A Real-Life Turkish Experience of Ruxolitinib in Polycythemia Vera

Introduction:Ruxolitinib is a small -molecule inhibitor of the JAK1/2 pathway. This study aimed to reveal the results and side-effect profile of the use of ruxolitinib as a treatment option in polycythemia vera (PV).Methods:A total of 34 patients with PV from 18 different centers were included in the study. The evaluation of the response under treatment with ruxolitinib was determined as a reduction in spleen volume (splenomegaly size: ≥35%) by imaging and control of hematocrit levels (≤45%) compared to baseline.Results:While the number of patients in which a reduction in spleen volume and hematocrit control was achieved was 19 (55.9%) at 3 months of treatment, it was 21 (61.8%) at 6 months. Additionally, while the number of side effects was negatively correlated with the reduction in spleen volume (Spearman’s rho: -0.365, p=0.034), a decrease in the hematocrit level was positively correlated (Spearman’s rho: 0.75, p=0.029). Those without a reduction in spleen volume experienced more constipation (chi-square: 5.988, Fisher’s exact test: p=0.033).Conclusion:This study shed light on the use of ruxolitinib in PV and the importance of splenomegaly on studies planned with larger patient groups

Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

Here we determined the in vitro inhibitory effects of 5-(2-hydroxyethyl)-3,4-dimethylthiazolium iodide (1), 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (2) and thiamine (3) on human erythrocyte carbonic anhydrase I, II isozymes (hCA I and hCA II) and secreted isoenzyme CA VI. K I values ranged from 0.38 to 2.27 mu M for hCA I, 0.085 to 0.784 mu M for hCA II and 0.062 to 0.593 mu M for hCA VI, respectively. The compounds displayed relatively strong actions on hCA II, in the same range as the clinically used sulfonamidesethoxzolamide, zonisamide and acetazolamide.WOS:0003145310000122-s2.0-84891458403PubMed: 2214567

EĞİTİM VE ÖĞRETİMİN GELİŞTİRİLMESİNDE ÖĞRETMENLER KURULU KARARLARININ ETKİSİ

Öğretmenler kurulu toplantıları, okulların işleyişinde önemli bir yere sahiptir. Öğretmenler kurulu toplantılarında, okulla ilgili bütün iş ve işlemlerin planlaması, okulun geliştirilmesi, okuldaki sorunların tespiti ve bu sorunların çözümüne yönelik kararlar alınmaktadır. Bu amaçla okulların işleyişinde önemli bir yere sahip olan öğretmenler kurulu kararlarını incelemek önem arz etmektedir. Araştırmanın amacı, öğretmenler kurulunda eğitim ve öğretim ile ilgili alınan kararları tespit etmek, öğretmen ve yönetici görüşlerine göre bu kararların okuldaki eğitim ve öğretimin geliştirilmesine etkilerini değerlendirmektir. Bu amaçla ilköğretim okullarının öğretmenler kurulu karar defterleri incelenmiş, ayrıca öğretmenler kurulu kararlarına ilişkin 8 okul müdürü ve 8 öğretmenin görüşüne başvurulmuştur. Araştırmada belgesel tarama yöntemi ve odak grup görüşmesi tekniği kullanılmıştır. Araştırmanın verileri, Mardin ilindeki toplam sekiz ilköğretim okuluna ait 2010-2012 yılları arasındaki öğretmenler kurulu karar defterlerinden elde edilmiştir. Öğretmenler kurulu kararlarında alınan kararlar temalara ayrılmıştır. Verilerin analizinde betimsel istatistik tekniklerinden frekans ve yüzde alma teknikleri kullanılmıştır. Öğretmenler kurulunda, eğitim ve öğretim çalışmalarının geliştirilmesine yönelik kararların, alınan diğer kararlara göre daha az olduğu tespit edilmiştir. Öğretmenler kurulunda alınan kararlara ilişkin okul müdürleri ve öğretmenlerle görüşmede genel olarak; okullarda özellikle okul idaresinin takip etmesi gereken çok sayıda kurul ve komisyonun olduğu, resmi yazışmaların fazla olduğu, toplantılarda daha çok bu konulara yer verildiği görüşleri ortaya çıkmıştır.Teachers’ committee meetings have an important place in the functioning of schools. In teachers’ committee meetings, decisions regarding the planning of all tasks and processes related to the school, the development of the school, the determination of the problems in the school and the resolution of these problems are taken. For this purpose it is important to examine the decisions of the teachers’ committee meetings, which has an important place in the functioning of the schools. The purpose of the research is to examine the decisions taken in the teachers’ committee meetings, to determine the decisions taken regarding education and training, and also to evaluate these decisions according to the opinions of teachers and administrators. For this purpose, minute book of the teachers’ committee meetings of the elementary schools were examined and the opinions of 8 school principals and 8 teachers on the decisions of the teachers' board were consulted. Documentary screening method and focus group interview technique were used in the research. The data of the study were obtained from the minute books of teachers’ committee meetings 2010-2012 from a total of eight primary schools in the province of Mardin. Decisions taken in teachers’ committee meetings decisions are divided into theme. In the analysis of the data, frequency and percentage sampling techniques were used from descriptive statistical techniques. Four school principals and seven teachers were interviewed via focus group about the decisions taken in the survey. In the teachers’ committee meetings, it was determined that decisions on the development of educational activities were less than those of other decisions taken. In general, in teachers’ committee meetings with school principals and teachers regarding the decisions taken; it has been argued that there are a large number of boards and commissions to be followed by schools especially by school administrations, that there is a lot of official correspondence, and that these topics are included more in the meetings