Electron Cloud Measurements in Fermilab Booster

Fermilab Booster synchrotron requires an intensity upgrade from 4.5x1012 to 6.5x1012 protons per pulse as a part of Fermilab's Proton Improvement Plan-II (PIP-II). One of the factors which may limit the high-intensity performance is the fast transverse instabilities caused by electron cloud effects. According to the experience in the Recycler, the electron cloud gradually builds up over multiple turns inside the combined function magnets and can reach final intensities orders of magnitude greater than in a pure dipole. Since the Booster synchrotron also incorporates combined function magnets, it is important to measure the presence of electron cloud. The presence or apparent absence of the electron cloud was investigated using two different methods: measuring bunch-by-bunch tune shift by changing the bunch train structure at different intensities and propagating a microwave carrier signal through the beampipe and analyzing the phase modulation of the signal. This paper presents the results of the two methods and corresponding simulation results conducted using PyECLOUD software.Comment: International Particle Accelerator Conference 202

Multivalued SK-contractions with respect to b-generalized pseudodistances

A new class of multivalued non-self-mappings, called SK-contractions with respect to b-generalized pseudodistances, is introduced and used to investigate the existence of best proximity points by using an appropriate geometric property. Some new fixed point results in b-metric spaces are also obtained. Examples are given to support the usability of our main result

Accuracy of elastic fusion biopsy in daily practice: results of a multicenter study of 2115 patients

OBJECTIVES: To assess the accuracy of Koelis fusion biopsy for the detection of prostate cancer and clinically significant prostate cancer in the everyday practice. METHODS: We retrospectively enrolled 2115 patients from 15 institutions in four European countries undergoing transrectal Koelis fusion biopsy from 2010 to 2017. A variable number of target (usually 2-4) and random cores (usually 10-14) were carried out, depending on the clinical case and institution habits. The overall and clinically significant prostate cancer detection rates were assessed, evaluating the diagnostic role of additional random biopsies. The cancer detection rate was correlated to multiparametric magnetic resonance imaging features and clinical variables. RESULTS: The mean number of targeted and random cores taken were 3.9 (standard deviation 2.1) and 10.5 (standard deviation 5.0), respectively. The cancer detection rate of Koelis biopsies was 58% for all cancers and 43% for clinically significant prostate cancer. The performance of additional, random cores improved the cancer detection rate of 13% for all cancers (P < 0.001) and 9% for clinically significant prostate cancer (P < 0.001). Prostate cancer was detected in 31%, 66% and 89% of patients with lesions scored as Prostate Imaging Reporting and Data System 3, 4 and 5, respectively. Clinical stage and Prostate Imaging Reporting and Data System score were predictors of prostate cancer detection in multivariate analyses. Prostate-specific antigen was associated with prostate cancer detection only for clinically significant prostate cancer. CONCLUSIONS: Koelis fusion biopsy offers a good cancer detection rate, which is increased in patients with a high Prostate Imaging Reporting and Data System score and clinical stage. The performance of additional, random cores seems unavoidable for correct sampling. In our experience, the Prostate Imaging Reporting and Data System score and clinical stage are predictors of prostate cancer and clinically significant prostate cancer detection; prostate-specific antigen is associated only with clinically significant prostate cancer detection, and a higher number of biopsy cores are not associated with a higher cancer detection rate

The Phoenix Mars Landing: An Initial Look

This presentation was part of the session : Ongoing and Proposed EDL Technology DevelopmentSixth International Planetary Probe WorkshopNASA's Phoenix Mars Lander will make a landing on Mars on May 25th, 2008. Following on from the overview of the Phoenix entry, descent and landing (EDL) system given at IPPW5, an initial look at the Phoenix landing will be presented, highlighting the salient, high level events that occurred during EDL. Initial EDL flight reconstruction results will be presented, along with a retelling of the flight operations events that occurred on approach to Mars, and during the landing event itself. Note: Given the short time duration between the Phoenix landing and IPPW6, only a presentation will be prepared for the workshop.NAS

Best proximity point theorems for α-nonexpansive mappings in Banach spaces

In this paper, we discuss sufficient and necessary conditions for the existence of best proximity points for non-self-a-nonexpansive mappings in Banach spaces. We obtain convergence results under some assumptions, and we prove the existence of common best proximity points for a family of non-self-a-nonexpansive mappings

Expression of UV-Sensitive Parapinopsin in the Iguana Parietal Eyes and Its Implication in UV-Sensitivity in Vertebrate Pineal-Related Organs

The pineal-related organs of lower vertebrates have the ability to discriminate different wavelengths of light. This wavelength discrimination is achieved through antagonistic light responses to UV or blue and visible light. Previously, we demonstrated that parapinopsin underlies the UV reception in the lamprey pineal organ and identified parapinopsin genes in teleosts and frogs of which the pineal-related organs were reported to discriminate light. In this study, we report the first identification of parapinopsin in the reptile lineage and show its expression in the parietal eye of the green iguana. Spectroscopic analysis revealed that iguana parapinopsin is a UV-sensitive pigment, similar to lamprey parapinopsin. Interestingly, immunohistochemical analyses using antibodies specific to parapinopsin and parietopsin, a parietal eye green-sensitive pigment, revealed that parapinopsin and parietopsin are colocalized in the outer segments of the parietal eye photoreceptor cells in iguanas. These results strongly suggest that parapinopsin underlies the wavelength discrimination involving UV reception in the iguana parietal eye. The current findings support the idea that parapinopsin is a common photopigment underlying the UV-sensitivity in wavelength discrimination of the pineal-related organs found from lampreys to reptiles

1967: Abilene Christian College Bible Lectures - Full Text

LIFTING UP THE CHRIST” Being the Abilene Christian College Annual Bible Lectures 1967 $3.95 Published by ABILENE CHRISTIAN COLLEGE STUDENTS EXCHANGE ACC Station Abilene, Texa

ORIGINAL ARTICLES Assessment of Jeopardized Myocardium in Patients with One-vessel Disease

SUMMARY The size of the perfusion defect was assessed from a quantitative analysis of exercise thallium-201 images. Quantitative analysis was determined by measuring the area and the perimeter of the perfusion defect and expressing it as a percentage of the total left ventricular area or perimeter in three projections. Using this technique, we studied 50 patients with one-vessel disease of 50% or greater diameter narrowing. The planimetric and the perimetric methods correlated well (p &lt; 0.001, r = 0.97). Of the 11 patients with less than 70% diameter narrowing, only one patient had abnormal exercise thallium-201 images. Of the remaining 39 patients with 70% or greater diameter narrowing, 35 circumflex disease. Mortality rates undoubtedly depend on left ventricular function: The worse the function, the poorer the prognosis. Therefore, the extent of jeopardized myocardium may have prognostic importance in patients with one-vessel disease; patients with more jeopardized myocardium may be at a higher risk of developing severe left ventricular dysfunction in the event of myocardium infarction. The purpose of this study was to assess the extent of jeopardized myocardium in patients with one-vessel disease by using quantitative analysis of exercise images, a simple technique that does not require computer manipulation, and to define the factors that affect the size of the defects in these patients. Materials and Methods We reviewed our records of exercise thallium-201 imaging and identified 50 patients with one-vessel disease who had undergone exercise perfusion imaging within 3 months of coronary angiography. There were 46 men and four women, ages 32-63 years (mean 52 years). Patients with associated cardiac diseases such as valvular heart disease or idiopathic hypertrophic subaortic stenosis and patients who had had previous bypass surgery were excluded. All patients were evaluated for symptoms of angina pectoris. No patient had unstable angina or historic or electrocardiographic evidence of myocardial infarction. Left-and right-heart catheterization, left ventriculography and coronary arteriography were per- formed with standard techniques. Each coronary vessel was visualized in multiple projections, including the sagittal oblique projection. Each patient had at least 50% diameter narrowing of one coronary artery. The lesion in the left anterior descending artery was classified as either proximal or distal to the first septal perforator and diagonal branches. In each patient with left circumflex artery disease, the lesion was before or involved the major posterolateral branch. In each patient with right coronary artery disease, the lesion was before the crux. The coronary circulation was rightdominant in patients with left circumflex or right coronary artery disease. The remaining vessels were either free of disease or had only slight luminal irregularities. Collaterals were considered present and significant if the collateral flow partially or completely opacified the diseased vessel beyond the site of occlusion or narrowing. The left ventriculograms, which were assessed qualitatively for wall-motion abnormalities, showed that none of these patients had akinetic or dyskinetic segments. The angiograms were reviewed by two experienced angiographers, and the consensus of both reviewers was used in the final interpretation. Exercise treadmill testing was performed according to the Bruce protocol. The end points of exercise were 2 2 mm of horizontal or downsloping ST depression (with or without angina), excessive fatigue or leg weakness, hypotension, frequent ventricular premature complexes, or attainment of at least 85% of the predicted maximal heart rate. Three electrocardiographic leads (V1, V, and aVF) were continuously monitored; lead V5 was used for interpretation. Blood pressure was obtained by the cuff method every 2 minutes. At peak exercise, 2 mCi of thallium-201 were injected intravenously and flushed with dextrose and water. The patient continued to exercise for 1 more minute. Within 10 minutes after injection, images were obtained in the anterior, left anterior oblique and left lateral projections by means of a commercially available scintillation camera (Baird Atomic System-77) equipped with a high-resolution, parallel-hole, 11/2-inch-thick collimator. Redistribution images were obtained 4 hours after exercise in the projections that showed the perfusion abnormalities. All patients in the study with initial abnormal images showed partia&apos;L or complete redistribution in the delayed images. Our method for obtaining the exercise thallium-201 scintigrams has been described.&quot; 6 8 21-24 In brief, images were accumulated for a preset count (750,000 to 1,250,000 total counts), which required 8-12 minutes per projection. All images were corrected for background and for detector nonuniformity. Images were displayed on a television screen on a scale of 16 gray shades or 16 colors. The highest count displayed represents 100% on the scale and all other counts are digitally normalized to the maximum. Each of the 16 shades or colors represents a 6.25% increment in counts within the image. Depending on the visual in--spection of the background contribution, 20-30% background subtraction is used and the 16 colors are displayed over the remaining count range. In addition, the images were processed using an algorithm that weighs and spatially averages five adjacent data points in the matrix. The net result is a color-coded isocount contour display of the myocardial thallium-201 distribution. Polaroid pictures were obtained of the computer-smoothed images. We and others7&apos; 25 have found that the color-coded display of the images improve the interpretation. Segments of the myocardium showing 25% decrease in counts (four-color shift) are considered abnormal. The borders of the defects are outlined by two independent observers and minor disagreements were settled by arbitration between the two observers. Quantitative analysis was done by two methods. In the first method, the size of the thallium-201 defect was determined by the method of Niess et al.26 with a computerized planimetry system (Hewlett-Packard 982A calculator and digitizer). This method expresses the size of thallium-201 perfusion defects as a percentage of total potential thallium uptake. The size of the defect was computed in each projection and expressed as a percentage of the total area of the myocardium, excluding the left ventricular cavity and the region of the valves. The average of the three projections was also determined ( In the second method, the perimeter of the defect was measured and expressed as a percentage of the total left ventricular perimeter in each projection ( Statistical analysis was performed using the t test or the analysis of variance when appropriate