Desempenho de cultivares de maracujá (Passiflora edulis f.flavicarpa) no sistema de produção orgânico

O presente trabalho teve como objetivo avaliar o cultivo de primeiro ano de maracujá azedo no sistema orgânico, analisando a produtividade e a produção mensal, a fim de comparar cultivares promissoras para a região da Grande Dourados. O experimento foi instalado na área experimental da UEMS em Glória de Dourados-MS, situada a 22°24’ de latitude Sul e a 54°14’ de Longitude Oeste, numa altitude de 400 m. O espaçamento utilizado foi de 5 m entre plantas e 2,5 m entre linhas, no sistema de condução em espadeira, com um fio de arame a 1,8 m de altura. Durante o ciclo produtivo, foram realizados cultivos nas entrelinhas com as culturas do milho e feijão. Foram utilizadas pulverizações foliares do biofertilizante Agrobio a 10%, de óleo de neem a 0,3%, de calda de pimenta a 3% e de calda bordalesa a 2%. As adubações de cobertura foram realizadas com dejeto líquido de suínos na dose de dois litros por planta. O experimento foi conduzido no delineamento em blocos casualizados no esquema de parcelas subdivididas, com cinco tratamentos e três repetições. Os tratamentos consistiram das cultivares BRS Gigante Amarelo, BRS Sol do Cerrado, BRS Rubi do Cerrado, FB 300 e FB 200. As colheitas se iniciaram no décimo mês após o transplante das mudas. Foi observada diferenças entre as épocas de colheita para massa fresca de frutos e produtividade, no entanto, não houve diferença quanto à produtividade entre as cultivares analisadas, considerando a produção no período de seis meses.This study aimed to evaluate the first year of cultivation of passion fruit under organic system, analyzing productivity and the monthly production, in order to compare promising cultivars for the region of Grande Dourados. The experiment was installed in the UEMS experimental area in Glória de Dourados-MS, located at 22 ° 24 'South latitude and 54 ° 14' West Longitude, elevation of 400 m. The spacing was 5 m between plants and 2.5 m between lines, trained in spalier system with a wire to 1.8 m tall. During the production cycle, cultivation was carried out between the lines with crops of corn and beans. Foliar sprays of Agrobio biofertilizer were used at 10%, also neem oil at 0.3%, pepper sauce at 3% and bordeaux mixture at 2%. Fertilization coverages were made with pig slurry at the rate of two liters per plant. The experiment was conducted in a randomized block design in a split plot, with five treatments and three replications. Treatments consisted of BRS Yellow Giant, BRS Sun Cerrado, BRS Rubi Cerrado, FB 300 and FB 200. The crops began in the tenth month after transplanting. It was observed differences between the harvest seasons for fresh fruit weight and productivity, however, there was no difference in productivity between the cultivars analyzed, considering the production within six months.Facultad de Ciencias Agrarias y Forestale

Desempenho de cultivares de maracujá (Passiflora edulis f.flavicarpa) no sistema de produção orgânico

O presente trabalho teve como objetivo avaliar o cultivo de primeiro ano de maracujá azedo no sistema orgânico, analisando a produtividade e a produção mensal, a fim de comparar cultivares promissoras para a região da Grande Dourados. O experimento foi instalado na área experimental da UEMS em Glória de Dourados-MS, situada a 22°24’ de latitude Sul e a 54°14’ de Longitude Oeste, numa altitude de 400 m. O espaçamento utilizado foi de 5 m entre plantas e 2,5 m entre linhas, no sistema de condução em espadeira, com um fio de arame a 1,8 m de altura. Durante o ciclo produtivo, foram realizados cultivos nas entrelinhas com as culturas do milho e feijão. Foram utilizadas pulverizações foliares do biofertilizante Agrobio a 10%, de óleo de neem a 0,3%, de calda de pimenta a 3% e de calda bordalesa a 2%. As adubações de cobertura foram realizadas com dejeto líquido de suínos na dose de dois litros por planta. O experimento foi conduzido no delineamento em blocos casualizados no esquema de parcelas subdivididas, com cinco tratamentos e três repetições. Os tratamentos consistiram das cultivares BRS Gigante Amarelo, BRS Sol do Cerrado, BRS Rubi do Cerrado, FB 300 e FB 200. As colheitas se iniciaram no décimo mês após o transplante das mudas. Foi observada diferenças entre as épocas de colheita para massa fresca de frutos e produtividade, no entanto, não houve diferença quanto à produtividade entre as cultivares analisadas, considerando a produção no período de seis meses.This study aimed to evaluate the first year of cultivation of passion fruit under organic system, analyzing productivity and the monthly production, in order to compare promising cultivars for the region of Grande Dourados. The experiment was installed in the UEMS experimental area in Glória de Dourados-MS, located at 22 ° 24 'South latitude and 54 ° 14' West Longitude, elevation of 400 m. The spacing was 5 m between plants and 2.5 m between lines, trained in spalier system with a wire to 1.8 m tall. During the production cycle, cultivation was carried out between the lines with crops of corn and beans. Foliar sprays of Agrobio biofertilizer were used at 10%, also neem oil at 0.3%, pepper sauce at 3% and bordeaux mixture at 2%. Fertilization coverages were made with pig slurry at the rate of two liters per plant. The experiment was conducted in a randomized block design in a split plot, with five treatments and three replications. Treatments consisted of BRS Yellow Giant, BRS Sun Cerrado, BRS Rubi Cerrado, FB 300 and FB 200. The crops began in the tenth month after transplanting. It was observed differences between the harvest seasons for fresh fruit weight and productivity, however, there was no difference in productivity between the cultivars analyzed, considering the production within six months.Facultad de Ciencias Agrarias y Forestale

