Constraints on the Equation-of-State of neutron stars from nearby neutron star observations

We try to constrain the Equation-of-State (EoS) of supra-nuclear-density matter in neutron stars (NSs) by observations of nearby NSs. There are seven thermally emitting NSs known from X-ray and optical observations, the so-called Magnificent Seven (M7), which are young (up to few Myrs), nearby (within a few hundred pc), and radio-quiet with blackbody-like X-ray spectra, so that we can observe their surfaces. As bright X-ray sources, we can determine their rotational (pulse) period and their period derivative from X-ray timing. From XMM and/or Chandra X-ray spectra, we can determine their temperature. With precise astrometric observations using the Hubble Space Telescope, we can determine their parallax (i.e. distance) and optical flux. From flux, distance, and temperature, one can derive the emitting area - with assumptions about the atmosphere and/or temperature distribution on the surface. This was recently done by us for the two brightest M7 NSs RXJ1856 and RXJ0720. Then, from identifying absorption lines in X-ray spectra, one can also try to determine gravitational redshift. Also, from rotational phase-resolved spectroscopy, we have for the first time determined the compactness (mass/radius) of the M7 NS RBS1223. If also applied to RXJ1856, radius (from luminosity and temperature) and compactness (from X-ray data) will yield the mass and radius - for the first time for an isolated single neutron star. We will present our observations and recent results.Comment: refereed NPA5 conference proceedings, in pres

DETERMINATION OF THE UAV POSITION BY AUTOMATIC PROCESSING OF THERMAL IMAGES

If images acquired from Unmanned Aerial Vehicles (UAVs) need to be accurately geo-referenced, the method of choice is classical aerotriangulation, since on-board sensors are usually not accurate enough for direct geo-referencing. For several different applications it has recently been proposed to mount thermal cameras on UAVs. Compared to optical images, thermal ones pose a number of challenges, in particular low resolution and weak local contrast. In this work we investigate the automatic orientation of thermal image blocks acquired from a UAV, using artificial ground control points. To that end we adapt the photogrammetric processing pipeline to thermal imagery. The pipeline achieves accuracies of about ±1 cm in planimetry and ±3 cm in height for the object points, respectively ±10 cm or better for the camera positions, compared to ±100 cm or worse for direct geo-referencing using on-board single-frequency GPS

Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio