Unevenly distributed: a systematic review of the health literature about socioeconomic inequalities in adult obesity in the United Kingdom

Background: There is a growing literature documenting socioeconomic inequalities in obesity risk among adults in the UK, with poorer groups suffering higher risk. Methods: In this systematic review, we summarize and appraise the extant peer-reviewed literature about socioeconomic inequalities in adult obesity risk in the UK published between 1980 and 2010. Only studies featuring empirical assessments of relations between socioeconomic indicators and measures of obesity among adults in the UK were included. Results: A total of 35 articles met inclusion criteria, and were reviewed here. Conclusion: Socioeconomic indicators of low socioeconomic position (SEP), including occupational social class of the head-of-household at birth and during childhood, earlier adulthood occupational social class, contemporaneous occupational social class, educational attainment, and area-level deprivation were generally inversely associated with adult obesity risk in the UK. Measures of SEP were more predictive of obesity among women than among men. We outline important methodological limitations to the literature and recommend avenues for future research

IL-13 R130Q single nucleotide polymorphism in asthmatic Egyptian children

Background: Asthma and its associated phenotypes are under a substantial degree of genetic control. The common variant IL-13 gene polymorphism R130Q is reported to be associated with the risk of development of asthma in some populations. Objective: We sought to study the association of IL-13 genetic variant R130Q with bronchial asthma in Egyptian children and its relation to various clinical and laboratory phenotypes of the disease. Methods: IL13 gene polymorphism (R130Q) was detected by PCR amplification followed by sequencing using pure script total DNA in 20 asthmatic patients in acute exacerbation. The results were compared to 20 healthy age and sex matched children. Results: Asthmatic children had significantly higher frequency of distribution of R130Q genotype (50%) than controls (15%). The serum total IgE as percent of high normal for age was significantly higher in asthmatic patients as compared to controls with a mean of 208.77 ±237.06% and 14.21 ± 8.08% respectively. No significant difference was observed in the mean AEC(as a percent of high normal for age) of both groups (80.85 ± 116.4% and 82.50 ± 81.4% respectively). No significant differences were observed between patients with IL-13 polymorphism R130Q and those without such polymorphism as regards family history, relation of exacerbations to upper respiratory tract infections, history of food allergy or asthma grading. Serum total IgE was significantly higher in asthmatics with GA genotype as compared to those with GG genotype with a mean of 373.25 ± 238.11% and 44.28 ± 42.65% respectively. A similar finding was also observed among the control group with a mean of 28.03 ± 9.12% and 11.77 ± 5.00% respectively. Finally a significantly higher AEC was observed in controls with GA as compared to GG genotype with a mean of 250.00 ± 51.96% versus 52.94 ± 36.87% respectively. Conclusion: The common variant IL-13 gene polymorphism R130Q is frequently associated with pediatric asthma. This variant is more active than the wild type in inducing allergic inflammation as reflected by the higher serum total IgE and AEC. Hence, IL-13R130Q may be candidate for future gene therapy targeted at reducing the ill-effects of this polymorphism.Keywords: IL-13R130Q – bronchial asthma - pediatricsEgypt J Pediatr Allergy Immunol 2010;8(1):9-1

Editorial – Healthcare Worker Stress and Burnout in the time of COVID-19: A Call for Action

This is an Editorial and does not have an abstract. Please download the PDF or view the article HTML

Electron dynamics in gold and gold–silver alloy nanoparticles: The influence of a nonequilibrium electron distribution and the size dependence of the electron–phonon relaxation

©1999 American Institute of Physics. The electronic version of this article is the complete one and can be found online at: http://link.aip.org/link/?JCPSA6/111/1255/1DOI: 10.1063/1.479310Electron dynamics in gold nanoparticles with an average diameter between 9 and 48 nm have been studied by femtosecond transient absorption spectroscopy. Following the plasmon bleach recovery after low power excitation indicates that a non-Fermi electron distribution thermalizes by electron–electron relaxation on a time scale of 500 fs to a Fermi distribution. This effect is only observed at low excitation power and when the electron distribution is perturbed by mixing with the intraband transitions within the conduction band (i.e., when the excitation wavelength is 630 or 800 nm). However, exciting the interband transitions at 400 nm does not allow following the early electron thermalization process. Electron thermalization with the lattice of the nanoparticle by electron–phonon interactions occurs within 1.7 ps under these conditions, independent of the excitation wavelength. In agreement with the experiments, simulations of the optical response arising from thermalized and nonthermalized electron distributions show that a non-Fermi electron distribution leads to a less intense bleach of the plasmon absorption. Furthermore, the difference between the response from the two electron distributions is greater for small temperature changes of the electron gas (low excitation powers). No size dependence of the electron thermalization dynamics is observed for gold nanoparticles with diameters between 9 and 48 nm. High-resolution transmission electron microscopy (HRTEM) reveals that these gold nanoparticles possess defect structures. The effect of this on the electron–phonon relaxation processes is discussed. 18 nm gold–silver alloy nanoparticles with a gold mole fraction of 0.8 are compared to 15 nm gold nanoparticles. While mixing silver leads to a blue-shift of the plasmon absorption in the ground-state absorption spectrum, no difference is observed in the femtosecond dynamics of the system