Desempenho de cultivares de maracujá (Passiflora edulis f.flavicarpa) no sistema de produção orgânico

O presente trabalho teve como objetivo avaliar o cultivo de primeiro ano de maracujá azedo no sistema orgânico, analisando a produtividade e a produção mensal, a fim de comparar cultivares promissoras para a região da Grande Dourados. O experimento foi instalado na área experimental da UEMS em Glória de Dourados-MS, situada a 22°24’ de latitude Sul e a 54°14’ de Longitude Oeste, numa altitude de 400 m. O espaçamento utilizado foi de 5 m entre plantas e 2,5 m entre linhas, no sistema de condução em espadeira, com um fio de arame a 1,8 m de altura. Durante o ciclo produtivo, foram realizados cultivos nas entrelinhas com as culturas do milho e feijão. Foram utilizadas pulverizações foliares do biofertilizante Agrobio a 10%, de óleo de neem a 0,3%, de calda de pimenta a 3% e de calda bordalesa a 2%. As adubações de cobertura foram realizadas com dejeto líquido de suínos na dose de dois litros por planta. O experimento foi conduzido no delineamento em blocos casualizados no esquema de parcelas subdivididas, com cinco tratamentos e três repetições. Os tratamentos consistiram das cultivares BRS Gigante Amarelo, BRS Sol do Cerrado, BRS Rubi do Cerrado, FB 300 e FB 200. As colheitas se iniciaram no décimo mês após o transplante das mudas. Foi observada diferenças entre as épocas de colheita para massa fresca de frutos e produtividade, no entanto, não houve diferença quanto à produtividade entre as cultivares analisadas, considerando a produção no período de seis meses.This study aimed to evaluate the first year of cultivation of passion fruit under organic system, analyzing productivity and the monthly production, in order to compare promising cultivars for the region of Grande Dourados. The experiment was installed in the UEMS experimental area in Glória de Dourados-MS, located at 22 ° 24 'South latitude and 54 ° 14' West Longitude, elevation of 400 m. The spacing was 5 m between plants and 2.5 m between lines, trained in spalier system with a wire to 1.8 m tall. During the production cycle, cultivation was carried out between the lines with crops of corn and beans. Foliar sprays of Agrobio biofertilizer were used at 10%, also neem oil at 0.3%, pepper sauce at 3% and bordeaux mixture at 2%. Fertilization coverages were made with pig slurry at the rate of two liters per plant. The experiment was conducted in a randomized block design in a split plot, with five treatments and three replications. Treatments consisted of BRS Yellow Giant, BRS Sun Cerrado, BRS Rubi Cerrado, FB 300 and FB 200. The crops began in the tenth month after transplanting. It was observed differences between the harvest seasons for fresh fruit weight and productivity, however, there was no difference in productivity between the cultivars analyzed, considering the production within six months.Facultad de Ciencias Agrarias y Forestale

Use of 2,4-D as a burndown treatment for soybeans in no-till cropping systems in the Cerrados region

