9 research outputs found
Comprehensive molecular characterization of the hippo signaling pathway in cancer
- Author
- Abdel-Rahman MH
- Abeshouse A
- Adebamowo C
- Adebamowo SN
- Agnew K
- Ahn K
- Ajani JA
- Akbani R
- Akeredolu T
- Al-Ahmadie H
- Albert M
- Alexopoulou I
- Ally A
- Alvaro D
- Anderson ML
- Andry C
- Antenucci A
- Anur P
- Appelbaum EL
- Aredes ND
- Armenia J
- Arnaout A
- Asa SL
- Auman JT
- Aymerich M
- Aziz D
- Bailey M
- Balasundaram M
- Balu S
- Barnett G
- Barnholtz-Sloan JS
- Barrett W
- Bartlett J
- Bathe O
- Baudin E
- Baylin S
- Becker K-F
- Beer D
- Behera M
- Behrens C
- Bell D
- Bell S
- Bellair M
- Bennett J
- Benz C
- Berchuck A
- Berger AC
- Bergeron A
- Berkowitz R
- Bernard B
- Beroukhim R
- Beuschlein F
- Bhavana VH
- Bifulco C
- Bigner D
- Birrer M
- Birsoy K
- Bocklage T
- Bodenheimer T
- Bondaruk J
- Bootwalla MS
- Borad M
- Borgia JA
- Bossler A
- Botnariuc N
- Boussioutas A
- Bowen J
- Bowlby R
- Bowman R
- Bradford C
- Bragazzi MC
- Brat DJ
- Breggia A
- Brewer C
- Brimo F
- Broaddus R
- Brooks D
- Broom BM
- Broudy T
- Bryce AH
- Bubley G
- Bueno R
- Burnette A
- Caesar-Johnson SJ
- Calatozzolo C
- Camargo F
- Campo E
- Campos B
- Caraman I
- Cardinale V
- Carey F
- Carey T
- Carlotti CG
- Carlsen R
- Carney M
- Carpino G
- Carroll PR
- Carter C
- Carvalho AL
- Castle E
- Castro PD
- Catto J
- Cebulla CM
- Cernat M
- Chabot J
- Chakravarty D
- Chambwe N
- Chan JM
- Chan TA
- Chandan V
- Chang K
- Chatila WK
- Chemencedji I
- Chen A
- Chen C
- Chen H
- Chen Z
- Cheng F
- Cherniack AD
- Chesla D
- Chevalier S
- Cheville J
- Cho J
- Chuah E
- Chudamani S
- Chung K
- Cibulskis C
- Clipca A
- Colman H
- Cope L
- Copland JA
- Corcoran N
- Cordes MG
- Costello T
- Cottingham S
- Couce M
- Covington K
- Crain D
- Cramer D
- Creaney J
- Creighton CJ
- Creighton CJ
- Cuppini L
- Curley E
- Cuzzubbo S
- Czerniak B
- Danilova L
- Davis A
- de Bruijn I
- de Carvalho AC
- de Krijger R
- De Rienzo A
- De Rose A
- DeFreitas T
- Delman K
- Demchok JA
- Desjardins L
- Devine K
- Deyarmin B
- Dhalla N
- Dhanasekaran R
- Dhankani V
- Dhir R
- Dill MT
- DiMeco F
- Ding L
- Dinh H
- Dinkin M
- DiPersio J
- Disaia P
- Doddapaneni H
- Donehower LA
- Doruc S
- Dos Santos JS
- Dottino PR
- Drake B
- Drummond J
- Drwiega P
- Du D
- Dubina M
- Duell R
- Duffy ER
- Eckman J
- Edenfield WJ
- Eijckenboom W
- Elder JB
- Engel J
- Eschbacher J
- Esmaeli B
- Evason K
- Facciolo F
- Fan C
- Fan H
- Fantacone-Campbell JL
- Farnell M
- Farver C
- Fassnacht M
- Fehrenbach A
- Felau I
- Feldman M
- Feltmate C
- Ferguson ML
