Biological behavior of familial papillary thyroid microcarcinoma: Spanish multicenter study

Purpose Familial papillary thyroid microcarcinoma (FPTMC) can present a more aggressive behavior than the sporadic microcarcinoma. However, few studies have analyzed this situation. The objective is to analyze the recurrence rate of FPTMC and the prognostic factors which determine that recurrence in Spain. Methods Spanish multicenter longitudinal analytical observational study was conducted. Patients with FPTMC received treatment with curative intent and presented cure criteria 6 months after treatment. Recurrence rate and disease-free survival (DFS) were analyzed. Two groups were analyzed: group A (no tumor recurrence) vs. group B (tumor recurrence). Results Ninety-four patients were analyzed. During a mean follow-up of 73.3 +/- 59.3 months, 13 recurrences of FPTMC (13.83%) were detected and mean DFS was 207.9 +/- 11.5 months. There were multifocality in 56%, bilateral thyroid involvement in 30%, and vascular invasion in 7.5%; that is to say, they are tumors with histological factors of poor prognosis in a high percentage of cases. The main risk factors for recurrence obtained in the multivariate analysis were the tumor size (OR: 2.574, 95% CI 1.210-5.473; p = 0.014) and the assessment of the risk of recurrence of the American Thyroid Association (ATA), both intermediate risk versus low risk (OR: 125, 95% CI 10.638-1000; p < 0.001) and high risk versus low risk (OR: 45.454, 95% CI 5.405-333.333; p < 0.001). Conclusion FPTMC has a recurrence rate higher than sporadic cases. Poor prognosis is mainly associated with the tumor size and the risk of recurrence of the ATA

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Análisis coste-beneficio de la introducción de dispositivos ahorradores de agua. Estudio de un caso en el sector hotelero

El agua es un factor productivo imprescindible para el desarrollo de la actividad de los establecimientos hoteleros. El consumo por persona alojada en estos establecimientos suele ser elevado, ya que llega a superar hasta en tres veces el consumo medio de la población que reside en su propia vivienda. Por ello, en un contexto de creciente presión sobre este recurso natural escaso y estratégico, resulta de interés el estudio del consumo de agua en los hoteles y de sus posibilidades de ahorro. Este trabajo se ocupa del caso de un hotel de la ciudad de Zaragoza (España) en el que se han introducido reformas en sus equipamientos, adoptando tecnologías ahorradoras con la finalidad de reducir la cantidad de agua consumida. El trabajo analiza el impacto de tales reformas en el consumo, así como su rentabilidad financiera y económica. Los resultados muestran cómo con una pequeña inversión puede obtenerse una muy significativa reducción del consumo de agua y, por tanto, de los costes asociados al mismo (de entre los que destaca el coste energético)

Biological behavior of familial papillary thyroid microcarcinoma: Spanish multicenter study.

Familial papillary thyroid microcarcinoma (FPTMC) can present a more aggressive behavior than the sporadic microcarcinoma. However, few studies have analyzed this situation. The objective is to analyze the recurrence rate of FPTMC and the prognostic factors which determine that recurrence in Spain. Spanish multicenter longitudinal analytical observational study was conducted. Patients with FPTMC received treatment with curative intent and presented cure criteria 6 months after treatment. Recurrence rate and disease-free survival (DFS) were analyzed. Two groups were analyzed: group A (no tumor recurrence) vs. group B (tumor recurrence). Ninety-four patients were analyzed. During a mean follow-up of 73.3 ± 59.3 months, 13 recurrences of FPTMC (13.83%) were detected and mean DFS was 207.9 ± 11.5 months. There were multifocality in 56%, bilateral thyroid involvement in 30%, and vascular invasion in 7.5%; that is to say, they are tumors with histological factors of poor prognosis in a high percentage of cases. The main risk factors for recurrence obtained in the multivariate analysis were the tumor size (OR: 2.574, 95% CI 1.210-5.473; p = 0.014) and the assessment of the risk of recurrence of the American Thyroid Association (ATA), both intermediate risk versus low risk (OR: 125, 95% CI 10.638-1000; p  FPTMC has a recurrence rate higher than sporadic cases. Poor prognosis is mainly associated with the tumor size and the risk of recurrence of the ATA

Support for the Development of Technological Innovations: Promoting Responsible Social Uses

International audienc

Late Holocene ecological history of Pinus pinaster forests in the Sierra de Gredos of central Spain

15 páginas, 4 figuras, 1 tabla.This article describes the patterns and processes of vegetation change and fire history in the Late Holocene (c. 2400 calendar year BP) palaeoecological sequence of Lanzahíta, Sierra de Gredos in central Spain, and provides the first Iberian pollen sequence undertaken within a monospecific Pinus pinaster woodland. These new data reassess not only the autochthonous nature of this pine species in the region and the Iberian Peninsula, but also the naturalness of well-developed cluster pine forests. Conflicts of palaeoecological evidence with phytosociological models of vegetation dynamics in the study region, and the relationships of P. pinaster with fire occurrence in Mediterranean-type ecosystems, are discussed.This study was funded by the projects HAR2008-06477-C03-03/HIST, CGL-2006-2956-BOS (Plan Nacional I + D + i, Ministry of Education and Science, Spain), CSD2007-00058 (Consolider Program, Consejo Superior de Investigaciones Científicas, Spain) and Paleodiversitas Network (Fundación Séneca, Murcia).Peer reviewe