Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure

Despite significant improvement in therapy and management, heart failure remains a worrisome disease state that is especially problematic in special populations. African Americans suffer a disproportionately higher prevalence of heart failure when compared to other populations. It has been recently demonstrated that vasodilator therapy using the combination of isosorbide dinitrate (ISDN) and hydralazine (HYD) as an adjunct to background evidence-based therapy appears to display the strongest signal of benefit in reducing mortality and morbidity in the African American population. Through review of the retrospective and more recent prospective data, we will focus on the benefit of ISDN-HYD as adjunctive therapy for use in African Americans with systolic heart failure on concomitant appropriate evidence based therapy. This review also closely examines some of the potential contributions to endothelial dysfunction in African Americans, and the relationship of vascular homeostasis and nitric oxide. The role of oxidative stress in left ventricular dysfunction will also be explored as a reduction of oxidative stress offers particular promise in the management of heart failure. Although neurohormonal blockade has been responsible for notable event reductions in patients with systolic heart failure, the addition of ISDN-HYD, vasodilator therapy that enhances nitric oxide and reduces oxidative stress, further improves quality of life and survival in African American patients with heart failure. These findings strongly imply that nitric oxide enhancement and/or oxidative stress reduction may be important new therapeutic directions in the management of heart failure

Long Fight for Freedom

The Sixteenth Jacoby-Lunin Humanitarian Lecture underwritten by the Frank Jacoby Foundation in collaboration with the Carl and Dorothy Bennett Center for Judaic Studies and Open VISIONS Forum… A conversation with Damien Echols, one of the \u27West Memphis Three\u27 wrongfully convicted of killing three small boys. Echols, his wife Lorri, and attorney Stephen Braga \u2778 discuss the twisted road to justice.https://digitalcommons.fairfield.edu/bennettcenter-posters/1304/thumbnail.jp

Evolution of the leadership behavior of a newly assigned principal and the organizational climate of the school

The purposes of this study were to investigate the evolution of the school climate during the first year of a new principal's assignment to the school as perceived by the principal and the teachers; and to investigate the relationship between the school climate and the leadership behavior of the principal as perceived by the principal and the teachers. In addition, an investigation was made of the relationship between the teachers' perception of the principal's leadership behavior and the self-evaluated leadership behavior of the principal

Feasibility of utilizing the 200-inch Hale telescope as a deep-space optical receiver

Capturing the very faint optical communications signals expected from the Mars Laser Communication Demonstration (MLCD) experiment to fly aboard the Mars Telecommunications Orbiter (MTO) in 2009 requires a sensitive receiver placed at the focus of a large collecting aperture. For the purpose of demonstrating the potential of deep-space optical communication, it makes sense to employ a large astronomical telescope as a temporary receiver. Because of its large collecting aperture, its reputation as a well-run instrument, and its relative convenience, the 200-inch Hale Telescope on Palomar Mountain is being considered as a demonstration optical 'antenna' for the experiment. However, use of the telescope in this manner presents unique challenges to be overcome, the greatest of which is pointing the telescope and maintaining the communication link to within a few degrees of the Sun. This paper presents our candidate approaches for adapting the Hale telescope to meet the demonstration requirements, modifications to the facilities and infrastructure, the derivation of requirements for baffles and filters to meet the near-Sun pointing objectives, and initial data on the potential of candidate modifications to meet the requirements

Cultivating equality: delivering just and sustainable food systems in a changing climate

T oday, the world faces a greater challenge perhaps than ever before: tackling hunger and malnutrition in the face of climate change and increasing natural resource scarcity. Civil society, governments, researchers, donors, and the private sector are simultaneously debating and collaborating to find solutions. But the dialogue is over-emphasizing food production. Improving yields is important, particularly in places where there is not enough food or where food producers live in poverty. But simply producing more is not enough to tackle hunger. Furthermore, acknowledging that lack of food is not the sole cause of hunger is important. Inequality shapes who has access to food and the resources to grow it and buy it. It governs who eats first and who eats worst. Inequality determines who can adapt more readily to a changing climate. Hunger and poverty are not an accident – they are the result of social and economic injustice and inequality at all levels, from household to global. The reality of inequality is no truer for anyone than it is for women – half the world’s population, with far less than their fair share of the world’s resources. If we are to achieve the new Sustainable Development Goal of ending hunger by 2030, we must address the underlying inequalities in food systems. In a changing climate, agriculture and food systems must be sustainable and productive – but our efforts cannot end there. They must be profitable for those for whom it is a livelihood; they must be equitable, to facilitate a level playing field in the market, to secure rights to resources for food producers, and to ensure access to nutritious food for all; they must be resilient to build the capacity of populations vulnerable to economic shocks, political instability, and increasing, climate-induced natural hazards to recover and still lift themselves out of poverty

Revisiting the transatlantic divergence over GMOs: Toward a cultural-political analysis

'Revisiting the transatlantic divergence over GMOs: towards a cultural-political analysis' applies a constructivist perspective to the persistent transatlantic divergence over the regulation of GM foods and crops. Political economy and institutionalism have so far dominated the literature. Notwithstanding their crucial insights, this article argues that to achieve a better understanding of the nature and depth of transatlantic regulatory divergence, one should also study prevalent cultural values and identity-related public concerns regarding food and agriculture. These factors can be identified in public opinion trends and have fuelled Europeans' resistance, while contributing to relative regulatory stability in the US. By conceptualizing cultural contexts as catalytic structures, the article also differs from more explicitly discursive accounts of political mobilization. The cultural politics of agricultural biotechnology (agbiotech) relies both on pre-existing values and identities, on the one hand, and on the strategies (and material or other power resources) of political agents

Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution

Recent developments in PHENIX are reported that allow the use of reference-model torsion restraints, secondary-structure hydrogen-bond restraints and Ramachandran restraints for improved macromolecular refinement in phenix.refine at low resolution

Macromolecular X-ray structure determination using weak, single-wavelength anomalous data.

We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD) X-ray analysis with weak anomalous signal. With the use of partial models and electron density maps in searches for anomalously scattering atoms, testing of alternative values of parameters and parallelized automated model-building, this method has the potential to extend the applicability of the SAD method in challenging cases

Feasibility of utilizing the 200-inch Hale telescope as a deep-space optical receiver

Capturing the very faint optical communications signals expected from the Mars Laser Communication Demonstration (MLCD) experiment to fly aboard the Mars Telecommunications Orbiter (MTO) in 2009 requires a sensitive receiver placed at the focus of a large collecting aperture. For the purpose of demonstrating the potential of deep-space optical communication, it makes sense to employ a large astronomical telescope as a temporary receiver. Because of its large collecting aperture, its reputation as a well-run instrument, and its relative convenience, the 200-inch Hale Telescope on Palomar Mountain is being considered as a demonstration optical 'antenna' for the experiment. However, use of the telescope in this manner presents unique challenges to be overcome, the greatest of which is pointing the telescope and maintaining the communication link to within a few degrees of the Sun. This paper presents our candidate approaches for adapting the Hale telescope to meet the demonstration requirements, modifications to the facilities and infrastructure, the derivation of requirements for baffles and filters to meet the near-Sun pointing objectives, and initial data on the potential of candidate modifications to meet the requirements