9 research outputs found
The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an at Motif-Driven Axis
- Author
- Barnard A.R. (Alun)
- Brancaccio M. (Marco)
- Butler R. (Rachel)
- Chesham J.E. (Johanna E.)
- Couch Y. (Yvonne)
- Edwards J.K. (Jessica K.)
- Esapa C. (Chris)
- Finelli M.J. (Mattéa J.)
- Foster R.G. (Russell G.)
- Hastings I.M. (Ian)
- Jagannath A. (Aarti)
- Joynson G. (Greg)
- Mallon A.-M. (Ann-Marie)
- Maywood E.S. (Elizabeth)
- Nolan P.M. (Patrick M.)
- Oliver P.L. (Peter L.)
- Parsons M.J. (Michael J.)
- Saito S. (Shoko)
- Satija R. (Rahul)
- Sethi S. (Siddharth)
- Simon M.M. (Michelle M.)
- Smyllie N.J. (Nicola J.)
- Wells S. (Sara)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2015
- Field of study
We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3Sci), which accelerates circadian locomotor rhythms in mice. ZFHX3 regulates transcription via direct interaction with predicted AT motifs in target genes. The mutant protein has a decreased ability to activate consensus AT motifs in vitro. Using RNA sequencing, we found minimal effects on core clock genes in Zfhx3Sci/+ SCN, whereas the expression of neuropeptides critical for SCN intercellular signaling was significantly disturbed. Moreover, mutant ZFHX3 had a decreased ability to activate AT motifs in the promoters of these neuropeptide genes. Lentiviral transduction of SCN slices showed that the ZFHX3-mediated activation of AT motifs is circadian, with decreased amplitude and robustness of these oscillations in Zfhx3Sci/+ SCN slices. In conclusion, by cloning Zfhx3Sci, we have uncovered a circadian transcriptional axis that determines the period and robustness of behavioral and SCN molecular rhythms
Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures
- Author
- Adams J.D. (John D.)
- Agel J. (Julie)
- Ahn H. (Henry)
- Ahn J. (Jaimo)
- Albers G.H.R. (G.H. Robert)
- Alexander D. (David)
- Alosky R. (Rachel)
- Amirault J.D. (J. David)
- Amundsen A. (Asgeir)
- Anand S. (Sanjeev)
- Anderson C.G. (Christopher G.)
- Anderson L.K. (Linda K.)
- Anderson S.A. (Sarah A.)
- Apostle K. (Kelly)
- Archdeacon M. (Michael)
- Arora V. (Vinod)
- Aurang K. (Kamran)
- Avram V. (Victoria)
- Axelrod T. (Terry)
- Baele J. (Joseph)
- Baker J.K. (Janell K.)
- Bannister E.R. (Evan R.)
- Bardana D. (Davide)
- Barden B.B. (Benjamin B.)
- Beckish M.L. (Michael L.)
- Bedi H. (Harvinder)
- Ben Schmidt G. (G.)
- Bhandari M. (Mohit)
- Bhatia M. (Mahesh)
- Bicknell R. (Ryan)
- Biddulph M. (Michael)
- Bielby S.A. (Shea A.)
- Biert J. (Jan)
- Blokhuis T.J. (Taco J.)
- Borch T. (Tor)
- Borsella V. (Vivian)
- Bosma J. (Jan)
- Bosman C.H.R. (Coks H.R.)
- Bowler C. (Carol)
- Boxma H. (Han)
- Boyer D. (Dory)
- Brattgjerd J.E. (Jan Egil)
- Brekke A.C. (Anne Christine)
- Brennan M.L. (Michael L.)
- Breslin M. (Mary)
- Brien H. (Heather)
- Broderick J.S. (J. Scott)
- Brom H.L.F.
- Bronkhorst M.W.G.A. (Maarten)
- Browner K. (Kieran)
- Bruijninckx M.M.M. (Milko)
- Buckingham L. (Lisa)
- Buckley R.E. (Richard E.)
- Bucknill A. (Andrew)
- Buijk S.E. (Steven E.)
- Butler M.S. (Mark S.)
- Bzovsky S. (Sofia)
- BĂže B. (Berthe)
- Caminiti S. (Stephanie)
- Campo M. (Martin)
- Cannada L.K. (Lisa K.)
- Cantu R.V. (Robert V.)
- Carcary K. (Kimberly)
- Carlisle H. (Hope)
- Carr A. (Ashley)
- Cass J.R. (Joseph R.)
- Charlton M. (Michael)
- Cherian J.J. (Joe Joseph)
- Chia A. (Andrew)
- Chuter G. (Graham)
- Clark C. (Callum)
- Clarke-Jenssen J. (John)
- Clarkson R. (Rachel)
- Cleffken B.I. (Berry)
- Clipper L. (Lydia)
- Coady C. (Catherine)
- Cole P.A. (Peter A.)
- Coles C. (Chad)
- Creek A.T. (Aaron T.)
- Crist B.D. (Brett D.)
- Cross W.W. (William W.)
- Csongvay S. (Steve)
- Cuento C. (Claudine)
- Curry H. (Hamish)
- Dadi A. (Akhil)
- Davis C.A. (Craig A.)
- Dawson I. (Imro)
- Dawson S.A. (Sarah A.)
- De Brauw M. (Maurits)
- De Meulemeester F.R.A.J. (Frank R.A.J.)
- De Mol Van Otterloo A. (Alexander)
- De Rooij P.D. (Peter D.)
- De Vries Reilingh T.S. (Tammo S.)
- De Vries J.P.P.M. (Jean Paul P.M.)
- De Waal Malefijt M.C. (Maarten C.)
- Della Rocca G.J. (Gregory J.)
- DePaolo C.J. (Charles J.)
- Devereaux P.J.
- Dobb C. (Christine)
- Dobbin G. (Gwendolyn)
- Dohm M.P. (Michael P.)
- Doig S. (Stephen)
- Dolenc A. (Andrea)
- Donald G. (Geoff)
- Donegan D. (Derek)
- Donohue C. (Craig)
- Doornebosch P. (Pascal)
- Dowrick A. (Adam)
- Duffy P. (Paul)
- Dulaney-Cripe L. (Liz)
- Dumais J. (Jules)
- Dunbar M. (Michael)
- Duraikannan A. (Aravin)
- Edison M. (Matt)
- Edwards E. (Elton)
- Edwards M.J.R. (Michael J.R.)
- Eickhoff L.S. (Linda S.)
- Eke K. (Kate)
- EkÄs G. (Guri)
- Elst M. (Maarten) van der
- Endres T.J. (Terrence J.)
- Ertl J.P. (Janos P.)
- Erwin K. (Katie)
- Esser M. (Max)
- Esterhai J. (John)
- Etherington G. (Greg)
- Evans A. (Andrew)
- Evans S. (Simone)
- Eversdijk M.G. (Martin)
- Fan M. (Mary)
- Farrell D.J. (Dana J.)
- Farrugia R.J. (Richard J)
- Festen S. (Sebastiaan)
- Ficke J. (James)
- Finley S.H. (Stephen H.)
