969 research outputs found
Comparative study of comfort indicators for school constructions in sustainability methodologies: schools in the amazon and the southeast region of Brazil
In the 1970s and 1980s, the effects of pollution in the atmosphere grew from a local to a global scale, affecting the entire planet. Consequently, economic and social issues began to be increasingly more connected with environmental protection. Several measures were taken towards environmental preservation, many of those related to the sustainable construction of buildings. This work intended to make a parallel between comfort indicators among different schools in Brazil, beginning with the specific analyses of schools in Juiz de Fora (Minas Gerais, MG), in the Southeast region, and in Macapá (Amapa, AP), in the Amazon or Northern region. This comparison between schools is made to demonstrate the need to adapt methodologies and certifications that promote sustainability in school buildings for each region of Brazil. Questionnaires about ergonomic, thermal, visual and acoustic comfort, and air quality, were applied in two high-school buildings in Juiz de Fora, Academia School and Santa Catarina School, and in two high schools in Macapá, Tiradentes School and Professor Gabriel Almeida Café school, to understand the difference between these two regions of Brazil regarding comfort conditions. A comparison between the results of the four schools was made, proving the necessity of the elaboration of a specific methodology for each Brazilian region.The authors wish to thank Parque Escolar Company (EPE) for providing all material necessaryfor the execution of the article; and Abílio Ferreira, the managing director of Francisco de Holanda SecondarySchool, for showing the school and providing necessary information
Reconsolidation effect on impact, compression after impact and thermal properties of poly (aryl ether ketone) composites for aeronautical applications
Bulbos úmidos a partir da irrigação por gotejamento subsuperficial com água de abastecimento e efluente de esgoto tratado
The use of treated sewage effluent (TSE) combined with the subsurface drip irrigation (SDI) method in agriculture can decrease the costs of agricultural production, in attempts to fertigate crops more efficiently. In this study it was compared the dimensions of the wet bulb formed by the application of TSE and municipal water supply (MWS) in an Oxisoil. We have evaluated the effect of water quality and discharge between drippers used in sugarcane crop. Three trenches were opened and 21 three-rod TDR probes were setup in a mesh and a dripper was buried at 0.30 m, for each constant discharge of 1.0 L h-1and 1.6 L h-1. Comparing results from different wetted soil profiles it was observed that the vertical and horizontal dimensions of the wet bulb are similar for both MWS and TSE, being peculiars according to the discharges used and volume applied. Regardless the water quality, an increase of 60% in discharge decreased the deepest infiltration.352242253O uso de efluente de esgoto tratado (EET), combinado com o método de irrigação por gotejamento subsuperfical (IGS) na agricultura, pode reduzir os custos de produção agrícola, fertirrigando de maneira eficiente as culturas. Neste artigo, compararam-se as dimensões do bulbo úmido formado pela aplicação de EET e água de abastecimento municipal (AAM), em um Latossolo Vermelho distroférrico. Avaliou-se o efeito da qualidade da água e da vazão entre gotejadores utilizados na cultura da cana-de-açúcar. Três trincheiras foram abertas e 21 sondas de TDR com três hastes foram instaladas em malha, e um gotejador foi enterrado a 0,30 m, para cada vazão constante de 1,0 Lh-1 e 1,6 Lh-1. Comparando os resultados de diferentes perfis de umidade do solo, sugere-se que as dimensões vertical e horizontal do bulbo úmido sejam similares para a AAM e para o EET, sendo peculiares de acordo com as vazões utilizadas e o volume aplicado. Independentemente da qualidade da água, o aumento de 60% na vazão reduziu a infiltração em profundidade
Distribuição do sistema radicular da cana-de-açúcar irrigada com efluente de esgoto doméstico por gotejamento subsuperficial
Irrigation with domestic sewage effluent (DSE) has been recommended by subsurface dripping, as it can obtain a high rate of irrigation efficiency and faster use of salts in comparison with other irrigation methods. The study aimed at evaluating the area, the length and the effective depth of the root system of sugarcane irrigated with DSE by subsurface drip system and with different irrigation rates at depths of 0.00-0.20, 0.20-0.40, 0.40-0.60 and 0.60-0.80m. The experiment was carried out in the municipality of Piracicaba, in the state of São Paulo (SP), Brazil, in a sugarcane area irrigated with DSE in a completely randomized blocks set up in furrows, with three replications and four treatments, which are: one area without irrigation (AWI) and three irrigated areas meeting 50% (T50%), 100% (T100%) and 200% (T200%) of the crop's water need between each round of irrigation. T100% and T200% provided smaller areas and lengths of roots in the two deepest layers, as compared to AWI and T50%, which stimulated the development of deeper roots due to the water stress. TWI, T100% and T200% presented 80% of the roots up to a depth of 0.40m and T50% treatment presented 76.43% of roots total.A irrigação com efluente de esgoto doméstico (EED) tem sido recomendada para aplicação por gotejamento subsuperficial, podendo-se obter elevados índices de eficiência de irrigação e mais rápido aproveitamento dos sais em comparação com outros métodos de irrigação. O trabalho objetivou avaliar a área de raiz, o comprimento e a profundidade efetiva do sistema radicular da cana-de-açúcar irrigada com EED aplicado por gotejamento subsuperficial e com diferentes lâminas de irrigação, nas camadas de solo de 0,00-0,20; 0,20-0,40; 0,40-0,60 e 0,60-0,80 m. O experimento foi realizado em Piracicaba-SP, numa área de cana-de-açúcar irrigada com EED, em um delineamento de blocos casualizados dispostos no esquema de faixas, com três repetições e quatro tratamentos, sendo estes: uma área sem irrigação (TSI) e três áreas irrigadas, atendendo a 50% (T50%), 100% (T100%) e 200% (T200%) da necessidade hídrica da cultura entre cada turno de rega. O T100% e o T200% proporcionaram menores áreas e comprimento de raízes nas duas camadas mais profundas, quando comparados ao TSI e ao T50%, que devido ao estresse hídrico, proporcionado à cultura, estimularam o desenvolvimento de raízes mais profundas. O TSI, T100% e T200% apresentaram 80% das raízes até 0,40 m e, nessa mesma profundidade, o tratamento T50% apresentou 76,43% do total de raízes.64765
Impactos da pandemia Covid-19 em empresas de grande porte: avaliação das mudanças na infraestrutura de tecnologia para o teletrabalho sob as óticas das teorias das capacidades dinâmicas e estrutura adaptativa
With the emergence of the new Covid-19 disease in Brazil in the beginning of 2020, many companies had to reduce their activities or even paralyze them completely, another part of these companies had an additional demand compared to the daily history of operation. The objective of this article is to understand and analyze the main difficulties in the IT field of three large companies to adapt their ICT infrastructure to the new scenario under the theoretical lenses of the Theory of Dynamic Capacities and Theory of Adaptive Structuring. The methodology of this research project proposes the study of multiple cases with a longitudinal perspective and the Dynamic Capabilities Research Model and the Technology Appropriation Model with an exploratory approach, through a case study. As a result, the two models prove that companies A, B and C were able to meet the new demands, adapting their ICT infrastructures to the new scenario caused by the Covid-19 pandemic, forcing employees to adopt the new form of work.Con el surgimiento de la nueva enfermedad Covid-19 en Brasil a principios de 2020, muchas empresas tuvieron que reducir sus actividades o incluso paralizarlas totalmente, otra parte de estas empresas tuvieron una demanda adicional en comparación con el cotidiano histórico de operación. El objetivo de este artículo es comprender y analizar las principales dificultades, en el ámbito de TI de tres grandes empresas para adecuar su infraestructura de TIC al nuevo escenario bajo las lentes teóricas de la Teoría de las Capacidades Dinámicas y Teoría de la Estructuración Adaptativa. La metodología de este proyecto de investigación propone el estudio de casos múltiples con perspectiva longitudinal y los frameworks Modelo de Investigación de Capacidades Dinámicas y el Modelo de Apropiación de Tecnología con abordaje de naturaleza exploratoria, por medio de estudio de caso. Como resultado, los dos modelos demuestran que las empresas A, B y C fueron capaces de soportar las nuevas demandas, adaptando sus infraestructuras de Tics al nuevo escenario causado por la pandemia de Covid-19, obligando a los empleados a adoptar la nueva forma de trabajo.Com o surgimento da nova doença Covid-19 no Brasil no início de 2020, muitas empresas tiveram que que reduzir suas atividades ou até mesmo paralisá-las totalmente, outra parte dessas empresas tiveram uma demanda adicional se comparado com o cotidiano histórico de operação. O objetivo deste artigo é compreender e analisar as principais dificuldades, no âmbito de TI de três empresas de grande porte para adequar sua infraestrutura de TIC ao novo cenário sob as lentes teóricas da Teoria das Capacidades Dinâmicas e Teoria da Estruturação Adaptativa. A metodologia deste projeto de pesquisa propõe o estudo de casos múltiplos com perspectiva longitudinal e os frameworks Modelo de Pesquisa de Capacidades Dinâmicas e o Modelo de Apropriação de Tecnologia com abordagem de natureza exploratória, por meio de estudo de caso. Como resultados, os dois modelos comprovam que as empresas A, B e C tiveram condições de suportar as novas demandas, adaptando as suas infraestruturas de TICs para o novo cenário causado pela pandemia do Covid-19, forçando os colaboradores a adotarem a nova forma de trabalho
Avaliação eletrocardiográfica em cães submetidos à pneumonectomia direita
O propósito das ressecções pulmonares em cães e gatos, quer sejam por lobectomia ou pneumonectomia, é a cura ou paliação de processos broncopulmonares sempre que os meios conservadores de tratamento clínico sejam considerados ineficientes. Tendo em vista as significativas alterações resultantes da pneumonectomia, novos estudos experimentais devem ser feitos para avaliar as vantagens dessa intervenção cirúrgica e determinar a maneira como aplicá-la com segurança. O presente estudo tem como objetivo avaliar as alterações eletrocardiográficas em dez cães adultos de ambos os sexos, sem raça definida, com 10-30 kg, submetidos à pneumonectomia direita. Foram avaliados diariamente os parâmetros clínicos de cada cão e as alterações em todas as derivações do eletrocardiograma. Todos os cães apresentaram um bom desenlace pós-operatório. Apenas um cão apresentou alteração de relevância clínica, um caso de complexos ventriculares prematuros, possivelmente decorrente da parada cardiorrespiratória, que foi revertido com sucesso. Houve diminuição da amplitude dos complexos QRS nos primeiros 14 dias, retornado ao normal após 60 dias de pós-operatórioThe purpose for using lobectomy or pneumonectomy in dogs and cats, is to cure or palliate of bronchopulmonary diseases whenever conservative clinical treatment proves ineffective. Considering the marked changes caused by pneumonectomy, new experimental studies have to be done to assess the advantages of this surgical intervention allow its performance without any risk. The aim of the current study was to evaluate the electrocardiographic alterations in ten adult mongrel dogs of both sexes with between 10 and 30 Kg that were submitted to right pneumonectomy. The clinical parameters of the dogs were evaluated in a daily basis and the alterations in every electrocardiogram derivation were recorded. All dogs presented a good post-operative outcome. In most cases there were no electrocardiographic alterations; when these alterations were observed they were of no clinical significance and included premature ventricular complexes in one dog, most likely resulting from a cardiorespiratory arrest that was reverted to successfully, and a decreased width in the QRS complex amplitude on the first 0-14 days post surgery which returned to normal after sixty days post surger
Leaf and Root Extracts from Campomanesia adamantium (Myrtaceae) Promote Apoptotic Death of Leukemic Cells via Activation of Intracellular Calcium and Caspase-3
Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer potential of this plant species, the aim of this study was to evaluate the antileukemic activity and the chemical composition of aqueous extracts from the leaves (AECL) and roots (AECR) of C. adamantium and their possible mechanisms of action. The extracts were analyzed by LC-DAD-MS, and their constituents were identified based on the UV, MS, and MS/MS data. The AECL and AECR showed different chemical compositions, which were identified as main compounds glycosylated flavonols from AECL and ellagic acid and their derivatives from AECR. The cytotoxicity promoted by these extracts were evaluated using human peripheral blood mononuclear cells and Jurkat leukemic cell line. The cell death profile was evaluated using annexin-V-FITC and propidium iodide labeling. Changes in the mitochondrial membrane potential, the activity of caspases, and intracellular calcium levels were assessed. The cell cycle profile was evaluated using propidium iodide. Both extracts caused concentration-dependent cytotoxicity only in Jurkat cells via late apoptosis. This activity was associated with loss of the mitochondrial membrane potential, activation of caspases-9 and -3, changes in intracellular calcium levels, and cell cycle arrest in S-phase. Therefore, the antileukemic activity of the AECL and AECR is mediated by mitochondrial dysfunction and intracellular messengers, which activate the intrinsic apoptotic pathway. Hence, aqueous extracts of the leaves and roots of C. adamantium show therapeutic potential for use in the prevention and treatment of diseases associated the proliferation of tumor cell.Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Mato Grosso do Sul (FUNDECT)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Instituto Nacional de Pesquisa do Pantanal - INPPFundação de Amparo e Desenvolvimento da Pesquisa FadespFed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab, Dourados, BrazilUniv Fed São Paulo, Dept Biochem, São Paulo, BrazilUniv Braz Cubas, Fac Pharm, Mogi Das Cruzes, BrazilUniv Mogi das Cruzes, Interdisciplinary Ctr Biochem Invest, Mogi Das Cruzes, BrazilUniv Fed São Paulo, Dept Pharmaceut Sci, São Paulo, BrazilUniv Fed Mato Grosso do Sul, Lab Nat Prod & Mass Spectrometry, Campo Grande, MS, BrazilUniv Fed São Paulo, Dept Biochem, São Paulo, BrazilUniv Fed São Paulo, Dept Pharmaceut Sci, São Paulo, BrazilWeb of Scienc
