RECENT LEGISLATIVE CHANGES IN THE FIELD OF COUNTY ROAD PASSENGER TRANSPORT

This article aims to capture the recent legislative evolution in the field of county road passenger transport and the impact of the new regulations on the material competence of the county councils in this matter. He highlights the succession of normative acts adopted in the field of county road transport of persons in the last two years, reviewing the changes in legal regime generated by them, as well as the consequences of legislative instability on all actors involved in providing this service and, of course, its beneficiaries

20 YEARS OF EUROPEAN FUNDS’ MANAGEMENT – WHAT WE HAVE LEARNED AND WHAT IS TO DO NEXT? A PRACTITIONER’S PERSPECTIVE

The management of European funds was part of the public agenda, in a consistent manner, for the past 15 to 20 years. Although visible progress has been made since the moment Romania started to access pre-accession funds (Phare, ISPA, SAPARD), to date, with direct effects on the economic growth, the efficiency in implementing it suffered a lot due to the political spectrum intervention, the human resource involved, the volatile administrative framework or even due to the influence, sometimes unwelcomed, of the private sector. The present material tries to unveil some of the causes that affected the implementation of European projects, and also to offer a range of solutions for a better management of it, taking into consideration the fact that the new programming period, 2021-2027, is at our doorstep

Malformaţiile congenitale de cord cu şunt stînga–dreapta la copil: protocol clinic naţional PCN-49

Acest protocol a fost elaborat de grupul de lucru al Ministerului Sănătăţii al Republicii Moldova (MS RM), constituit din specialiştii catedrei Pediatrie nr.1 a Universităţii de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, în colaborare cu Programul Preliminar de Ţară al „Fondului Provocările Mileniului” pentru Buna Guvernare, finanţat de Guvernul SUA prin Corporaţia Millenium Challenge Corporation şi administrat de Agenţia Statelor Unite ale Americii pentru Dezvoltare Internaţională. Protocolul naţional este elaborat în conformitate cu ghidurile internaţionale actuale privind malformaţiile congenitale de cord cu şunt stînga-dreapta la copil şi va servi drept bază pentru elaborarea protocoalelor instituţionale. La recomandarea MS RM, pentru monitorizarea protocoalelor instituţionale pot fi folosite formulare suplimentare, care nu sunt incluse în protocolul clinic naţional

Underactive bladder - an underestimated entity

Introduction. The concept of underactive bladder is relatively new. Currently there is no generally accepted definition of this pathology. Diagnosis depends on urodynamic findings, and symptoms are usually rare and intricated with the symptoms of other urinary pathology. Matherials and methods. This review examines the current literature on underactive bladder regarding pathology, definition, diagnosis, current guidelines, and any further potential medical developments. Conclusions. Underactive bladder is a poorly understood pathologic condition. Only since 2002 has there been any consensus regarding the definition. The diagnosis relies only on urodynamics; clinical diagnosis is a challenge even for a consultant; and treatment does not seem to alleviate much of the suffering. This disease remains underrecognized and undertreated. More research is needed to identify less invasive diagnosis tools and treatment for this pathology

Хирургическое лечение генитального пролапса

Surgical treatment of genital prolapseDin anul 2004 până în anul 2018, în secția ginecologică a Spitalului Clinic Municipal „Sf. Arhanghel Mihail” au fost spitalizați și operați 1195 de pacienți cu prolaps genital. Metode de operații de tratare vaginale: colporafia anterioară cu colpeperineomiorafie - 460, operația Manchester - 500, extirparea vaginală a uterului - 155, colporafia medie după Neugebauer Lefort – 42, pexia transvaginală a cupolei vaginului la anoneuroza mușchiului drept abdominal - 38%. Eficacitatea tratamentului chirurgical după 3 ani la 873 pacienți (73%): 1. Colporafia anterioară cu colpeperineomiorafie - 92% 2. Operația Manchester - 88% 3. Extirparea vaginală a uterului - 89% 4. Colporafia medie și lexia transvaginală a cupolei vaginale fără recidive de prolaps.Хирургическое лечение генитального пролапс

