779 research outputs found
Universality in Systems with Power-Law Memory and Fractional Dynamics
There are a few different ways to extend regular nonlinear dynamical systems
by introducing power-law memory or considering fractional
differential/difference equations instead of integer ones. This extension
allows the introduction of families of nonlinear dynamical systems converging
to regular systems in the case of an integer power-law memory or an integer
order of derivatives/differences. The examples considered in this review
include the logistic family of maps (converging in the case of the first order
difference to the regular logistic map), the universal family of maps, and the
standard family of maps (the latter two converging, in the case of the second
difference, to the regular universal and standard maps). Correspondingly, the
phenomenon of transition to chaos through a period doubling cascade of
bifurcations in regular nonlinear systems, known as "universality", can be
extended to fractional maps, which are maps with power-/asymptotically
power-law memory. The new features of universality, including cascades of
bifurcations on single trajectories, which appear in fractional (with memory)
nonlinear dynamical systems are the main subject of this review.Comment: 23 pages 7 Figures, to appear Oct 28 201
Phase diagram of bismuth in the extreme quantum limit
Elemental bismuth provides a rare opportunity to explore the fate of a
three-dimensional gas of highly mobile electrons confined to their lowest
Landau level. Coulomb interaction, neglected in the band picture, is expected
to become significant in this extreme quantum limit with poorly understood
consequences. Here, we present a study of the angular-dependent Nernst effect
in bismuth, which establishes the existence of ultraquantum field scales on top
of its complex single-particle spectrum. Each time a Landau level crosses the
Fermi level, the Nernst response sharply peaks. All such peaks are resolved by
the experiment and their complex angular-dependence is in very good agreement
with the theory. Beyond the quantum limit, we resolve additional Nernst peaks
signaling a cascade of additional Landau sub-levels caused by electron
interaction
New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8
The intermediate filament protein keratin 8 (K8) interacts with the nucleotide-binding domain 1 (NBD1) of the cystic fibrosis transmembrane regulator (CFTR) with phenylalanine 508 deletion (ÎF508), and this interaction hampers the biogenesis of functional ÎF508-CFTR and its insertion into the plasma membrane. Interruption of this interaction may constitute a new therapeutic target for cystic fibrosis patients bearing the ÎF508 mutation. Here we aimed to determine the binding surface between these two proteins, to facilitate the design of the interaction inhibitors. To identify the NBD1 fragments perturbed by the ÎF508 mutation, we used hydrogenâdeuterium exchange coupled with mass spectrometry (HDX-MS) on recombinant wild-type (wt) NBD1 and ÎF508-NBD1 of CFTR. We then performed the same analysis in the presence of a peptide from the K8 head domain, and extended this investigation using bioinformatics procedures and surface plasmon resonance, which revealed regions affected by the peptide binding in both wt-NBD1 and ÎF508-NBD1. Finally, we performed HDX-MS analysis of the NBD1 molecules and full-length K8, revealing hydrogen-bonding network changes accompanying complex formation. In conclusion, we have localized a region in the head segment of K8 that participates in its binding to NBD1. Our data also confirm the stronger binding of K8 to ÎF508-NBD1, which is supported by an additional binding site located in the vicinity of the ÎF508 mutation in NBD1. This article is protected by copyright. All rights reserved
Field-induced polarisation of Dirac valleys in bismuth
Electrons are offered a valley degree of freedom in presence of particular
lattice structures. Manipulating valley degeneracy is the subject matter of an
emerging field of investigation, mostly focused on charge transport in
graphene. In bulk bismuth, electrons are known to present a threefold valley
degeneracy and a Dirac dispersion in each valley. Here we show that because of
their huge in-plane mass anisotropy, a flow of Dirac electrons along the
trigonal axis is extremely sensitive to the orientation of in-plane magnetic
field. Thus, a rotatable magnetic field can be used as a valley valve to tune
the contribution of each valley to the total conductivity. According to our
measurements, charge conductivity by carriers of a single valley can exceed
four-fifth of the total conductivity in a wide range of temperature and
magnetic field. At high temperature and low magnetic field, the three valleys
are interchangeable and the three-fold symmetry of the underlying lattice is
respected. As the temperature lowers and/or the magnetic field increases, this
symmetry is spontaneously lost. The latter may be an experimental manifestation
of the recently proposed valley-nematic Fermi liquid state.Comment: 14 pages + 5 pages of supplementary information; a slightly modified
version will appear as an article in Nature physic
Simultaneous TE Analysis of 19 Heliconiine Butterflies Yields Novel Insights into Rapid TE-Based Genome Diversification and Multiple SINE Births and Deaths
Transposable elements (TEs) play major roles in the evolution of genome structure and function. However, because of their repetitive nature, they are difficult to annotate and discovering the specific roles they may play in a lineage can be a daunting task. Heliconiine butterflies are models for the study of multiple evolutionary processes including phenotype evolution and hybridization. We attempted to determine how TEs may play a role in the diversification of genomes within this clade by performing a detailed examination of TE content and accumulation in 19 species whose genomes were recently sequenced. We found that TE content has diverged substantially and rapidly in the time since several subclades shared a common ancestor with each lineage harboring a unique TE repertoire. Several novel SINE lineages have been established that are restricted to a subset of species. Furthermore, the previously described SINE, Metulj, appears to have gone extinct in two subclades while expanding to significant numbers in others. This diversity in TE content and activity has the potential to impact how heliconiine butterflies continue to evolve and diverge
MRI of the lung (1/3):methods
Proton magnetic resonance imaging (MRI) has recently emerged as a clinical tool to image the lungs. This paper outlines the current technical aspects of MRI pulse sequences, radiofrequency (RF) coils and MRI system requirements needed for imaging the pulmonary parenchyma and vasculature. Lung MRI techniques are presented as a âtechnical toolkitâ, from which MR protocols will be composed in the subsequent papers for comprehensive imaging of lung disease and function (parts 2 and 3). This paper is pitched at MR scientists, technicians and radiologists who are interested in understanding and establishing lung MRI methods. Images from a 1.5 T scanner are used for illustration of the sequences and methods that are highlighted.
