From creation to consolidation: a novel framework for memory processing

Long after playing squash, your brain continues to process the events that occurred during the game, thereby improving your game, and more generally, enhancing adaptive behavior. Understanding these mysterious processes may require novel theories

Off-line processing: reciprocal interactions between declarative and procedural memories

The acquisition of declarative (i.e., facts) and procedural (i.e., skills) memories may be supported by independent systems. This same organization may exist, after memory acquisition, when memories are processed off-line during consolidation. Alternatively, memory consolidation may be supported by interactive systems. This latter interactive organization predicts interference between declarative and procedural memories. Here, we show that procedural consolidation, expressed as an off-line motor skill improvement, can be blocked by declarative learning over wake, but not over a night of sleep. The extent of the blockade on procedural consolidation was correlated to participants' declarative word recall. Similarly, in another experiment, the reciprocal relationship was found: declarative consolidation was blocked by procedural learning over wake, but not over a night of sleep. The decrease in declarative recall was correlated to participants' procedural learning. These results challenge the concept of fixed independent memory systems; instead, they suggest a dynamic relationship, modulated by when consolidation takes place, allowing at times for a reciprocal interaction between memory systems

Dual enhancement mechanisms for overnight motor memory consolidation

Our brains are constantly processing past events<sup>1</sup>. These offline processes consolidate memories, leading in the case of motor skill memories to an enhancement in performance between training sessions. A similar magnitude of enhancement develops over a night of sleep following an implicit task, in which a sequence of movements is acquired unintentionally, or following an explicit task, in which the same sequence is acquired intentionally<sup>2</sup>. What remains poorly understood, however, is whether these similar offline improvements are supported by similar circuits, or through distinct circuits. We set out to distinguish between these possibilities by applying transcranial magnetic stimulation over the primary motor cortex (M1) or the inferior parietal lobule (IPL) immediately after learning in either the explicit or implicit task. These brain areas have both been implicated in encoding aspects of a motor sequence and subsequently supporting offline improvements over sleep<sup>3,​4,​5</sup>. Here we show that offline improvements following the explicit task are dependent on a circuit that includes M1 but not IPL. In contrast, offline improvements following the implicit task are dependent on a circuit that includes IPL but not M1. Our work establishes the critical contribution made by M1 and IPL circuits to offline memory processing, and reveals that distinct circuits support similar offline improvements

Exercising control over memory consolidation

Exercise can improve human cognition. A mechanistic connection between exercise and cognition has been revealed in several recent studies. Exercise increases cortical excitability and this in turn leads to enhanced memory consolidation. Together these studies dovetail with our growing understanding of memory consolidation and how it is regulated through changes in motor cortical excitability

Are men difficult to find? Identifying male-specific studies in MEDLINE and Embase.

Systematic reviews often investigate the effectiveness of interventions for one sex. However, identifying interventions with data presented according to the sex of study participants can be challenging due to suboptimal indexing in bibliographic databases and poor reporting in titles and abstracts. The purposes of this study were to develop a highly sensitive search filter to identify literature relevant to men's health and to assess the performance of a range of sex-specific search terms used individually and in various combinations

Transverse oscillations of two parallel coronal loops

Context. Collective oscillations of two or more coronal magnetic loops are observed very often. Aims. We study the eigenmodes of oscillations of a system consisting of two parallel magnetic loops. Methods. The linearised MHD equations for a cold plasma are solved analytically in bicylindrical coordinates using the longwavelength approximation. A dispersion equation determining the frequencies of eigenmodes is derived and solved analytically. Results. Two solutions of the dispersion relation were found. The higher frequency corresponds to the antisymmetric mode polarised in the direction parallel to the line connecting the loop centres, and the symmetric mode polarised in the perpendicular direction. Depending on the polarisation of modes corresponding to the lower frequency, the systems of two parallel loops are classified as standard and anomalous. In standard systems the lower frequency corresponds to the symmetric mode polarised in the direction parallel to the line connecting the loop centres, and the antisymmetric mode polarised in the perpendicular direction. In anomalous systems the lower frequency corresponds to the antisymmetric mode polarised in the direction parallel to the line connecting the loop centres, and the symmetric mode polarised in the perpendicular direction. The limiting case of two identical loops is studied. The results for this case are compared with recent numerical results