- Finocchiaro G
- Flotte T
- Fong KM
- Force S
- Forgie I
- Frazer S
- Fregnani JH
- Fronick CC
- Fujimoto J
- Fulop J
- Fulton LA
- Fulton RS
- Gabra H
- Gabriel SB
- Galbraith J
- Gao GF
- Gao J
- Gardner J
- Gastier-Foster JM
- Gaudio E
- Ge Z
- Gehlenborg N
- Gerken M
- Gershenwald J
- Getz G
- Ghossein R
- Giama N
- Gibbs RA
- Gilbert S
- Gillis A
- Gimenez-Roqueplo A-P
- Giné E
- Giordano T
- Girard N
- Giuliante F
- Glenn P
- Glenn R
- Godwin AK
- Godwin EM
- Gonzalez AMA
- Goodman M
- Gopalan A
- Goparaju C
- Gorincioi G
- Govindan R
- Graefen M
- Grazi G
- Grizzle WE
- Gross BE
- Guillermo AL
- Guo C
- Ha G
- Haddad A
- Hagedorn CH
- Hale W
- Han L
- Han Y
- Hanh PT
- Hansen P
- Harr J
- Hartmann A
- Haydu L
- Hayes DN
- Hayward N
- Heath S
- Hegde AM
- Heiman DI
- Heins ZJ
- Henderson J
- Hermes B
- Hernandez B
- Herold-Mende C
- Hersey P
- Hess J
- Hibshoosh H
- Hilty J
- Hinoue T
- Ho T
- Hoadley KA
- Holt R
- Hooke JA
- Hoon D
- Horowitz N
- Houck J
- Hovens C
- Hoyle AP
- Hu H
- Hu J
- Huland H
- Hung NP
- Huntsman D
- Hutter CM
- Iacocca M
- Ittmann M
- Jacobus L
- Jakrot V
- Janssen K-P
- Jefferys SR
- Jeong KJ
- Jimeno A
- Jones CD
- Jones SJM
- Ju Z
- Juhl H
- Jungk C
- Junker K
- Kakavand H
- Kalkanis S
- Kanchi RS
- Kandoth C
- Kang KJ
- Karlan BY
- Kasaian K
- Kasapi M
- Kastl A
- Kebebew E
- Kefford R
- Kelley RK
- Kemp R
- Kendall S
- Kendler A
- Kendrick M
- Khuri F
- Kibel A
- Kim J
- Knijnenburg T
- Knudson M
- Knutson T
- Kocher J-P
- Kohl B
- Kopp K
- Korchina V
- Korkut A
- Korpershoek E
- Korst R
- Kovatich AJ
- Kramer R
- Kucherlapati MH
- Kucherlapati RS
- Kumar B
- Kundra R
- Kvecher L
- Kycler W
- La K
- Lacombe L
- Ladanyi M
- Lai PH
- Laird PW
- Landen CN
- Landrum L
- Lang J
- Larson C
- Latour M
- Lau K
- Lawrence MS
- Lazar AJ
- Le X
- Lechan R
- Lee D
- Lee JI
- Lee K
- Lee S
- Lehman NL
- Leinonen K
- Leraas KM
- Levine DA
- Lewis L
- Ley T
- Li J
- Li J
- Li W
- Liang H
- Liang H
- Lichtenberg TM
- Lin P
- Linehan WM
- Ling S
- Lipp E
- Liptay MJ
- Liu J
- Liu W
- Liu X
- Liu Y
- Logothetis C
- Lohavanichbutr P
- Lolla L
- Long G
- Longatto-Filho A
- Looijenga L
- Lu Y
- Luketich J
- Luna A
- Lyadov V
- Ma D
- Ma Y
- Madan R
- Maglic D
- Maglinte DT
- Magliocca K
- Maithel S
- Mallery D
- Malykh A
- Mandt R
- Manikhas G
- Mann G
- Mannel R
- Mannelli M
- Mardis ER
- Mariamidze A
- Mariani O
- Marino M
- Marks J
- Marra MA
- Martignetti JA
- Martin J
- Mattei L
- Mayo M
- McCall S
- McGraw M
- McKercher G
- McLellan MD
- McLendon R
- McPherson C
- Meier S
- Melamed J
- Meng S
- Meric-Bernstam F
