CdTe-Based Thin Film Solar Cells: Past, Present and Future

CdTe is a very robust and chemically stable material and for this reason its related solar cell thin film photovoltaic technology is now the only thin film technology in the first 10 top producers in the world. CdTe has an optimum band gap for the Schockley-Queisser limit and could deliver very high efficiencies as single junction device of more than 32%, with an open circuit voltage of 1 V and a short circuit current density exceeding 30 mA/cm2. CdTe solar cells were introduced at the beginning of the 70s and they have been studied and implemented particularly in the last 30 years. The strong improvement in efficiency in the last 5 years was obtained by a new redesign of the CdTe solar cell device reaching a single solar cell efficiency of 22.1% and a module efficiency of 19%. In this paper we describe the fabrication process following the history of the solar cell as it was developed in the early years up to the latest development and changes. Moreover the paper also presents future possible alternative absorbers and discusses the only apparently controversial environmental impacts of this fantastic technolog

Support Decision Tool for Sustainable Energy Requalification the Existing Residential Building Stock. The Case Study of Trevignano Romano

The control and improvement of energy-environmental quality in buildings are responsible for almost 40% of the emissions related to energy and processes, and are essential to achieve the commitment of the Paris Agreement and the Sustainable Development Goals (SDGs) United Nations (UN). This paper provides a support tool to planners and administrators of the territory for the identification of interventions aimed at the energy requalification of the existing Italian building heritage, mainly for residential use. The purpose of this tool is to reduce energy consumption by intervening on the building envelope with specific solutions that are identified through a matrix resulting from the study. In the first part of the study, an analysis was carried out on various factors such as the existing residential building, the building and construction types and the materials of the envelope typical of each construction period, which are critical for energy efficiency issues. In the second part of the study, the analysis of the state of the art of the insulating materials existing on the international and national market was carried out, in order to standardize the efficiency interventions of the building envelope. By exploiting the potential of the proposed matrix, and integrating it with Geographic Information System (GIS) technology, it would be possible to create a database containing information regarding the characteristics of the building envelope of the residential building stock and to identify a set of insulation interventions more suited to each specific case near Rome, Italy

Neurosteroids as Neuromodulators in the Treatment of Anxiety Disorders

Anxiety disorders are the most common psychiatric disorders. They are frequently treated with benzodiazepines, which are fast acting highly effective anxiolytic agents. However, their long-term use is impaired by tolerance development and abuse liability. In contrast, antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are considered as first-line treatment but have a slow onset of action. Neurosteroids are powerful allosteric modulators of GABAA and glutamate receptors. However, they also modulate sigma receptors and they are modulated themselves by SSRIs. Both pre-clinical and clinical studies have shown that neurosteroid homeostasis is altered in depression and anxiety disorders and antidepressants may act in part through restoring neurosteroid disbalance. Moreover, novel drugs interfering with neurosteroidogenesis such as ligands of the translocator protein (18 kDa) may represent an attractive pharmacological option for novel anxiolytics which lack the unwarranted side effects of benzodiazepines. Thus, neurosteroids are important endogenous neuromodulators for the physiology and pathophysiology of anxiety and they may constitute a novel therapeutic approach in the treatment of these disorders

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged recently as valuable anticancer agents. Here, we have designed, synthesized, and tested new Hh inhibitors taking advantage by the highly versatile and privileged isoflavone scaffold. The introduction of specific substitutions on the isoflavone's ring B allowed the identification of molecules targeting preferentially Smo or Gli1. Biological assays coupled with molecular modeling corroborated the design strategy, and provided new insights into the mechanism of action of these molecules. The combined administration of two different isoflavones behaving as Smo and Gli antagonists, respectively, in primary medulloblastoma (MB) cells highlighted the synergistic effects of these agents, thus paving the way to further and innovative strategies for the pharmacological inhibition of Hh signaling

Hammersmith Infant Neurological Examination in infants born at term : Predicting outcomes other than cerebral palsy