O experimento foi conduzido em solo originalmente sob vegetação de Cerrado com textura leve. Utilizou-se para dessecação da cobertura vegetal, composta de plantas daninhas com predominância de Commelina benghalensis, o herbicida 2,4-D amina nas doses de 72, 144,216,288,432,576 e 720 g/ha, aplicadas em uma única vez. A semeadura da soja foi feita com um, dois, três, quatro, cinco, oito e dez dias após a dessecação. Os tratamentos foram constituídos pelas épocas de semeadura da soja após a aplicação do herbicida, combinadas com as doses do 2,4-D, no delineamento em blocos casualizados com três repetições. Avaliou-se a densidade e o crescimento das plantas de soja, através da medição da altura das plantas aos 45 dias após a semeadura e na pré-colheita, altura da inserção da primeira vagem, peso de grãos por planta e produtividade: Os resultados demonstraram que todas as variáveis analisadas foram influenciadas pelo herbicida quando aplicado de um até cinco dias antes da semeadura da soja. A produtividade, embora não tenha sido influenciada significativamente pelas épocas de semeadura, foi sensivelmente reduzida com o aumento das doses do herbicida. Mesmo em baixa concentração, o 2,4-D afetou o crescimento da soja nas seis épocas de semeadura após a aplicação. Desse modo, o uso do 2,4-D poderá ser recomendado para solos leves de Cerrados, nas aplicações de dessecação, até a dose de 720 g/ha, desde que aplicado com um intervalo mínimo de 8 dias antes da semeadura direta da soja.  A field experiment was carried out in the Cerrados region in Rondonõpolis, MT, Brazil, in order to evaluate the behavior of2,4-D amine, applied alone and as a pre-site preparation at 72, 144,216,288,432,576 and 720 grams per hectare, to control the weed spectrum in no-till soybean. Commelina benghalensis was the predominant weed species. Soybean was seeded at 1,2,3, 4,5,8 and 10 days after burndown treatment and the planting timing was crossed with 2,4-D rates, applied in a randomized block design in three replications. The crop response as measured by stand and plant height was evaluated at 45 days after spraying and as a pre-harvest evaluation at the first pod insertion. The number of pods per plant, dry weight and productivity were assessed. The results sbowed that ali the variables analyzed were affected by the herbicide when soybean was planted up to 5 days after spray treatment. Considering only the planting time, the productivity was not statisticaIly different, however it was significantly reduced when the rates of2,4-D were increased. Even at the lower rate, a plant growth reduction was observed. As conclusion, 2,4-D amine can be recommended as a burndown treatment for Cerrados sandy soil, up to 720 g/ha, since soybeans are planted at least 8 days after the herbicide application

Clinical study of a multivitamin and polymineral complex associated with Panax ginseng extract (Natus Gerin®)

This study aimed to stablish the efficacy of a multivitamin and polyminerals supplemented with Panax ginseng extract (Natus Gerin®) on patients subjected to common physical or mental stress. Patients were randomly divided in two groups and underwent a thorough clinical examination. Group A received Natus Gerin® capsules and B placebo capsules. Two capsules were taken daily during meals during four weeks. Mood and physical activity were evaluated through a questionnaire assessing quality of life. From the 176 patients enrolled, 17 were excluded due to voluntary withdrawal, 81 completed the study in group A and 78 in group B. The treatment with Natus Gerin® increased the quality of life when compared to placebo. After 15 and 30 days, group A showed a significant increase in average scoring score from 1.78 to 3.78, and finally 5.32 points. The study has shown that the daily use of Natus Gerin® can be effective in improving quality of life in patients suffering from physical and mental stressColegio de Farmacéuticos de la Provincia de Buenos Aire

Antiplasmodial Properties and Cytotoxicity of Endophytic Fungi from Symphonia globulifera (Clusiaceae)

Ateba JET, Toghueo RMK, Awantu AF, et al. Antiplasmodial Properties and Cytotoxicity of Endophytic Fungi from Symphonia globulifera (Clusiaceae). JOURNAL OF FUNGI. 2018;4(2): UNSP 70.There is continuing need for new and improved drugs to tackle malaria, which remains a major public health problem, especially in tropical and subtropical regions of the world. Natural products represent credible sources of new antiplasmodial agents for antimalarial drug development. Endophytes that widely colonize healthy tissues of plants have been shown to synthesize a great variety of secondary metabolites that might possess antiplasmodial benefits. The present study was carried out to evaluate the antiplasmodial potential of extracts from endophytic fungi isolated from Symphonia globulifera against a chloroquine-resistant strain of Plasmodium falciparum (PfINDO). Sixty-one fungal isolates with infection frequency of 67.77% were obtained from the bark of S. globulifera. Twelve selected isolates were classified into six different genera including Fusarium, Paecilomyces, Penicillium, Aspergillus, Mucor, and Bipolaris. Extracts from the 12 isolates were tested against PfINDO, and nine showed good activity (IC50 < 10 mu g.mL(-1)) with three fungi including Paecilomyces lilacinus (IC50 = 0.44 mu g.mL(-1)), Penicillium janthinellum (IC50 = 0.2 mu g.mL(-1)), and Paecilomyces sp. (IC50 = 0.55 mu g.mL(-1)) showing the highest promise. These three isolates were found to be less cytotoxic against the HEK293T cell line with selectivity indices ranging from 24.52 to 70.56. Results from this study indicate that endophytic fungi from Symphonia globulifera are promising sources of hit compounds that might be further investigated as novel drugs against malaria. The chemical investigation of active extracts is ongoing