- Merola R
- Mes-Masson A-M
- Metwalli AR
- Meyerson M
- Mieczkowski PA
- Mikkelsen T
- Milhem M
- Miller CA
- Miller J
- Miller M
- Mills GB
- Mills GB
- Mirsaidi C
- Moiseenko F
- Mojumdar K
- Moncrieff M
- Moore K
- Moore RA
- Moran C
- Moreno D
- Morgan M
- Morris S
- Morrison C
- Morton D
- Mose LE
- Moser C
- Moxley K
- Moyer J
- Mungall AJ
- Mungall K
- Mura S
- Mural RJ
- Murawa D
- Muto M
- Muzny D
- Myers J
- Nagorney D
- Nair P
- Naresh R
- Naska T
- Nelson M
- Ng K-S
- Ng PK-S
- Nguyen P
- Nissan MG
- Noble MS
- Noss A
- Noushmehr H
- Ochoa A
- Olabode O
- Olson JJ
- Omberg L
- Oosterhuis W
- Ostrom QT
- Owonikoko T
- OâBrien D
- OâNeill BP
- Pacak K
- Paklina O
- Parfitt J
- Park J-W
- Parker JS
- Pass H
- Patel T
- Paulauskis J
- Peng X
- Pennell NA
- Penny R
- Perin A
- Perou AH
- Perou CM
- Petersen G
- Peterson L
- Peto M
- Phillips J
- Phillips SM
- Phu BD
- Piché A
- Pickens A
- Pihl T
- Pilarski R
- Pinero EMM
- Pinto PA
- Pirtac M
- Pollo B
- Pool M
- Porten S
- Postier R
- Potapova O
- Powers J
- Prados M
- Prince M
- Que F
- Quinn M
- Quintero-Aguilo M
- Rabeno B
- Rai K
- Ramalingam S
- Ramirez NC
- Ramondetta L
- Rao A
- Rassl DM
- Rathmell WK
- Raut CP
- Raymond D
- Reis RM
- Reuter V
- Reynolds S
- Reznik E
- Rice D
- Richards WG
- Rintoul RC
- Rivera M
- Roach J
- Roberts L
- Robertson AG
- Robinson B
- Roggin K
- Roman-Roman S
- Rosenthal HG
- Rozek L
- Rubin MA
- Ryan M
- Saad F
- Sadeghi S
- Saksena G
- Sanchez-Vega F
- Sander C
- Sankarankuty A
- Santibanez J
- Sastre X
- Sauter G
- Saw R
- Scapulatempo-Neto C
- Scarpace L
- Schadendorf D
- Schein JE
- Schiffman M
- Schilero C
- Schlomm T
- Schmidt HK
- Schmidt LS
- Schoenfield L
- Schultz N
- Schumacher SE
- Scolyer R
- Secord A
- Seder CW
- Sekhon H
- Senecal K
- Sepulveda A
- Setdikova G
- Sexton KC
- Shabunin A
- Shannon K
- Sharp A
- Shelley CS
- Shelton C
- Shelton T
- Shen H
- Sheridan R
- Sherman M
- Sheth M
- Shi Y
- Shih J
- Shimmel K
- Shin DM
- Shinbrot E
- Shipman C
- Shmulevich I
- Shriver CD
- Sica G
- Sifri S
- Sigmund R
- Signoretti S
- Silveira HCS
- Simko J
- Simon R
- Simons JV
- Singer S
- Singh B
- Singh R
- Sipahimalani P
- Skelly T
- Sloan AE
- Slotta-Huspenina J
- Smallridge R
- Smith J
- Smith-McCune K
- Smolenski K
- Smyrk T
- Sofia HJ
- Soloway MG
- Somiari S
- Sood A
- Spellman P
- Spillane A
- Stancul I
- Stanton M
- Staugaitis SM
- Steele R
- Stepa S
- Stern M-H
- Stoehr C
- Stoehr R
- Stoop H
- Stretch J
- Stuart JM
- Su T
- Sumer SO
- Sun Q
- Sun Y
- Swanson P
- Swisher E
- Synott M
- Tam A
- Tamakawa R