Tackling Male Obesity: the ROMEO (Review Of MEn Obesity) study

Background: Male obesity is particularly problematic in that men are less likely than women to realise they have a weight problem and are also less likely to engage in weight reduction programmes. Little is known about the most effective ways to engage obese men with obesity services in order to manage weight loss successfully. Aim: Funded by the National Institute of Health Research Health Technology Assessment Programme, theROMEO (Review Of MEn and Obesity) project is an on-going integrated series of five quantitative and qualitative systematic reviews of the evidence associated with management strategies for treating obesity in men, and how to engage men in these obesity services Methods: Studies included in the review are men 16 years or over, with no upper age limit. Ideally all groups of participants in studies must have a mean or median BMI of 30kg/m2. However, in most qualitative papers, BMI is not clearly stated. We are aiming to find out not only ‘what works’ for men in terms of weight management, but also ‘for which men, and under what circumstances’. Our pragmatic approach to this mixed methods evidence synthesis is informed by methods such as realist synthesis, thematic synthesis, framework synthesis, and analytical approaches developed from methods of inquiry such as grounded theory. Findings: We will present initial findings from the qualitative arm of the project. Conclusions: Our work will identify the existing evidence with which to develop guidance for the NHS onthe subject of men and obesity management. The individual reviews and integrated report will also provide guidance on whether further research is needed to develop better methods for engaging and retaining men in obesity interventions

Clinical Effectiveness of Weight Loss and Weight Maintenance Interventions for Men: A Systematic Review of Men-Only Randomized Controlled Trials (The ROMEO Project).

Men are underrepresented in obesity services, suggesting current weight loss service provision is suboptimal. This systematic review evaluated evidence-based strategies for treating obesity in men. Eight bibliographic databases and four clinical trials' registers were searched to identify randomized controlled trials (RCTs) of weight loss interventions in men only, with mean/median body mass index of ≥30 kg/m(2) (or ≥28 kg/m(2) with cardiac risk factors), with a minimum mean/median duration of ≥52 weeks. Interventions included diet, physical activity, behavior change techniques, orlistat, or combinations of these; compared against each other, placebo, or a no intervention control group; in any setting. Twenty-one reports from 14 RCTs were identified. Reducing diets produced more favorable weight loss than physical activity alone (mean weight change after 1 year from a reducing diet compared with an exercise program -3.2 kg, 95% confidence interval -4.8 to -1.6 kg, reported p < .01). The most effective interventions combined reducing diets, exercise, and behavior change techniques (mean difference in weight at 1 year compared with no intervention was -4.9 kg, 95% confidence interval -5.9 to -4.0, reported p < .0001). Group interventions produced favorable weight loss results. The average reported participant retention rate was 78.2%, ranging from 44% to 100% retention, indicating that, once engaged, men remained committed to a weight loss intervention. Weight loss for men is best achieved and maintained with the combination of a reducing diet, increased physical activity, and behavior change techniques. Strategies to increase engagement of men with weight loss services to improve the reach of interventions are needed

Daytime Sleep Enhances Consolidation of the Spatial but Not Motoric Representation of Motor Sequence Memory

Motor sequence learning is known to rely on more than a single process. As the skill develops with practice, two different representations of the sequence are formed: a goal representation built under spatial allocentric coordinates and a movement representation mediated through egocentric motor coordinates. This study aimed to explore the influence of daytime sleep (nap) on consolidation of these two representations. Through the manipulation of an explicit finger sequence learning task and a transfer protocol, we show that both allocentric (spatial) and egocentric (motor) representations of the sequence can be isolated after initial training. Our results also demonstrate that nap favors the emergence of offline gains in performance for the allocentric, but not the egocentric representation, even after accounting for fatigue effects. Furthermore, sleep-dependent gains in performance observed for the allocentric representation are correlated with spindle density during non-rapid eye movement (NREM) sleep of the post-training nap. In contrast, performance on the egocentric representation is only maintained, but not improved, regardless of the sleep/wake condition. These results suggest that motor sequence memory acquisition and consolidation involve distinct mechanisms that rely on sleep (and specifically, spindle) or simple passage of time, depending respectively on whether the sequence is performed under allocentric or egocentric coordinates