Vote Buying

We examine the consequences of vote buying, assuming this practice were allowed and free of stigma. Two parties competing in a binary election may purchase votes in a sequential bidding game via up-front binding payments and/or campaign promises (platforms) that are contingent upon the outcome of the election. We analyze the role of the parties' budget constraints and voter preferences in determining the winner and the payments to voters.vote buying, elections, campaign promises

Vote Bying I: General Elections

We examine the consequences of vote buying, assuming this practice were al- lowed and free of stigma. Two parties compete in a binary election and may purchase votes in a sequential bidding game via up-front binding payments and/or campaign promises (platforms) that are contingent upon the outcome of the elec- tion. We analyze the role of the parties' and voters' preferences in determining the winner and the payments to voters.vote buying, political economy, campaign promises.

Vote Buying II: Legislatures and Lobbying

We examine the consequences of lobbying and vote buying, assuming this prac- tice were allowed and free of stigma. Two "lobbyists" compete for the votes of legislators by offering up-front payments to the legislators in exchange for their votes. We analyze how the lobbyists' budget constraints and legislator preferences determine the winner and the payments.vote buying, lobbying, legislatures, political economy.

Take Me To The Midnight Cake Walk Ball

https://digitalcommons.library.umaine.edu/mmb-vp/6355/thumbnail.jp

Third Annual Families and Neighborhoods Network Update

Welcome to the Third Annual Families and Neighborhoods Network Update. In this edition, which focuses on Family Development, you'll find plenty of relevant, interesting news, as well as diversity and spirituality in the context of family development.As always, we strive to provide information and resources regarding human service efforts that support families and neighborhoods. The selection of information and articles for this issue of the Network Update was based on issues raised by the seven Comprehensive Community-BasedModels (CCBMs).Among the highlights of this issue is an article by Dr. Susan Stern and Cassandra Clay, professors at Boston University School of Social Work. In their article, titled "Supporting Children and Families in a Caring Community," they challenge our thinking about family development, while guiding practitioners, policymakers, fund providers, and grassroots community-based organizations into the next century.Also in this issue, you'll find two annotated bibliographies that explore community-based, family centered strategies for integrating education and human services. These bibliographies also present practical ways to design policies that reflect the importance of the family in the development of children and society. As an additional resource, you'll also find a directory of federally-funded resource centers and clearinghouses that compile information on child andfamily welfare, health, and education issues.This issue of the Network Update also offers a personal glimpse of the seven W.K. Kellogg Foundation-funded family development sites. Each of the sites was asked to share its definition of family development, and to specify how that definition translates into services or opportunities for families. Staff members at the seven sites also were asked to discuss their philosophies about family development and how that philosophy differs from a mainstream view. Their thought provoking answers are just a few pages away

The Cellists

Program listing performers and works performed

Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is associated with abnormal organ positioning (situs) and congenital heart disease (CHD). This study investigated genotype–phenotype associations in PCD to facilitate risk predictions for cardiac and laterality defects. This retrospective cohort study of 389 UK patients with PCD found 51% had abnormal situs and 25% had CHD and/or laterality defects other than situs inversus totalis. Patients with biallelic mutations in a subset of nine PCD genes had normal situs. Patients with consanguineous parents had higher odds of situs abnormalities than patients with non-consanguineous parents. Patients with abnormal situs had higher odds of CHD and/or laterality defects

Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort

Background Primary ciliary dyskinesia (PCD), a genetically heterogeneous condition enriched in some consanguineous populations, results from recessive mutations affecting cilia biogenesis and motility. Currently, diagnosis requires multiple expert tests.Methods The diagnostic utility of multigene panel next-generation sequencing (NGS) was evaluated in 161 unrelated families from multiple population ancestries.Results Most (82%) families had affected individuals with biallelic or hemizygous (75%) or single (7%) pathogenic causal alleles in known PCD genes. Loss-of-function alleles dominate (73% frameshift, stop-gain, splice site), most (58%) being homozygous, even in non-consanguineous families. Although 57% (88) of the total 155 diagnostic disease variants were novel, recurrent mutations and mutated genes were detected. These differed markedly between white European (52% of families carry DNAH5 or DNAH11 mutations), Arab (42% of families carry CCDC39 or CCDC40 mutations) and South Asian (single LRRC6 or CCDC103 mutations carried in 36% of families) patients, revealing a striking genetic stratification according to population of origin in PCD. Genetics facilitated successful diagnosis of 81% of families with normal or inconclusive ultrastructure and 67% missing prior ultrastructure results.Conclusions This study shows the added value of high-throughput targeted NGS in expediting PCD diagnosis. Therefore, there is potential significant patient benefit in wider and/or earlier implementation of genetic screening