- Tamboli P
- Tan D
- Tang Y
- Tarnuzzer R
- Taubert H
- Tavobilov M
- Taylor BS
- Tcaciuc D
- Tennstedt P
- Thiessen N
- Thomas G
- Thompson E
- Thompson J
- Thompson RH
- Thompson T
- Thorp R
- Thorsson V
- Tien NV
- Timmers H
- Tirapelli D
- Tischler A
- Torbenson M
- Troncoso P
- Tsang YH
- Tsao A
- Tse K
- Tucker K
- TĂȘtu B
- Unterberg A
- Urba W
- Valdivieso F
- Van Bang N
- Van Den Berg DJ
- van Kessel KE
- Van Meir EG
- Van Tine B
- VandenBerg S
- Veluvolu U
- Vicha A
- Vidal DO
- Vocke CD
- Voet D
- von Deimling A
- Voronina O
- Wach S
- Wakely P
- Waldmann J
- Walker J
- Wan Y
- Wang J
- Wang J
- Wang L
- Wang M
- Wang T
- Wang Y
- Wang Z
- Warnick R
- Weinstein JN
- Weisenberger DJ
- Wentzensen N
- Westervelt P
- Wheeler DA
- Wilkerson MD
- Williams F
- Wilmott J
- Wilson RK
- Wise L
- Wistuba I
- Wiznerowicz M
- Wolf G
- Wolinsky Y
- Wong CK
- Wong T
- Worrell R
- Wu Y
- Wullich B
- Xi L
- Xu X
- Yang H
- Yang I
- Yang JD
- Yang L
- Yau C
- Yena P
- Zach LA
- Zaren H
- Zelinka T
- Zenklusen JC
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang JJ
- Zhang L
- Zhang W
- Zhao F
- Zhou W
- Zmuda E
- Zuna R
- Zwarthoff EC
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional âomicâ data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era
Napabucasin DrugâDrug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers
- Author
- Ancrenaz V
- Backman JT
- Becerra C
- Becerra C
- Becerra C
- Beijnen JH
- BekaiiâSaab TS
- BekaiiâSaab TS
- Bendell JC
- Borad MJ
- Bosilkovska M
- Chang AâY
- Christensen M
- Dai X
- Edenfield WJ
- Edenfield WJ
- ElâRayes BF
- Ermer J
- Froeling FEM
- Given BA
- Gujjarlamudi HB
- Harris JW
- Honkalammi J
- Jonker DJ
- Kalra M
- Kawazoe A
- Kawazoe A
- Larson T
- Laurie SA
- Madajewski B
- Martin P
- Mason WP
- Nordmark A
- Polli JW
- Rahman A
- Riechelmann RP
- Riechelmann RP
- Riechelmann RP
- Ryu JY
- Salwe KJ
- Shah M
- Shah MA
- Shitara K
- Snyder BD
- Streetman DS
- Turpault S
- US Food and Drug Administration
- Van Leeuwen RWF
- Viktil KK
- Zadoyan G
- Zgheib NK
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Assessing the Value of Next-Generation Sequencing Tests in a Dynamic Environment
- Author
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Density-effect and economic threshold of purple nutsedge (Cyperus rotundus) in soybean
- Author
- A. K. Paul
- AG Thomas
- AK Gomez
- AM Rambakudzibga
- BM Dodamani
- BM Santos
- CJ Swanton
- D Hazra
- GG Wilkerson
- HD Coble
- HH Rogers
- I Dev
- JE Jordan-Molero
- JE Miles
- KA Nelson
- KA Nelson
- Kumar Mukesh
- LG Holm
- MD Vyas
