Analysis of strong-interaction dynamic stall for laminar flow on airfoils

A compressible Navier-Stokes solution procedure is applied to the flow about an isolated airfoil. Two major problem areas were investigated. The first area is that of developing a coordinate system and an initial step in this direction has been taken. An airfoil coordinate system obtained from specification of discrete data points developed and the heat conduction equation has been solved in this system. Efforts required to allow the Navier-Stokes equations to be solved in this system are discussed. The second problem area is that of obtaining flow field solutions. Solutions for the flow about a circular cylinder and an isolated airfoil are presented. In the former case, the prediction is shown to be in good agreement with data

Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions

Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD. Secondary interactions significantly change the primordial hadronic cocktail of the system. A comparison to data shows a strong dependence on rapidity. Without assuming thermal and chemical equilibrium, predicted hadron yields and ratios agree with many of the data, the few observed discrepancies are discussed.Comment: 12 pages, 4 figure

Probing the equation of state in the AGS energy range with 3-d hydrodynamics

The effect of (i) the phase transition between a quark gluon plasma (QGP) and a hadron gas and (ii) the number of resonance degrees of freedom in the hadronic phase on the single inclusive distributions of 16 different types of produced hadrons for Au+Au collisions at AGS energies is studied. We have used an exact numerical solution of the relativistic hydrodynamical equations without free parameters which, because of its 3-d character, constitutes a considerable improvement over the classical Landau solution. Using two different equations of state (eos) - one containing a phase transition from QGP to the Hadronic Phase and two versions of a purely hadronic eos - we find that the first one gives an overall better description of the Au+Au experimental data at $AGS$ energies. We reproduce and analyse measured meson and proton spectra and also make predictions for anti-protons, deltas, anti-deltas and hyperons. The low m_t enhancement in pi- spectra is explained by baryon number conservation and strangeness equilibration. We also find that negative kaon data are more sensitive to the eos, as well as the K-/pi- ratio. All hyperons and deltas are sensitive to the presence of a phase transition in the forward rapidity region. Anti-protons, Omegas and heavy anti-baryons are sensitive in the whole rapidity range.Comment: 25 pages (.tex) and 9 figures (.ps

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

We reported that p62 (sequestosome 1) serves as a signaling hub in bone marrow stromal cells (BMSCs) for the formation of signaling complexes, including NFκB, p38MAPK and JNK, that are involved in the increased osteoclastogenesis and multiple myeloma (MM) cell growth induced by BMSCs that are key contributors to multiple myeloma bone disease (MMBD), and demonstrated that the ZZ domain of p62 (p62-ZZ) is required for BMSC enhancement of MMBD. We recently identified a novel p62-ZZ inhibitor, XRK3F2, which inhibits MM cell growth and BMSC growth enhancement of human MM cells. In the current study, we evaluate the relative specificity of XRK3F2 for p62-ZZ, characterize XRK3F2's capacity to inhibit growth of primary MM cells and human MM cell lines, and test the in vivo effects of XRK3F2 in the immunocompetent 5TGM1 MM model. We found that XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocked the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC. Interestingly, XRK3F2 had no effect on non-MM bearing bone. These results demonstrate that targeting p62 in MM models has profound effects on MMBD

Evidence for Exotic J^{PC}=1^{-+} Meson Production in the Reaction pi- p --> eta pi- p at 18 GeV/c

Details of the analysis of the eta pi- system studied in the reaction pi^{-} p --> eta pi^{-} p at 18 GeV/c are given. Separate analyses for the 2 gamma and pi+ pi- pi0 decay modes of the eta are presented. An amplitude analysis of the data indicates the presence of interference between the a(2)(1320)- and a J^{PC}=1^{-+} wave between 1.2 and 1.6 GeV/c^2. The phase difference between these waves shows phase motion not attributable solely to the a(2)(1320)-. The data can be fitted by interference between the a(2)(1320)- and an exotic 1^{-+} resonance with M = 1370 +-16 +50 -30} MeV/c^2 and Gamma = 385 +- 40 +65 -105 MeV/c^2. Our results are compared with those of other experiments.Comment: 50 pages of text and 34 figure

EVALUATION OF DENTAL HEALTH EDUCATION IN A SCHOOL DENTAL CARE PROGRAM

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65546/1/j.1752-7325.1978.tb03715.x.pd

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a `two-way road' - from bench to bedside and backwards from bedside to bench. Copyright (c) 2012 S. Karger AG, Base

The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Evidence for Exotic Meson Production in the Reaction π−p→ηπ−p \pi^{-} p \to \eta \pi^{-} p at 18 GeV/c

The $\eta \pi^{-}$ system has been studied in the reaction $\pi^{-} p \to \eta \pi^{-} p$ at 18 GeV/c. A large asymmetry in the angular distribution is observed indicating interference between L-even and L-odd partial waves. The $a_{2}(1320)$ is observed in the $J^{PC}$ = $2^{++}$ wave, as is a broad enhancement between 1.2 and 1.6 GeV/c^{2} in the $J^{PC} = 1^{-+}$ wave. The observed phase difference between these waves shows that there is phase motion in addition to that due to $a_{2}(1320)$ decay. The data can be fitted by interference between the $a_{2}(1320)$ and an exotic $1^{-+}$ resonance with $M = (1370 \pm 16 {+50}\atop{-30}$) MeV/c^2 and $\Gamma =(385 \pm 40 {+65}\atop{-105}$) MeV/c^2