170 research outputs found
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine
Superparticle Models with Tensorial Central Charges
A generalization of the Ferber-Shirafuji formulation of superparticle
mechanics is considered. The generalized model describes the dynamics of a
superparticle in a superspace extended by tensorial central charge coordinates
and commuting twistor-like spinor variables. The D=4 model contains a
continuous real parameter and at a=0 reduces to the SU(2,2|1)
supertwistor Ferber-Shirafuji model, while at a=1 one gets an OSp(1|8)
supertwistor model of ref. [1] (hep-th/9811022) which describes BPS states with
all but one unbroken target space supersymmetries. When 0<a<1 the model admits
an OSp(2|8) supertwistor description, and when a>1 the supertwistor group
becomes OSp(1,1|8). We quantize the model and find that its quantum spectrum
consists of massless states of an arbitrary (half)integer helicity. The
independent discrete central charge coordinate describes the helicity spectrum.
We also outline the generalization of the a=1 model to higher space-time
dimensions and demonstrate that in D=3,4,6 and 10, where the quantum states are
massless, the extra degrees of freedom (with respect to those of the standard
superparticle) parametrize compact manifolds. These compact manifolds can be
associated with higher-dimensional helicity states. In particular, in D=10 the
additional ``helicity'' manifold is isomorphic to the seven-sphere.Comment: 32 pages, LATEX, no figure
The Role of Color Neutrality in Nuclear Physics--Modifications of Nucleonic Wave Functions
The influence of the nuclear medium upon the internal structure of a
composite nucleon is examined. The interaction with the medium is assumed to
depend on the relative distances between the quarks in the nucleon consistent
with the notion of color neutrality, and to be proportional to the nucleon
density. In the resulting description the nucleon in matter is a superposition
of the ground state (free nucleon) and radial excitations. The effects of the
nuclear medium on the electromagnetic and weak nucleon form factors, and the
nucleon structure function are computed using a light-front constituent quark
model. Further experimental consequences are examined by considering the
electromagnetic nuclear response functions. The effects of color neutrality
supply small but significant corrections to predictions of observables.Comment: 37 pages, postscript figures available on request to
[email protected]
IBM-1 description of the fission products Ru
IBM-1} calculations for the fission products Ru have been
carried out. The even-even isotopes of Ru can be described as transitional
nuclei situated between the U(5) (spherical vibrator) and SO(6)
(-unstable rotor) symmetries of the Interacting Boson Model. At first,
a Hamiltonian with only one- and two-body terms has been used. Excitation
energies and (E2) ratios of gamma transitions have been calculated. A
satisfactory agreement has been obtained, with the exception of the odd-even
staggering in the quasi- bands of Ru. The observed pattern
is rather similar to the one for a rigid triaxial rotor. A calculation based on
a Hamiltonian with three-body terms was able to remove this discrepancy. The
relation between the IBM and the triaxial rotor model was also examined.Comment: 22 pages, 8 figure
Factorization Breaking in Dijet Photoproduction with a Leading Neutron
The production of dijets with a leading neutron in ep-interactions at HERA is
calculated in leading order and next-to-leading order of perturbative QCD using
a pion-exchange model. Differential cross sections for deep-inelastic
scattering (DIS) and photoproduction are presented as a function of several
kinematic variables. By comparing the theoretical predictions for DIS dijets to
recent H1 data, the pion flux factor together with the parton distribution
functions of the pion is determined. The dijet cross sections in
photoproduction show factorization breaking if compared to the H1
photoproduction data. The suppression factor is S = 0.48 (0.64) for resolved
(global) suppression.Comment: 16 pages, 5 figure
LHC as and Collider
We propose an experiment at the LHC with leading neutron production.The
latter can be used to extract from it the total cross-sections. With
two leading neutrons we can get access to the total
cross-sections. In this note we give some estimates and discuss related
problems and prospects.Comment: 22 pages, 18 figures, 8 tables, to be publishe
The Parallel Magnetoconductance of Interacting Electrons in a Two Dimensional Disordered System
The transport properties of interacting electrons for which the spin degree
of freedom is taken into account are numerically studied for small two
dimensional diffusive clusters. On-site electron-electron interactions tend to
delocalize the electrons, while long-range interactions enhance localization.
On careful examination of the transport properties, we reach the conclusion
that it does not show a two dimensional metal insulator transition driven by
interactions. A parallel magnetic field leads to enhanced resistivity, which
saturates once the electrons become fully spin polarized. The strength of the
magnetic field for which the resistivity saturates decreases as electron
density goes down. Thus, the numerical calculations capture some of the
features seen in recent experimental measurements of parallel
magnetoconductance.Comment: 10 pages, 6 figure
Conformal Higher Spin Symmetries of 4d Massless Supermultiplets and Invariant Equations in Generalized (Super)Space
Realization of the conformal higher spin symmetry on the 4d massless field
supermultiplets is given. The self-conjugated supermultiplets, including the
linearized SYM theory, are considered in some detail. Duality
between non-unitary field-theoretical representations and the unitary
doubleton--type representations of the 4d conformal algebra is
formulated in terms of a Bogolyubov transform. The set of 4d massless fields of
all spins is shown to form a representation of .
The obtained results are extended to the generalized superspace invariant
under supersymmetries. World line particle interpretation of the
free higher spin theories in the invariant (super)space is
given. Compatible with unitarity free equations of motion in the
invariant (super)space are formulated. A conjecture on the chain of
dualities in the higher spin
gauge theories is proposed.Comment: Latex, 63 pages; no figures.V2 Typos corrected, References updated.
V3.Typos correced, references and an explanation on the relationship with
previous work in section 4 are added. The version to appear in Phys.Rev.
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
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