- Finn E. (Erin)
- Finnan R. (Ryan)
- Fioole B. (Bram)
- FlatĂžy B. (Bernhard)
- Flynn A. (Annette)
- Foley A.L. (Amy L.)
- Foret J.L. (Jonathan L.)
- Frihagen F. (Frede)
- Frizzell V. (Valda)
- Frölke J.P.M. (Jan Paul)
- Ganguly U. (Utsav)
- Gardeniers J.W.M. (Jean W.M.)
- Garfi J.S. (John S.)
- Garibaldi A. (Alisha)
- Gayton C. (Chris)
- Geeraedts L.M.G. (Leo M.G.)
- Gervais T. (Trevor)
- Ghent W. (Wesley)
- Gibula D. (Douglas)
- Gichuru M. (Mark)
- Gissel H. (Hannah)
- Glazebrook M. (Mark)
- Go P.M.N.Y.M. (Peter M.N.Y.M.)
- Goetz D.R. (David R.)
- Gofton W.T. (Wade T.)
- Gong A. (Andrew)
- Gorczyca J.T. (John T.)
- Goslings J.C. (Carel)
- Govaert L. (Lonneke)
- Graaf E.J.R. (Eelco) de
- Groenendijk R.P.R. (Richard)
- Gross J.M. (Jonathan M.)
- Gross M. (Michael)
- Gruen G. (Gary)
- Gudger G.K. (Garland K.)
- Guicherit O.R. (Onno R.)
- Gupta A. (Ajay)
- Gurich R.W. (Richard W.)
- Guyatt G.H. (Gordon)
- Hak D. (David)
- Hall J.A. (Jeremy A.)
- Halliday B. (Brett)
- Hammacher E.R. (Eric)
- Hammerberg E.M. (E. Mark)
- Hampton L. (Lynne)
- Hanusch B.C. (Birgit C.)
- Harrison M. (Mark)
- Hart C.P. (Cor P.) van der
- Hartog D. (Dennis) den
- Hasselund S. (Sondre)
- Haug K.J. (Knut JĂžrgen)
- Haverlag R. (Robert)
- Heels-Ansdell D. (Diane)
- Heetveld M.J. (Martin J.)
- Heijden F.H.W.M. (Frank) van der
- Hemlock K. (Kim)
- Henderson C. (Corey)
- Henderson E.R. (Eric R.)
- Herriott C. (Chris)
- Hesketh P.J. (Patrick J.)
- Hess S. (Shelley)
- Hewitt M. (Michael)
- Hidy J.T. (Jennifer T.)
- Hileman B. (Barbara)
- Hill A.D. (Austin D.)
- Hjorthaug G. (Geir)
- Hoffman J.M. (Jodi M.)
- Hoffman W.H. (W. H.)
- Hollenbeck S.M. (Steven M.)
- Holt M. (Michael)
- Hoogendoorn J. (Jochem)
- Horan A.D. (Annamarie D.)
- Horner G. (Gillian)
- Horwitz D. (Daniel)
- Hoseth T.M. (Tor Magne)
- Howells F. (Fiona)
- Hsu J.R. (Joseph R.)
- Huff R.B. (Roger B.)
- Hull P. (Peter)
- Humphrey C.A. (Catherine A.)
- Hurley M. (Meghan)
- Ianssen T. (Torben)
- Inman D. (Dominic)
- Iorio R. (Richard)
- Irrgang J. (James)
- Jackson L.T. (Lyle T.)
- Jain A. (Arvind)
- Jain N. (Neeraj)
- Jenkins M. (Mark)
- Jenkinson R. (Richard)
- Jennings A. (Andrew)
- Jeray K.J. (Kyle J.)
- Johnson G. (Garth)
- Johnston D. (David)
- Johnston K. (Kelly)
- Jomaas G. (Geir)
- Jones C.B. (Clifford B.)
- Jones V. (Vicki)
- Josaputra H.A. (Hong A.)
- Kain M.S.H. (Michael S.H.)
- Kampen A. (A.) van
- Karges D.E. (David E.)
- Karlsten A. (Anders)
- Karsten T.M. (Thomas)
- Kates S. (Stephen)
- Keeve J.P. (Jonathan P.)
- Keller P. (Paul)
- Ketz J.P. (John P.)
- Khan F. (Farah)
- Khan R.M. (Ryan M.)
- Khanna A. (Angshuman)
- KibsgÄrd T. (Thomas)
- Kile E. (Evelyn)
- Kingwell S.P. (Stephen P.)
- Knobe M. (Matthias)
- Koppert C.L. (Cees L.)
- Korley R. (Robert)
- Kottam L. (Lucksy)
- Kreder H. (Hans)
- Kregor P. (Philip)
- Kruse K.K. (Kevin K.)
- Kuiken H. (Hans)
- Kunz M. (Monica)
- Lackey W.G. (Wesley G.)
- Lafferty P.M. (Paul M.)
- Lambert S. (Sue)
- Langan J.W. (Justin W.)
- Laughlin R. (Richard)
- Lawendy A.-R. (Abdel-Rahman)
- Lawson D. (Deanna)
- Le T. (Toan)
- Lee J. (Julia)
- Leenen L.P.H.
- Leffler L.C. (Lauren C.)
- Leighton R. (Ross)
- Lemke H.M. (H. Michael)
- Lewis C.G. (Courtland G.)
- Lewis S. (Sophie)
- Li D. (Doug)
- Li M. (Mengnai)
- Lieberman S. (Shane)
- Liem R. (Ronald)
- Lieshout E.M.M. (Esther) van
- Liew A. (Allen)
- Liew S. (Susan)
- Lindenbaum S. (Stephen)
- Linehan C. (Colleen)
- Lobo M.J. (Margaret J.)
- Logishetty R. (Rajanikanth)
- Lona T. (Tarjei)
- Lorenzo M. (Melissa)
- Love D. (David)
- Luther A. (Arlene)
- Ly T.V. (Thuan V.)
- Lyle L. (Lindsey)
- MacDonald S. (Shelley)
- MacLeod M. (Mark)
- Maddock D. (Deborah)
- Marcantonio A.J. (Andrew J.)
- Marston S.B. (Scott B.)
- Mauffrey C. (Cyril)
- May J. (Jedediah)
- McBeth J.C. (Jessica Cooper)
- McCormack R. (Robert)
- McDonald M.D. (Michael D.)
- McIntyre A.W. (Allison W.)
- McKay P. (Paula)
- McKee M.D. (Michael D.)
- McKercher R. (Ross)
- Mehta S. (Samir)
- Meijer J. (Joost)
- Meylaerts S.A.G. (Sven)
- Miller R. (Russell)
- Miller T.J. (Timothy J.)
- Mills K. (Kelli)
- Milner K. (Katrine)
- Mishra V. (Vimlesh)
- Mitchell K. (Khalis)
- Moatshe G. (Gilbert)
- Moaveni A. (Ash)
- Molund M. (Marius)
- Monica J.T. (James T.)
- Moola F. (Farhad)
- Moon K. (Karyn)
- Moon R. (Raely)
- Moore M.M. (Molly M.)