Aim We explored the ability of the Hammersmith Infant Neurological Examination (HINE) to identify cognitive performance delay at 2 years in a large cohort of infants born at term. Method We conducted a retrospective study of infants born at term at risk of neurodevelopmental impairments assessed using the HINE between 3 and 12 months post-term age and compared them with a cohort of typically developing infants born at term. All infants performed a neurodevelopmental assessment at 2 years of age using the Mental Development Index (MDI) of the Bayley Scales of Infant Development, Second Edition; the presence of cerebral palsy (CP) was also reported. The infants were classified as being cognitively normal/mildly delayed or significantly delayed (MDI < 70). The predictive validity of HINE scores for significantly delayed cognitive performance, in infants with and without CP, was calculated using specific cut-off scores according to age at assessment. Results A total of 446 at-risk and 235 typically developing infants (345 males, 336 females; mean [SD] gestational age 38.7 weeks [1.4], range 25-36 weeks) were included. Of the at-risk infants, 408 did not have CP at 2 years; 243 had a normal/mild delayed MDI and 165 had an MDI less than 70. Of the at-risk infants, 38 developed CP. HINE scores showed a good sensitivity and specificity, mainly after 3 months, for identifying significantly delayed cognitive performance in infants without CP. In those with CP, the score was associated with their cognitive performance. The comparison group had the highest HINE scores. Interpretation The HINE provides evidence about the risk of delayed cognitive performance at age 2 years in infants born at term with and without CP.Peer reviewe

Analysing product development process and plm features in the food and fashion industries

The food and fashion industries are well-known as areas of excellence representing Italy globally. Their products include innovative features, have short lifecycles and a high level of customisation. Both the pipelines have to respond quickly to unpredictable demand in order to minimize stock-outs, forced markdowns, obsolete inventory and they focus their Supply Chain (SC) strategies on quality and time-to-market. Although they are characterized by many different aspects, both leverage on the same point of strength: their internal Product Development (PD) process. The opposite occurs in the automotive industry, with its standard and functional products and its efficient pipeline centred on cost reduction. Starting from previous works presented during the last PLM conference (PLM16), the research aims at investigating similarities and differences between these sectors, focusing on their PD process and their main critical success factors. Moreover, the authors analyse how Food and Fashion companies are managing the entire set of information throughout PD and the strategic role of Product Lifecycle Management (PLM). In order to reach these goals, a multiple case study analysis has been performed, involving companies belonging to the Food and Fashion industries. The results will be relevant both for academics and practitioners. Indeed, there is a literature gap about this topic, because of the lack of researches concerning Food and Fashion PD. From the practitioners point of view, the results of this work will help Food and Fashion companies to support their business analysing the PD process and to better understand how the use of the PLM system could improve it

Product development kpis: A case study analysis in food and fashion companies

Two of the main industries that are currently paying huge attention to Product Development (PD) are Food & Fashion (F&F). Even if the remaining supply chain processes (production, distribution, sales) are managed in different ways and dissimilar outsourcing policies are adopted, PD is the most valuable process that both the industries are emphasizing. In the Italian context, F&F also represent two of the three excellences of the Made in Italy (Furniture is the third element), also known as "3F". Therefore, this research constitutes a progress of a previous work, which has examined critical success factors, PD features and PLM functionalities in the two sectors. The aim of this study is to analyse how to control, to monitor and to enhance PD through Key Performance Indicators (KPIs) in F&F companies. From the methodological point of view, case study is adopted as a research strategy, designing two questionnaires with a common structure in order to obtain the required information. Indeed, different companies, belonging to the sectors of interest, have been selected and interviewed. As a result, KPIs are identified and classified. Moreover, a comparison between the previously listed metrics is performed and the drivers affecting similarities and differences are highlighted. This research helps to fill the literature gap, given the few contributions related to product development in the F&F supply chains. It also represents a valuable insight for practitioners who are trying to improve business processes and to increase the control over product development

Lean economies and innovation in mental health systems

Poor access to mental health care is widely reported, although it differs according to sociopolitical and economic contexts. In emerging economies, including Brazil, Russia, India, China, and South Africa (BRICS), there has been increased public investment in recent years, but rapid economic growth in these countries has now slowed. Precarious global transitions affect both the burden of mental health problems and demand for services. Innovations prompted by these transitions, in both high-income and low-income countries, could help meet population needs during times of economic shock, whether scarcity or affluence