Tris(ethane-1,2-diamine)copper(II) bis­(trifluoro­acetate)

In the title complex, [Cu(H2NCH2CH2NH2)3](CF3COO)2, the environment of the Cu atom is distorted octa­hedral, formed by six N atoms from three chelating ethane-1,2-diamine ligands. The Cu—N distances range from 2.050 (2) to 2.300 (2) Å. This complex cation and the two trifluoro­acetate anions are connected by weak N—H⋯O and N—H⋯F hydrogen bonds, forming a three-dimensional framework. In both anions, the F atoms are disordered over two positions; in one the site-occupancy factors are 0.55 and 0.45, in the other the values are 0.69 and 0.31

Teaching motor skills by means of biomechanical analysis of the motion: the physiological basis and applied information technologies

The article proves the possibility of training athletes using motor skills on the basis of biomechanical analysis of movements with application of information technologies. Motion Tracking – digital single frame shooting photography – is proposed as a method for biomechanical analysis. The relevance of this method is conditioned by the results of the study of a repulsion phase in the performing of the standing jump by athletes of different qualifications. The conclusion about the importance of an optimal model of a jump based on biomechanical analysis is given, and the formation of athletes’ skills, using information technologies and the principle of urgent information, is discussed

Genome-Wide Mycobacterium tuberculosis Variation (GMTV) Database: A New Tool for Integrating Sequence Variations and Epidemiology

Background Tuberculosis (TB) poses a worldwide threat due to advancing multidrug-resistant strains and deadly co-infections with Human immunodeficiency virus. Today large amounts of Mycobacterium tuberculosis whole genome sequencing data are being assessed broadly and yet there exists no comprehensive online resource that connects M. tuberculosis genome variants with geographic origin, with drug resistance or with clinical outcome. Description Here we describe a broadly inclusive unifying Genome-wide Mycobacterium tuberculosis Variation (GMTV) database, (http://mtb.dobzhanskycenter.org) that catalogues genome variations of M. tuberculosis strains collected across Russia. GMTV contains a broad spectrum of data derived from different sources and related to M. tuberculosis molecular biology, epidemiology, TB clinical outcome, year and place of isolation, drug resistance profiles and displays the variants across the genome using a dedicated genome browser. GMTV database, which includes 1084 genomes and over 69,000 SNP or Indel variants, can be queried about M. tuberculosis genome variation and putative associations with drug resistance, geographical origin, and clinical stages and outcomes. Conclusions Implementation of GMTV tracks the pattern of changes of M. tuberculosis strains in different geographical areas, facilitates disease gene discoveries associated with drug resistance or different clinical sequelae, and automates comparative genomic analyses among M. tuberculosis strains

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Reliability level research in distribution electrical networks of Irkutsk

Forecasting of level of reliability of power supply of consumers is one of the major tasks at implementation of actions for improvement of operational characteristics of distribution electrical networks. On the one hand, assessment of damageability allows to develop a number of actions for increase in reliability of electric equipment and elements of electrical networks, with another, to create a stock of that equipment which is subject to risk of premature failure. The purpose of the present article is implementation of statistical assessment of damageability of basic elements of distribution electrical networks of 10 kV on the basis of the predicted information on possible refusals in these networks. The main objectives for achievement of the specified purpose are: 1. Implementation of preventive assessment of refusals in electrical networks on the basis of data of dispatching magazines of observations; 2. Statistical assessment of casual events of failures of electric equipment and detection of their laws of distribution

Antifungal Activity of the Dry Biomass of Penicillium chrysogenum F-24-28 and Is Application in Combination with Azoxystrobin for Efficient Crop Protection