Main Messages
âą Outline of the hardware and pulse sequence requirements for proton lung MRI
âą Overview of pulse sequences for lung parenchyma, vascular and functional imaging with protons
âą Demonstration of the pulse-sequence building blocks for clinical lung MRI protocol
SPECIAL ISSUE HIV and CHRONIC PAIN (The Global Task Force for Chronic Pain in People with HIV (PWH): Developing a research agenda in an emerging field)
Chronic pain is a common comorbidity in people with HIV (PWH), with prevalence estimates of 25-85%. Research in this area is growing, but significant gaps remain. A Global Task Force of HIV experts was organized to brainstorm a scientific agenda and identify measurement domains critical to advancing research in this field. Experts were identified through literature searches and snowball sampling. Two online questionnaires were developed by Task Force members. Questionnaire 1 asked participants to identify knowledge gaps in the field of HIV and chronic pain and identify measurement domains in studies of chronic pain in PWH. Responses were ranked in order of importance in Questionnaire 2, which was followed by a group discussion. 29 experts completed Questionnaire 1, 25 completed Questionnaire 2, and 21 participated in the group. Many important clinical and research priorities emerged, including the need to examine etiologies of chronic pain in PWH. Pain-related measurement domains were discussed, with a primary focus on domains that could be assessed in a standardized manner across various cohorts that include PWH in different countries. We collaboratively identified clinical and research priorities, as well as gaps in standardization of measurement domains, that can be used to move the field forward
Temporal Stability and the Effects of Training on Saccade Latency in âExpress Saccade Makersâ
The temporal stability of saccade latency, and the effects of training, particularly in âexpress saccade makersâ (ESMs), has received little attention. ESMs are healthy, naĂŻve, adults, who persist in executing very many low latency âexpress saccadesâ (ES; saccades with latency of 80 ms to 130 ms), in conditions designed to suppress such responses. We investigated the stability of ES production (%ES) in 59 ESM and 54 non-ESM participants in overlap tasks. Within a single session, the intraclass correlation coefficient (ICC) for %ES in two runs of 200 trials was 0.97 (p30% of saccades over the two runs were ES, were classified as ESMs. For 60 participants tested over two sessions 12 weeks apart, and 30 participants tested in three sessions over approximately six months, the ICC for %ES was uniformly high (0.95, p<0.001 and 0.97, p<0.001 respectively) and participants behaved consistently with their initial classification. Fourteen participants (7 ESMs) were then exposed to training consisting of either gap or overlap tasks. Training increased %ES in both groups. However, when tested in overlap tasks, it was not sufficient to transform Normal participants into ESMs. We conclude that the pattern of saccade behaviour exhibited by ESMs constitutes a stable and distinct oculomotor phenotype
Fractional Zaslavsky and Henon Discrete Maps
This paper is devoted to the memory of Professor George M. Zaslavsky passed
away on November 25, 2008. In the field of discrete maps, George M. Zaslavsky
introduced a dissipative standard map which is called now the Zaslavsky map. G.
Zaslavsky initialized many fundamental concepts and ideas in the fractional
dynamics and kinetics. In this paper, starting from kicked damped equations
with derivatives of non-integer orders we derive a fractional generalization of
discrete maps. These fractional maps are generalizations of the Zaslavsky map
and the Henon map. The main property of the fractional differential equations
and the correspondent fractional maps is a long-term memory and dissipation.
The memory is realized by the fact that their present state evolution depends
on all past states with special forms of weights.Comment: 26 pages, LaTe
SEAS: A System for SEED-Based Pathway Enrichment Analysis
Pathway enrichment analysis represents a key technique for analyzing high-throughput omic data, and it can help to link individual genes or proteins found to be differentially expressed under specific conditions to well-understood biological pathways. We present here a computational tool, SEAS, for pathway enrichment analysis over a given set of genes in a specified organism against the pathways (or subsystems) in the SEED database, a popular pathway database for bacteria. SEAS maps a given set of genes of a bacterium to pathway genes covered by SEED through gene ID and/or orthology mapping, and then calculates the statistical significance of the enrichment of each relevant SEED pathway by the mapped genes. Our evaluation of SEAS indicates that the program provides highly reliable pathway mapping results and identifies more organism-specific pathways than similar existing programs. SEAS is publicly released under the GPL license agreement and freely available at http://csbl.bmb.uga.edu/~xizeng/research/seas/
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