Binary open clusters in the Milky Way: photometric and spectroscopic analysis of NGC 5617 and Trumpler 22

Using photometry and high resolution spectroscopy we investigate for the first time the physical connection between the open clusters NGC 5617 and Trumpler 22. Based on new CCD photometry we report their spatial proximity and common age of ~70 Myr. Based on high resolution spectra collected using the HERMES and UCLES spectrographs on the Anglo-Australian telescope, we present radial velocities and abundances for Fe, Na, Mg, Al, Si, Ca and Ni. The measured radial velocities are -38.63 +/-2.25 km/s for NGC 5617 and -38.46 +/-2.08 km/s for Trumpler 22. The mean metallicity of NGC 5617 was found to be [Fe/H] =-0.18 +/-0.02 and for Trumpler 22 was found to be [Fe/H] = -0.17 +/-0.04. The two clusters share similar abundances across the other elements, indicative of a common chemical enrichment history of these clusters. Together with common motions and ages we confirm that NGC 5617 and Trumpler 22 are a primordial binary cluster pair in the Milky Way.Comment: 7 pages, 3 figure, accepted by MNRA

Estimate or the effectiveness of intelligent information system of early diagnosis and prognosis of cardiovascular disease

This article describes a new approach to the implementation of the training program of risk probability of coronary heart disease (CHD) remote evaluation. It describes an example of training sample formation based on the statistical analysis of medical data. The proposed solution will allow medical personnel to carry out the personification of cardiac services and first of all, preventive orientation. Also a method for assessing the effectiveness of the program of expert system "ARM-Cardiologist" on the results of ongoing clinical trials is providedyesБелгородский государственный университе

Development and investigation of common wheat lines of winter cultivar Bezostaya 1 with combinations of dominant alleles of VRN-1 loci

VRN genes, determining wheat sensitivity to vernalization, are the main genetic system that defnes the duration of the entire growing period and the durations of the main organogenesis phases. To date, several alleles have been described for VRN-1 loci, and allele­specifc primers have been developed that allow rapid identifcation of allelic spectra in common wheat varieties and lines. The unequal influence of different alleles of VRN-1 loci on the duration of the growing period has also been shown; however, there is little information on the effect of the combination of different alleles on heading time. In developing genotypes having different alleles of dominant VRN genes on the base of the same genetic background, it is necessary to study the genetic effects of VRN genes on the duration of the growing season and the individual developmental phases, as well as on productivity. Most varieties presently grown in Russia carry the dominant alleles of two VRN-1 genes: Vrn-A1a and Vrn-B1a or Vrn-B1c; thus, the task was to create lines combining the dominant alleles of Vrn-A1a with Vrn-B1a and Vrn-B1c against the genetic background of the winter variety Bezostaya 1 (Bez1 Vrn-A1a/Vrn-B1a and Bez1 Vrn-A1a/Vrn-B1c). Homozygous plants were isolated in the F2 generation by using known allele­specifc primers for the Vrn-A1 and Vrn-B1 loci. The durations of the tillering–frst node period, which is the key stage determining growing duration, and the period from shoots to heading were signifcantly reduced in lines with a combination of two dominant alleles of VRN-1 loci compared to isogenic lines of Bezostaya 1 with the dominant alleles Vrn-B1a and Vrn-B1c. The duration of these developmental phases also decreased in the obtained lines as compared to the isogenic line containing the dominant Vrn-A1a allele, but the differences were not signifcant. No substantial differences were found in the duration of other growing phases in lines with two dominant alleles of the VRN-1 loci as compared to isogenic lines of Bezostaya 1

A rare combination of noncompact myocardium and coronary dilatation with type 1 neurofibromatosis

The article describes the observation of a child with a very rare combination of noncompact left ventricular myocardium and coronary dilatation in type 1 neurofibromatosis (NF1). The first of these complications, undifferentiated cardiomyopathy, also known as noncompact myocardium, is not described in combination with nF 1 in available literature, although cases of hypertrophic cardiomyopathy in patients with NF 1 have been previously reported. Dilatation of the coronary arteries also refers to infrequent manifestations of vascular pathology against the background of neurofibromatosis, and the combination of all three signs (NF 1, noncompact myocardium and coronary dilatation) has not yet been reported by other authors. When examining the patient, we found the characteristic signs of NF 1 (foci of "coffee" pigmentation on the skin, multiple nevuses, fibroids of the forearm, cognitive disorders), electrocardiogram features of left ventricular hypertrophy, negative T-tooth and ST-segment displacement 1 mm below the isoline in Leads V4-6, in echocardiography - pronounced trabecularity, thinning of the compact myocardium layer and a "spongy myocardium" in the region of the left ventricle apex, dilatation of the coronary arteries. With magnetic resonance imaging, signs of noncompact myocardium of the left ventricle were found, with selective coronary angiography - slowing of the coronary blood flow. The patient receives the permanent treatment for heart failure and aspirin, his condition remains stable for 4 years of follow-u

