5 research outputs found
Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey
Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised
CLINICAL AND LABORATORY CHARACTERISTICS OF HYPERPROLACTINEMIC CHILDREN AND ADOLESCENTS: NATIONAL SURVEY
CLINICAL AND LABORATORY CHARACTERISTICS OF HYPERPROLACTINEMIC CHILDREN AND ADOLESCENTS: NATIONAL SURVEY
CLINICAL AND LABORATORY CHARACTERISTICS OF HYPERPROLACTINEMIC CHILDREN AND ADOLESCENTS: NATIONAL SURVEY
Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey
Objective: We aimed to report the characteristics at admission,
diagnosis, treatment, and follow-up of cases of pediatric
hyperprolactinemia in a large multicenter study.
Methods: We reviewed the records of 233 hyperprolactinemic patients,
under 18 years of age, who were followed by different centers. The
patients were divided as having microadenomas, macroadenomas,
drug-induced hyperprolactinemia and idiopathic hyperprolactinemia.
Complaints of the patients, their mode of treatment (medication and/or
surgery) and outcomes were evaluated in detail.
Results: The mean age of the patients with hyperprolactinemia was 14.5
years, and 88.4\% were females. In terms of etiology, microadenomas were
observed in 32.6 \%, macroadenomas in 27 \%, idiopathic
hyperprolactinemia in 22.7\% and drug-induced hyperprolactinemia in 6.4
\%. Other causes of hyperprolactinemia were defined in 11.3\%. Common
complaints in females (n = 206) were sorted into menstrual
irregularities, headaches, galactorrhea, primary or secondary amenorrhea
and weight gain, whereas headache, gynecomastia, short stature and
blurred vision were common in males (n = 27). Median prolactin levels
were 93.15 ng/mL, 241.8 ng/ml, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for
microadenomas, macroadenomas, idiopathic hyperprolactinemia,
drug-induced hyperprolactinemia, and other causes of hyperprolactinemia,
respectively. Of 172 patients with hyperprolactinemia, 77.3 \% were
treated with cabergoline and 13.4 \% with bromocriptine. 20.1 \% of the
patients with pituitary adenomas underwent pituitary surgery.
Conclusion: We present the largest cohort of children and adolescents
with hyperprolactinemia in the literature to date. Hyperprolactinemia is
more common in females and cabergoline is highly effective and practical
to use in adolescents, due to its biweekly dosing. Indications for
surgery in pediatric cases need to be revised