9 research outputs found
Clinical and Biochemical Characteristics in PCOS Women With Menstrual Abnormalities
Objective: The purpose of the present study was to examine the impact of menstrual cycle abnormalities among patients with polycystic ovary syndrome (PCOS) on biochemical and anthropometric characteristics.
Materials and methods: We conducted a prospective observational study of patients 17-35 years of age with PCOS that attended the department of Gynecological Endocrinology of our hospital.
Results: A total of 309 women with PCOS participated in the study. In total, 72.2% suffered from menstrual cycle disorders. In our study 15.1% of women were overweight and 24% were obese. Also, 36% of the sample had androgenetic alopecia and 56.4% had acne. According to the stepwise discriminant analysis, we observed that glucose displayed the strongest association to the menstrual status (F to eliminate = 14.13), followed by endometrial thickness (F to eliminate = 10.89), waist circumference (F to eliminate = 10.17), LH levels (F to eliminate = 8.15) and PRL (F to eliminate = 4.45). Significantly higher levels of LH and TSH and lower levels of prolactin were found in women with menstrual disorders compared to those with normal menstrual cycles. Fasting glucose was also considerably higher among these patients although markers of insulin resistance such as the Matsuda, Quicki and HOMA-IR indices did not differ.
Conclusion: According to the findings of our study PCOS patients with menstrual disorders exhibit hormonal alterations and elevated fasting glucose. Future studies are needed in this field to corroborate our findings and determine the anthropometric and biochemical profile of patients with menstrual cycle irregularities
Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: A prospective controlled study
Background: SAHA syndrome is characterized by the tetrad: seborrhea,
acne, hirsutism, and androgenetic alopecia. No previous study has
examined the prevalence of glucose abnormalities in ovarian SAHA and
explored whether it may be an independent risk factor for glucose
abnormalities.
Objective: In a prospective controlled study, we investigated the
spectrum of glucose abnormalities in ovarian SAHA and explored whether
it is associated with a more insulin-resistant profile.
Methods: In all, 316 patients with a diagnosis of polycystic ovary
syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were
examined and underwent a 2-hour oral glucose tolerance test. Serum
glucose homeostasis parameters, hormones, and adipokines were
determined.
Results: SAHA prevalence was 17.7% in patients with PCOS and
predominance of the severe PCOS phenotype. Ovarian SAHA was
independently associated with a more insulin-resistant profile (higher
homeostatic model assessment of insulin resistance score, lower
quantitative insulin sensitivity check index [QUICKI] and MATSUDA
indices, and relative hypoadiponectinemia), and represented an
independent risk factor for glucose abnormalities regardless of
anthropometric features, age, and PCOS phenotype.
Limitation: There was no performance of skin biopsies.
Conclusion: The prompt recognition of SAHA syndrome in women with PCOS
permits an earlier diagnosis and surveillance of metabolic
abnormalities, especially in Mediterranean PCOS population exhibiting a
lower prevalence of glucose abnormalities
Autoimmune hemolytic anemia caused by cold agglutinins in a young pregnant woman
Autoimmune hemolytic anemia is a rare disorder. A 34-year old woman
presented with thrombophlebitis after her first delivery, during
puerperium. A high titer of cold agglutinins was found. Lymphomas,
systemic lupus erythematosus, and tumors were excluded. She conceived
again. Due to the anemia she had frequent blood transfusions and she
delivered at 38 weeks of gestation
The contribution of sildenafil (Viagra) to ovarian stimulation with gonadotropins in a woman with poor ovarian response
We aim to present the first case of a pregnancy achieved by
administering sildenafil (Viagra) to a woman not responding to
controlled ovarian hyperstimulation (COH) with the sole use of
gonadotropins. A 37-year-old woman underwent COH, as part of an
intracytoplasmic sperm injection (ICSI) cycle, with the combination of
r-FSH and HMG for 13 d, without evidence of follicular growth. The
addition of oral sildenafil at a dose of 50mg per day for a total of
five doses improved the ovarian response and resulted in the retrieval
of 10 oocytes. Three embryos were transferred to the uterine cavity
resulting in a successful pregnancy and, eventually, the delivery of a
healthy neonate. Conclusively, the use of sildenafil as an adjunct to
COH protocols may enhance ovarian response in a woman with poor ovarian
response (POR) and merits further research
Dehydroepiandrosterone-Sulfate, Insulin Resistance and Ovarian Volume Estimation in Patients With Polycystic Ovarian Syndrome
Objective: To investigate the potential association of DHEA-S with metabolic and hormonal alterations and with disorders of ovarian morphology.
Materials and methods: The present study was based on women with PCOS that attended the Gynaecological Endocrinology – Paediatric and Adolescence Endocrinology Department of our clinic. Overall, 321 patients who met the Rotterdam ESHRE/ ASRM – Sponsored criteria for the definition of PCOS were included. Women’s personal medical history was recorded, anthropometric parameters were assessed and blood was drawn for analysis of metabolic and hormonal parameters. A gynaecological ultrasound was also performed to evaluate ovarian morphology.
Results: Correlation analysis revealed a significant negative correlation of DHEA-S with the mean volume of the right and left ovary and with the maximum volume of the largest ovary. This finding remained significant after adjusting for age and BMI (β ± SE = -0.39 ± 0.17, p = 0.023 in the case of mean ovarian volume and β ± SE = -0.36 ± 0.17, p = 0.032 in the case of the maximum volume of the maximum ovarian volume).
Conclusion: The findings of our study reveal a clear negative association of DHEA-S with ovarian volume. To date, however, current evidence in this field are restricted to experimental animal models. Future clinical studies are needed in this field to corroborate our findings