Mutation of the surface layer protein SlpB has pleiotropic effects in the probiotic propionibacterium freudenreichii CIRM-BIA 129
Propionibacterium freudenreichii is a beneficial Gram-positive bacterium, traditionally used as a cheese-ripening starter, and currently considered as an emerging probiotic. As an example, the P. freudenreichii CIRM-BIA 129 strain recently revealed promising immunomodulatory properties. Its consumption accordingly exerts healing effects in different animal models of colitis, suggesting a potent role in the context of inflammatory bowel diseases. This anti-inflammatory effect depends on surface layer proteins (SLPs). SLPs may be involved in key functions in probiotics, such as persistence within the gut, adhesion to host cells and mucus, or immunomodulation. Several SLPs coexist in P. freudenreichii CIRM-BIA 129 and mediate immunomodulation and adhesion. A mutant P. freudenreichii CIRM-BIA 129ΔslpB (CB129ΔslpB) strain was shown to exhibit decreased adhesion to intestinal epithelial cells. In the present study, we thoroughly analyzed the impact of this mutation on cellular properties. Firstly, we investigated alterations of surface properties in CB129ΔslpB. Surface extractable proteins, surface charges (ζ-potential) and surface hydrophobicity were affected by the mutation. Whole-cell proteomics, using high definition mass spectrometry, identified 1,288 quantifiable proteins in the wild-type strain, i.e., 53% of the theoretical proteome predicted according to P. freudenreichii CIRM-BIA 129 genome sequence. In the mutant strain, we detected 1,252 proteins, including 1,227 proteins in common with the wild-type strain. Comparative quantitative analysis revealed 97 proteins with significant differences between wild-type and mutant strains. These proteins are involved in various cellular process like signaling, metabolism, and DNA repair and replication. Finally, in silico analysis predicted that slpB gene is not part of an operon, thus not affecting the downstream genes after gene knockout. This study, in accordance with the various roles attributed in the literature to SLPs, revealed a pleiotropic effect of a single slpB mutation, in the probiotic P. freudenreichii. This suggests that SlpB may be at a central node of cellular processes and confirms that both nature and amount of SLPs, which are highly variable within the P. freudenreichii species, determine the probiotic abilities of strains.Fil: do Carmo, Fillipe L. R.. Institut National de la Recherche Agronomique; Francia. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Marques Da Silva, Wanderson. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tavares, Guilherme C.. Universidade Federal de Minas Gerais; BrasilFil: Ibraim, Izabela C.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Cordeiro, Barbara F.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Oliveira, Emiliano R.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Rabah, Houem. Institut National de la Recherche Agronomique; FranciaFil: Cauty, Chantal. Institut National de la Recherche Agronomique; FranciaFil: da Silva, Sara H.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Canário Viana, Marcus V.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: Caetano, Ana C. B.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: dos Santos, Roselane G.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; BrasilFil: de Oliveira Carvalho, Rodrigo D.. Instituto de Ciencias Da Saúde; BrasilFil: Jardin, Julien. Institut National de la Recherche Agronomique; FranciaFil: Pereira, Felipe L.. Universidade Federal de Minas Gerais; BrasilFil: Folador, Edson L.. Universidade Estadual da Paraiba; BrasilFil: Le Loir, Yves. Institut National de la Recherche Agronomique; FranciaFil: Figueiredo, Henrique C. P.. Universidade Federal de Minas Gerais; BrasilFil: Jan, Gwénaël. Institut National de la Recherche Agronomique; FranciaFil: Azevedo, Vasco. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; Brasi
Inter-relation between soybean yield and soil compaction under degraded pasture in Brazilian Savannah
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