Análisis del comportamiento mecánico estructural de un prototipo de semirremolque sometido a carga estática vertical

El objetivo del presente trabajo consiste en analizar el comportamiento mecánico estructural de un prototipo de semirremolque tipo 2+1 (dos ejes traseros fijos y un tercer eje central retráctil) sometido a carga estática vertical. Se comparan los valores de tensión obtenidos, en puntos preestablecidos de la estructura, de un modelo computacional y mediciones a campo realizadas con con galgas extensiométricas (técnica strain gauge). Se consideran dos configuraciones de apoyo para el semirremolque: la primera configuración consiste en la estructura apoyada entre el camión tractor y las ruedas de ejes traseros; en la segunda configuración, a los apoyos antes descriptos, se adiciona el apoyo de las ruedas del tercer eje central de la estructura. En cuanto al modelo computacional, se implementa el Método de los Elementos Finitos, utilizando el software ANSYS Mechanical (R). Los ensayos a campo se realizan en instalaciones de la empresa constructora del prototipo.Publicado en: Mecánica Computacional vol. XXXV no.38Facultad de Ingenierí

[Synopsis] : Hasidic tales of the Holocaust.

Synopsis for the book Hasidic tales of the Holocaust [compiled by Yaffa Eliach], New York, Oxford University Press, 1982. LBI Library call number: D 810 J4 H375.Eliach, Yaffa comp. Hasidic tales of the Holocaust. New York, Oxford University Press, 1982. D 810 J4 H375

iPLA2-VIA is Required for Healthy Aging of Neurons, Muscle, and the Female Germline in Drosophila melanogaster

Neurodegenerative disease (ND) is a growing health burden worldwide, but its causes and treatments remain elusive. Although most cases of ND are sporadic, rare familial cases have been attributed to single genes, which can be investigated in animal models. We have generated a new mutation in the calcium-independent phospholipase A2 (iPLA2) VIA gene CG6718, the Drosophila melanogaster ortholog of human PLA2G6/PARK14, mutations in which cause a suite of NDs collectively called PLA2G6-associated neurodegeneration (PLAN). Our mutants display age-related loss of climbing ability, a symptom of neurodegeneration in flies. Although phospholipase activity commonly is presumed to underlie iPLA2VIA function, locomotor decline in our mutants is rescued by a transgene carrying a serine-to-alanine mutation in the catalytic residue, suggesting that important functional aspects are independent of phospholipase activity. Additionally, we find that iPLA2-VIA knockdown in either muscle or neurons phenocopies locomotor decline with age, demonstrating its necessity in both neuronal and non-neuronal tissues. Furthermore, RNA in situ hybridization shows high endogenous iPLA2-VIA mRNA expression in adult germ cells, and transgenic HA-tagged iPLA2-VIA colocalizes with mitochondria there. Mutant males are fertile with normal spermatogenesis, while fertility is reduced in mutant females. Mutant female germ cells display age-related mitochondrial aggregation, loss of mitochondrial potential, and elevated cell death. These results suggest that iPLA2-VIA is critical for mitochondrial integrity in the Drosophila female germline, which may provide a novel context to investigate its functions with parallels to PLAN