Ultrasound diagnostics of left ventricular noncompaction

The clinical cases of rare, genetically heterogeneous cardiomyopathy are described - the left ventricular noncompaction (LVNC) cardiomyopathy for four children (three boys and one girl) in age from two months to 6 years. Description of echocardiography signs is presented in accordance with modern diagnostic criteria. Noncompaction of the left ventricle is recognized in three patients, of the left and right ventricle - in one. In three patients out of four, LVNC was a separate disease, and yet in one it was associated with neurofibromatosis type 1, in combination with dilatation of coronary arteries and pericardial effusion. Three of four patients were admitted with congestive heart failure (CHF) of New York Heart Association (NYHA) functional class 3-4 (FC), and one - with CHF 2 FC. The echocardiograms are brought with description of characteristic features of LVNC (hypertrabecularity, spongy myocardium on the apex of the left ventricle, typical correlation of incompact and compact layer from 2.0 to 2.6). All four patients received treatment for CHF (diuretics, beta-blockers, captopril, in one case - digoxin); two out of four got antithrombotic therapy (aspirin, warfarin). Results of follow-up observation of the patients are described with the estimation of echocardiography signs, including dilatation of coronary arteries. Left ventricular ejection fraction - both by Simpson and Teicholz - increased in two patients, with therapy of chronic heart failure at a follow-up visits over > 5 years simultaneously with the decline of severity of CHF. Another two patients have been examined from 2 months to 5 years and have had CHF 3 FC; their left ventricular ejection fraction increased too, but cardiomegaly and right ventricular heart failure preserved

Дослідження клінічної ефективності комплексного методу лікування гіперестезії зубів у дітей

