231 research outputs found
Expatriates' salary expectations, age, experience and country image
Purpose: The purpose of this paper is to explain how candidates' expectations of salary in relation to job offers as expatriates in developing societies are related to country image and to age. Design/methodology/approach: Data were collected from over 500 engineers living in France, Portugal and Spain, evaluating two hypothetical expatriate proposals to six different African and Latin American countries. Multivariate hierarchical regression was applied to statistically detect significant predictors, with a broad range of control variables, to investigate expatriate salary expectations. Findings: Results evidence the role of age, seniority, previous international experience and culture attraction for the host country in influencing salary expectations for potential expatriate postings. These results are discussed at the light of selection, optimisation and compensation theory (SOC), conservation of resources theory (COR) and social identity theory. Practical implications: Findings call for multinational companies to consider age, individual background, career attributes and location concerns when evaluating salary expectations involved in expatriation to developing countries. Originality/value: The study shows how individual expectations about required salaries for accepting expatriate job offers in developing countries (hardly addressed in the extant literature) result from the potential for professional development opportunities and the responsibility of the jobs being offered, the country image, and the age and motivation of the individuals. Furthermore, it integrates research through use of SOC and COR theories.info:eu-repo/semantics/acceptedVersio
Influence of thirteen different strains of ericoid endomycorrhizae on rooting and growth of micropropagated azalea mollis
In the wild, most of the Ericaceae are mycorrhized by typical ericoid
endomycorrhizae thus overcoming the absence of root hairs and the difficulty of
absorption of some nutrients in low pH soils. Many authors studied the relationship
between root colonization and soil composition but only a few of them took in
consideration the species of the fungi mycorrhizing the roots. Our previous works on
Vaccinium pointed out the effects of different fungal strains on rooting and growth
of in vitro produced plants. The aim of this research was to study the effect of the
inoculum with different fungal strains on rooting, acclimatization and growth of the
deciduous Azalea mollis cv. Glowing Embers (Rhododendron japonicum),
micropropagated in vitro. Sterile microcuttings, planted on a sterilized turf
substrate, were inoculated with Hymenoschiphus ericae, seven different strains of
Oidiodendron maius, and some unidentified sterile mycelia, by superimposing the
rooting medium on a pure fungal culture in agar. Rooting time and percentage was
checked. Plant height and rosette diameter, leaf and shoot number of each plant
were measured one year after transferring to ex vitro conditions. All tested strains
were able to infect the roots of the azalea, but different effects were shown on
microcutting rooting time and percentage. Oidiodendron strains were generally more
effective than Hymenoschiphus on growth of established plantlets
Life cycle assessment of households in Santiago, Chile: Environmental hotspots and policy analysis
Indexación ScopusThe aim of this study is to assess the environmental impacts of household life cycles in Santiago, Chile, by household income level. The assessment considered scenarios associated with environmental policies. The life cycle assessment was cradle-to-grave, and the functional unit considered all the materials and energy required to meet an inhabitant’s needs for one year (1 inh/year). Using SimaPro 9.1 software, the Recipe Midpoint (H) methodology was used. The impact categories selected were global warming, fine particulate matter formation, terrestrial acidification, freshwater eutrophication, freshwater ecotoxicity, mineral resource scarcity, and fossil resource scarcity. The inventory was carried out through the application of 300 household surveys and secondary information. The main environmental sources of households were determined to be food consumption, transport, and electricity. Food consumption is the main source, responsible for 33% of the environmental impacts on global warming, 69% on terrestrial acidification, and 29% on freshwater eutrophica-tion. The second most crucial environmental hotspot is private transport, whose contribution to environmental impact increases as household income rises, while public transport impact increases in the opposite direction. In this sense, both positive and negative environmental effects can be generated by policies. Therefore, life-cycle environmental impacts, the synergy between policies, and households’ socio-economic characteristics must be considered in public policy planning and consumer decisions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.https://www.mdpi.com/2071-1050/13/5/252
Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking
Background: Biobanks are vital research infrastructures aiming to collect, process, store, and distribute biological specimens along with associated data in an organized and governed manner. Exploiting diverse datasets produced by the biobanks and the downstream research from various sources and integrating bioinformatics and "omics" data has proven instrumental in advancing research such as cancer research. Biobanks offer different types of biological samples matched with rich datasets comprising clinicopathologic information. As digital pathology and artificial intelligence (AI) have entered the precision medicine arena, biobanks are progressively transitioning from mere biorepositories to integrated computational databanks. Consequently, the application of AI and machine learning on these biobank datasets holds huge potential to profoundly impact cancer research. Methods: In this paper, we explore how AI and machine learning can respond to the digital evolution of biobanks with flexibility, solutions, and effective services. We look at the different data that ranges from specimen-related data, including digital images, patient health records and downstream genetic/genomic data and resulting "Big Data" and the analytic approaches used for analysis. Results: These cutting-edge technologies can address the challenges faced by translational and clinical research, enhancing their capabilities in data management, analysis, and interpretation. By leveraging AI, biobanks can unlock valuable insights from their vast repositories, enabling the identification of novel biomarkers, prediction of treatment responses, and ultimately facilitating the development of personalized cancer therapies. Conclusions: The integration of biobanking with AI has the potential not only to expand the current understanding of cancer biology but also to pave the way for more precise, patient-centric healthcare strategies
Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review
Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up
Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies
<p>Abstract</p> <p>Background</p> <p>Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation.</p> <p>Aim</p> <p>To test the efficacy of computer assisted image analysis (CAIA) applied to completely digitized slides and to assess its feasibility in routine practice and compare the results obtained using two different Ki67 monoclonal antibodies.</p> <p>Materials and methods</p> <p>315 consecutive breast cancer routinely immunostained for Ki-67 (223 with SP6 and 92 with MM1 antibodies previously examined by an experienced pathologist, have been re-evaluated using Aperio Scanscope Xs.</p> <p>Results</p> <p>Mean human Ki67 LI values were 36%± 14.% and 28% ± 18% respectively for SP6 and MM1 antibodies; mean CAM Ki67 LI values were 31%± 19% and 22% ± 18% respectively for SP6 and MM1. Human and CAIA evaluation are statistically highly correlated (Pearson: 0.859, p<0.0001), although human LI are systematically higher. An interobserver variation study on CAIA performed on 84 cases showed that the correlation between the two evaluations was linear to an excellent degree.</p> <p>Discussion</p> <p>Our study shows that a) CAIA can be easily adopted in routine practice, b) human and CAIA Ki67 LI are highly correlated, although human LI are systematically higher, c) Ki67 LI using different evaluation methods and different antibodies shows important differences in cut-off values.</p
The 2:1 cycloadducts from [3+2] 1,3-dipolar cycloaddition of nitrile oxide and vinylacetic acid. Synthesis and liquid crystal behaviour
Four liquid crystals (LC) 3,7a-bis(4-alkyloxyphenyl)-7,7a-dihydro-6H-isoxazolo[2,3-d][1,2,4]oxadiazol-6-yl)acetic acid (7a-d) were synthesised and the mesomorphic behaviour reported. The LCs were characterised as 2: 1 bisadducts, which were obtained from a double [3+2] 1,3-dipolar cycloaddition. In the first step, the cycloaddition of 4-alkyloxyphenylnitrile oxide (4a-d) and vinylacetic acid (5) gave the initial unobserved 1:1 cycloadducts 2-[3-(4-alkyloxyphenyl)-4,5-dihydroisoxazol-5-yl]acetic acid (6a-d). In the second step, the addition of a second equivalent of 4 to 6 yielded the 2: 1 bisadducts 7a-d without any traces of 6. All compounds 7a-d were unstable during the transition from the mesophase to the isotropic state upon first heating as evidenced by the large peaks in the differential scanning calorimetry traces. Due to the chemical instability of the compounds upon heating, the transition temperature related to the smectic C to smectic A transitions was acquired by means of an image processing method. X-Ray diffraction experiments were also used to analyse the liquid-crystalline phases. A theoretical calculation was performed using density functional theory (DFT) methods at the PBE1PBE/6-311+G(2d,p) level (with solvent effect) in order to get information about the energetic profile of the 2: 1 cycloaddition. DFT studies revealed that the cycloaddition process is controlled by the HOMO(dipolarophile) - LUMO(1,3-dipole), and that the double [3+2] 1,3-dipolar cycloaddition reaction is quite possible.CNPq [471194-2008-5]CAPESINCT-Catalise[PROCAD-2007/CAPES
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