- Mullis B. (Brian)
- Murdoch Z. (Zoe)
- Murnaghan J. (John)
- Murphy R.L. (R. Lee)
- Murtha Y.M. (Yvonne M.)
- MĂŒller O. (Oliver)
- Nam D. (Diane)
- Nanda R. (Rajesh)
- Nanney T. (Tracy)
- Napierala M. (Matthew)
- Nastoff L.A. (Lauren A.)
- Naumetz V. (V.)
- Nauth A. (Aaron)
- Newman H. (Heike)
- Nicolaisen T. (Tor)
- Nies F. (Frank) de
- Nilsen F. (Fredrik)
- Noble K. (Krista)
- Nousiainen M. (Markku)
- O'Malley L.K. (Lawrence K.)
- O'Neil J. (Joseph)
- Oatt A. (Amber)
- Obremskey W. (William)
- Olakkengil D.J. (Davy J)
- Oliver T.M. (Todd M.)
- Oprel P.P. (Pim)
- Out N.J.M. (Nico J.M.)
- Oxner W. (William)
- Pace T.B. (Thomas B.)
- Palla N. (Naveen)
- Pape H.-C. (Hans-Christoph)
- Papp S. (Steve)
- Parr J.A. (J. Andrew)
- Patka P. (Peter)
- Payton K. (Krystal)
- Pecorella K. (Kaili)
- Perey B. (Bertrand)
- Peters M.E. (Melissa E.)
- Peters R. (Rolf)
- Peterson B. (Brett)
- Pfeifer R. (Roman)
- Pilling L. (Lindsey)
- Pincus P. (Paul)
- Pirpiris M. (Marinis)
- Poelhekke L.M.S.J.
- Pol C. (Carmen) van der
- Ponsen K.J. (Kees-jan)
- Poolman R.W. (Rudolf)
- Porter S.E. (Scott E.)
- Pourmand D. (Deeba)
- Powell J. (James)
- Prasad A.S. (Amal Shankar)
- Prayson M.J. (Michael J.)
- Price D.M. (Dustin M.)
- Probe R. (Robert)
- Puloski S. (Shannon)
- Rai A. (Anil)
- Rai B.S. (B. Sachidananda)
- Rai K. (Kamal)
- Rajakumar J. (Janakiraman)
- Rangan A. (Amar)
- Reardon G. (Gerald)
- Reed M.R. (Mike)
- Reeves C. (Christina)
- Rhemrev S. (Steven)
- Richards J.E. (Justin E.)
- Richardson C.G. (C. Glen)
- Richardson M. (Martin)
- Rieser G.R. (Geoffrey Ryan)
- Riet M. (Martijne) van 't
- Rijbroek B. (Bram)
- Rijcke P.A.R. (Piet)
- Rijna H.
- Ringler J.R. (James R.)
- Ritchie E.D. (Ewan D.)
- Robbins K. (Kristin)
- Roffey D.M. (Darren M.)
- Romero A.W. (Amanda W.)
- Roper E. (Elizabeth)
- Rose G. (Glynis)
- Roukema G.R. (Gert)
- Rubino L.J. (L. Joseph)
- Russ M. (Matthias)
- Rutherford T. (Tori)
- Rydinge J. (Jonas)
- Sage C. (Claire)
- Sagebien C.A. (Carlos A.)
- Sanders D. (David)
- Sanghavi A. (Amir)
- Schaller T.M. (Thomas M.)
- Scheepers J.J. (Joris J.)
- Schemitsch E.H. (Emil H.)
- Schep N.W.L. (Niels)
- Schmidt A.H. (Andrew H.)
- Schreurs B. (Bart)
- Schrickel T. (Tyson)
- Schwappach J. (John)
- Scott T. (Taryn)
- Scrabeck T. (Tyson)
- Segers M.J.M. (Michiel)
- Sems S.A. (Stephen A.)
- Seuffert P. (Patricia)
- Shaer J. (James)
- Sharma A. (Ateet)
- Sharma G. (Gaurav)
- Shell L.E. (Leslie E.)
- Shepard S. (Stephanie)
- Shively K. (Karl)
- Sietsema D.L. (Debra L.)
- Silva H. (Heather)
- Silvis R. (Rob)
- Simmermacher R.K.J.
- Simons M.P.
- Simunovic N. (Nicole)
- Singh S. (Sanjay)
- Siroen M.P.C. (Michiel P.C.)
- Siska P. (Peter)
- Slobogean G.P. (Gerard P.)
- Smedsrud M. (Morten)
- Smits A.B. (Anke B.)
- Snellen J.P. (Jaap P.)
- Snider R.G. (Rebecca G.)
- Specht L.M. (Lawrence M.)
- Sprag S. (Sheila)
- Sprague S. (Sheila)
- Stahel P. (Philip)
- Stassen L.P.S. (Laurents P.S.)
- Stephen D. (David)
- Stinner D. (Daniel)
- Stockmann H. (Heyn)
- Stone T. (Trevor)
- Stringfellow K. (Kenya)
- Strohecker K. (Kent)
- Stull P. (Philip)
- StĂždle A. (Are)
- Subash ()
- Sullivan R.J. (Raymond J.)
- Sundaresh D.C. (D. C.)
- Swenson T.K. (Teresa K.)
- Swinton M. (Marilyn)
- Swiontkowski M.F. (Marc )
- Switzer J.A. (Julie A.)
- Tan E.C.T.H. (Edward C.T.H.)
- Tanksley J.A. (John A.)
- Tanner S.L. (Stephanie L.)
- Tannoury C. (Chadi)
- Tarkin I. (Ivan)
- Teasdall R.J. (Robert J.)
- Tetsworth K. (Kevin)
- Tetteroo G.W.M. (Geert)
- Thabane L. (Lehana)
- Theunissen E.B.M. (Evert B.M.)
- Tieszer C. (Christina)
- Tilzey J.F. (John F.)
- Ton L. (Lu)
- Torchia M.E. (Michael E.)
- Tornetta III P. (Paul)
- Torres E.T. (Erick T.)
- Trask K. (Kelly)
- Trenholm J.A. (J. Andrew)
- Trivedi M. (Mittal)
- Trommer A. (Axel)
- Turckan K. (Kahn)
- Tyagi V. (Vivek)
- Tynan M.C. (Martin C.)
- Ugland S. (Stein)
- Vallier H.A. (Heather A.)
- Van Der Brand I. (Igor)
- Van Der Hoeven H. (Henk)
- Van Egmond T. (Teun)
- Van Gaalen S.M. (Steven M.)
- Van Mulken J. (Jeroen)
- Van Vugt A.B. (Arie B.)
- Vang S. (Sandy)
- Verhagen R. (Ronald)
- Verhoeven B. (Bart)
- Verhofstad M.H.J. (Michiel)
- Vermeulen E.G.J. (Erik G.J.)
- Vesterhus E.B. (Elise Berg)
- Vicente M.R. (Milena R.)
- Vis H.M. (Harm) van der
- Viskontas D. (Darius)
- Visser G.A. (Gijs A.)