The article presents the results of a study of the influence of comprehensive method for the treatment of hyperesthesia of hard tooth tissues in 12 years old children. The aim of the study – to learn the effectiveness of the use of a comprehensive method of treating dental hyperesthesia in 12 years old children. Materials and Methods. The study involved 44 children aged 12 years with hyperesthesia of the teeth degree II of severity. Children, depending on the method of treatment, were divided into 2 groups. The comparison group included 23 children of 12 years of both sexes who used the standard treatment regimen for hyperesthesia. The main group included 23 children aged 12 years of both sexes. Prior to treatment, children underwent rehabilitation and professional oral hygiene. The complex treatment method that was developed by us was used in children of the main group. In children of each group, the indices of the prevalence of hyperesthesia of the teeth and the intensity of hyperesthesia of the teeth were determined. To determine the electroexcitability of dental pulp with increased sensitivity, we used the PulpTester-P device. Results and Discussion. As a result of the studies, we found a significant decrease in the prevalence index of dental hyperesthesia in children of the main group and the comparison group after the course of treatment, but this index in children of the main group was six months later 9.31 times less than the indicator of the comparison group. The values of the intensity index of hyperesthesia of the teeth after 6 months, a year and one and half year indicate a prolonged effect after the application of the treatment method proposed by us. Conclusions. Our comprehensive treatment method allows to reduce the manifestations of dental hyperesthesia in children, which is confirmed by the values of prevalence indices, intensity of dental hyperesthesia and indicators of electroodontometry. The children who were subjected to treatment for tooth hypersensitivity decreased the number of relapses.В статье представлены результаты исследования влияния комплексного метода лечения гиперестезии твердых тканей зубов у детей 12 лет. Цель исследования – изучить эффективность применения комплексного метода лечения гиперестезии зубов у детей 12 лет. Материалы и методы. В исследованиях приняли участие 44 ребенка в возрасте 12 лет с гиперестезией зубов II степени тяжести. Детей, в зависимости от метода лечения, разделили на 2 группы. В группу сравнения вошли 23 ребенка 12 лет обоего пола, которым применялась стандартная схема лечения гиперестезии. В основную группу вошли 23 ребенка в возрасте 12 лет обоих полов. До начала лечения детям проводилась санация и профессиональная гигиена полости рта. У детей основной группы применялся разработанный нами комплексный метод лечения. У детей каждой группы определяли индексы распространенности гиперестезии зубов и интенсивности гиперестезии зубов. Для определения электровозбудимости пульпы зубов с повышенной чувствительностью мы использовали аппарат «PulpTester-P». Результаты исследований и их обсуждение. В результате проведенных исследований мы установили достоверное снижение индекса распространенности гиперестезии зубов у детей основной группы и группы сравнения после проведенного курса лечения, но этот индекс у детей основной группы через полгода был в 9,31 раза меньше, чем показатель группы сравнения. Показатели индекса интенсивности гиперестезии зубов через 6 месяцев, год и полтора года свидетельствуют об пролонгированном эффекте после применения, предложенного нами метода лечения. Выводы. Использование предложенного нами комплексного метода лечения позволяет уменьшить проявления гиперестезии зубов у детей, что подтверждается показателями индексов распространенности, интенсивности гиперестезии зубов и показателями электроодонтометрии. У детей, у которых использовался разработанный нами метод лечения гиперчувствительности зубов, уменьшалось количество рецидивов заболевания.У статті представлено результати дослідження впливу комплексного методу лікування гіперестезії твердих тканин зубів у дітей 12 років. Мета дослідження – вивчити ефективність застосування комплексного методу лікування гіперестезії зубів у дітей 12 років. Матеріали і методи. У дослідженнях взяли участь 44 дитини віком 12 років із гіперестезією зубів ІІ ступеня тяжкості. Дітей, залежно від методу лікування, поділили на 2 групи. До  групи порівняння ввійшли 23 дитини 12 років обох статей, яким застосовували стандартну схему лікування гіперестезії. До основної групи увійшли 23 дитини віком 12 років обох статей. До початку лікування їм проводили санацію та професійну гігієну ротової порожнини. У дітей  основної групи застосовували комплексний метод лікування, який ми розробили. У дітей кожної групи визначали індекси розповсюдження гіперестезії зубів та інтенсивності гіперестезії зубів. Для визначення електрозбудливості пульпи зубів із гіперчутливістю ми використовували апарат «PulpTester-P». Результати досліджень та їх обговорення. У результаті проведених досліджень ми  встановили достовірне зниження індексу розповсюдження гіперестезії зубів у дітей основної групи та групи порівняння після проведеного курсу лікування, але цей індекс у дітей основної групи через півроку був в 9,31 раза менше, ніж показник групи порівняння. Показники індексу інтенсивності гіперестезії зубів через 6 місяців, рік та півтора року засвідчують пролонгований ефект після застосування запропонованого нами методу лікування. Висновки. Використання комплексного методу лікування дозволяє зменшити прояви гіперестезії зубів у дітей, що підтверджується показниками індексів розповсюдження, інтенсивності гіперестезії зубів та показниками електроодонтометрії. У дітей,  яким використовували розроблений метод лікування гіперчутливості зубів, зменшувалась кількість рецидивів захворювання

Взаимодействие значимого взрослого с ребенком раннего возраста в России и Вьетнаме

The article discusses the role of child interaction with a significant adult (parent, kindergarten teacher, caregiver) in child’s neurocognitive development within socio-cultural contexts of Russia and Vietnam. The article presents the results of a pilot study that included focus group interviews with kindergarten specialists from Russia and Vietnam. The pilot study sample consisted of 74 participants (72 women, 2 men), aged 32 to 54 years (M = 43.04; SD = 6.61). Of these, Russian participants (10 cities) — 42 people (40 women and 2 men) aged 32 to 50 (M = 40.19; SD = 6.28) and Vietnamese participants (1 city) — 32 people (32 women) aged 38 to 54 years (M = 46.67; SD = 5.12). The interviews followed the questionnaire developed by the authors. It consisted of 21 open-ended questions grouped in 3 blocks: Block 1. What characteristics and skills should be developed during early childhood? Where and how should these be developed? Block 2. How are children under 3 years of age developed? Block 3. Who is involved in the development of a child under 3 years of age? A comparative analysis of the responses of the Russian and Vietnamese kindergarten specialists revealed no significant differences between the groups, which suggests similarities in educational and developmental strategies of young children in a kindergarten environment. © 2019 Moscow State University of Psychology& Education.The reported study was funded by RFBR and VASS, project number 19-513-92001

Binary open clusters in the Milky Way: photometric and spectroscopic analysis of NGC 5617 and Trumpler 22

