, 1989; Bloom et al., 2010). A sample of elementary school children was involved for this purpose. The assessment tools used were the Social Skills Improvement System (SSIS, Gresham & Elliott, 2008) and the Visuospatial Questionnaire (VSQ, adapted from Cornoldi et al., 2003; Ferrara & Mammarella, 2013; Hegarty et al., 2002). In the present study, the results of the analysis will be presented and then discussed in the light of the hypothesis and the extant literature

Assessment of air pollutants removal by green infrastructure and urban and peri-urban forests management for a greening plan in the Municipality of Ferrara (Po river plain, Italy)

Air pollution is a serious concern for human health and is even more worrying in areas that are known to be "pollution hotspots", such as the Po Plain in northern Italy. The Urban Green Infrastructure (UGI), which includes urban and peri-urban forests, enhances human health and wellbeing delivering a wide range of ecosystem services, including air quality improvement. In this research, we analyzed, in biophysical and monetary terms, the role of the UGI in removing PM10 and O-3 from the atmosphere in the Municipality of Ferrara using established removal models. We used a multiscale approach that includes geospatial data, field sampling and laboratory analysis. Then, using a local green areas database, we located public areas that could potentially undergo forestation actions without requiring any land conversion and evaluated the benefit in terms of ESs provision that these actions may exert. We found that, in 2019, the UGI in the Municipality of Ferrara removed about 19.8 Mg of PM10 and 8.6 Mg of O-3, for a monetary benefit of (sic) 2.12 million (sic) and 147*103 respectively. We then identified about 121 ha within the urban core of the Municipality that could potentially be forested. Such an action would increase the PM10 and O-3 removal by about 49% and 18%, respectively. Our findings comply with the EU Biodiversity strategy for 2030, which calls for the development of an ambitious greening plan for cities with more than 20,000 inhabitants

Visuospatial imagery in healthy individuals with different hypnotizability levels

Hypnotizability is a psychophysiological trait associated with morpho-functional brain differences. Since also cerebellar peculiarities have been reported in individuals with different hypnotizability levels and the cerebellar function is relevant to spatial imagery, the present study was aimed at investigating possible hypnotizability-related differences in the ability of spatial imagery. Highly (highs, N=31), low (lows, N=17) and medium (mediums, N=16) hypnotizable participants (classified by Stanford Hypnotic Susceptibility Scale, form A) of both genders were submitted to a test of mental rotation, which requires the integrity of both executive and cerebellar structures. In order to disentangle the role of the cerebellum from that of executive circuits as much as possible, visuospatial and verbal working memory tests, which mainly reflect executive processes, were also performed. Healthy highs exhibited higher scores of mental rotation ability compared to mediums in the absence of significant differences in visual-spatial and verbal working memory. Lows reported intermediate scores not significantly different from both highs’ and mediums’. Different cognitive strategies were observed in the three groups as the correlations between mental rotation, visuospatial and verbal working memory were different in highs, mediums and lows. In conclusion, present findings represent the first report of hypnotizability-related differences in a mental rotation task, which is relevant to several cognitive functions

Degradation rate of 5-fluorouracil in metastatic colorectal cancer. A new predictive outcome biomarker?

BACKGROUND: 5-FU based chemotherapy is the most common first line regimen used for metastatic colorectal cancer (mCRC). Identification of predictive markers of response to chemotherapy is a challenging approach for drug selection. The present study analyzes the predictive role of 5-FU degradation rate (5-FUDR) and genetic polymorphisms (MTHFR, TSER, DPYD) on survival. MATERIALS AND METHODS: Genetic polymorphisms of MTHFR, TSER and DPYD, and the 5-FUDR of homogenous patients with mCRC were retrospectively studied. Genetic markers and the 5-FUDR were correlated with clinical outcome. RESULTS: 133 patients affected by mCRC, treated with fluoropyrimidine-based chemotherapy from 2009 to 2014, were evaluated. Patients were classified into three metabolic classes, according to normal distribution of 5-FUDR in more than 1000 patients, as previously published: poor-metabolizer (PM) with 5-FU-DR ≤ 0,85 ng/ml/106 cells/min (8 pts); normal metabolizer with 0,85 < 5-FU-DR < 2,2 ng/ml/106 cells/min (119 pts); ultra-rapid metabolizer (UM) with 5-FU-DR ≥ 2,2 ng/ml/106 cells/min (6 pts). PM and UM groups showed a longer PFS respect to normal metabolizer group (14.5 and 11 months respectively vs 8 months; p = 0.029). A higher G3-4 toxicity rate was observed in PM and UM, respect to normal metabolizer (50% in both PM and UM vs 18%; p = 0.019). No significant associations between genes polymorphisms and outcomes or toxicities were observed. CONCLUSION: 5-FUDR seems to be significantly involved in predicting survival of patients who underwent 5-FU based CHT for mCRC. Although our findings require confirmation in large prospective studies, they reinforce the concept that individual genetic variation may allow personalized selection of chemotherapy to optimize clinical outcomes

Circulating microRNA (miRNA) expression profiling in plasma of patients with gestational diabetes mellitus reveals upregulation of miRNA miR-330-3p

