New ADS Functionality for the Curator

In this paper we provide an update concerning the operations of the NASA Astrophysics Data System (ADS), its services and user interface, and the content currently indexed in its database. As the primary information system used by researchers in Astronomy, the ADS aims to provide a comprehensive index of all scholarly resources appearing in the literature. With the current effort in our community to support data and software citations, we discuss what steps the ADS is taking to provide the needed infrastructure in collaboration with publishers and data providers. A new API provides access to the ADS search interface, metrics, and libraries allowing users to programmatically automate discovery and curation tasks. The new ADS interface supports a greater integration of content and services with a variety of partners, including ORCID claiming, indexing of SIMBAD objects, and article graphics from a variety of publishers. Finally, we highlight how librarians can facilitate the ingest of gray literature that they curate into our system.Comment: Submitted to the Proceedings of Library and Information Services in Astronomy VIII, Strasbourg, Franc

Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus

The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Danish Research CouncilFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, BrazilUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, EnglandState Univ São Paulo UNESP, Dept Zool, BR-13506900 Rio Claro, SP, BrazilAarhus Univ, Dept Biosci, DK-8000 Aarhus C, DenmarkFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, BrazilWeb of Scienc

Structural insights on TRPV5 gating by endogenous modulators.

TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and calmodulin (CaM) have been shown to directly bind to TRPV5 and activate or inactivate the channel, respectively. Using cryo-electron microscopy (cryo-EM), we determined TRPV5 structures in the presence of dioctanoyl PI(4,5)P2 and CaM. The PI(4,5)P2 structure reveals a binding site between the N-linker, S4-S5 linker and S6 helix of TRPV5. These interactions with PI(4,5)P2 induce conformational rearrangements in the lower gate, opening the channel. The CaM structure reveals two TRPV5 C-terminal peptides anchoring a single CaM molecule and that calcium inhibition is mediated through a cation-π interaction between Lys116 on the C-lobe of calcium-activated CaM and Trp583 at the intracellular gate of TRPV5. Overall, this investigation provides insight into the endogenous modulation of TRPV5, which has the potential to guide drug discovery

A UME e a projecção da Europa no mundo : referência à posição portuguesa

A projecção da Europa no Mundo depende grandemente da consolidação do processo de integração económica que tem vindo a ser impulsionado pela globalização e pelo lançamento da moeda única europeia. Em particular, vai depender da imagem de credibilidade do euro, das reformas estruturais necessárias à competitividade e à atractividade dos mercados europeus, da adopção de polí- ticas pan-europeias de segurança e de defesa e das reformas institucionais indispensáveis para o avanço do alargamento. No caso de Portugal, o nosso País enfrenta hoje uma situação complexa, marcada por alguns desequilíbrios macro-económicos insustentáveis a prazo – déficit externo e finanças públicas – e por bloqueios estruturais que estão a travar o crescimento e o desenvolvimento económicos. O modo como os ultrapassarmos condicionará a nossa posição na União e no Mund