The developing resistance of plant pathogenic fungi to commercial fungicides has become a serious problem for efficient plant disease control. The use of antifungal preparations based on living microorganisms or their metabolites represents one of the possible environmentally friendly approaches. However, since a complete rejection of chemical fungicides is impossible, the combining of biopreparations and fungicides may be considered a promising biocontrol approach. Promising strains for the development of antifungal biopreparations include Penicillium fungi producing various biologically active compounds with antimicrobial and antiviral activities. A dry biomass of the P. chrysogenum F-24-28 strain (DMP) obtained from the P. chrysogenum VKPM F-1310 strain by induced mutagenesis possessed a high antifungal efficiency. According to in vitro experiments, supplementation of agarized medium with DMP (7.5–10 g/L) resulted in a significant growth inhibition in several plant pathogenic Fusarium fungi. The combination of DMP with a commercial azoxystrobin-based fungicide resulted in a prolonged growth inhibition in F. oxysporum, F. graminearum and F. culmorum even at fungicide concentrations significantly below the recommended level (0.5–2.5 mg/L or 2.5–12.5 g/ha vs. the recommended 100–275 g/ha). These results demonstrate a possibility to develop an efficient environmentally friendly biopreparation suitable to control crop diseases caused by a wide range of plant pathogens, and to prevent a possible selection and spreading of resistant pathogen strains

Nonenzymatic Sensor for Lactate Detection in Human Sweat

For noninvasive diagnostics of hypoxia, we propose the nonenzymatic sensor based on screen-printed structures with the working surface modified in course of electropolymerization of 3-aminophenylboronic acid (3-APBA) with imprinting of lactate. Impedimetric sensor allows lactate detection in the range from 3 mM to 100 mM with the detection limit of 1.5 mM; response time is 2–3 min. Sensor sensitivity remains unchanged within 6 months of storage unpacked in dry state at a room temperature, which is unachievable for enzyme based devices. Analysis of human sweat with poly­(3-APBA) based sensor is possible due to (i) much higher lactate content compared to other polyols and (ii) high sensor selectivity (<i>K</i>_lactate^glucose < 3 × 10^–2). Successful detection of lactate in human sweat by means of the poly­(3-APBA) based sensor has been confirmed using the highly specific reference method based on lactate oxidase enzyme (correlation coefficient <i>r</i> > 0.9). The attractive performance characteristics of poly­(3-APBA) based enzyme-free sensors justify their future use for noninvasive clinical analysis and sports medicine

Animation creativity as a factor in the development of children’s giftedness

The main premise of the study is the objective need to find new means for the development of children’s personality in the modern educational process. Scientific and technological progress, the active use of technology and gadgets by children, even young children, the expansion of the use of distance learning and communication, artificial intelligence, and social networks are the realities in which we already live. Therefore, high relevance is gained by the means that are based on information technologies on the one hand but have the potential for the development of children’s personality on the other. What can be considered as one such instrument is animation creativity of children that involves the process of children jointly composing, creating, and discussing a cartoon of their own making. The assumption of the potential effectiveness of animation creativity as a means of developing children’s giftedness is based on the fact that in the process of joint creation of a cartoon, children show and develop several abilities as they create the script, images of characters, their characters and appearances, as they are involved in filming, montage, editing, as well as the presentation and promotion of the finished animated film. Children interact with one another and with technical devices, learn to listen to and hear each other, substantiate their opinion, carry the responsibility for collective work, distribute responsibilities between each other, and bring the creative idea to fruition in the finished product. The goal of the study is to conduct an empirical study to determine the effect of the author’s children’s animation technique on the development of figurative thinking in older preschool-age children. Methods: observation, conversation, measurement, creative tasks, comparative analysis of experimental data

Effects of Electrospinning Parameter Adjustment on the Mechanical Behavior of Poly-ε-caprolactone Vascular Scaffolds

Electrospinning is a perspective method widely suggested for use in bioengineering applications, but the variability in currently available data and equipment necessitates additional research to ascertain the desirable methodology. In this study, we aimed to describe the effects of electrospinning technique alterations on the structural and mechanical properties of (1,7)-polyoxepan-2-one (poly-ε-caprolactone, PCL) scaffolds, such as circumferential and longitudinal stress/strain curves, in comparison with corresponding properties of fresh rat aorta samples. Scaffolds manufactured under different electrospinning modes were analyzed and evaluated using scanning electronic microscopy as well as uniaxial longitudinal and circumferential tensile tests. Fiber diameter was shown to be the most crucial characteristic of the scaffold, correlating with its mechanical properties