- Viveiros H. (Helena)
- Vogt M. (Michelle)
- Vries A.C. (Alexander) de
- Vries M.R. (Mark) de
- Vuylsteke R. (Ronald)
- Wadey V. (Veronica)
- Waes O.J.F. (Oscar) van
- Wai E.K. (Eugene K.)
- Walker J.E. (Jane E.)
- Walter S.D. (Stephen D.)
- Wang O. (Otis)
- Ward A. (Angela)
- Watson D.J. (Dylan J.)
- Watson S.T. (Scott T.)
- Weber T. (Timothy)
- Weening B. (Brad)
- Weinerman S. (Stuart)
- Weingarten P. (Peter)
- Weinrauch P. (Patrick)
- Wessel R.N. (Ronald N.)
- Wessem K.J.P. van
- Westberg J.R. (Jerald R.)
- Whatley E. (Erica)
- Whelan D.B. (Daniel B.)
- Wild L.M. (Lisa M.)
- Wille J.C. (Jan)
- Willems W.J. (Jaap)
- Wittich P. (Philippe)
- Wong I. (Ivan)
- Wood G. (Gavin)
- Worman R. (Ripley)
- Wright D.M. (David M.)
- Wyrick J. (John)
- Yach J. (Jeff)
- Yadav V. (Vineet)
- Yang S. (Steven)
- Yee A. (Albert)
- Yen D. (David)
- Yu M. (Michelle)
- Zalzal P. (Paul)
- Zamorano D.P. (David P.)
- Zellar A. (Abby)
- Zhou Q. (Qi)
- Zielinski S.M. (Stephanie)
- Zijl J.A.C. (Jacco A.C.)
- Zohman G. (Gary)
- Zomar M. (Mauri)
- Zurcher A.W. (Arthur W.)
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/05/2018
- Field of study
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
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- Tilley Jo
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- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
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- Walker S.
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- Wallis T
- Walmsley S
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- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
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- Weir-McCall Jonathan R
- Welch C
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- Wynter Inez
- Xie Cheng
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- Yasmin Najira
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged â„18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2â6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5â5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4â10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32â4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23â11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
âMaintaining the connexionâ: Orangeism in the British North Atlantic World, 1795â1844
- Author
- Akenson Donald
- Akenson Donald
- Armitage David
- Bailyn Bernard
- Bielenberg Andy
- Boyd Andrew
- Brown William
- Bull William Perkins
- Burnard Trevor
- Careless J.M.S.
- Colley Linda
- Craig Gerald M.
- Davin Nicholas Flood
- de Vere White Terence
- Dewar Michael W.
- Dudley Edwards Ruth
- Elliott Bruce
- Errington Jane
- Fairley Margaret
- Farrell Sean
- Firth Edith
- Firth Edith
- Firth Edith
- Fitzgibbon Mary
- Glazebrook George
- Grand Orange Lodge
- Gray Tony
- Greene Jack
- Haddick-Flynn Kevin
- Holland James
- Houston Cecil J.
- Houston Cecil J.
- Jessica Harland-Jacobs
- Johnson J.K.
- Kealey Gregory S.
- Kirk Neville
- MacRaild Donald M.
- McFarland Elaine
- McLeod Hugh
- Meinig D.W.
- Mills David
- Reid Richard
- Rodgers Daniel
- See Scott W.
- Senior Hereward
- Senior Hereward
- Steele Ian K.
- Vaughan W. E.
- Whelan Kevin
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial
- Author
- Adams J.D. (John D.)
- Agel J. (Julie)
- Ahn H. (Henry)
- Ahn J. (Jaimo)
- Albers G.H.R. (G.H. Robert)
- Alexander D. (David)
- Alosky R. (Rachel)
- Amirault J.D. (J. David)
- Amundsen A. (Asgeir)
- Anand S. (Sanjeev)
- Anderson C.G. (Christopher G.)
- Anderson L.K. (Linda K.)
- Anderson S.A. (Sarah A.)
- Apostle K. (Kelly)
- Archdeacon M. (Michael)
- Arora V. (Vinod)
- Aurang K. (Kamran)
- Avram V. (Victoria)
- Axelrod T. (Terry)
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- de Meulemeester F.R.A.J. (Frank R.A.J.)
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- de Waal Malefijt M.C. (Maarten C.)
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- Elst Maarten
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- Gissel H. (Hannah)
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- Gofton W.T. (Wade T.)
- Gong A. (Andrew)
- Gorczyca J.T. (John T.)
- Goslings Carel
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- Hammerberg E.M. (E. Mark)
- Hampton L. (Lynne)
- Hanusch B.C. (Birgit C.)
- Harrison M. (Mark)
- Hart Cor P.
- Hartog Dennis
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- Haverlag Robert
- Heels-Ansdell Diane
- Heetveld Martin
- Heijden Frank
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- Henderson C. (Corey)
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- Herriott C. (Chris)
- Hesketh P.J. (Patrick J.)
- Hess S. (Shelley)
- Hewitt M. (Michael)
- Hidy J.T. (Jennifer T.)
- Hileman B. (Barbara)
- Hill A.D. (Austin D.)
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- Hoffman J.M. (Jodi M.)
- Hoffman W.H. (W. H.)
- Hollenbeck S.M. (Steven M.)
- Holt M. (Michael)
- Hoogendoorn J. (Jochem)
- Horan A.D. (Annamarie D.)
- Horner G. (Gillian)
- Horwitz D. (Daniel)
- Hoseth T.M. (Tor Magne)
- Howells F. (Fiona)
- Hsu J.R. (Joseph R.)
- Huff R.B. (Roger B.)
- Hull P. (Peter)
- Humphrey C.A. (Catherine A.)
- Hurley M. (Meghan)
- Ianssen T. (Torben)
- Inman D. (Dominic)
- Iorio R. (Richard)
- Irrgang J. (James)
- Jackson L.T. (Lyle T.)
- Jain A. (Arvind)
- Jain N. (Neeraj)
- Jenkins M. (Mark)
- Jenkinson R. (Richard)
- Jennings A. (Andrew)
- Jeray K.J. (Kyle J.)
- Johal H. (Herman)
- Johnson G. (Garth)
- Johnston D. (David)
- Johnston K. (Kelly)
- Jomaas G. (Geir)
- Jones C.B. (Clifford B.)
- Jones V. (Vicki)
- Josaputra H.A. (Hong A.)
- JĂžrgen Haug K. (Knut)
- Kain M.S.H. (Michael S.H.)
- Kampen A.
- Karges D.E. (David E.)
- Karlsten A. (Anders)
- Karsten Thomas
- Kates S. (Stephen)
- Keeve J.P. (Jonathan P.)
- Keller P. (Paul)
- Ketz J.P. (John P.)
- Khan F. (Farah)
- Khan R.M. (Ryan M.)
- Khanna A. (Angshuman)
- KibsgÄrd T. (Thomas)
- Kile E. (Evelyn)
- Kingwell S.P. (Stephen P.)
- Knobe M. (Matthias)
- Koppert C.L. (Cees L.)
- Korley R. (Robert)
- Kottam L. (Lucksy)
- Kreder H. (Hans)
- Kregor P. (Philip)
- Kruse K.K. (Kevin K.)
- Kuiken H. (Hans)
- Kunz M. (Monica)
- Lackey W.G. (Wesley G.)
- Lafferty P.M. (Paul M.)
- Lambert S. (Sue)
- Langan J.W. (Justin W.)
- Laughlin R. (Richard)
- Lawendy A.-R. (Abdel-Rahman)
- Lawson D. (Deanna)
- Le T. (Toan)
- Lee Murphy R. (R.)
- Lee J. (Julia)
- Leenen Luke
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- Leighton R. (Ross)
- Lemke H.M. (H. Michael)
- Lewis C.G. (Courtland G.)
- Lewis S. (Sophie)
- Li D. (Doug)
- Li M. (Mengnai)
- Lieberman S. (Shane)
- Liem R. (Ronald)
- Lieshout Esther
- Liew A. (Allen)
- Liew S. (Susan)
- Lindenbaum S. (Stephen)
- Linehan C. (Colleen)
- Lobo M.J. (Margaret J.)
- Logishetty R. (Rajanikanth)
- Lona T. (Tarjei)
- Lorenzo M. (Melissa)
- Love D. (David)
- Luther A. (Arlene)
- Ly T.V. (Thuan V.)
- Lyle L. (Lindsey)
- MacDonald S. (Shelley)
- MacLeod M. (Mark)
- Maddock D. (Deborah)
- Marcantonio A.J. (Andrew J.)
- Marston S.B. (Scott B.)
- Mauffrey C. (Cyril)
- May J. (Jedediah)
- McBeth J.C. (Jessica Cooper)
- McCormack R. (Robert)
- McDonald M.D. (Michael D.)
- McIntyre A.W. (Allison W.)
- McKay P. (Paula)
- McKee M.D. (Michael D.)
- McKercher R. (Ross)
- Mehta S. (Samir)
- Meijer J. (Joost)
- Meylaerts Sven
- Miller R. (Russell)
- Miller T.J. (Timothy J.)
- Mills K. (Kelli)
- Milner K. (Katrine)
- Mishra V. (Vimlesh)
- Mitchell K. (Khalis)
- Moatshe G. (Gilbert)
- Moaveni A. (Ash)
- Molund M. (Marius)
- Monica J.T. (James T.)
- Moola F. (Farhad)
- Moon K. (Karyn)
- Moon R. (Raely)
- Moore M.M. (Molly M.)
- Mullis B. (Brian)
- Murdoch Z. (Zoe)
- Murnaghan J. (John)
- Murtha Y.M. (Yvonne M.)
- MĂŒller O. (Oliver)
- Nam D. (Diane)
- Nanda R. (Rajesh)
- Nanney T. (Tracy)
- Napierala M. (Matthew)
- Nastoff L.A. (Lauren A.)
- Naumetz V. (V.)
- Nauth A. (Aaron)
- Newman H. (Heike)
- Nicolaisen T. (Tor)
- Nies Frank
- Nilsen F. (Fredrik)
- Noble K. (Krista)
- Nousiainen M. (Markku)
- O'Malley L.K. (Lawrence K.)
- O'Neil J. (Joseph)
- Oatt A. (Amber)
- Obremskey W. (William)
- Olakkengil D.J. (Davy J)
- Oliver T.M. (Todd M.)
- Oprel Pim
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- Oxner W. (William)
- Pace T.B. (Thomas B.)
- Palla N. (Naveen)
- Pape H.-C. (Hans-Christoph)
- Papp S. (Steve)
- Parr J.A. (J. Andrew)
- Patka Peter
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- Pincus P. (Paul)
- Pirpiris M. (Marinis)
- Poelhekke L.M.S.J.
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- Poolman Rudolf
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- Powell J. (James)
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- Probe R. (Robert)
- Puloski S. (Shannon)
- Rai A. (Anil)
- Rai B.S. (B. Sachidananda)
- Rai K. (Kamal)
- Rajakumar J. (Janakiraman)
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- Reardon G. (Gerald)
- Reed Mike
- Reeves C. (Christina)
- Rhemrev Steven
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- Rieser G.R. (Geoffrey Ryan)
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- Rijcke Piet
- Rijna H.
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- Ritchie E.D. (Ewan D.)
- Robbins K. (Kristin)
- Rocca G.J.D. (Gregory J. Della)
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- Romero A.W. (Amanda W.)
- Roper E. (Elizabeth)
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- Roukema Gert
- Rubino L.J. (L. Joseph)
- Russ M. (Matthias)
- Rutherford T. (Tori)
- Rydinge J. (Jonas)
- Sage C. (Claire)
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- Sanders D. (David)
- Sanghavi A. (Amir)
- Schaller T.M. (Thomas M.)
- Scheepers Joris J.
- Schemitsch Emil
- Schep Niels
- Schmidt A.H. (Andrew H.)
- Schmidt G.B. (G. Ben)
- Schreurs B. (Bart)
- Schrickel T. (Tyson)
- Schwappach J. (John)
- Scott T. (Taryn)
- Scrabeck T. (Tyson)
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- Segers Michiel
- Sems S.A. (Stephen A.)
- Seuffert P. (Patricia)
- Shaer J. (James)
- Sharma A. (Ateet)
- Sharma G. (Gaurav)
- Shell L.E. (Leslie E.)
- Shepard S. (Stephanie)
- Shively K. (Karl)
- Sietsema D.L. (Debra L.)
- Silva H. (Heather)
- Silvis R. (Rob)
- Simmermacher R.K.J.
- Simons M.P.
- Simunovic N. (Nicole)
- Simunovic N. (Nicole)
- Singh S. (Sanjay)
- Siroen M.P.C. (Michiel P.C.)
- Siska P. (Peter)
- Slobogean G.P. (Gerard P.)
- Smedsrud M. (Morten)
- Smits A.B. (Anke B.)
- Snellen J.P. (Jaap P.)
- Snider R.G. (Rebecca G.)
- Specht L.M. (Lawrence M.)
- Sprague S. (Sheila)
- Stahel P. (Philip)
- Stassen Laurents
- Stephen D. (David)
- Stinner D. (Daniel)
- Stockmann H. (Heyn)
- Stone T. (Trevor)
- Stringfellow K. (Kenya)
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- Stull P. (Philip)
- StĂždle A. (Are)
- Subash ()
- Sullivan R.J. (Raymond J.)
- Sundaresh D.C. (D. C.)
- Swenson T.K. (Teresa K.)
- Swinton M. (Marilyn)
- Swiontkowski Marc
- Switzer J.A. (Julie A.)
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- Tetsworth K. (Kevin)
- Tetteroo Geert
- Thabane Lehana
- Theunissen E.B.M. (Evert B.M.)
- Tieszer C. (Christina)
- Tilzey J.F. (John F.)
- Ton L. (Lu)
- Torchia M.E. (Michael E.)
- Tornetta Paul
- Torres E.T. (Erick T.)