Geophysical investigations of a geothermal anomaly at Wadi Ghadir, eastern Egypt

During regional heat flow studies a geothermal anomaly was discovered approximately 2 km from the Red Sea coast at Wadi Ghadir, in the Red Sea Hills of Eastern Egypt. A temperature gradient of 55 C/km was measured in a 150 m drillhole at this location, indicating a heat flow of approximately 175 mw/sqm, approximately four times the regional background heat flow for Egypt. Gravity and magnetic data were collected along Wadi Ghadir, and combined with offshore gravity data, to investigate the source of the thermal anomaly. Magnetic anomalies in the profile do not coincide with the thermal anomaly, but were observed to correlate with outcrops of basic rocks. Other regional heat flow and gravity data indicate that the transition from continental to oceanic type lithosphere occurs close to the Red Sea margin, and that the regional thermal anomaly is possibly related to the formation of the Red Sea

Phytochemicals and protective effects of Moringa oleifera seed extract on CCl4- induced hepatotoxicity and hemotoxicity in rats

Background: Moringa oleifera is high valued plant and used in many countries around the world. The seed of Moringa oleifera (MO) is an important part and has a remarkable medicinal, nutritional and socio-economic values, this study, therefore, was designed to clarify the protective effect of Moringa oleifera hydroethanolic seed extract (MOSE) against carbon tetrachloride (CCl4) induced hepatoxicity and hemotoxicity in rats.Methods: A total of one hundred and five male rats were randomly divided into 7 groups of 15 rats each. The hydroethanolic seed extract (30%) was administered orally for one month at 250 and 500mg/kg body weight. Samples were collected after day1,15 and 30 post administration.Results: Phytochemical, biochemical, hematological and hisopathological examinations were utilized to investigate hepatoprotective activity of MOSE. The results obtained demonstrated that, phytochemicals such as alkaloids, glycosides, anthraquinones, tannins, flavonoids, gum, resin, saponins, terponoids, protein and fats were detected in the seeds. Treatment with the MOSE caused a significant (P<0.05) decrease in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, triglyceride and lipid peroxidation (MDA), while total protein and albumin level significantly (P<0.05) increased compared to CCl4 group. Also, treatment with the MOSE showed a significant (P<0.05) increase Hb content and RBCs, whereas WBCs and lymphocyte count significantly (P<0.05) decreased throughout the period of administration when compared to the rats in CCl4 group. The results obtained were comparable to silymarin. Histopathological examination of liver tissues confirmed the biochemical data.Conclusions: It could be concluded that, CCl4 induced hepatotoxicity and hemotoxicity is ameliorated by MOSE especially in high dose of (500mg/kg). This effect is attributed to free radical scavenging activity and potent antioxidant activity of its components (Flavonoid, tannin, alkaloid and saponin)

Development of chitosan-glucose and chitosan-citric complexes edible coating to improve tomatoes post-harvest quality

 The effect of different shrimp chitosan molecular weights as well as shrimp chitosan complexes (chitosan-glucose and chitosan-citric) on the quality characteristics of the stored (at 7°C±2°C and 90% RH) tomato fruits (Lycopersicum esculentum) was investigated.  Coating tomatoes with high molecular weight chitosan (H.M.C.G) significantly improved firmness and weight loss.  The lowest weight loss was found in high molecular weight chitosan-glucose (H.M.C.G) treatment followed by the fruits coated with high molecular weight chitosan (HMC) and then uncoated tomato fruits.  Both molecular weights was clear on retarding the total acidity loss especially for stored tomato fruit coated with low molecular weight chitosan, while control tomatoes exhibited a larger reduction (p ≤ 0.05) in total acidity over storage.  Meanwhile, the increasing of cold storage time significantly (p ≥ 0.05) increased the pH in all uncoated and coated tomatoes.  Generally, no significant (P > 0.05) difference was observed in pH, titratable acidity and total soluble solids (T.S.S.) as well as sensory attributes among the tomato fruits coated with chitosan, chitosan citric and chitosan glucose.  Meanwhile, the fruits coated with low molecular weight chitosan had a higher (p ≥ 0.05) T.S.S. compared with that coated by the high molecular weight chitosan.   Keywords: chitosan, edible coating, tomatoes, firmness and weight loss