Optimized pulse source employing an externally injected gain-switched laser diode in conjunction with a nonlinearly chirped grating

In this paper, we demonstrate the generation of transform-limited short optical pulses, which display excellent spectral and temporal qualities by employing a novel technology, based on an externally injected gain-switched laser in conjunction with a nonlinearly chirped grating. Using this technique, 3.5-ps optical pulses exhibiting a time-bandwidth product (TBP) of 0.45 are generated, which are suitable for use in high-speed 80 Gb/s optical time-division multiplexing (OTDM) communications systems. The numerical integration of a set of rate equations using suitable parameters for the devices used in the experiments were carried out to further confirm the feasibility of the proposed method for developing an optimized pulse source for high-speed photonic systems

Pulse source for 80 Gb/s systems using a gain-wwitched laser diode followed by a nonlinearly chirped grating

This work presents the generation of 3.5 ps pulses at a repetition rate of 10 GHz and the optimization of the pulse spectrum. The output pulses are near transform limited and have pulse pedestals that are virtually eliminated to 35 dB down from the peak of the pulse, thus providing a source suitable for use in 80 Gb/s OTDM systems

Optimized pulse source based on a gain-switched laser diode in conjuction with a non-linearly chirped grating for 40 Gbit/s systems

A technique based on the design of an optimized source of pico-second optical pulses, which exhibits excellent temporal and spectral purity, is presented. The procedure entails an initial complete intensity and chirp characterization of pulses, from an externally injected-gain switched laser (EI-GSL), using the technique of frequency resolved optical gating (FROG). This characterization yields the parameters that are required for the design of a non-linearly chirped fibre Bragg grating (NC FBG) with a chirp profile that is opposite to that measured across the pulse. By employing the tailor made NC FBG after the gain-switched laser, direct compression of the gain-switched pulses is achieved, to obtain pedestal-free, near transform-limited, 7 ps pulses. The system viability, characterized by simulations, portrays a 6 dB difference in performance between a pulse source with insufficient TPSR and one that exhibits adequate TPSR &(ge; 30 dB)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

OBJECTIVE—We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the MIMETIBODY platform have improved biochemical and biophysical properties that are quite distinct from those of Fc-fusion proteins. CNTO736 is a glucagon-like peptide 1 (GLP-1) receptor agonist engineered in our MIMETIBODY platform. It retains many activities of native GLP-1 yet has a significantly enhanced pharmacokinetic profile. Our goal was to develop a long-acting GLP-1 receptor agonist with sustained efficacy