- Trask K. (Kelly)
- Trenholm J.A. (J. Andrew)
- Trivedi M. (Mittal)
- Trommer A. (Axel)
- Turckan K. (Kahn)
- Tyagi V. (Vivek)
- Tynan M.C. (Martin C.)
- Ugland S. (Stein)
- Vallier H.A. (Heather A.)
- van der Brand I. (Igor)
- van der Hoeven H. (Henk)
- van Egmond T. (Teun)
- van Gaalen S.M. (Steven M.)
- van Mulken J. (Jeroen)
- van Vugt A.B. (Arie B.)
- van ât Riet M. (Martijne)
- Vang S. (Sandy)
- Verhagen R. (Ronald)
- Verhoeven B. (Bart)
- Verhofstad Michiel
- Vermeulen E.G.J. (Erik G.J.)
- Vesterhus E.B. (Elise Berg)
- Vicente M.R. (Milena R.)
- Vis Harm
- Viskontas D. (Darius)
- Visser G.A. (Gijs A.)
- Viveiros Helena
- Vogt M. (Michelle)
- Vries Alexander
- Vries Mark
- Vuylsteke R. (Ronald)
- Wadey V. (Veronica)
- Waes Oscar
- Wai E.K. (Eugene K.)
- Walker J.E. (Jane E.)
- Walter S.D. (Stephen D.)
- Wang O. (Otis)
- Ward A. (Angela)
- Watson D.J. (Dylan J.)
- Watson S.T. (Scott T.)
- Weber T. (Timothy)
- Weening B. (Brad)
- Weinerman S. (Stuart)
- Weingarten P. (Peter)
- Weinrauch P. (Patrick)
- Wessel R.N. (Ronald N.)
- Wessem K.J.P.
- Westberg J.R. (Jerald R.)
- Whatley E. (Erica)
- Whelan D.B. (Daniel B.)
- Wild L.M. (Lisa M.)
- Wille Jan
- Willems Jaap
- Wittich Philippe
- Wong I. (Ivan)
- Wood G. (Gavin)
- Worman R. (Ripley)
- Wright D.M. (David M.)
- Wyrick J. (John)
- Yach J. (Jeff)
- Yadav V. (Vineet)
- Yang S. (Steven)
- Yee A. (Albert)
- Yen D. (David)
- Yu M. (Michelle)
- Zalzal P. (Paul)
- Zamorano D.P. (David P.)
- Zellar A. (Abby)
- Zhou Q. (Qi)
- Zielinski Stephanie
- Zijl J.A.C. (Jacco A.C.)
- Zohman G. (Gary)
- Zomar M. (Mauri)
- Zurcher A.W. (Arthur W.)
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/04/2017
- Field of study
Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between Mar
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- AgĂŒero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz MarĂa JesĂșs
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin Karen
- Austin Pauline
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie John Kenneth
- Baines Balvinder
- Baines D.
- Baines K.
- Baird Yolanda
- Bakthavatsalam Dhanalakshmi
- Balaconis Mary K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford Peter
- Banach Dorota
- Bancroft Hollie
- Band G.
- Bandini M.
- Bandla Nageswar
- Bano S.
- Baptista David
- Barakeh D.
- Baras Aris
- Baratti S.
- Barber R.
- Barberis L.
- Barbieri C.
- Barclay Lucy
- Bargagli E.
- Barhoush E.
- Barker J.
- Barnes K.C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley Shauna
- Baruah R.
- Bashyal Archana
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates Michelle
- Batini Chiara
- Battle Ceri
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.A.
- Beadle Jane
- Bean S.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
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- Afrough Mohammad
- Agarwal Bhanu
- Agatsuma Kazuhiro
- Aggarwal Nancy
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- Granata Massimo
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- Gray Corey
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- Grote Hartmut
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- Guidi Gianluca M.
- Guo Xiangyu
- Gupta Anuradha
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- Jacqmin Thibaut
- Jani Karan
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- Kondrashov Veronica
- Kontos Antonios
- Korobko Mikhail
- Korth William Z.
- Kowalska Izabela
- Kozak Dan B.
- Kringel Volker
- Krishnan Badri
- KrÀmer Christina
- KrĂłlak Andrzej
- Kuehn Gerrit
- Kumar Prayush
- Kumar Rakesh
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- Kuo L.
- Kutynia Adam
- Kwang Shawn
- Kéfélian Fabien
- Lackey Benjamin D.
- Lai K.H.
- Landry Michael
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- Lange Jacob
- Lantz Brian
- Lanza Robert K.
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- Laxen Michael
- Lazzarini Albert
- Lazzaro Claudia
- Leaci Paola
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- Lee Hyungwon W.
- Lee Hyunkyu K.
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- Lenon Amber
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- Li Tjonnie G.F.
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- Liu J.
- Lockerbie Nick A.
- London Lionel T.
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- Lorenzini Matteo
- Loriette Vincent
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- Lousto Carlos O.
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- Lumaca D.
- Lundgren Andrew P.
- Lynch Ryan
- LĂŒck Harald
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- Macinnis M.
- Macleod Duncan M.
- Magaña Hernandez I.
- Magaña Zertuche L.
- Magaña-Sandoval F.
- Magee Ryan M.
- Majorana Ettore
- Maksimovic Ivan
- Man N.
- Mandel Ilya
- Mandic Vuk
- Mangano Valentina
- Mansell Georgia L.
- Manske Michael
- Mantovani Maddalena
- Marchesoni Fabio
- Marion Frederique
- Markakis Charalampos
- Markosyan Ashot S.
- Maros E.
- Martelli Filippo
- Martellini Lionel
- Martin Ian W.
- Martynov Denis V.
- Marx Jay N.
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- Massinger Thomas J.
- Masso-Reid M.
- Mastrogiovanni Simone
- Matas Andrew
- Matichard Fabrice
- Matone Luca
- Mavalvala Nergis
- Mayani Rajiv
- Mazumder Nairwita
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- Mcclelland D.E.
- Mccormick S.
- McCuller L.
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- Mcintyre G.
- Mciver J.
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- Meadors Grant D.
- Meidam Jeroen
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- Melatos Andrew
- Mendell Gregory
- Mercer R.A.
- Merilh Edmond L.
- Merzougui Mourad
- Meshkov Syd
- Messenger Chris
- Messick Cody
- Metzdorff R.
- Meyers Patrick M.
- Mezzani F.
- Miao Haixing
- Michel Christophe
- Middleton Hannah
- Mikhailov Eugeniy E.
- Milano Leopoldo
- Miller Andrewlawrence
- Miller Andrewlawrence L.
- Miller Brandon B.
- Miller John
- Millhouse Meg
- Minazzoli Olivier
- Minenkov Yuri
- Ming Jing
- Mishra Chandra
- Mitra Sanjit
- Mitrofanov Valery P.
- Mitselmakher Guenakh
- Mittleman Richard
- Moggi A.
- Mohan Martin
- Mohapatra S.R.P.
- Montani Matteo
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- Moore Christopher J.
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- Moreno Gerardo
- Morriss Sean R.
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- Mow-Lowry C.M.