Clinical study of a multivitamin and polymineral complex associated with Panax ginseng extract (Natus Gerin®)

This study aimed to stablish the efficacy of a multivitamin and polyminerals supplemented with Panax ginseng extract (Natus Gerin®) on patients subjected to common physical or mental stress. Patients were randomly divided in two groups and underwent a thorough clinical examination. Group A received Natus Gerin® capsules and B placebo capsules. Two capsules were taken daily during meals during four weeks. Mood and physical activity were evaluated through a questionnaire assessing quality of life. From the 176 patients enrolled, 17 were excluded due to voluntary withdrawal, 81 completed the study in group A and 78 in group B. The treatment with Natus Gerin® increased the quality of life when compared to placebo. After 15 and 30 days, group A showed a significant increase in average scoring score from 1.78 to 3.78, and finally 5.32 points. The study has shown that the daily use of Natus Gerin® can be effective in improving quality of life in patients suffering from physical and mental stressColegio de Farmacéuticos de la Provincia de Buenos Aire

Phase II clinical study of an association for the treatment of interstitial cystitis (Cystex?).

Painful bladder syndrome associated with interstitial cystitis (PBS/IC) is a clinical condition characterized pelvic pain, urinary urgency, and urinary frequency. In this study, 22 patients were assigned to make two visits over a three weeks period. The patients were randomly, double-blinded assigned in two groups. The first group received Cystex? capsules. The second group received placebo capsules. Two capsules were taken three times a day away from meals. The change from baseline in the O?Leary-Sant IC symptom and problem index was the primary outcome parameter. Changes in functional bladder capacity and intensity of pain and urgency have been chosen as secondary outcome parameters. Mood as well as physical and sexual activity were rated by 10 questions on a scale 0 to 6. The ratings were analyzed and the average for each patient in both groups Cystex? and placebo was determined as the quality of life index. For the primary outcome there was a statistically significant difference between the groups. Mean symptom score-sum decreased from 28.4 to 20.5 in the Cystex? group compared with 29.5 to 26.8 in the placebo group (p<0.05). For the secondary end points, pain and urgency intensity improved statistically significantly in the Cystex? group compared with the placebo group (p<0.05). The frequency and functional bladder capacity improved to greater degree in the Cystex? group. The differences were statistically significant for comparison of frequency (p<0.05) and not for functional bladder capacity (p>0.05). In our study, Cystex? enhanced quality of life over the placebo showing a statistically significant. This trial have shown that the efficacy and safety of therapy with Cystex? in the treatment of interstitial cystitis and is an alternative for patients suffering from this pathology. Therefore, it can be concluded that the composition of Cystex?, increased the quality of life in treated patients

Effect of simvastatin in the autonomic system is dependent on the increased gain/sensitivity of the baroreceptors

A number of mechanisms have been proposed to explain the pleiotropic effect of statin therapy to reduce sympathetic outflow in cardiovascular disease. We tested the hypothesis that statin treatment could improve baroreflex gain-sensitivity triggered by morphological adaptations in the mechanoreceptor site, thus reducing sympathetic activity, regardless of arterial pressure (AP) level reduction. Male spontaneously hypertensive rats (SHR) were divided into control (SHR, n = 8) and SHR-simvastatin (5 mg/kg/day, for 7 days) (SHR-S, n = 8). After treatment, AP, baroreflex sensitivity (BRS) in response to AP-induced changes, aortic depressor nerve activity, and spectral analyses of pulse interval (PI) and AP variabilities were performed. Internal and external carotids were prepared for morphoquantitative evaluation. Although AP was similar between groups, sympathetic modulation, represented by the low frequency band of PI (SHR: 6.84 ± 3.19 vs. SHR-S: 2.41 ± 0.96 msec2) and from systolic AP variability (SHR: 3.95 ± 0.36 vs. SHR-S: 2.86 ± 0.18 mmHg2), were reduced in treated animals. In parallel, simvastatin induced an increase of 26% and 21% in the number of elastic lamellae as well as a decrease of 9% and 25% in the carotid thickness in both, external and internal carotid, respectively. Moreover, improved baroreceptor function (SHR: 0.78 ± 0.03 vs. SHR-S: 1.06 ± 0.04% mv/mmHg) was observed in addition to a 115% increase in aortic depressor nerve activity in SHR-S rats. Therefore, our data suggest that the reduction of sympathetic outflow in hypertension by simvastatin treatment may be triggered by structural changes in the carotid arteries and increased BRS in response to an improvement of the baroreceptors discharge and consequently of the afferent pathway of the baroreflex arch.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP- 01/00,009-0; 2012/20,141-5)Fundação E.J. ZerbiniConselho Nacional de Pesquisa e Desenvolvimento (CNPq