- MS Cheema
- MW Edenfield
- N. T. Yaduraju
- PE Keeley
- PK Thornton
- R Cousens
- R Cousens
- RF Norris
- RL Zimdahl
- T. K. Das
- TK Das
- TK Das
- TK Das
- TK Das
- TM Webster
- WJ Grichar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Modified Donor Lymphocyte Infusion (DLI) for the Prophylaxis of Leukemia Relapse after Hematopoietic Stem Cell Transplantation in Patients with Advanced LeukemiaâFeasibility and Safety Study
- Author
- A Devergie
- A Mengarelli
- C Schmid
- Dai-Hong Liu
- DM Durnam
- EP Alessandrino
- F Frassoni
- HJ Kolb
- Hong-Xia Shi
- Huan Chen
- J Zhou
- JC Biggs
- JE Levine
- K Anslinger
- Kai-Yan Liu
- Lan-Ping Xu
- M Lima De
- M Michallet
- O Ringden
- R Pawson
- RA Clift
- S Singhal
- S Slavin
- SH Chen
- SK Sohn
- T Robak
- Wei Han
- WJ Edenfield
- Xiao-Jun Huang
- XJ Huang
- XJ Huang
- XJ Huang
- XJ Huang
- XJ Huang
- Yu Wang
- Yu-Hong Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Engraftment syndrome: double-edged sword of hematopoietic cell transplants
- Author
- A Dispenzieri
- A Maiolino
- AB Farris
- AD Hess
- AK Omer
- C Colby
- C Miller
- C Ravoet
- C Salat
- CK Lee
- D Marin
- DH Kim
- E Carreras
- E Gorak
- F de Arriba
- H Takatsuka
- HM Lazarus
- I Schmid
- J Antin
- J Kanda
- J Kline
- J Koreth
- J Rabinowitz
- JS Moreb
- KJ Patel
- KR Brownback
- KT Hong
- L Chang
- L Madero
- M Akasheh
- M Gonzalez-Vincent
- M Park
- MA Foncillas
- N Nishio
- RA Cahill
- RM Saliba
- S Mossad
- SA Khan
- T Ikezoe
- T R Spitzer
- T Toubai
- TR Spitzer
- W Nurnberger
- W Nurnberger
- WJ Edenfield
- X Wang
- Y Oyama
- Y-H Lee
- YB Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Biology, agricultural impact, and management of Cyperus rotundus L.: the worldâs most tenacious weed
- Author
- A Cirujeda
- A Mahmood
- A Matloob
- A Rahnavard
- A Zanuncio
- AJ Loustalot
- AL Oladipupo
- AM Peerzada
- Arslan Masood Peerzada
- B Callow
- BA Auld
- BJ Wilson
- BM Santos
- BM Santos
- BM Santos
- BM Santos
- BM Santos
- BM Santos
- BS Chauhan
- BS Chauhan
- BS Chauhan
- C Neeser
- CA Ellison
- CAN Okoli
- CB Yandoc
- CS Geethambigai
- CT Bryson
- CT Bryson
- CT Bryson
- D Ali
- D Ali
- D Dhanasekaran
- D Kavitha
- DA Simpson
- DKM Donayre
- E Dor
- EW Stoller
- F Efil
- F Munsif
- F Nyahoza
- FA Tuor
- FI Jahan
- G Mahajan
- G Siriwardana
- G Wang
- G Wang
- GA Mohamed
- GD Wills
- GD Wills
- GD Wills
- GW Ivens
- HH Rogers
- HM Sayed
- IC Burke
- IO Akobundu
- IS Travlos
- J Cavero
- J Hershenhorn
- J Iqbal
- J Iqbal
- J Iqbal
- J Schroeder
- J Tveten
- JB Kadir
- JB Kadir
- JH Norsworthy
- JK Norsworthy