Underactive bladder - an underestimated entity

Introduction. The concept of underactive bladder is relatively new. Currently there is no generally accepted definition of this pathology. Diagnosis depends on urodynamic findings, and symptoms are usually rare and intricated with the symptoms of other urinary pathology. Matherials and methods. This review examines the current literature on underactive bladder regarding pathology, definition, diagnosis, current guidelines, and any further potential medical developments. Conclusions. Underactive bladder is a poorly understood pathologic condition. Only since 2002 has there been any consensus regarding the definition. The diagnosis relies only on urodynamics; clinical diagnosis is a challenge even for a consultant; and treatment does not seem to alleviate much of the suffering. This disease remains underrecognized and undertreated. More research is needed to identify less invasive diagnosis tools and treatment for this pathology

Local and systemic effects of bioactive food ingredients: is there a role for functional foods to prime the gut for resilience?

Scientific advancements in understanding the impact of bioactive components in foods on the gut microbiota and wider physiology create opportunities for designing targeted functional foods. The selection of bioactive ingredients with potential local or systemic effects holds promise for influencing overall well-being. An abundance of studies demonstrate that gut microbiota show compositional changes that correlate age and disease. However, navigating this field, especially for non-experts, remains challenging, given the abundance of bioactive ingredients with varying levels of scientific substantiation. This narrative review addresses the current knowledge on the potential impact of the gut microbiota on host health, emphasizing gut microbiota resilience. It explores evidence related to the extensive gut health benefits of popular dietary components and bioactive ingredients, such as phytochemicals, fermented greens, fibres, prebiotics, probiotics, and postbiotics. Importantly, this review distinguishes between the potential local and systemic effects of both popular and emerging ingredients. Additionally, it highlights how dietary hormesis promotes gut microbiota resilience, fostering better adaptation to stress—a hallmark of health. By integrating examples of bioactives, this review provides insights to guide the design of evidence-based functional foods aimed at priming the gut for resilience

Using high density EEG to assess TMS treatment in patients with schizophrenia.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadWe present preliminary results from the ongoing study entitled "Icelandic AVH-TMS" which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory verbal hallucinations (AVH) using symptoms and psychometric scales and high-density EEG system (256 channels). The aim of the present work was to describe cortical topography of the auditory evoked responses like P50 and N100-P300 complex in healthy participants and patients with schizophrenia and to define a robust methodology of signal quantification using dense-array EEG. Preliminary data is shown for three healthy participants and three patients in baseline conditions and for two patients we show the results recorded before and after 10 days rTMS treatment. Our results show differences in sensory gating (P50 suppresion) and a stronger N100-P300 response to rare audio stimulus after the treatment. Moreover we show the value of assessing brain electrical activity from high-density EEG (256 channels) analyzing the results in different regions of interest. However, it is premature and hazardous to assume that rTMS treatment effectiveness in patients with AVH can be assessed using P50 suppression ratio. Keywords: P300; P50; Transcranial magnetic stimulation; high density EEG; schizophrenia

Electrochemical Nanoprobes for Single-Cell Analysis

The measurement of key molecules in individual cells with minimal disruption to the biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal analytical tools because of their small size and their potential for high spatial and temporal resolution recordings. Here, we report the fabrication of disk-shaped carbon nanoelectrodes whose radius can be precisely tuned within the range 5–200 nm. The functionalization of the nanoelectrode with platinum allowed the monitoring of oxygen consumption outside and inside a brain slice. Furthermore, we show that nanoelectrodes of this type can be used to impale individual cells to perform electrochemical measurements within the cell with minimal disruption to cell function. These nanoelectrodes can be fabricated combined with scanning ion conductance microscopy probes, which should allow high resolution electrochemical mapping of species on or in living cells