- Mueller Guido
- Muir Alistair W.
- Mukherjee Arunava
- Mukherjee Debnandini
- Mukherjee Soma
- Mukund Nikhil
- Mullavey Adam
- Munch Jesper
- Muniz Erik A.M.
- Murray Peter G.
- MĂĄrka Szabolcs
- MĂĄrka Zsuzsanna
- Napier Kate
- Nardecchia Ilaria
- Naticchioni Luca
- Nayak Rajesh K.
- Nelemans Gijs
- Nelson Timothy J.N.
- Neri Martina
- Nery Marina
- Neunzert Ansel
- Newport Jonathan M.
- Newton Gavin
- Ng K.K.Y.
- Nguyen Thanh T.
- Nichols David
- Nielsen Alex B.
- Nissanke Samaya
- Noack Andreas
- Nocera Flavio
- Nolting David
- Normandin Marc E.N.
- Nuttall Laura K.
- O'Reilly B.
- O'Shaughnessy R.
- Oberling Jason
- Ochsner Evan
- Oelker Eric
- Ogin Greg H.
- Oh John J.
- Oh Sanghoon H.
- Ohme Frank
- Oliver Miquel
- Oppermann Patrick
- Oram Richard J.
- Ormiston Rich
- Ortega Luis F.
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- Owen Ben J.
- Pace Alexander E.
- Page Jessica
- Page Michael A.
- Pai Archana
- Pai Siddhesh A.
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- Palamos Jordan R.
- Palashov Oleg
- Palomba Cristiano
- Pan H.
- Pang Belinda
- Pang P.T.H.
- Pankow Chris
- Pannarale Francesco
- Pant Brijesh C.
- Paoletti Federico
- PAOLI Andrea
- Papa Maria A.
- Paris Hugo R.
- Parker William
- Pascucci Daniela
- Pasqualetti Antonio
- Passaquieti Roberto
- Passuello Diego
- Patricelli Barbara
- Pearlstone Brynley L.
- Pedraza Mike
- Pedurand Richard
- Pekowsky Larne
- Pele Arnaud
- Penn Steven
- Perez Carlos J.
- Perreca Antonio
- Perri Leah M.
- Pfeiffer Harald P.
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- Piccinni Ornella J.
- Pichot Mikhael
- Piergiovanni Francesco
- Pierro Vincenzo
- Pillant Gabriel
- Pinard Laurent
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- Pitkin Matthew
- Poggiani Rosa
- Popolizio Pasquale
- Porter K.
- Post Alexander
- Powell Jade
- Prasad Jayanti
- Pratt James W.W.
- Predoi Valeriu
- Prestegard Tanner
- Prijatelj Mirko
- Principe Maria
- Privitera Stephen
- Prodi Giovanni A.
- Prokhorov Leonid G.
- Puncken Oliver
- Punturo Michele
- Puppo Paola
- PĂŒrrer Michael
- Qi Hong
- Qin Jiayi
- Qiu Shi
- Quetschke Volker
- Quintero Eric A.
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- Raab Fred J.
- Rabeling David S.
- Radkins Hugh
- Raffai Peter
- Raja Sendhil
- Rajan C.
- Rakhmanov Malik
- Ramirez Karla E.
- Rapagnani Piero
- Raymond Vivien
- Razzano Massimiliano
- Read Jocelyn
- Regimbau Tania
- Rei Luca
- Reid Stuart
- Reitze David H.
- Rew Hunter
- Reyes Steven D.
- Ricci Fulvio
- Ricker Paul M.
- Rieger Sascha
- Riles Keith
- Rizzo Monica
- Robertson Norna A.
- Robie Raymond
- Robinet Florent
- Rocchi Alessio
- ROLLAND Loic
- Rollins Jameson G.
- Roma Vincent J.
- Romano Rocco
- Romel Chandra L.
- Romie Janeen H.
- RosiĆska Dorota
- Ross Michael P.
- Rowan Sheila
- Ruggi Paolo
- Ryan Kyle
- Rynge Mats
- RĂŒdiger Albrecht
- Sachdev Surabhi
- Sadecki Travis
- Sadeghian Laleh
- Sakellariadou Mairi
- Salconi Livio
- Saleem Muhammed
- Salemi Francesco
- Samajdar Anuradha
- Sammut Letizia
- Sampson Laura M.
- Sanchez Eduardo J.
- Sandberg Vernon
- Sandeen Benjamin
- Sanders Jaclyn R.
- Sassolas Benoit
- Sathyaprakash B.S.
- Saulson Peter R.
- Sauter Orion
- Savage Richard L.
- Sawadsky Andreas
- Schale Paul
- Scheuer Jacob
- Schmidt Eric
- Schmidt Justus
- Schmidt Patricia
- Schnabel Roman
- Schofield Robert M.S.
- Schreiber Emil
- Schuette Dirk
- Schulte Bernd W.
- Schutz Bernard F.
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- Schönbeck Axel
- Scott Jamie
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- Seidel E.
- Sellers Danny
- Sengupta Anand S.
- Sentenac Daniel
- Sequino Valeria
- Sergeev Alexander
- Shaddock Daniel A.
- Shaffer Thomas J.
- Shah Ankur A.
- Shahriar M.S.
- Shao Lijing
- Shapiro Brett
- Shawhan Peter
- Sheperd Alec
- Shoemaker David H.
- Shoemaker Deirdre M.
- Siellez Karelle
- Siemens Xavier
- Sieniawska Magdalena
- Sigg Daniel
- Silva Allan D.
- Singer Abe
- Singer Leo P.
- Singh Avneet
- Singh Robinjeet
- Singhal Akshat
- Sintes Alicia M.
- Slagmolen Bram J.J.
- Smith Bryan
- Smith Joshua R.
- Smith Rory J.E.
- Son Edwin J.
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- Sorazu Borja
- Sorrentino Fiodor
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- Staley Alexan
- Steinke Michael
- Steinlechner Jessica
- Steinlechner Sebastian
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- Stratta Giulia
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- Summerscales Tiffany Z.
- Sun Ling
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- Swinkels Bas L.
- SzczepaĆczyk Marek J.
- Tacca Matteo
- Talukder Dipongkar
- Tanner David B.
- Taracchini Andrea
- Taylor Jordan A.
- Taylor Robert
- Theeg Thomas
- Thomas E.G.
- Thomas Michael
- Thomas Patrick
- Thorne Keith A.
- Thorne Kip S.
- Thrane Eric
- Tiwari Shubhanshu
- Tiwari Vaibhav
- Tokmakov Kirill V.
- Toland Karl
- Tonelli Mauro
- Tornasi Zeno
- Torrie Calum I.
- Travasso Flavio
- Traylor Gary
- TrifirĂČ Daniele
- Trinastic Jonathan
- Tringali Maria C.
- Trozzo Lucia
- Tsang K.W.
- Tse Maggie
- Tso Rhondale
- Tuyenbayev Darkhan
- TĂĄpai Marton
- TöyrÀ Daniel
- Ueno Koh
- Ugolini Dennis
- Unnikrishnan Cs S.