Using photometry and high resolution spectroscopy we investigate for the first time the physical connection between the open clusters NGC 5617 and Trumpler 22. Based on new CCD photometry we report their spatial proximity and common age of ~70 Myr. Based on high resolution spectra collected using the HERMES and UCLES spectrographs on the Anglo-Australian telescope, we present radial velocities and abundances for Fe, Na, Mg, Al, Si, Ca and Ni. The measured radial velocities are -38.63 ± 2.25 km s⁻¹ for NGC 5617 and -38.46 ± 2.08 km s⁻¹ for Trumpler 22. The mean metallicity of NGC 5617 was found to be [Fe/H] = -0.18 ± 0.02 and for Trumpler 22 was found to be [Fe/H] = -0.17 ± 0.04. The two clusters share similar abundances across the other elements, indicative of a common chemical enrichment history of these clusters. Together with common motions and ages we confirm that NGC 5617 and Trumpler 22 are a primordial binary cluster pair in the Milky Way.Facultad de Ciencias Astronómicas y Geofísica

Современные представления о патогенетических механизмах фиброза печени

This review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage populations is required. The initiation and progression of liver fibrosis is promoted by a complex interaction of different types of liver cells, mediated by cytokines, growth factors, miRNAs. Repeated cycles of apoptosis and regeneration of hepatocytes contribute to the pathogenesis of fibrosis. Modern experimental work has proven the role of mesenchymal stem cells in liver regeneration by inhibiting the expression of the proapoptotic BAX gene. The involution of liver fibrosis is associated with monocytes of the prorestorative phenotype LY6Clow. On in vivo models, regression of fibrosis and utilization of the extracellular matrix depot by inhibition of miRNA-221-3p of hepatocytes have been proven. В данном обзоре представлено обобщение современных данных о патогенетических механизмах фиброза при хронических заболеваниях печени. Контролируемое воспаление и трансдифференцировка звездчатых клеток печени в миофибробласты являются ключевым элементом фиброгенеза, однако требуется дальнейшее изучение роли каждой из популяций макрофагов. Инициации и прогрессированию фиброза печени способствует сложное взаимодействие различных типов клеток печени, опосредованное цитокинами, факторами роста, микроРНК. Свой вклад в патогенез фиброза вносят повторяющиеся циклы апоптоза и регенерации гепатоцитов. Современные экспериментальные работы доказали роль мезенхимальных стволовых клеток в регенерации печени путем ингибирования экспрессии проапоптотического гена BAX. Инволюцию фиброза печени связывают с моноцитами прореставрационного фенотипа LY6Clow. На моделях in vivo доказан регресс фиброза и утилизация депо экстрацеллюлярного матрикса путем ингибирования mi-RNA-221-3p гепатоцитов.

State of rat colon microbiocenosis in chronic restraint stress treated with Selank

It is currently accepted that stress significantly affects composition of microbiocenosis due to changes in permeability of intestinal barrier and pro-inflammatory effects. This, in turn, changes behavioral reactions, anxiety and stress response. In this regard, it seems promising to use regulatory peptide-based neurotropic drugs including Selank to correct stress-induced dysbiosis. Our study was aimed at assessing state of rat colon microbiocenosis in modelled chronic restraint stress and treated with Selankby using 65 Wistar male rats divided into five groups (per 13 rats in each): group 1 — rats injected with saline; group 2 — injected with saline and induced chronic restraint stress; group 3–5 — administered with Selank at dose of 80 μg/kg, 250 μg/kg and 750 μg/kg body weight, respectively, and induced chronic restraint stress. Quantitative and qualitative study of animal colon microbiota was carried out according to the method by L.I. Kafarskaja and V.M. Korshunov. Identification of microorganisms was carried out by using a Maldi Biotyper Microflex mass spectrometer (Bruker, United States). Microbial species-specific composition was presented as lg CFU/g mass of examined sample. For each identified microbial genus, the relative mean and frequency of occurrence were calculated. Statistical significance of differences in mean values was determined by using Student’s t-test. Chronic restraint stress in the experiment did not result in affecting dominant microbiota species in rat colon nor reduce their frequency, however, it significantly influenced examined parameters for commensal microbiota disturbing pattern of pathogenic bacterial strains. Use of Selank led to the reversing changes in composition of colonic microbiocenosis caused by stress model. Moreover, magnitude of parameters examined in experiment after applying Selank at dose of 750 μg/kg reached those in non-stressed animals. Thus, effects related to Selank administration may presumably be mediated due to both central and peripheral effects including immunotropic and anti-inflammatory activities which contributed to restoring colon microbiocenosis composition in stress model