Gestational diabetes mellitus (GDM) is characterized by insulin resistance accompanied by low/absent beta-cell compensatory adaptation to the increased insulin demand. Although the molecular mechanisms and factors acting on beta-cell compensatory response during pregnancy have been partially elucidated and reported, those inducing an impaired beta-cell compensation and function, thus evolving in GDM, have yet to be fully addressed. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs, which negatively modulate gene expression through their sequence-specific binding to 3'UTR of mRNA target. They have been described as potent modulators of cell survival and proliferation and, furthermore, as orchestrating molecules of beta-cell compensatory response and function in diabetes. Moreover, it has been reported that miRNAs can be actively secreted by cells and found in many biological fluids (e.g., serum/plasma), thus representing both optimal candidate disease biomarkers and mediators of tissues crosstalk(s). Here, we analyzed the expression profiles of circulating miRNAs in plasma samples obtained from n = 21 GDM patients and from n = 10 non-diabetic control pregnant women (24-33 weeks of gestation) using TaqMan array microfluidics cards followed by RT-real-time PCR single assay validation. The results highlighted the upregulation of miR-330-3p in plasma of GDM vs non-diabetics. Furthermore, the analysis of miR-330-3p expression levels revealed a bimodally distributed GDM patients group characterized by high or low circulating miR-330 expression and identified as GDM-miR-330highand GDM-miR-330low. Interestingly, GDM-miR-330highsubgroup retained lower levels of insulinemia, inversely correlated to miR-330-3p expression levels, and a significant higher rate of primary cesarean sections. Finally, miR-330-3p target genes analysis revealed major modulators of beta-cell proliferation and of insulin secretion, such as the experimentally validated genes E2F1 and CDC42 as well as AGT2R2, a gene involved in the differentiation of mature beta-cells. In conclusion, we demonstrated that plasma miR-330-3p could be of help in identifying GDM patients with potential worse gestational diabetes outcome; in GDM, miR-330-3p may directly be transferred from plasma to beta-cells thus modulating key target genes involved in proliferation, differentiation, and insulin secretion

Evolution of Rheumatoid-Arthritis-Associated Interstitial Lung Disease in Patients Treated with JAK Inhibitors: A Retrospective Exploratory Study

Background: The aim of this multicenter retrospective study was to investigate the effectiveness and safety of the available JAK-inhibitors (JAKi) in patients with rheumatoid arthritis (RA) and interstitial lung disease (ILD). Methods: We retrospectively analyzed patients with classified RA and RA-ILD undergoing JAKi in 6 Italian tertiary centers from April 2018 to June 2022. We included patients with at least 6 months of active therapy and one high-resolution chest tomography (HRCT) carried out within 3 months of the start of JAKi treatment. The HRCT was then compared to the most recent one carried out within 3 months before the last available follow-up appointment. We also kept track of the pulmonary function tests. Results: We included 43 patients with RA-ILD and 23 males (53.48%) with a median age (interquartile range, IQR) of 68.87 (61.46–75.78) treated with JAKi. The median follow-up was 19.1 months (11.03–34.43). The forced vital capacity remained stable in 22/28 (78.57%) patients, improved in 3/28 (10.71%) and worsened in 3/28 (10.71%). The diffusing capacity of lung for carbon monoxide showed a similar trend, remaining stable in 18/25 (72%) patients, improving in 2/25 (8%) and worsening in 5/25 (20%). The HRCT remained stable in 37/43 (86.05) cases, worsened in 4/43 (9.30%) and improved in the last 2 (4.65%). Discussion: This study suggests that JAKi therapy might be a safe therapeutic option for patients with RA-ILD in a short-term follow-up

Axial Spondyloarthritis: Reshape the Future—From the “2022 GISEA International Symposium”

The term &ldquo;axial spondyloarthritis&rdquo; (axSpA) refers to a group of chronic rheumatic diseases that predominantly involve the axial skeleton and consist of ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA) and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Moreover, pain is an important and common symptom of axSpA. It may progress to chronic pain, a more complicated bio-psychosocial phenomena, leading to a significant worsening of quality of life. The development of the axSpA inflammatory process is grounded in the complex interaction between genetic (such as HLA B27), epigenetic, and environmental factors associated with a dysregulated immune response. Considering the pivotal contribution of IL-23 and IL-17 in axSpA inflammation, the inhibition of these cytokines has been evaluated as a potential therapeutic strategy. With this context, here we discuss the main pathogenetic mechanisms, therapeutic approaches and the role of pain in axSpA from the 2022 International GISEA/OEG Symposium

Circulating MicroRNAs as biomarkers of gestational diabetes mellitus: Updates and perspectives

Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screening for abnormal glucose levels is generally recommended as a routine component of care for pregnant women. However, additional biomarkers are needed in order to predict the onset or accurately monitor the status of gestational diabetes. Recently, microRNAs, a class of small noncoding RNAs demonstrated to modulate gene expression, have been proven to be secreted by cells of origin and can be found in many biological fluids such as serum or plasma. Such feature renders microRNAs as optimal biomarkers and sensors of in situ tissue alterations. Furthermore, secretion of microRNAs via exosomes has been reported to contribute to tissue cross talk, thus potentially represents, if disrupted, a mechanistic cause of tissue/cell dysfunction in a specific disease. In this review, we summarized the recent findings on circulating microRNAs and gestational diabetes mellitus with particular focus on the potential use of microRNAs as putative biomarkers of disease as well as a potential cause of GDM complications and β cell dysfunction

Arthritis in Systemic Lupus Erythematosus: From 2022 International GISEA/OEG Symposium

Musculoskeletal involvement is one of the most common manifestations of systemic lupus erythematosus (SLE), with a negative impact on both quality of life and overall prognosis. SLE arthritis can be classified into three different subtypes, with different prevalence and characteristic biomarkers and MRI findings. Identifying the pathogenetic mechanisms underlying musculoskeletal manifestations' development is crucial to develop therapeutic strategies to suppress synovial inflammation, prevent erosions and deformities, and improve SLE patients' quality of life. Hence, here we discuss the main pathogenetic mechanisms and therapeutic approaches of musculoskeletal manifestations of SLE from the 2022 International GISEA/OEG Symposium