- JL Hammeron
- JP Gilreath
- JP Gilreath
- JP Morales-Payan
- JP Morales-Payan
- JP Morales-Payan
- JR Summerlin
- JT Pena-Fronteras
- K El-Rokiek
- K Jabran
- K Kalaichelvi
- K Usman
- KN Reddy
- L Kumar
- L Roshan
- LE Bendixen
- LG Holm
- M Ameena
- M Ameena
- M Ameena
- M Chand
- M Horowitz
- M Kumar
- M Singh
- MA El-Sheikh
- MA Mohamed
- MD Tuti
- MM Kamrozzaman
- MM Maqbool
- MM Riemens
- MN Dogan
- MN Islam
- MW Edenfield
- N Akbar
- N Rabbani
- NB Singh
- NK Messiha
- O Boz
- PC Bhowmik
- PE Keeley
- PJ Morales-Payan
- PJ Terry
- R Absy
- R Aly
- R Devendra
- R Khan
- R Sharma
- R Shyam
- RD Wallace
- RD William
- RG Fuentes
- RJ Thullen
- RK Nishimoto
- RK Srivastava
- RN Lati
- S Ahmed
- S Khalid
- S Singh
- SC Marble
- SH Lorzadeh
- SJ Jeong
- SK Bangarwa
- SK Bangarwa
- SK Bangarwa
- T Geretharan
- TGLG Gunasekera
- TK Das
- TM Webster
- TM Webster
- TM Webster
- TM Webster
- TM Webster
- TM Webster
- TZ Zhang
- VP Gupta
- VP Singh
- WJ Grichar
- WT Parsons
- YX Li
- Z Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Effects of Stress on Physical Activity and Exercise
- Author
- A Baum
- A Danese
- A Hill
- A Hubbs
- A Kouvonen
- A Kouvonen
- A Rodriguez
- A Rosengren
- A Rosengren
- A Rozanski
- A Sanchez-Villegas
- A Sgoifo
- A Steptoe
- A Steptoe
- A Steptoe
- AC King
- AC King
- AC King
- AC King
- AE Bauman
- AE Bauman
- AE Paluch
- AJ Lang
- AJM Loon van
- AL Divin
- AL Dougall
- AL Dunn
- AL Zen
- AM Burdette
- AM Hansen
- AM Knab
- AM Stranahan
- AT Ludlow
- AW Smith
- B Choi
- B Gardell
- B McEwen
- B Roshanaei-Moghaddam
- B Singer
- B Sternfeld
- B Wu
- BA Stetson
- BC Long
- BC Long
- BC Mulder
- BM McGilley
- BM Pinto
- BM Pinto
- BM Wagner
- BM Wipfli
- BN Greenwood
- BN Greenwood
- BP Buchman
- BS McEwen
- C Brisson
- C Giuli
- C Sandi
- C Zunker
- CA LeardMann
- CA Smith
- CD Rethorst
- CE Garber
- Centers for Disease Control
- CF Emery
- CJ Caspersen
- CL Carmack
- CL Park
- CL Smith
- CM Castro
- CM Connell
- CM Connell
- CM Devine
- CM Friedenreich
- CM McBride
- CR Lemmon
- CR Nigg
- CR Rao
- CS Carver
- CS Woolley
- D Ah Von
- D Jonsson
- D Jonsson
- D Korotkov
- D Korotkov
- D Magoc
- D Ridder de
- D Spillman
- D Zillman
- DA Gutman
- DA Krummel
- DB OâConnor
- DB OâConnor
- DB OâConnor
- DH Jones
- DJ Crews
- DJ Wiebe
- DK Ingledew
- DK Sherman
- DL Padden
- DM Griffith
- DM Ng
- DM Reed
- DR Anderson
- DR Young
- DS Holmes
- DS Ludwig
- DW Brown
- DX Marquez
- E Atlantis
- E Engberg
- E Epel
- E Fondell
- E Newman
- E Orsega-Smith
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