- Urban Alexander L.
- Usman Samantha A.
- Vahi Karan
- Vahlbruch Henning
- Vajente Gabriele
- Valdes Guillermo
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- van Beuzekom Martin
- Van Den Brand J.F.J.
- Van Den Broeck C.
- van der Schaaf L.
- van Heijningen J.V.
- van Veggel A.A.
- Vander-Hyde D.C.
- Vardaro Marco
- Varma Vijay
- Vass Steve
- VasĂșth Matyas
- Vecchio Alberto
- Vedovato Gabriele
- Veitch John
- Veitch Peter J.
- Venkateswara Krishna
- Venugopalan Gautam
- Verkindt Didier
- Vetrano Flavio
- Viceré Andrea
- Viets Aaron D.
- Vinciguerra Serena
- Vine David J.
- Vinet J.-Y.
- Vitale Salvatore
- Vo Thomas
- Vocca Helios
- Vorvick Cheryl
- Voss D.V.
- Vousden Will D.
- Vyatchanin Sergey P.
- Wade Andrew R.
- Wade Leslie E.
- Wade Madeline
- Walet R.
- Walker Marissa
- Wallace Larry
- Walsh Sinead
- Wang Gang
- Wang Haoyu
- Wang Jonathan Z.
- Wang Mengyao
- Wang Y.-F.
- Ward Robert L.
- Warner Jim
- Was Michal
- Watchi Jennifer
- Weaver Betsy
- Wei L.-W.
- Weinert Michael
- Weinstein Alan J.
- Weiss Rainer
- Wen Linqing
- Wessel Erik K.
- Westphal Tobias
- Wette Karl
- WeĂels Peter
- Whelan John T.
- Whiting Bernard F.
- Whittle Chris
- Williams Daniel
- Williams Roy D.
- Williamson Andrew R.
- Willis Joshua L.
- Willke Benno
- Wimmer Maximilian H.
- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wu Guimin
- Yam William
- Yamamoto Hiro
- Yancey Cregg C.
- Yap M.J.
- Yu Hang
- Yu Haocun
- Yvert Michel
- ZadroĆŒny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceDuring their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100ââMâ, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93ââGpcâ3âyrâ1 in comoving units at the 90%Â confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits
First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- Amato A.
- Ananyeva Alena
- Anderson D.P.
- Anderson Stuart B.
- Anderson Warren G.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Aufmuth Peter
- Aulbert Carsten
- Aultoneal K.
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
- Bartos Imre
- Bassiri Riccardo
- Basti Andrea
- Batch James C.
- Baune Christoph
- Bawaj M.
- Bazzan Marco
- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
- Bhandare Rohan
- Bilenko Igor A.
- Billingsley Garilynn
- Billman Chris R.
- Birch Jeremy
- Birney Ross
- Birnholtz Ofek
- Biscans Sebastien
- Bisht Aparna
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- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wu Guimin
- Yam William
- Yamamoto Hiro
- Yancey Cregg C.
- Yap M.J.
- Yu Hang
- Yu Haocun
- Yvert Michel
- ZadroĆŒny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceWe report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100Â Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7ââ[1/Hz]. At the frequency of best strain sensitivity, near 100Â Hz, we set 90% confidence upper limits of 1.8Ă10-25. At the low end of our frequency range, 20Â Hz, we achieve upper limits of 3.9Ă10-24. At 55Â Hz we can exclude sources with ellipticities greater than 10-5 within 100Â pc of Earth with fiducial value of the principal moment of inertia of 1038ââkgâm2
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Angelova Svetoslava V.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Arun Kg G.
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Atallah Dany V.
- Aufmuth Peter
- Aulbert Carsten
- Aultoneal K.
- Austin Corey
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barkett Kevin
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
- Bartos Imre
- Bassiri Riccardo
- Basti Andrea
- Batch James C.
- Bawaj Mateusz
- Bayley Joseph C.
- Bazzan Marco
- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Bero John J.
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
- Bhandare Rohan
- Bilenko Igor A.
- Billingsley Garilynn
- Billman Chris R.
- Birch Jeremy
- Birney Ross
- Birnholtz Ofek
- Biscans Sebastien
- Biscoveanu Sylvia
- Bisht Aparna
- Bitossi Massimiliano
- Biwer Christopher
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- Blackburn J.K.
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- Bork Rolf
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- Bose Sukanta
- Bossie Ken
- Bouffanais Yann
- Bozzi Antonella
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- Branchesi Marica
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- Brillet Alain
- Brinkmann Marc
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- Traylor Gary
- Trinastic Jonathan
- Tringali Maria C.
- Trozzo Lucia
- Tsang K.W.
- Tse Maggie
- Tso Rhondale
- Tsukada Leo
- Tsuna Daichi
- Tuyenbayev Darkhan
- TĂĄpai Marton
- TöyrÀ Daniel
- Ueno Koh
- Ugolini Dennis
- Unnikrishnan Cs S.
- Urban Alexander L.
- Usman Samantha A.
- Vahlbruch Henning
- Vajente Gabriele
- Valdes Guillermo
- van Bakel N.
- van Beuzekom Martin
- van den Brand J.F.J.
- van den Broeck C.
- van Der Schaaf L.
- van Heijningen J.V.
- van Veggel A.A.
- Vander-Hyde D.C.
- Vardaro Marco
- Varma Vijay
- Vass Steve
- VasĂșth Matyas
- Vecchio Alberto
- Vedovato Gabriele
- Veitch John
- Veitch Peter J.
- Venkateswara Krishna
- Venugopalan Gautam
- Verkindt Didier
- Vetrano Flavio
- Viceré Andrea
- Viets Aaron D.
- Vinciguerra Serena
- Vine David J.
- Vinet J.-Y.
- Vitale Salvatore
- Vo Thomas
- Vocca Helios
- Vorvick Cheryl
- Vyatchanin Sergey P.
- Wade Andrew R.
- Wade Leslie E.
- Wade Madeline
- Walet Rob
- Walker Marissa
- Wallace Larry
- Walsh Sinead
- Wang Gang
- Wang Haoyu
- Wang Jonathan Z.
- Wang Wenhui H.
- Wang Yifan F.
- Ward Robert L.
- Warner Jim
- Was Michal
- Watchi Jennifer
- Weaver Betsy
- Wei L.-W.
- Weinert Michael
- Weinstein Alan J.
- Weiss Rainer
- Wen Linqing
- Wessel Erik K.
- Wessels Peter
- Westerweck Julian
- Westphal Tobias
- Wette Karl
- Whelan John T.
- Whiting Bernard F.
- Whittle Chris
- Wilken D.
- Williams Daniel
- Williams Roy D.
- Williamson Andrew R.
- Willis Joshua L.
- Willke Benno
- Wimmer Maximilian H.
- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Sophia
- Yamamoto Hiro
- Yancey Cregg C.
- Yang Le
- Yap M.J.
- Yazback Maher
- Yu Hang
- Yu Haocun
- Yvert Michel
- ZadroĆŒny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceSpinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11Â pulsars using data from Advanced LIGOâs first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far