5 research outputs found
The Atacama Cosmology Telescope: Dynamical Masses and Scaling Relations for a Sample of Massive Sunyaev-Zel'dovich Effect Selected Galaxy Clusters
We present the first dynamical mass estimates and scaling relations for a
sample of Sunyaev-Zel'dovich effect (SZE) selected galaxy clusters. The sample
consists of 16 massive clusters detected with the Atacama Cosmology Telescope
(ACT) over a 455 sq. deg. area of the southern sky. Deep multi-object
spectroscopic observations were taken to secure intermediate-resolution
(R~700-800) spectra and redshifts for ~60 member galaxies on average per
cluster. The dynamical masses M_200c of the clusters have been calculated using
simulation-based scaling relations between velocity dispersion and mass. The
sample has a median redshift z=0.50 and a median mass M_200c~12e14 Msun/h70
with a lower limit M_200c~6e14 Msun/h70, consistent with the expectations for
the ACT southern sky survey. These masses are compared to the ACT SZE
properties of the sample, specifically, the match-filtered central SZE
amplitude y, the central Compton parameter y0, and the integrated Compton
signal Y_200c, which we use to derive SZE-Mass scaling relations. All SZE
estimators correlate with dynamical mass with low intrinsic scatter (<~20%), in
agreement with numerical simulations. We explore the effects of various
systematic effects on these scaling relations, including the correlation
between observables and the influence of dynamically disturbed clusters. Using
the 3-dimensional information available, we divide the sample into relaxed and
disturbed clusters and find that ~50% of the clusters are disturbed. There are
hints that disturbed systems might bias the scaling relations but given the
current sample sizes these differences are not significant; further studies
including more clusters are required to assess the impact of these clusters on
the scaling relations.Comment: 15 pages, 4 figures. Accepted for publication in The Astrophysical
Journal; matches published version. Full Table 8 with complete spectroscopic
member sample available in machine-readable form in the journal site and upon
request to C. Sif\'o
Recommended from our members
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.
BACKGROUND: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). OBJECTIVES: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. METHODS: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. RESULTS: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). CONCLUSION: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
Thrombotic and hemorrhagic complications of COVID-19 for adults hospitalized in high-income countries compared to low- and middle-income countries in an international registry
Background: COVID-19 has been associated with a broad range of thromboembolic,
ischemic, and hemorrhagic complications (coagulopathy complications). Most studies
have focused on patients with severe disease from high-income countries (HIC).
Objectives: The main aims were to compare the frequency of coagulopathy
complications in developing countries (low- and middle-income countries (LMIC)) with
those in HICs, to delineate the frequency across a range of treatment levels, and to
determine associations with in-hospital mortality.
Patients/Methods: Adult patients enrolled in an observational, multinational registry,
the International Severe Acute Respiratory and Emerging Infections COVID-19 study,
between January 1, 2020 and September 15, 2021 met inclusion criteria, including
admission to the hospital for lab-confirmed, acute COVID-19 and data on complications
and survival. The advanced treatment cohort received care such as admission to
intensive care, mechanical ventilation, or inotropes or vasopressors- the basic treatment
cohort did not receive any of these interventions.
Results: The study population was 495,682 patients from 55 countries- 63% from
LMIC; 85% were in the basic treatment cohort. The frequency of coagulopathy
complications was higher in HICs (0.76-3.4%) than in LMICs (0.09-1.22%).
Complications were more frequent in the advanced treatment cohort compared to the
basic treatment cohort. Coagulopathy complications were associated with increased inhospital mortality (OR 1.58, 95% CI 1.52-1.64). The increased mortality associated with
these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling
for coagulopathy complications, treatment intensity, and multiple other factors, mortality
was higher for patients in LMICs than for patients in HICs (OR 1.45, 95% CI 1.39-1.51).
Conclusions: In a large, international registry of patients hospitalized with COVID-19,
coagulopathy complications were more frequent in HICs than in LMICs (developing
countries). Increased mortality associated with coagulopathy complications was of
greater magnitude for patients in LMICs. Additional research is needed regarding timely
diagnosis and intervention for coagulation derangements associated with COVID-19,
particularly for limited resource settings
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings.</p
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings