The contrast between north and south in England, 1918-1939 : a study of economic, social and political problems with particular reference to the experience of Burnley, Halifax, Ipswich and Luton

The thesis begins with a discussion of present views on the nature of the contrast between North and South in England. It proceeds to test those views against the experience of four English towns - Burnley, Halifax, Ipswich and-Luton - between 1918 and 1939. Chapter Two examines the causes and extent of economic growth in the four towns, and devotes special attention to employment and factory construction. A discussion of industrial change in the four towns as individual entities comprises a major section of this chapter. Chapter Three discusses incomes. An attempt is made to establish the proportion of the population in each of the towns living in poverty. Account is taken of the impact of rent and union activities on incomes. Chapters Four, Five and Six analyse social conditions in the four towns. Chapter Four looks at changes in population, the role played by migration, compares the health of the towns, and concludes with a discussion of the development of the public health services. Chapter Five takes for its subject the provision of housing and the demolition of slums, and incorporates a note on town planning. In Chapter Six, the educational services are compared and special attention is given to the impact the depression had on their development. Chapter Seven reviews the financing of local government and compares the contributions made by the rates and by Central Government grants. Year-to-year management of local authority finance is surveyed, and the varying roles played by the Chairmen of the Finance Committees are considered. Chapter Eight examines local government, and isolates for special consideration movements in party support; the contrasting fortunes of the parties, and especially the rise of Labour and the decline of the Liberals; changes in the social composition of councils; the role of clubs, societies and religious organisations; and the contribution these factors made to the quality of local government, and to the interest the public showed in municipal elections. Chapter Nine looks into the relationship between councils and the business organisations they controlled, with special reference to the transport systems, which underwent a crisis in this period. The chapter concludes with a discussion of the relations between chairmen and local government officials. Chapter Ten presents the main findings of the thesis, and sums up the factors responsible for these conclusions

Book Reviews

Reviews of the following books: Maine: A Bibliography of Its History by John D. Haskell, Jr.; Tombstones and Paving Blocks: The History of the Granite Industry in Maine by Roger E. Grindle; Josiah Volunteered: A Collection of Diaries, Letters and Photographs of Josiah H. Sturtevant, His Wife Helen and His Four Children edited by Arnold H. Sturtevan

ISR3: Communication and Data Storage for an Unmanned Ground Vehicle*

Computer vision researchers working in mobile robotics and other real-time domains are forced to con- front issues not normally addressed in the computer vision literature. Among these are communication, or how to get data from one process to another, data storage and retrieval, primarily for transient, image- based data, and database management, for maps, ob- ject models and other permanent (typically 3D) data. This paper reviews eorts at CMU, SRI and UMass to build real-time computer vision systems for mobile robotics, and presents a new tool, called ISR3, for com- munication, data storage/retrieval and database man- agement on the UMass Mobile Perception Laboratory (MPL), a NAVLAB-like autonomous vehicle

Integration for navigation on the UMASS mobile perception lab

Integration of real-time visual procedures for use on the Mobile Perception Lab (MPL) was presented. The MPL is an autonomous vehicle designed for testing visually guided behavior. Two critical areas of focus in the system design were data storage/exchange and process control. The Intermediate Symbolic Representation (ISR3) supported data storage and exchange, and the MPL script monitor provided process control. Resource allocation, inter-process communication, and real-time control are difficult problems which must be solved in order to construct strong autonomous systems

Developing a food exposure and urine sampling strategy for dietary exposure biomarker validation in free-living individuals

SCOPE: Dietary choices modulate the risk of chronic diseases and improving diet is a central component of public health strategies. Food-derived metabolites present in urine could provide objective biomarkers of dietary exposure. To assist biomarker validation we aimed to develop a food intervention strategy mimicking a typical annual diet over a short period of time and assessed urine sampling protocols potentially suitable for future deployment of biomarker technology in free-living populations. METHODS AND RESULTS: Six different menu plans representing comprehensively a typical UK annual diet that were split into two dietary experimental periods. Free-living adult participants (n = 15 and n = 36, respectively) were provided with all their food, as a series of menu plans, over a period of 3 consecutive days. Multiple spot urine samples were collected and stored at home. CONCLUSION: We established a successful food exposure strategy following a conventional UK eating pattern, which was suitable for biomarker validation in free-living individuals. The urine sampling procedure was acceptable for volunteers and delivered samples suitable for biomarker quantification. Our study design provides scope for validation of existing biomarker candidates and potentially for discovery of new biomarker-leads and should help inform the future deployment of biomarker technology for habitual dietary exposure measurement

Spot and Cumulative Urine Samples Are Suitable Replacements for 24-Hour Urine Collections for Objective Measures of Dietary Exposure in Adults Using Metabolite Biomarkers

BACKGROUND: Measurement of multiple food intake exposure biomarkers in urine may offer an objective method for monitoring diet. The potential of spot and cumulative urine samples that have reduced burden on participants as replacements for 24-h urine collections has not been evaluated. OBJECTIVE: The aim of this study was to determine the utility of spot and cumulative urine samples for classifying the metabolic profiles of people according to dietary intake when compared with 24-h urine collections in a controlled dietary intervention study. METHODS: Nineteen healthy individuals (10 male, 9 female, aged 21-65 y, BMI 20-35 kg/m2) each consumed 4 distinctly different diets, each for 1 wk. Spot urine samples were collected ∼2 h post meals on 3 intervention days/wk. Cumulative urine samples were collected daily over 3 separate temporal periods. A 24-h urine collection was created by combining the 3 cumulative urine samples. Urine samples were analyzed with metabolite fingerprinting by both high-resolution flow infusion electrospray mass spectrometry (FIE-HRMS) and proton nuclear magnetic resonance spectroscopy (1H-NMR). Concentrations of dietary intake biomarkers were measured with liquid chromatography triple quadrupole mass spectrometry and by integration of 1H-NMR data. RESULTS: Cross-validation modeling with 1H-NMR and FIE-HRMS data demonstrated the power of spot and cumulative urine samples in predicting dietary patterns in 24-h urine collections. Particularly, there was no significant loss of information when post-dinner (PD) spot or overnight cumulative samples were substituted for 24-h urine collections (classification accuracies of 0.891 and 0.938, respectively). Quantitative analysis of urine samples also demonstrated the relation between PD spot samples and 24-h urines for dietary exposure biomarkers. CONCLUSIONS: We conclude that PD spot urine samples are suitable replacements for 24-h urine collections. Alternatively, cumulative samples collected overnight predict similarly to 24-h urine samples and have a lower collection burden for participants

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

Self-sorting in low molecular weight hydrogels can be achieved using a pH triggered approach. We show here that this method can be used to prepare gels with different types of mechanical properties. Cooperative, disruptive or orthogonal assembled systems can be produced. Gels with interesting behaviour can be also prepared, for example self-sorted gels where delayed switch-on of gelation occurs. By careful choice of gelator, co-assembled structures can also be generated, which leads to synergistic strengthening of the mechanical properties

An Analytical Pipeline for Quantitative Characterization of Dietary Intake:Application To Assess Grape Intake

Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r² = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes