Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine

Superparticle Models with Tensorial Central Charges

A generalization of the Ferber-Shirafuji formulation of superparticle mechanics is considered. The generalized model describes the dynamics of a superparticle in a superspace extended by tensorial central charge coordinates and commuting twistor-like spinor variables. The D=4 model contains a continuous real parameter $a\geq 0$ and at a=0 reduces to the SU(2,2|1) supertwistor Ferber-Shirafuji model, while at a=1 one gets an OSp(1|8) supertwistor model of ref. [1] (hep-th/9811022) which describes BPS states with all but one unbroken target space supersymmetries. When 0<a<1 the model admits an OSp(2|8) supertwistor description, and when a>1 the supertwistor group becomes OSp(1,1|8). We quantize the model and find that its quantum spectrum consists of massless states of an arbitrary (half)integer helicity. The independent discrete central charge coordinate describes the helicity spectrum. We also outline the generalization of the a=1 model to higher space-time dimensions and demonstrate that in D=3,4,6 and 10, where the quantum states are massless, the extra degrees of freedom (with respect to those of the standard superparticle) parametrize compact manifolds. These compact manifolds can be associated with higher-dimensional helicity states. In particular, in D=10 the additional ``helicity'' manifold is isomorphic to the seven-sphere.Comment: 32 pages, LATEX, no figure

The Role of Color Neutrality in Nuclear Physics--Modifications of Nucleonic Wave Functions

The influence of the nuclear medium upon the internal structure of a composite nucleon is examined. The interaction with the medium is assumed to depend on the relative distances between the quarks in the nucleon consistent with the notion of color neutrality, and to be proportional to the nucleon density. In the resulting description the nucleon in matter is a superposition of the ground state (free nucleon) and radial excitations. The effects of the nuclear medium on the electromagnetic and weak nucleon form factors, and the nucleon structure function are computed using a light-front constituent quark model. Further experimental consequences are examined by considering the electromagnetic nuclear response functions. The effects of color neutrality supply small but significant corrections to predictions of observables.Comment: 37 pages, postscript figures available on request to [email protected]

IBM-1 description of the fission products 108,110,112^{108,110,112}Ru

IBM-1} calculations for the fission products $^{108,110,112}$Ru have been carried out. The even-even isotopes of Ru can be described as transitional nuclei situated between the U(5) (spherical vibrator) and SO(6) ($\gamma$-unstable rotor) symmetries of the Interacting Boson Model. At first, a Hamiltonian with only one- and two-body terms has been used. Excitation energies and $B$(E2) ratios of gamma transitions have been calculated. A satisfactory agreement has been obtained, with the exception of the odd-even staggering in the quasi-$\gamma$ bands of $^{110,112}$Ru. The observed pattern is rather similar to the one for a rigid triaxial rotor. A calculation based on a Hamiltonian with three-body terms was able to remove this discrepancy. The relation between the IBM and the triaxial rotor model was also examined.Comment: 22 pages, 8 figure

Factorization Breaking in Dijet Photoproduction with a Leading Neutron

The production of dijets with a leading neutron in ep-interactions at HERA is calculated in leading order and next-to-leading order of perturbative QCD using a pion-exchange model. Differential cross sections for deep-inelastic scattering (DIS) and photoproduction are presented as a function of several kinematic variables. By comparing the theoretical predictions for DIS dijets to recent H1 data, the pion flux factor together with the parton distribution functions of the pion is determined. The dijet cross sections in photoproduction show factorization breaking if compared to the H1 photoproduction data. The suppression factor is S = 0.48 (0.64) for resolved (global) suppression.Comment: 16 pages, 5 figure

LHC as πp\pi p and ππ\pi\pi Collider

We propose an experiment at the LHC with leading neutron production.The latter can be used to extract from it the total $\pi^+ p$ cross-sections. With two leading neutrons we can get access to the total $\pi^+\pi^+$ cross-sections. In this note we give some estimates and discuss related problems and prospects.Comment: 22 pages, 18 figures, 8 tables, to be publishe

The Parallel Magnetoconductance of Interacting Electrons in a Two Dimensional Disordered System

The transport properties of interacting electrons for which the spin degree of freedom is taken into account are numerically studied for small two dimensional diffusive clusters. On-site electron-electron interactions tend to delocalize the electrons, while long-range interactions enhance localization. On careful examination of the transport properties, we reach the conclusion that it does not show a two dimensional metal insulator transition driven by interactions. A parallel magnetic field leads to enhanced resistivity, which saturates once the electrons become fully spin polarized. The strength of the magnetic field for which the resistivity saturates decreases as electron density goes down. Thus, the numerical calculations capture some of the features seen in recent experimental measurements of parallel magnetoconductance.Comment: 10 pages, 6 figure

Conformal Higher Spin Symmetries of 4d Massless Supermultiplets and osp(L,2M)osp(L,2M) Invariant Equations in Generalized (Super)Space

Realization of the conformal higher spin symmetry on the 4d massless field supermultiplets is given. The self-conjugated supermultiplets, including the linearized ${\cal N}=4$ SYM theory, are considered in some detail. Duality between non-unitary field-theoretical representations and the unitary doubleton--type representations of the 4d conformal algebra $su(2,2)$ is formulated in terms of a Bogolyubov transform. The set of 4d massless fields of all spins is shown to form a representation of $sp(8)$. The obtained results are extended to the generalized superspace invariant under $osp(L, 2M)$ supersymmetries. World line particle interpretation of the free higher spin theories in the $osp(2\N, 2M)$ invariant (super)space is given. Compatible with unitarity free equations of motion in the $osp(L,2M)$ invariant (super)space are formulated. A conjecture on the chain of $AdS_{d+1}/CFT_d \to AdS_{d}/CFT_{d-1} \to ...$ dualities in the higher spin gauge theories is proposed.Comment: Latex, 63 pages; no figures.V2 Typos corrected, References updated. V3.Typos correced, references and an explanation on the relationship with previous work in section 4 are added. The version to appear in Phys.Rev.

Observation of Scaling Violations in Scaled Momentum Distributions at HERA

Charged particle production has been measured in deep inelastic scattering (DIS) events over a large range of $x$ and $Q^2$ using the ZEUS detector. The evolution of the scaled momentum, $x_p$, with $Q^2,$ in the range 10 to 1280 $GeV^2$, has been investigated in the current fragmentation region of the Breit frame. The results show clear evidence, in a single experiment, for scaling violations in scaled momenta as a function of $Q^2$.Comment: 21 pages including 4 figures, to be published in Physics Letters B. Two references adde